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31 Results Found

  • Article
  • Open Access
1 Citations
1,534 Views
13 Pages

Rapid Identification of Constituents in Polygonatum cyrtonema Hua Using UHPLC-Q-Exactive Orbitrap Mass Spectrometry

  • Qingrui Yang,
  • Jieyao Ma,
  • Shenlong Yan,
  • Suyu Yang,
  • Lingxuan Fan,
  • Yanghui Huo,
  • Bowen Gao and
  • Wei Cai

5 February 2025

Polygonatum cyrtonema Hua (PCH) belongs to the genus Polygonatum Mill of the Liliaceae family. As a traditional tonic herb, the rhizome of PCH has been widely used as a functional food and traditional Chinese medicine, mainly for the treatment of spl...

  • Article
  • Open Access
7 Citations
2,749 Views
18 Pages

8 December 2023

Cannabinoids are an important group of secondary metabolites found in the plant Cannabis sativa L. The growing interest in the use of hemp in food production (e.g., hemp teas, hemp cookies) makes it necessary to develop a method for determining these...

  • Article
  • Open Access
1,568 Views
13 Pages

A Systematic Method for the Identification of Oligosaccharide Constituents in Polygonatum cyrtonema Hua Using UHPLC-Q-Exactive Orbitrap Mass Spectrometry

  • Suyu Yang,
  • Bowen Gao,
  • Qingrui Yang,
  • Yanghui Huo,
  • Kailin Li,
  • Liangyin Shu,
  • Lingxuan Fan,
  • Yiliang Liu,
  • Huanting Li and
  • Wei Cai

24 March 2025

A Polygonatum cyrtonema Hua (PCH) is a common medicinal and edible plant whose rhizomes are widely used for the treatment and prevention of various diseases. Previous studies have revealed a variety of chemical components such as polysaccharides, sap...

  • Communication
  • Open Access
46 Citations
9,720 Views
8 Pages

The Paeonia genus, an important source of crude drugs, has been extensively used in traditional Chinese medicine (TCM) to treat cardiovascular and female-related diseases. Although many peony species have been investigated, the study of Paeonia rocki...

  • Article
  • Open Access
1,577 Views
11 Pages

29 March 2025

Gelatin from deer has garnered attention as a high-value health-promoting resource given its history of usage as a traditional Chinese medicine and recent studies demonstrating its biological activities. Mass spectrometry-based methods have increasin...

  • Article
  • Open Access
16 Citations
4,612 Views
15 Pages

Unraveling the Formation Mechanism of Egg’s Unique Flavor via Flavoromics and Lipidomics

  • Zheng Zhou,
  • Shuang Cui,
  • Jing Che,
  • Yuying Zhang,
  • Dayong Zhou,
  • Xuhui Huang and
  • Lei Qin

10 January 2024

Egg products after thermal treatment possess a unique flavor and are favored by consumers. In this study, the key aroma-active compounds of egg yolk products and their formation mechanism during thermal treatment were investigated. The volatile aroma...

  • Article
  • Open Access
1,082 Views
12 Pages

In-Depth Exploration of Chemical Constituents from Justicia procumbens L. Through UHPLC-Q-Exactive Orbitrap Mass Spectrometry

  • Liangjun Guan,
  • Huibin Luo,
  • Siqiong Liu,
  • Xinrong Ming,
  • Mengdie Hu,
  • Lan Luo,
  • Jingyi Tan and
  • Shunli Xiao

30 August 2025

Justicia procumbens L. (JP) has been traditionally used to treat colds with fever, swollen and sore throat, jaundice, malaria and eczema. Studies indicate that lignans constitute the primary bioactive components, yet systematic phytochemical investig...

  • Article
  • Open Access
932 Views
11 Pages

22 August 2025

Daphne odora is an evergreen shrub belonging to the Thymelaeaceae family that is widely cultivated as an ornamental garden plant. Its roots, leaves, and flowers have traditionally been used in Chinese medicine to treat pain, skin diseases, and rheuma...

  • Article
  • Open Access
11 Citations
3,435 Views
22 Pages

Systematically Exploring the Chemical Ingredients and Absorbed Constituents of Polygonum capitatum in Hyperuricemia Rat Plasma Using UHPLC-Q-Orbitrap HRMS

  • Huanyu Guan,
  • Pengfei Li,
  • Qian Wang,
  • Fanli Zeng,
  • Daoping Wang,
  • Mei Zhou,
  • Meng Zhou,
  • Xun He,
  • Shanggao Liao and
  • Weidong Pan

Polygonum capitatum as an ethnic medicine has been used to treat urinary tract infections, pyelonephritis and urinary calculi. In our previous study, P. capitatum was found to have anti-hyperuricemia effects. Nevertheless, the active constituents of...

  • Article
  • Open Access
16 Citations
4,679 Views
17 Pages

11 February 2021

The roots of Fissistigma oldhamii (FO) are widely used as medicine with the effect of dispelling wind and dampness, promoting blood circulation and relieving pains, and its fruits are considered delicious. However, Hakka people always utilize its abo...

