2026 July-2 - 445 articles
Residential greenness has been consistently associated with multiple health benefits; however, the underlying molecular mechanisms remain insufficiently understood. DNA methylation-based epigenetic clocks have emerged as robust biomarkers of biologic...
Myocardial ischemia and reperfusion initiate spatially organized injury–repair programs that subsequently shape ventricular remodeling. Although cardiac fibroblasts are indispensable for scar formation, single-cell and spatial transcriptomic st...
A bidirectional relationship has been observed between COVID-19 and respiratory disorders, where respiratory comorbidities increase severity, and COVID-19 induces respiratory sequelae. The underlying biological and genetic mechanisms remain unclear....
Methylation of proteins is a critical post-translational modification that regulates diverse cellular processes, including signal transduction, protein stability, and enzymatic activity. The methyltransferase enzymes that catalyse the addition of suc...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an idiopathic, multisystem disorder marked by debilitating fatigue, post-exertional malaise, cognitive dysfunction and neuroinflammation. Its etiology remains unclear, yet emerging eviden...
Cancer progression is driven by dysregulated kinase signaling and apoptotic evasion across multiple malignancies. Although targeted kinase inhibitors have improved outcomes, resistance and toxicity remain major challenges. Natural phytochemicals offe...
In recent years, a novel class of highly stable multiprotein complexes, with molecular masses ranging from 1 to 2 MDa, has been identified in human milk, placenta, sea urchin eggs, and sea cucumbers. These complexes exhibit extraordinary stability, d...
Polyethylene terephthalate (PET) is one of the most widely used synthetic plastics and a major contributor to global plastic pollution because of its high resistance to degradation. Enzymatic degradation by PET hydrolases (PETase) has emerged as a su...
Obesity and obesity-associated hepatic steatosis represent major metabolic health challenges, yet effective pharmacological interventions remain limited. Rosmarinic acid (RA), a natural polyphenol, has been reported to exert anti-obesity effects; how...
Excessive adipose tissue expansion contributes to metabolic dysfunction, highlighting the need to identify compounds that restrain adipocyte differentiation without causing nonspecific cytotoxicity. This study investigated whether 2-O-methylhonokiol...
Electronic cigarettes (e-cigarettes) have gained widespread diffusion as a perceived safer alternative to conventional smoking, particularly among women of reproductive age. The present systematic review provides an overview of the current literature...
The liver’s regenerative capacity is essential for resection and transplantation, but chronic liver diseases compromise this ability. Conventional preoperative tests poorly predict regeneration in diseased livers, necessitating new intraoperati...
Fabry disease is a rare X-linked lysosomal storage disorder characterized by progressive glycosphingolipid accumulation and multisystem organ involvement. Globotriaosylsphingosine (Lyso-Gb3) has emerged as a promising biomarker of disease burden; how...
Perfluorotetradecanoic acid (PFTeDA), a long-chain per- and polyfluoroalkyl substance (PFAS), is highly persistent and bioaccumulative, yet its effects on soil bacterial communities remain poorly understood. This study evaluated the impact of PFTeDA...
Vascular dementia (VaD) represents a spectrum of neurodegenerative disorders driven by chronic or acute cerebral hypoperfusion, converging on the structural collapse of the neurovascular unit (NVU). While vascular mechanics and neuroinflammation have...
Astrocytes are increasingly recognized as key regulators of multiple sclerosis (MS) pathogenesis, known to actively influence neuroinflammation, blood–brain barrier integrity, leukocyte recruitment, glial scar formation, and tissue repair. Evid...
Terminal glial cells (TGCs) of cutaneous end-organ complexes have traditionally been regarded as structural and trophic elements, although they may also participate in mechanosensory processing. We performed an exploratory immunohistochemical and imm...
Halogen bonding develops when an electrophilic region associated with a covalently bonded halogen interacts attractively with a nucleophilic site on another same or different molecular entity. Here, we show that in many crystals in the Cambridge Stru...
Melatonin has evolved from its classical role as a pineal-derived circadian regulator to a molecule increasingly recognized for its mitochondrial and cytoprotective functions. This review examines the molecular mechanisms and translational implicatio...
Radiotherapy is a cornerstone of breast cancer treatment, but its efficacy is frequently limited by intrinsic and acquired radioresistance as well as dose-limiting toxicity to surrounding normal tissues. Nanoparticle-mediated radiosensitization has e...
The COVID-19 pandemic underscored the need to better characterize immune and molecular responses following SARS-CoV-2 infection and vaccination. Beyond antibody and cellular immunity, COVID-19 involves oxidative stress and DNA damage, affecting repai...
Temozolomide (TMZ) remains the cornerstone of chemotherapeutic agent for glioblastoma (GBM), yet intrinsic and acquired resistance severely limits its clinical benefit. While O6-methylguanine-DNA methyltransferase (MGMT)–mediated repair of TMZ-...
Biomarker discovery in sarcoidosis mechanisms represents an innovative research tool. Inflammatory responses in sarcoidosis patients were analyzed by flow cytometry to highlight CD8a+CD45+, CD45+CD8a−, CD4+CD19+, CD4+CD19−, CD3+CD56+CD16+...
Human skin is continuously exposed to microbial invasion and oxidative stress, highlighting the need for safe and effective natural skin-protective agents. This study aims to investigate the antibacterial, antioxidant, and anti-tyrosinase activities...
