ijms-logo

Journal Browser

Journal Browser

Insights in Multiple Sclerosis (MS) and Neuroimmunology: 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 849

Special Issue Editor


E-Mail Website
Guest Editor
Department of Medicine, Neurology Division, University of Saskatchewan, Saskatoon, SK S7N 0X8, Canada
Interests: neurology; neuroscience; multiple sclerosis; RNA-binding proteins; neurodegeneration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue, “Insights in Multiple Sclerosis (MS) and Neuroimmunology: 2nd Edition”.

Neurodegeneration, defined as damage to neurons, oligodendrocytes, and axons, is now acknowledged to be the primary driver of disability in multiple sclerosis (MS) patients. Therefore, research into the mechanisms of neurodegeneration in MS has expanded over the past several years. Furthermore, with the development and implementation of more precise technologies, including sequencing and advanced imaging, we can more confidently define processes that cause damage to neurons, oligodendrocytes, and axons in MS.

For this Special Issue, “Insights in Multiple Sclerosis (MS) and Neuroimmunology”, we accept papers that explore the mechanisms of neurodegeneration, including those with an immunological mediator (i.e., macrophages, T-cells, B-cells, astrocytes, etc.). Reviews should highlight the most recent findings with regard to this topic and emphasize novel approaches that are helping advance this area of research. Original articles should demonstrate potential mechanisms of neurodegeneration—including damage to neurons, oligodendrocytes, and axons—in any MS models, including in vitro, in vivo, and in situ systems, with particular emphasis on immunological mediators. Original articles may also include potential therapies to combat neurodegeneration in MS.

This Special Issue is supervised by Prof. Dr. Michael C. Levin and assisted by Dr. Catherine Hutchinson. We warmly welcome the submission of short communications, original research articles, and review articles.

Prof. Dr. Michael C. Levin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurodegeneration
  • neuroimmunology
  • macrophage
  • T-cell
  • B-cell
  • antibody
  • neurons
  • oligodendrocytes
  • axon
  • axonal damage
  • cell death
  • multiple sclerosis

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issues

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

32 pages, 18012 KB  
Article
Early Reduction in Mitochondrial Membrane Potential in Synaptic Mitochondria Contribute to Synaptic Pathology in the EAE Mouse Model of Multiple Sclerosis
by Dalia R. Ibrahim, Karin Schwarz, Ajay Kesharwani, René Tinschert, Shweta Suiwal and Frank Schmitz
Int. J. Mol. Sci. 2026, 27(6), 2579; https://doi.org/10.3390/ijms27062579 - 11 Mar 2026
Viewed by 611
Abstract
Multiple sclerosis (MS) is a highly disabling chronic autoimmune disease of the central nervous system with neuroinflammatory and neurodegenerative alterations found in the white and grey matter of the brain. The pathogenesis of MS is complex and not fully understood. Mitochondrial dysfunctions are [...] Read more.
Multiple sclerosis (MS) is a highly disabling chronic autoimmune disease of the central nervous system with neuroinflammatory and neurodegenerative alterations found in the white and grey matter of the brain. The pathogenesis of MS is complex and not fully understood. Mitochondrial dysfunctions are suspected to play an important role. The visual system is often affected in MS. Optic neuritis is a frequent symptom, but also the retina itself, including retinal synapses appear compromised in MS independent from demyelination of the optic nerve. A previous study demonstrated synapse-specific alterations of mitochondria in photoreceptor synapses in the Experimental Autoimmune Encephalomyelitis (EAE) mouse model of MS at day 9 after injection, an early time point in pre-clinical EAE. In the present study, we analysed even earlier stages of pre-clinical EAE for possible alterations of synaptic mitochondria. For this purpose, we performed qualitative and quantitative immunolabelling analyses of the mitochondrial cristae organising protein MIC60 at retinal synapses and functional analyses by measuring synaptic mitochondrial membrane potential (during rest and depolarisation-induced exocytosis) and visually guided behaviour (optometry analyses). At day 3 after injection, morphological and functional data were indistinguishable between MOG/CFA-injected EAE mice and CFA-injected control mice. But already on day 5 after injection, we observed a decreased expression of the mitochondrial MIC60 protein at synaptic mitochondria, a decreased synaptic mitochondrial membrane potential at rest, an enhanced drop of mitochondrial membrane potential during stimulated exocytosis and a decreased visual performance of the respective EAE mice. These data argue that synaptic pathology in the EAE retina begins as early as day 5 after injection. Our data propose that dysfunctions of mitochondria play an important role already at the very early stages of synaptic pathology in EAE. Full article
(This article belongs to the Special Issue Insights in Multiple Sclerosis (MS) and Neuroimmunology: 3rd Edition)
Show Figures

Figure 1

Back to TopTop