  • Article
  • Open Access
8 Citations
2,985 Views
16 Pages

7 November 2022

Sabia schumanniana Diels (SSD) is a plant whose stems are used in traditional folk medicine for the treatment of lumbago and arthralgia. Previous studies have revealed chemical constituents of SSD, including triterpenoids and aporphine alkaloids. Apo...

  • Article
  • Open Access
9 Citations
5,181 Views
17 Pages

18 September 2021

In our previous study, intravenous (IV) injection of selenium alleviated breast cancer-related lymphedema (BCRL). This secondary analysis aimed to explore the metabolic effects of selenium on patients with BCRL. Serum samples of the selenium-treated...

  • Article
  • Open Access
1,236 Views
21 Pages

Unlocking the Anti-Breast Cancer Potential of Aralia chinensis L.

  • Juan Xue,
  • Lei Li,
  • Yongjia Shu,
  • Chengshi Xie,
  • Tian Lu and
  • Huifang Chai

Aralia chinensis L. has shown potential in breast cancer treatment, yet its pharmacodynamically active components and mechanisms remain undefined. To systematically identify the bioactive constituents absorbed into the bloodstream and elucidate their...

  • Article
  • Open Access
1,532 Views
20 Pages

Biocontrol Effect of Bacillus velezensis D7-8 on Potato Common Scab and Its Complete Genome Sequence Analysis

  • Yu Jiang,
  • Pengfei He,
  • Huihui Kong,
  • Pengbo He,
  • Yixin Wu,
  • Guowen Tang,
  • Ping Tang,
  • Yining Di,
  • Xingyu Li and
  • Yueqiu He
  • + 2 authors

Potato common scab, caused by Streptomyces species, is a widespread soil-borne disease that poses a significant threat to potato cultivation globally. In this study, a Bacillus velezensis D7-8 strain was isolated from a potato. This endophytic bacter...

  • Article
  • Open Access
6 Citations
2,877 Views
19 Pages

28 February 2023

Genistin, an isoflavone, has been reported to have multiple activities. However, its improvement of hyperlipidemia is still unclear, and the same is true with regard to its mechanism. In this study, a high-fat diet (HFD) was used to induce a hyperlip...

  • Article
  • Open Access
3 Citations
1,236 Views
18 Pages

Assessment of Pesticide Contamination of Groundwater from Titu-Sarata Plain, Romania

  • Crinela Dumitrescu,
  • Claudia Stihi,
  • Diana Costinel,
  • Elisabeta Irina Geana,
  • Corina Teodora Ciucure,
  • Diana Ionela Popescu (Stegarus),
  • Danut Tanislav and
  • Petre Bretcan

23 May 2025

In Romania, groundwater is an important source of drinking water, especially in rural areas. This study investigated the concentrations of organophosphorus, carbamate, and triazine pesticides (OPs) along with organochlorine pesticides (OCPs) in groun...

  • Article
  • Open Access
12 Citations
3,062 Views
25 Pages

Citri Reticulatae Pericarpium Viride (CRPV) is the processed product of Citrus reticulata Blanco. We systematically analyzed two CRPV types, Geqingpi (GQP) and Sihuaqingpi (SHQP), based on powder color, microscopic characteristics, and chemical compo...

  • Communication
  • Open Access
29 Citations
3,551 Views
13 Pages

Standards-Based UPLC-Q-Exactive Orbitrap MS Systematically Identifies 36 Bioactive Compounds in Ampelopsis grossedentata (Vine Tea)

  • Rongxin Cai,
  • Xican Li,
  • Chunhou Li,
  • Jiayi Zhu,
  • Jingyuan Zeng,
  • Jianwu Li,
  • Boxu Tang,
  • Zheng Li,
  • Shuqin Liu and
  • Yan Yan

Ampelopsis grossedentata (vine tea) has been used as a detoxifying beverage in China for centuries. To systematically identify its bioactive compounds, the study adopted standards-based ultra-high-performance liquid chromatography coupled with quadru...

  • Article
  • Open Access
6 Citations
3,329 Views
11 Pages

31 December 2022

Objective: To find the metabolomic characteristics of tumor or para-tumor tissues, and the differences in serums from papillary thyroid cancer (PTC) patients with or without lymph node metastasis. Methods: We collected serums of PTC patients with/wit...

  • Article
  • Open Access
1,516 Views
20 Pages

Detection of Cereibacter azotoformans-YS02 as a Novel Source of Coenzyme Q10 and Its Metabolic Analysis

  • Meijie Song,
  • Qianqian Xu,
  • Rifat Nowshin Raka,
  • Chunhua Yin,
  • Xiaolu Liu and
  • Hai Yan

Coenzyme Q10 (CoQ10), a high-value-added nutraceutical antioxidant, exhibits an excellent ability to prevent cardiovascular disease. Here, a novel Cereibacter azotoformans strain, designated YS02, was isolated for its ability to produce CoQ10 and gen...

