Molecular and Translational Mechanisms of Cardiac Arrhythmias: From Oxidative Stress to Novel Therapeutic Strategies

Dear Colleagues,

Cardiac arrhythmias, particularly atrial fibrillation, represent a major and growing global health burden, driven by complex interactions between molecular, cellular, and electrophysiological mechanisms. Increasing evidence highlights the central role of oxidative stress, inflammation, and structural and electrical remodeling in arrhythmia initiation and progression. This Special Issue will provide a comprehensive overview of the molecular and translational mechanisms underlying cardiac arrhythmias, bridging experimental discoveries and clinical relevance. We welcome original research articles and state-of-the-art reviews addressing mechanistic pathways, experimental models, and emerging therapeutic strategies, including pharmacological, device-based, and electrophysiological approaches. By integrating basic, translational, and clinically orientated research, this Special Issue will advance our understanding and foster innovation in arrhythmia prevention and treatment.

We are pleased to invite you to contribute to this Special Issue of International Journal of Molecular Sciences, focusing on the molecular and translational mechanisms of cardiac arrhythmias. Despite major advances in electrophysiology, arrhythmias such as atrial fibrillation remain associated with significant morbidity, mortality, and healthcare burdens. Growing evidence indicates that oxidative stress, molecular signaling pathways, and structural and electrical remodeling play a pivotal role in arrhythmogenesis. Understanding these mechanisms is essential in the development of more effective, personalized therapeutic strategies. This Special Issue will provide a platform for high-quality contributions that share molecular insights of translational and clinical relevance.

This Special Issue will highlight recent advances in the molecular, cellular, and translational mechanisms underlying cardiac arrhythmias and their therapeutic implications. This topic aligns closely with the scope of International Journal of Molecular Sciences by emphasizing molecular pathways, oxidative stress, signaling mechanisms, and experimental models while also extending to translational and clinically relevant applications. Fostering collaboration between basic scientists and clinicians, this Special Issue will comprise a focused yet comprehensive resource, including at least ten high-quality articles, with the potential for publication in book form.

Dr. Stefan Simović
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.