Molecular Mechanisms and Therapy of Heart Failure
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 10 October 2026 | Viewed by 195
Editor
Special Issue Information
Dear Colleagues,
Heart failure (HF) is a complex clinical syndrome driven by diverse molecular and cellular mechanisms. Current trends in HF management have shifted toward incorporating SGLT2 inhibitors across all HF phenotypes. Despite these recommendations, mortality and morbidity rates for HF remain high because the mechanisms driving the disease are not purely metabolic and are heterogeneous in terms of pathophysiology, and patients often require multiple drug therapies to improve outcomes. For example, the HF phenotype HFpEF shows distinct population and gender prevalence as well as multi-organ involvement that are still under intense investigation, highlighting the need to understand the drivers of disease at the molecular level. This Special Issue aims to explore the molecular underpinnings of HF pathogenesis. We welcome original research articles and reviews focusing on signaling pathways, epigenetic regulation, metabolic derangements, hypertrophy, fibrosis, and emerging topics such as non-coding RNAs, gene therapy, and mechanisms related to organ/tissue-cross talk or sex-specific differences influencing HF pathophysiology. Submissions addressing translation, including preclinical models, drug development, and biomarker discovery, are especially encouraged. Contributions that integrate molecular data will be prioritized.
Dr. Ruth Magaye
Guest Editor
Manuscript Submission Information
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Keywords
- heart failure
- organ-cross talk
- metabolic derangements
- molecular mechansims
- sex differences
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