Novel Insights into Reproductive Toxicology

Dear Colleagues,

The aim of the Special Issue, entitled “Novel insights into reproductive toxicology”, is to update our knowledge of the possible toxicants capable of inducing ovarian toxicity, as well as its underlying molecular mechanisms. It has been known that the ovary represents a susceptible target for toxic compounds. Environmental substances, including pesticides, heavy metals, solvents and other pollutants, can represent a severe hazard for healthy ovarian functionality. Additionally, lifestyle habits such as smoking cigarettes, alcohol consumption, and the intake of certain drugs, foods and xenobiotics with gonadotoxic effects—including plastic components of resin containers used for food and drinks—may negatively influence female fertility.

Furthermore, an additional aim of the present Special Issue is to update the experimental data concerning the effects of possible teratogens and drug-induced birth defects. It is noteworthy that the current advancements in teratogenesis and the use of integrated molecular approaches (combination of transcriptomics and metabolomics, in addition to morphological evaluations) have enabled the considerable addition of information on the mechanisms of teratogenicity over the last decade. In view of the profound clinical relevance of this topic, experimental data in this perspective are needed.

Dr. Maria Cristina Budani
Guest Editor

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• endocrine disruptors
• environmental toxicants
• fertility
• heavy metals
• lifestyle habits
• molecular mechanisms
• pregnancy
• teratology
• teratogenic compounds
• reproductive toxicology