2026 October-1 - 505 articles
The economic output of sea urchin aquaculture depends almost entirely on a single organ. Gonads, marketed as uni, determine value through their size, color, texture and flavor, and feed formulations have been optimized empirically for decades with li...
The gut microbiome is increasingly recognized as an important determinant of host immune regulation, intestinal homeostasis, and recovery after colorectal cancer (CRC) surgery. Although our previous randomized, double-blind, placebo-controlled clinic...
In the context of the global diabetes epidemic, diabetic nephropathy (DN)—a condition directly associated with diabetes—has become the primary cause of end-stage renal disease, significantly impacting patients’ quality of life and p...
Temporomandibular joint osteoarthritis (TMJ OA) is characterized by progressive degeneration of the fibrocartilaginous articular surface. We previously demonstrated that combined bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth fa...
Intraosseous lidocaine trigger point injection (LTPI) has been utilized for an extended period in the management of chronic vertebrogenic pain; yet, its molecular mechanisms and clinical efficacy require critical appraisal. This narrative review high...
Type 1 diabetes mellitus (T1DM) is an autoimmune disease involving progressive loss of pancreatic β-cells. Although B cells have been implicated in T1DM progression, the molecular characteristics associated with disease-related B-cell states rem...
Bladder cancer surveillance remains challenging because conventional methods do not fully capture the biological heterogeneity within histologically low-grade urothelial carcinoma (LGUC). We evaluated whether urinary DNA methylation profiling using B...
This prospective single-center cohort study evaluated changes in serum levels of novel adipokines and myokines, including isthmin-1 and irisin, as well as the advanced glycation end product (AGE)–soluble receptor for AGE (sRAGE) axis and monome...
The rising incidence of lung cancer is increasingly linked to fine particulate matter (PM2.5) exposure, highlighting its role as a risk factor of lung carcinogenesis. However, the molecular mechanisms behind PM2.5 and the disease remain incompletely...
Exiangsimiao (EXSM) is a high-yield and high-quality indica variety and restorer line. However, its grains are not sufficiently slender. In this study, the long-grain allele of the grain shape gene GL7/GW7 was introgressed into EXSM via marker-assist...
Automated analysis of cystoscopic images may support consistent characterization of bladder tissue patterns, but reported performance is highly sensitive to patient composition, data partitioning, and evaluation methodology. Objective: This study pro...
Radiotherapy can simultaneously promote tumor immunogenicity and damage the systemic immune compartments required to sustain antitumor responses. In breast cancer, radiation-induced lymphopenia is influenced by treatment geometry, irradiated volume,...
Waterpipe (shisha or hookah) smoking is recognized as a risk factor for lung cancer; however, its interference with hypoxia stress and tumor suppressor pathways in non-small cell lung cancer (NSCLC) is poorly defined. In this study, NSCLC cell lines...
Withaferin A (WA), a bioactive steroidal lactone derived from Withania somnifera, has been reported to exhibit diverse pharmacological activities, including anti-inflammatory and metabolic regulatory effects. Although previous studies suggest a poten...
Soybean (Glycine max) quality and metabolic composition are shaped by complex interactions between genetic background and agro-ecological conditions, making metabolic characterization across major production regions valuable for germplasm evaluation...
Food allergy is an IgE-mediated response of the immune system of sensitive subjects to specific proteins. The recent WHO/FAO consultation included hazelnut (Corylus avellana L.) in the list of global priority allergenic ingredients. One of the most c...
Itaconic acid (IA) is an important bio-based platform chemical with applications in the production of polymers, coatings, resins, and other value-added materials. However, its conventional microbial production relies predominantly on microorganisms t...
Epitalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide developed from the amino-acid composition of epithalamin, a chemically distinct pineal-derived polypeptide preparation. This narrative review evaluates the mechanistic, preclinical, and human evi...
Mitochondria are central regulators of cellular energy metabolism, stress responses, and physiological adaptation, with their functions depending on the coordinated interaction between mitochondrial DNA (mtDNA) and nuclear DNA (nDNA). These mito&ndas...
How sugars other than glucose affect trophoblast function is poorly understood, particularly under the metabolic stress of diabetic pregnancy. We compared glucose, fructose, and the minimally metabolized sugar allulose in two trophoblast cell lines,...
Transient Receptor Potential Ankyrin 1 (TRPA1) is a membrane cation channel activated by oxidative stress products that are chronically elevated in class III obesity. Although tissue-level TRPA1 biology is increasingly well described, the biological...
Psoriasis is a chronic, immune-mediated inflammatory disease affecting the skin, nails, and joints. Its complex pathogenesis results from interactions between genetic susceptibility and environmental factors and is accompanied by an increased risk of...
Immune thrombocytopenia (ITP) is the most common pediatric thrombocytopenia, characterized by immune-mediated platelet destruction and altered inflammatory responses. Among these alterations, mesenchymal stromal cells (MSCs) from ITP patients display...
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Annexin A2 (ANXA2) is involved in cell-surface fibrinolysis and has been associated with hepatocellular carcinoma (HCC). We examined ANXA2 expression in HCC and its associations with survival and immune–hemostatic gene expression. ANXA2 transcr...
Identifying the specific residues that initiate protein folding is critical for understanding protein stability and the mechanisms of misfolding-related diseases. However, the systematic, proteome-wide identification of these early folding residues (...
