Search Results (5,134)

Population aging intensifies the need for built environments that support healthy and independent living while reducing preventable risks. This integrative review examines how architectural design, safety measures, and corporate security can function as an integrated, layered system for creating age-friendly environments across public spaces, housing, and intergenerational community settings. Drawing on a systematic search of literature published between 2010 and 2026 across databases including Scopus, Web of Science, Google Scholar, and PubMed, supplemented by international standards and policy documents, the review analyses how universal design principles, injury prevention strategies, and governance routines intersect to sustain mobility, reduce harms, and protect data, devices, and operational continuity. The findings indicate that gaps in any layer, such as inaccessible layouts, poorly maintained safety systems, or weak cybersecurity, can undermine overall effectiveness, compromise trust, and affect older adults’ autonomy. The COVID-19 pandemic further exposed these interdependencies, accelerating smart technology adoption while exacerbating digital inequality and social isolation, particularly in rural settings. This review concludes that age-friendly environments require not only barrier-free architecture and proportionate safety measures, but also robust governance structures that ensure accountability, lifecycle maintenance, and responsible data practices. Integrating these three domains provides a foundation for resilient, trustworthy, and health-promoting environments that enable older adults to remain active, socially connected, and secure. Full article

The digital preservation and dissemination of historical and cultural heritage is a pivotal area at the intersection of digital humanities and geographic information science. To address the challenges of multi-source heterogeneity, limited dimensionality, and inadequate public engagement, this study designed and implemented an interactive visualization platform using modern Web technologies. Taking the Leshan Confucian Temple (religious heritage) and the former site of Wuhan University (educational heritage) as case studies, the platform integrates four types of heterogeneous data (geospatial coordinates, architectural attributes, visitor behavioral records, and multimedia imagery) into a unified spatiotemporal information model. Core technical implementations are built upon a lightweight front-end stack including the Gaode Map JavaScript API for geographic visualization, ECharts for dynamic statistical charting, and the Tailwind CSS framework for a fully responsive front-end interface. Key interactive features encompass linked map markers with contextual information windows, user-driven chart filtering, and paginated loading of cultural relic cards. Evaluation results demonstrate that the platform achieves cross-device response delay ≤3 s, supports spatially grounded, dynamic, and presentation of cultural heritage information, and attains a System Usability Scale (SUS) score of 82.5. This work offers a lightweight, scalable technical solution for advancing digital recording and public communication of historical and cultural heritage, while contributing to the theoretical discourse on spatial narrative and multi-source data integration in digital humanities. Full article

The skin–brain axis constitutes a complex, bidirectional network integrating cutaneous sensory, immune, and neuroendocrine systems with central neural circuits involved in emotion regulation, stress responsivity, and social cognition. Advances in psychodermatology and cosmetic science have progressively extended this framework to the emerging field of neurocosmetics, which explores how topical formulations, sensorial properties, and cutaneous neuromodulators may influence psychological well-being, affective states, and perceived stress. The aim of this narrative review is to synthesize current evidence on the biological foundations of the skin–brain axis and to critically examine the implications of these mechanisms for neurocosmetic interventions from a psychological and psychiatric perspective. It describes the biological substrates underlying skin–brain communication, including the cutaneous hypothalamic–pituitary–adrenal axis, neuropeptides, neurotrophins, transient receptor potential channels, and endocannabinoid signaling, and examines how these pathways are targeted by neurocosmetic interventions. Particular attention is devoted to neuroactive compounds, such as peptides, cannabinoids, botanicals, and aromatherapeutic molecules, as well as to sensorial strategies involving texture, temperature, and olfactory cues, which may modulate mood, anxiety, and self-perception through peripheral mechanisms. From a psychological and psychiatric perspective, the review discusses the intersection between stress-related skin conditions, body image disturbances, and emotional dysregulation, highlighting how cosmetic practices may influence subjective well-being beyond purely aesthetic outcomes. Methodological limitations of the existing literature, including the heterogeneity of study designs and outcome measures, as well as ethical considerations related to mood- and stress-related claims in cosmetic products, are critically examined. Finally, future research directions are outlined, and a translational framework is proposed to integrate dermatology, neuroscience, and mental health within next-generation cosmetic science. Full article

