Modern Approaches in Regenerative Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 2
Special Issue Editors
Interests: genetics and epigenetics; neurosciences; cancer biology; cell fate; differentiation; reprogramming; stem cell biology; regenerative therapy; personalized therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Regenerative therapies are critically important for addressing socially significant diseases that currently lack effective pathogenetic or disease-modifying therapies. Developing and advancing such therapies creates novel treatment options for conditions such as neurodegenerative diseases, chronic injuries, cardiovascular disorders, and many other pathological conditions, ultimately improving patient outcomes and quality of life.
A broad spectrum of cell-based therapies—including the use of mesenchymal stromal/stem cells (MSCs) and other cell types—have shown potential in promoting tissue regeneration. In addition to cell-based therapies, acellular therapeutic options with reduced risk for patients are particularly promising. An example of such therapies is the use of cell-derived extracellular vesicles (EVs), including engineered/modified ones, delivering bioactive molecules and mediating cell-to-cell communication.
Biocompatible scaffolds (including those combined with electrostimulation and other complementary physical, cellular, or biochemical approaches) serve as instruments to provide structural support to regenerating tissue, mechanical and biochemical cues enhancing cell survival, and functional integration.
Various approaches to cellular reprogramming, applied both ex vivo and in situ, enable conversion of cells into pro-regenerative phenotypes or progenitor states to aid tissue repair and functional recovery. The rigorously selected, best-suited, and well-characterized in vitro and in vivo models provide valuable systems for studying mechanisms of tissue regeneration, developing and validating regenerative therapies, and facilitating clinical success in regenerative medicine.
Finally, advances in high-throughput transcriptomic, proteomic, metabolomic, genomic, and other omics technologies, combined with artificial intelligence and machine learning, play a crucial role in broadening our understanding of fundamental molecular and cellular mechanisms of complex regenerative processes. They allow for the identification of novel therapeutic targets, facilitate tissue regeneration or cell reprogramming, uncover previously unknown regenerative mechanisms and key pathways, and enable drug repositioning to enhance outcomes of regenerative therapy.
This Special Issue explores cutting-edge approaches to regenerative therapy, highlighting innovative curative strategies and molecular tools, and aims to cover the following topics:
- Cell-based (including the use of MSCs and other cell types) and cell-derived acellular curative approaches (including the use of EVs) in regenerative therapy;
- Development and application of biocompatible scaffolds for tissue regeneration;
- Various approaches to cellular reprogramming, applied both ex vivo and in situ;
- Systemic omics-driven insights into regeneration;
- In vitro and in vivo models to study tissue regeneration and develop regenerative therapies, approaches to large-scale manufacturing of regenerative therapy products.
In this Special Issue, original research articles and reviews are welcome.
Dr. Daria Chudakova
Dr. Vladimir P. Baklaushev
Guest Editors
Manuscript Submission Information
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Keywords
- regenerative therapy
- regeneration
- neuroregeneration
- cell reprogramming
- cell therapy
- regenerative bio-scaffolds
- extracellular vesicles
- mesenchymal stromal/stem cells (MSCs)
- cell differentiation
- omics technologies
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