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The Interactions Between Nutrients and Adipose Tissue

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 810

Special Issue Editor


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Guest Editor
1. Nutrigenomics and Exercise Biology Laboratory, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA
2. Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Interests: nutritional intervention; nutrients; metabolites; stem (progenitor) cell; myocytes; adipocytes

Special Issue Information

Dear Colleagues,

Adipose tissue plays a key role in metabolic health by actively responding to nutrient availability. When nutrient intake is balanced, adipose tissue helps maintain energy homeostasis by storing and releasing fat. However, excessive intake of calories, especially from unhealthy fats and sugars, can lead to adipose tissue dysfunction. This includes chronic inflammation, impaired insulin signaling, and abnormal secretion of adipokines, which contribute to metabolic disorders like obesity, insulin resistance, and type 2 diabetes. Moreover, the balance between white and brown adipose tissues, influenced by diet, affects energy expenditure, highlighting the importance of nutrition in metabolic regulation.

This Special Issue aims to explore how different nutrients influence the function of adipose tissue and, in turn, affect overall metabolic health. Understanding this relationship is key to preventing and managing metabolic disorders such as obesity and type 2 diabetes.

Dr. Junseok Son
Guest Editor

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Keywords

  • adipose tissue
  • nutrients
  • metabolic health
  • insulin resistance
  • inflammation
  • energy homeostasis
  • adipokines
  • obesity
  • lipolysis
  • thermogenesis

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Published Papers (1 paper)

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Research

12 pages, 1550 KB  
Article
Extracellular Vesicles from Lactobacillus rhamnosus BS-Pro-08, Kefir Grain, Suppress Adipogenesis and Enhance Lipolysis in Adipocytes
by Bi-Oh Park, Ho Woon Lee, Chang-Hyun Song, Miji Yeom, Seoungwoo Shin, Hyesoo Wang, Junbo Sim, Eunae Cho, Deokhoon Park and Eunsun Jung
Int. J. Mol. Sci. 2025, 26(23), 11732; https://doi.org/10.3390/ijms262311732 - 4 Dec 2025
Viewed by 252
Abstract
Extracellular vesicles (EVs) derived from probiotic bacteria have recently emerged as postbiotic mediators that regulate host cellular responses. This study investigated the effects of EVs from Lactobacillus rhamnosus BS-Pro-08, isolated from kefir grains (Lacto EV), on adipocyte differentiation and lipid metabolism. Lacto [...] Read more.
Extracellular vesicles (EVs) derived from probiotic bacteria have recently emerged as postbiotic mediators that regulate host cellular responses. This study investigated the effects of EVs from Lactobacillus rhamnosus BS-Pro-08, isolated from kefir grains (Lacto EV), on adipocyte differentiation and lipid metabolism. Lacto EV treatment markedly suppressed the differentiation of 3T3-L1 preadipocytes into mature adipocytes, as reflected by reduced lipid accumulation and decreased expression of the adipogenic transcription factors peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα). This inhibitory effect was most pronounced at the early stage of adipogenesis. In mature adipocytes, Lacto EV enhanced lipolysis in a dose-dependent manner, accompanied by increased glycerol release and total lipase activity. Interestingly, these lipolytic responses occurred despite reduced protein levels of adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL), suggesting that Lacto EVs may mediate an EV-enhanced lipolysis that is not fully explained by canonical ATGL/HSL signaling. Collectively, these findings demonstrate that Lacto EV modulates both adipogenic and lipolytic processes in vitro, providing insight into the metabolic actions of probiotic-derived vesicles. Full article
(This article belongs to the Special Issue The Interactions Between Nutrients and Adipose Tissue)
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