Background/Objectives: Aging is associated with physiological, biochemical, and psychosocial changes that can significantly affect nutritional status and overall health. In Sub-Saharan Africa (SSA), older adults face unique age-related challenges that may compromise healthy aging, yet evidence remains fragmented. This systematic review synthesized the existing literature on the nutritional status, age-related challenges, and strategies to promote healthy aging of older adults in SSA. Methods: A systematic literature search was conducted on PubMed, Scopus, ScienceDirect, and Cochrane Library to identify relevant studies published up to 10 December 2025. Results: Fifty-five studies met the inclusion criteria, with most of the studies coming from South Africa, Ghana, and Nigeria. Amongst community-dwelling populations, approximately 30–65% of the older adults were either malnourished or at risk of malnutrition, while hospital-based studies reported markedly higher burdens, with malnutrition prevalence exceeding 70% in some settings. Undernutrition, micronutrient deficiencies, and the coexistence of overweight and obesity were frequently observed, reflecting the region’s ongoing nutrition transition. Frailty emerged as the predominant age-related challenge, with prevalence ranging around 10–60%. Other common challenges included sarcopenia, reduced muscle strength, functional disability, cognitive impairment, and dysphagia, all of which were closely related to poor nutritional status, food insecurity, multimorbidity, and reduced quality of life. Few studies reported on healthy aging strategies, with the limited evidence suggesting that nutrition education, physical activity, and psychosocial interventions may enhance nutritional and functional outcomes. Conclusions: The need for context-specific, nutrition-sensitive interventions, and stronger health and social support systems is warranted to promote healthy aging in SSA older adults. Full article

This research, funded by the National Science Foundation (Award #2412054) as part of the NH-LIFT project, provides a critical analysis of a successful public health initiative addressing food insecurity in New Hampshire, which affects nearly 10% of residents and 13.4% of children. The study’s primary objective was to analyze the effectiveness, unique characteristics, and replicability of The Community Kitchen’s Mobile Food Pantry program in collaboration with the Healthy Monadnock Alliance and Cheshire Medical Center. Methods: A survey design was employed over a four-week period (July–August 2025) to collect qualitative data from n = 97 voluntary participants attending mobile pantry events in four rural southwest New Hampshire towns, Gilsum, Richmond, Winchester, and Fitzwilliam, during the period of May-June of 2025. The anonymous, 25-question instrument gathered information on program benefits and needed improvements. Results indicate the model is highly effective in mitigating increased financial stressors and overcoming transportation barriers, which are critical challenges for families and aging adults in this rural region. While demonstrating success in promoting local health and well-being, the research also highlights factors crucial for long-term sustainability. This study contributes to an evidence-based public health model suitable for replication in other food-insecure rural communities. Full article

Home Energy Management Systems (HEMS) are increasingly positioned at the center of residential flexibility, particularly as homes integrate photovoltaics, battery storage, electric vehicles, and responsive loads. This systematic review examines recent advances in optimization and multi-asset coordination for HEMS. Searches were conducted in Scopus, Web of Science, IEEE Xplore, and ScienceDirect for studies published between 2020 and 2025; after screening and eligibility assessment, 90 studies were included. The findings indicates that deterministic optimization remains well suited to structured scheduling problems, whereas metaheuristic, hybrid, and learning-based methods are better able to address nonlinearity, uncertainty, and real-time adaptation. Across the reviewed literature, multi-asset integration generally improves cost, peak demand, self-consumption, and, in some cases, user comfort and emissions. Yet the field remains dominated by simulation-based validation. Future progress of HEMS will depend on real-world validation, interoperable system design, explainable control, and stronger alignment with user behavior, communication constraints, and regulatory frameworks. Full article

Genome Analysis Toolkit (GATK) is a rigorously maintained collection of 430 analysis tools and a core bioinformatics engine. First released in 2010 as a toolkit for next-generation sequencing (NGS) data analysis, GATK remains one of the least celebrated yet foundational tools of the NGS era. By employing state-of-the-art approaches and continuously adapting to the evolving demands of NGS analysis, it has effectively unified the variant calling process worldwide. In a field as rapidly evolving as genomics, it is remarkable that, over a decade later, the same toolkit remains the gold standard. This critical review explores the pre-history of GATK, the reasons for its broad and enduring adoption by the scientific community, its developmental evolution, contributions to science, and future prospects. Full article