  • Article
  • Open Access
22 Citations
3,943 Views
19 Pages

29 June 2021

Polygoni Multiflori Radix Praeparata (PMRP), as the processed product of tuberous roots of Polygonum multiflorum Thunb., is one of the most famous traditional Chinese medicines, with a long history. However, in recent years, liver adverse reactions l...

  • Article
  • Open Access
2 Citations
2,283 Views
16 Pages

In Vivo Metabolite Profiling of DMU-212 in ApcMin/+ Mice Using UHPLC-Q/Orbitrap/LTQ MS

  • Jing Li,
  • Xinghua Li,
  • Xiaohang Zhou,
  • Le Yang,
  • Hui Sun,
  • Ling Kong,
  • Guangli Yan,
  • Ying Han and
  • Xijun Wang

30 April 2023

3,4,5,4’-Trans-tetramethoxystilbene (Synonyms: DMU-212) is a resveratrol analogue with stronger antiproliferative activity and more bioavailability. However, the metabolite characterization of this component remains insufficient. An efficient s...

  • Article
  • Open Access
10 Citations
2,372 Views
17 Pages

15 December 2022

Gentiana macrophylla Pall. (G. macrophylla)—a member of the family Gentianaceae—is a well-known traditional Chinese medical herb. Iridoids are the main active components of G. macrophylla, which has a wide range of pharmacological activit...

  • Article
  • Open Access
24 Citations
4,487 Views
17 Pages

3 November 2021

Panax ginseng was employed in the treatment of “Xiao-Ke” symptom, which nowadays known as diabetes mellitus, in traditional Chinese medicine for more than a thousand years. Ginsenoside Re was the major pharmacologic ingredient found abundantly in gin...

  • Article
  • Open Access
27 Citations
3,518 Views
15 Pages

Screening of Regulated and Emerging Mycotoxins in Bulk Milk Samples by High-Resolution Mass Spectrometry

  • Gabriele Rocchetti,
  • Francesca Ghilardelli,
  • Francesco Masoero and
  • Antonio Gallo

28 August 2021

In this work, a retrospective screening based on ultra-high-performance liquid chromatography (UHPLC) coupled with high-resolution mass spectrometry (HRMS) based on Orbitrap-Q-Exactive Focus™ was used to check the occurrence of regulated and emerging...

  • Article
  • Open Access
15 Citations
5,504 Views
17 Pages

Investigation of Equine In Vivo and In Vitro Derived Metabolites of the Selective Androgen Receptor Modulator (SARM) ACP-105 for Improved Doping Control

  • Malin Nilsson Broberg,
  • Heather Knych,
  • Ulf Bondesson,
  • Curt Pettersson,
  • Scott Stanley,
  • Mario Thevis and
  • Mikael Hedeland

1 February 2021

Selective Androgen Receptor Modulators (SARMs) have anabolic properties but less adverse effects than anabolic androgenic steroids. They are prohibited in both equine and human sports and there have been several cases of SARMs findings reported over...

  • Article
  • Open Access
907 Views
17 Pages

10 October 2025

An integrative approach combining network pharmacology, molecular docking, and cellular assays was used to elucidate the potential mechanisms by which the n-butanol extract of Biebersteinia heterostemon ameliorates type 2 diabetes mellitus (T2DM). Ch...

  • Communication
  • Open Access
6 Citations
2,911 Views
11 Pages

2 February 2023

Royal jelly is a specific product secreted by honeybees, and has been sought after to maintain health because of its valuable bioactive substances, e.g., lipids and vitamins. The lipids in royal jelly come from the bee pollen consumed by honeybees, a...

  • Article
  • Open Access
4 Citations
3,263 Views
15 Pages

Potential and Metabolic Pathways of Eugenol in the Management of Xanthomonas perforans, a Pathogen of Bacterial Spot of Tomato

  • Mustafa Ojonuba Jibrin,
  • Qingchun Liu,
  • Timothy J. Garrett,
  • Jeffrey B. Jones and
  • Shouan Zhang

24 November 2022

Bacterial spot of tomato continues to pose a significant problem to tomato production worldwide. In Florida, bacterial spot of tomato caused by Xanthomonas perforans is one of the most important diseases responsible for tomato yield loss. This diseas...

  • Article
  • Open Access
788 Views
30 Pages

19 November 2025

Background: Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow. (ZS) is a valuable plant with diverse economic applications, as all its organs contain bioactive secondary metabolites. The seeds, known as Suanzaoren in traditional Chinese med...

  • Article
  • Open Access
16 Citations
4,359 Views
13 Pages

Mycotoxin Occurrence and Risk Assessment in Gluten-Free Pasta through UHPLC-Q-Exactive Orbitrap MS

  • Josefa Tolosa,
  • Yelko Rodríguez-Carrasco,
  • Giulia Graziani,
  • Anna Gaspari,
  • Emilia Ferrer,
  • Jordi Mañes and
  • Alberto Ritieni

25 April 2021

Celiac disease (CD) is a genetic-based autoimmune disorder which is characterized by inflammation in the small intestinal mucosa due to the intolerance to gluten. Celiac people should consume products without gluten, which are elaborated mainly with...