Advances in Bone Homeostasis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 30 July 2026 | Viewed by 93
Special Issue Editor
Interests: exercise; immunology; microgravity; bone physiology; bone homeostasis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Bone is a living, dynamic tissue constantly renewed through the balanced activities of bone-forming osteoblasts and bone-resorbing osteoclasts. This delicate equilibrium—collectively termed bone homeostasis—is essential for maintaining skeletal integrity and mineral metabolism. Its disruption leads to a broad spectrum of disorders, including osteoporosis, osteoarthritis, and metabolic bone diseases, which represent major global health challenges.
In recent years, remarkable progress has been made in uncovering the molecular and cellular mechanisms governing bone remodeling. Advances in molecular biology, multi-omics technologies, single-cell sequencing, mechanobiology, and systems medicine have deepened our understanding of the complex interplay among osteogenic, immune, and metabolic pathways that sustain skeletal health.
This Special Issue of the International Journal of Molecular Sciences, “Advances in Bone Homeostasis,” invites high-quality original research articles, short communications, and comprehensive reviews that address emerging molecular mechanisms, signaling pathways, and translational strategies related to bone biology and pathology.
We particularly welcome submissions exploring novel therapeutic targets, regulatory molecules, and bioengineering approaches that may advance the prevention or treatment of skeletal disorders. Studies elucidating inter-organ crosstalk, such as bone–immune or bone–adipose interactions, are also highly encouraged.
Prof. Dr. John Kelly Smith
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- bone remodeling
- osteoblasts and osteoclasts
- osteoimmunology
- osteometabolism
- signaling pathways
- bone diseases
- epigenetic regulation
- extracellular vesicles
- mechanotransduction
- therapeutic targets
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