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Molecular Advances in Oral and Periodontal Health

Editors


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Guest Editor
Department of Oral Rehabilitation, Faculty of Dentistry, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Interests: oral health; laser in dentistry; laser coagulation; laser therapy; orthodontics

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Guest Editor
Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, Italy
Interests: oral surgery; periodontics; regenerative medicine; orthodontics; oral pathology; prevention of tumors and chronic diseases; prevention of oral health in children; clinical dentistry and oral medicine; endodontics; pedodontics

Special Issue Information

Dear Colleagues,

It is with great pleasure that we invite you to submit your manuscripts on one of the most current topics in dentistry: “Molecular Advances In Oral And Periodontal Health.

The history of the use of molecular advances in oral and periodontal health and the oral microbiome in dentistry is constantly evolving, thanks to the understanding of new therapies and treatments for inflammation and its causes.

These advances have been made possible by ongoing research into new therapies and in-depth study of systemic inflammation, increasingly based on “omics” (genomics, transcriptomics, proteomics, and metabolomics).

A modern approach often requires interdisciplinary and multidisciplinary skills.

Developments in interdisciplinary fields such as cardiology, diabetology, internal medicine, dentistry, and regenerative medicine have only been possible thanks to this collaboration.

Biomolecular studies have identified a close correlation between cognitive health, cardiovascular health, oral and periodontal health, and the oral microbiome.

This Special Issue will provide an excellent forum for bringing together different communities and publishing high-level research that will be useful for healthcare and, above all, for the prevention of chronic diseases.

To this end, we invite you to submit original research articles, reviews, and clinical or model-based studies that include biomolecular experiments or provide molecular insights into any of the above-mentioned topics.

Dr. Giuseppina Malcangi
Dr. Roxana Ioana Bordea
Dr. Grazia Marinelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dental disease
  • dental materials
  • orthodontic diseases
  • growth factor
  • regenerative tissue
  • peritonitis
  • regulatory T cells
  • systemic disease
  • systemic inflammation
  • scaling and root planning

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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23 pages, 950 KB  
Review
Candidate Biomarkers Linking Periodontitis with Atherosclerotic and Related Cardiovascular Phenotypes: A Systematic Review Focused on Sex-Specific Evidence
by Marco Severino, Angelo Michele Inchingolo, Francesca Calò, Claudia Ciocia, Francesco Inchingolo, Grazia Marinelli, Arianna Viarchi, Claudia Theodora Truppa, Andrea Palermo, Ioana Roxana Bordea, Alessio Danilo Inchingolo and Gianna Dipalma
Int. J. Mol. Sci. 2026, 27(14), 6495; https://doi.org/10.3390/ijms27146495 - 22 Jul 2026
Viewed by 596
Abstract
Periodontitis and cardiovascular disease share inflammatory, immune, endothelial, oxidative, and lipid-related pathways. Although sex-related differences are well established for many cardiovascular biomarkers, it remains unclear whether sex modifies biomarker patterns at the intersection of periodontal and cardiovascular disease. PubMed, Scopus, and Web of [...] Read more.
Periodontitis and cardiovascular disease share inflammatory, immune, endothelial, oxidative, and lipid-related pathways. Although sex-related differences are well established for many cardiovascular biomarkers, it remains unclear whether sex modifies biomarker patterns at the intersection of periodontal and cardiovascular disease. PubMed, Scopus, and Web of Science were searched in accordance with PRISMA 2020. Eligible adult human studies evaluated periodontitis or periodontal inflammation together with atherosclerotic or related cardiovascular phenotypes and reported candidate biomarkers in blood or, as supportive evidence, oral fluids. High-throughput omics studies were eligible when available. Data on study design, periodontal and cardiovascular assessment, biological matrix, biomarker findings, sex-stratified analyses, and menopausal status were extracted. Twelve studies were included. Most assessed single biomarkers or small predefined panels rather than discovery-scale omics. Reported markers involved inflammation and immunity (CRP, hs-CRP, IL-6, LPS, and periodontal antibodies), endothelial or vascular injury, lipid and autoimmune pathways (PCSK9 and anti-ApoA-1 IgG), innate-immune and metabolic regulation (MBL and SIRT1), cardiac stress, and oxidative stress. Findings were heterogeneous across cardiovascular phenotypes, and several key associations were null or imprecise. Only two studies performed direct male–female comparisons: one enrolled women only, and none stratified women by menopausal status. No study derived and validated a sex-specific omics signature. The literature identifies overlapping candidate-biomarker pathways but does not establish a causal, clinically validated, sex-specific, or menopause-specific signature of periodontitis-associated cardiovascular disease. The current evidence should be considered hypothesis-generating. Full article
(This article belongs to the Special Issue Molecular Advances in Oral and Periodontal Health)
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