The study investigates the effect of cerium dioxide (CeO2) nanoparticles on ribosomal DNA (rDNA) transcriptional activity and the status of ribosomal genes in human skin fibroblasts. Nano-CeO2 has attracted attention due to its antioxidant and redox...
Renal ischemia–reperfusion (I/R) injury is a major cause of graft dysfunction. Flourensia cernua possesses antioxidant properties that may protect against this injury. This study evaluated its antioxidant capacity and nephroprotective effects i...
Clozapine (Clo) is the most effective antipsychotic for treatment-resistant schizophrenia (TRS), yet the mechanisms underlying its unique clinical profile remain insufficiently understood. Neuroactive steroids (NASs) influence neuronal excitability,...
The pursuit of efficient approaches for the production of promising antiviral and cytostatic pharmaceuticals is a crucial direction in medical biotechnology, especially after the COVID-19 pandemic. Modified nucleosides and nucleotides represent a hig...
Irritable bowel syndrome (IBS) is a prevalent yet poorly understood functional gut disorder frequently associated with microbial dysbiosis, making microbiome-targeting interventions a promising management strategy. In this study, we evaluated the mic...
AI-powered gene-based breeding (AI-GBB) has the potential to be a next-generation breeding technology. However, it is unclear whether agronomic genes identified with one population can be reliably used for AI-GBB across diverse populations, environme...
Carnivorous plants recruit defense-related pathways for prey digestion, yet the cis-regulatory architecture underlying their expression remains poorly characterized. In addition to herbivore and fungal pathogen responses, chitinases play an important...
Chronic tympanic membrane (TM) perforations remain a significant clinical problem due to limited spontaneous healing and the drawbacks of surgical interventions. The present study aimed to evaluate the effects of low-intensity infrared laser irradiat...
Staphylococcus haemolyticus is an opportunistic coagulase-negative staphylococcus increasingly recognized as an important reservoir of antimicrobial resistance within the One Health framework. However, comparative studies simultaneously evaluating is...
Organ-specific allocation of phenolic metabolites may shape antioxidant responses in Crocus species. This study characterized stamen, pistil, tepal, perigon tube, and corm of Crocus cancellatus Herb. using ultrasound-assisted methanolic extraction, l...
We investigated the antiradical properties of antioxidants: carnitinate 2-ethyl-6-methyl-3-hydroxypyridine (CAR-3-HP) and carboxychromate-2-ethyl-6-methyl-3-hydroxypyridine (CCR-3-HP), and also assessed the mitochondrial response to stress (hypoxia)...
Autism spectrum disorder (ASD) is a genetically heterogeneous condition; however, genomic data from Latin American populations remain limited. We investigated the molecular and phenotypic landscape of ASD in 916 Colombian patients who underwent whole...
Myocardial fibrosis is a major pathological component of cardiac remodelling and contributes to ventricular stiffness, impaired myocardial function, heart failure progression, and arrhythmic vulnerability across a broad spectrum of cardiomyopathies....
Multimodal prehabilitation aims to enhance resilience to cancer therapy through exercise, nutrition, and psychological optimization. While prehabilitation can improve physical condition and functional status, its biologic influence on the tumor micro...
Knee osteoarthritis (OA) is highly prevalent in women and is characterized by structural joint alterations and synovial inflammatory processes that contribute to pain and impaired mobility. In a previous study, we identified a positive correlation be...
Food adulteration and species mislabeling represent important challenges for food safety, regulatory control, and consumer protection, particularly for products requiring species-specific authentication. This study investigated two complementary anal...
The clinical response to elexacaftor/tezacaftor/ivacaftor (ETI) in people with cystic fibrosis carrying the rare cystic fibrosis transmembrane conductance regulator (CFTR) variant W1282R has not been well characterized. We retrospectively analyzed 12...
It is known that the progressive climate changes and environmental pollution prevalent all over the world lead to increasingly frequent and prolonged episodes of stress, and it challenges plants to adapt to changing adverse conditions. Given the sign...
Drought stress severely limits rice growth, while roots play a key role in sensing water deficits and triggering adaptive responses. To investigate time-dependent molecular responses in rice (Oryza sativa L. cv. Koshihikari) under drought stress indu...
Parathyroid hormone 1 receptor (PTH1R) regulates chondrocyte differentiation and mandibular condylar cartilage development, but its contribution to adult mandibular morphology remains unclear. We investigated associations of two PTH1R single-nucleoti...
Leishmania (L.) major modulates host microRNA (miR) expression to promote intracellular survival, yet the roles of specific miRs during early infection of human macrophages remain poorly defined. We investigated the dynamic regulation of miR-21-5p an...
Unc-51-like autophagy-activating kinase 1 (ULK1), a serine/threonine kinase, is the central regulator of autophagy initiation and plays a crucial role in cellular homeostasis, metabolic adaptation, and stress responses. We performed a large-scale pho...
Currently, there is no doubt that insulin resistance (IR) in prediabetes and type 2 diabetes mellitus (T2DM) is associated with chronic systemic metabolic inflammation (SMI). SMI is typically considered a form of low-grade systemic inflammation (LGSI...
Legg–Calvé–Perthes disease (LCPD) is a rare pediatric disorder characterized by avascular osteonecrosis of the femoral head. Its pathogenesis is multifactorial, and genetic, epigenetic, vascular, and inflammatory mechanisms may con...
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