Inflammation is essential for host defense, but, when dysregulated, it contributes to tissue damage and chronic disease. MicroRNA-146a (miR-146a) is a well-recognized negative regulator of inflammatory signaling, primarily through suppression of the...
The prediction of the therapeutic response and of the patient outcome following neoadjuvant chemoradiotherapy (nCRT) in rectal cancer (RC) is still a challenging issue. The role of Annexin 1 (ANXA1) in the modulation of the tumor cells’ growth...
The Journal retracts the article “Inhibition of AKT2 Enhances Sensitivity to Gemcitabine via Regulating PUMA and NF-κB Signaling Pathway in Human Pancreatic Ductal Adenocarcinoma” [...]
Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease characterized by mucosal inflammation and epithelial barrier disruption. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, the principal cytos...
Brain-derived neurotrophic factor (BDNF) is a key mediator of central sensitization and chronic pain through activation of TrkB receptors. Although the Pannexin 1 (Panx1) channel has been implicated in chronic pain, its involvement in BDNF-TrkB signa...
Alcohol-related liver disease (ALD) and metabolic dysfunction and alcohol-related liver disease (MetALD) are increasingly recognised as biologically heterogeneous conditions, but circulating novel adipokines have not been systematically synthesised i...
Tay-Sachs disease is a rare genetic disorder characterized by the accumulation of GM2 ganglioside in neuronal lysosomes due to deficient β-hexosaminidase A (HexA) activity. Progressive GM2 storage leads to severe neurodegeneration, including dev...
The journal retracts the article “The Autophagic Process Occurs in Human Bone Metastasis and Implicates Molecular Mechanisms Differently Affected by Rab5a in the Early and Late Stages” [...]
Breast cancer is one of the prominent reasons of death in women. HER2 is a promising target to counter breast cancer. In the current research, a structure-based pharmacophore model was generated to map and screen CMNPD, a comprehensive database of ma...
Boar sperm freezability (SF) is an economically important trait that influences reproductive efficiency and genetic improvement in pigs. However, its genetic basis remains poorly understood. In this study, semen samples from 382 Duroc and 151 Yorkshi...
Posterior axis development during mammalian embryogenesis is driven by transient progenitor states that give rise to neural and mesodermal lineages, including neuromesodermal progenitors (NMPs). In vitro derivation of posterior progenitor populations...
Molecule Interacting with CasL 1 (MICAL1) is a flavoprotein monooxygenase that promotes filamentous actin (F-actin) depolymerization. Transcriptomic studies have linked MICAL1 downregulation to skeletal muscle atrophy and muscular dystrophy, yet its...
Obesity and type 2 diabetes mellitus (T2DM) are multifactorial disorders characterized by insulin resistance, chronic low-grade inflammation, adipose tissue dysfunction, and multi-organ metabolic impairment. MicroRNAs (miRNAs) act as post-transcripti...
Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are chronic inflammatory diseases resulting from complex interactions between host genetics, environmental factors, immune dysregulation, and the gut...
Phytotherapy has emerged as a promising strategy for the management of obesity and related metabolic disorders. In this context, species of the Physalis genus have been widely recognized in traditional medicine for their potential therapeutic effects...
Although the potential role of carbohydrate antigen 125 (CA125) in acute cellular rejection (ACR) has been explored, its role in antibody-mediated rejection (AMR) remains unclear. Since CA125 is associated with inflammation and congestion, we hypothe...
Periodontitis and cardiovascular disease share inflammatory, immune, endothelial, oxidative, and lipid-related pathways. Although sex-related differences are well established for many cardiovascular biomarkers, it remains unclear whether sex modifies...
Salivary adenoid cystic carcinoma (SACC) is an immunologically cold malignancy with limited response to current immunotherapies. Integrated transcriptomic profiling of peripheral blood, primary tumors, lung metastases, and a two-donor single-cell dat...
Despite extensive research, the complex relationship between cellular senescence, aging, and host–pathogen interactions remains incompletely understood. This paper aims to review cellular and molecular alterations of senescent cells and critica...
Neuroimmune dysregulation and altered pro- and anti-inflammatory signaling have been implicated in selected phenotypes of depressive and anxiety disorders. Interleukin-37 (IL-37), a member of the IL-1 family, exerts anti-inflammatory effects through...
Gastric cancer is strongly associated with chronic inflammation and dysregulated immune signaling. Molecules involved in purinergic and innate immune pathways, including Toll-like receptor 3 (TLR3), P2Y purinoceptor 2 (P2RY2), and pannexin-1 (PANX1),...
In the original publication [...]
Light heterogeneity shapes plant survival, yet how shade-tolerant species balance photoprotection and photosynthesis under changing light remains unclear. Tradescantia spathacea Sw, with green adaxial and purple-red abaxial leaf surfaces, exhibits bo...
Modulating the immune microenvironment has become an emerging strategy for promoting functional bone regeneration, identifying key therapeutic targets remains challenging. Our previous work showed that Nucleotide-binding oligomerization domain-like r...
Neuroglobin (NGB), initially identified for its oxygen-binding capacity in neuronal tissues, has emerged as a multifunctional protein involved in neuroprotection, oxidative stress regulation, and mitochondrial homeostasis. Although its functions have...
Arterial hypertension is a well-known risk factor for cardiac arrhythmias, while certain antihypertensive agents may also create conditions for arrhythmia occurrence. The aim of this study was to evaluate the effects of selected class III antiarrhyth...
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