Advanced Molecular Research in Brain Tumors
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 February 2026 | Viewed by 445
Special Issue Editor
Special Issue Information
Dear Colleagues,
Treating brain tumors remains a major challenge due to therapy resistance, restrictive blood–brain and blood–glioma barriers, and immunosuppressive tumor microenvironments. Despite advances in drug development, prognosis remains poor, emphasizing the need for innovative solutions. Recent molecular insights into brain tumor biology have driven the development of targeted therapies, including tyrosine kinase, angiogenesis inhibitors, gene therapies, viro-therapies, and immuno-therapies. There is an ongoing effort for the development of sensitization strategies to enhance chemo- and radiotherapy efficacy. To foster active discussion and accelerate progress in this field, we invite the submission of original research articles and comprehensive reviews for our Special Issue "Advanced Molecular Research in Brain Tumors". This Special Issue aims to highlight cutting-edge discoveries revealing molecular mechanisms underlying brain tumor initiation, progression, and therapeutic resistance.
We welcome submissions exploring various aspects of brain tumor biology, including, but not limited, to the following: tumor pathogenesis, molecularly targeted therapies and resistance mechanisms, and the molecular basis of responses to DNA damage response (DDR)-targeted therapeutics. We also encourage the submission of studies on radio-sensitization strategies, immunotherapy, and tumor microenvironment modulation. Additionally, we invite articles utilizing single-cell and spatial multi-omics approaches, and research focused on liquid biopsy and biomarker discovery. We look forward to your contributions, which will advance the molecular understanding of critical factors that shape brain tumor progression and treatment outcomes.
Dr. Shiv K. Gupta
Guest Editor
Manuscript Submission Information
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Keywords
- targeted therapy
- blood–brain barrier
- GBM
- glioma
- immune checkpoint blockers
- TME
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