Anticipating the socio-environmental impacts of spatial planning strategies is a prerequisite for sustainable development pathways. Land change models are increasingly employed to evaluate the impacts of spatial planning on land use and land cover, and their subsequent effects on ecosystem services and environmental resources. Nevertheless, modelling land use and land cover changes, and their interactions, at a fine scale to preserve future landscape patterns has been identified as a key challenge in the land change science community. This paper presents an innovative process-based model—the FORecasting landscapE SCEnarios Model (FORESCEM)—designed to spatially simulate fine-scale future land use and land cover changes (LUCC) based on narratives developed through participatory or expert-driven approaches. By clearly distinguishing land covers and land uses as two different but related inputs, its conception and architecture enable the assessment of interactions among LUCC within human-managed landscapes. It relies on conventional functions and properties of LUCC models, and aims at completing the existing land change models. Applied on a French case study, the validation results demonstrate the model’s capability to replicate LUCC dynamics, effectively simulating trend-based and trend-breaking LUCC trajectories under contrasting scenarios. More broadly, this paper questions and discusses the validation of land change models used for simulating future LUCC. Full article

The life sciences are currently undergoing a serious transition from the reductive biochemical analysis of dissociated tissues to non-destructive “spatial forensics”. In addition to discovering new molecules, we are moving towards finding out their precise tissue localization and performing in situ interrogation to uncover a biological logic within preserved cellular “neighborhoods”. Our perspective is focused on exploring the spatial imperative, including the structural logic and “neighborhood effects” of the tissue microenvironment, which is a prerequisite to understanding cellular function in normal and in pathological conditions. Beginning with a historical foundation of the origins of histochemistry, dating back to the 19th century with pioneer botanist François-Vincent Raspail, we emphasize the technological metamorphosis, transitioning from classical immunohistochemistry to modern multi- and high-plex spatial multi-omics. A critical evaluation of the current operational landscape has been made, addressing the engineering strategies behind multiplexed immunofluorescence (mIF), the challenges of experimental design in spatial transcriptomics, and the functional symbiosis between targeted and unbiased spatial proteomics. There are many layers of genomic and proteomic information we have to consider in order to unravel the mechanisms underlying body function. If we learn how to combine all this information together, we will be able to better understand how cells communicate with each other and what disrupts their communication, leading to cancer and many other pathologies. It is obvious that by implementing spatial biology tools, it becomes possible to develop new medicines and treat diseases in the most efficient ways. At the same time, we realize that there is an urgent need to learn how to put data pieces together so that they blend seamlessly into a meaningful output, further transitioning spatial biology over time into a routine tool to cure for both common and rare diseases and improve our lives and health. Full article

This study examines the evolution of the scientific literature on mining and heavy metals, with a particular focus on biosanitary risks associated with childhood exposure. The research integrates a systematic literature review following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology, combined with a bibliometric analysis of Scopus-indexed publications, international epidemiological data, and an evaluation of the socio-environmental context in Ecuadorian mining regions. The PRISMA-based screening process was applied to identify, filter, and select relevant peer-reviewed studies, enabling the delimitation of a focused corpus of literature, with particular attention given to scientific contributions produced by Latin American researchers and institutions. The results reveal a significant concentration of knowledge production among a limited number of countries and institutions, the dominance of English as the main language of scientific communication, and the centrality of journals in environmental sciences and toxicology. While notable progress has been made in identifying contaminants and exposure pathways, governance structures, territorial disparities, and policy implementation processes remain insufficiently explored. In Ecuador, the rapid growth of mining concessions in ecologically sensitive zones presents potential threats to children’s neurocognitive development, highlighting the urgent need for ongoing surveillance, biomonitoring programs, and preventive public health measures. The study emphasizes the importance of strengthening regional research capacity and fostering more equitable international scientific collaborations to ensure that knowledge production is responsive to local contexts and effectively safeguards vulnerable populations. Full article

Uncertainty is a central feature of sport and has been extensively examined in sport science, primarily from performance-oriented perspectives such as anticipation, decision-making, and motor control. However, less attention has been given to how athletes subjectively perceive and experience uncertainty and how these interpretations shape their responses. The present study addresses this gap by exploring athletes’ lived experiences of uncertainty in sport. Using a qualitative design, semi-structured interviews were conducted with former youth athletes from various sports. Data were analyzed using thematic analysis, generating 15 themes organized across key dimensions of uncertainty, including unpredictability, lack of information, internal versus external sources, and the appraisal of uncertainty as a threat or a challenge. Findings indicate that uncertainty is experienced as a multifaceted and subjective phenomenon shaped by perceived control, prior experience, and situational context. Athletes differed in how they interpreted uncertainty, with some perceiving it as threatening and others as an opportunity for growth, which in turn influenced emotional responses and coping strategies. Key coping mechanisms included communication, information seeking, social support, and focusing on controllable aspects of performance. These findings extend existing sport science literature by integrating experiential and interpretative dimensions of uncertainty with established performance-based approaches. Furthermore, the results suggest conceptual links with the construct of intolerance of uncertainty (IU), highlighting the potential value of examining individual differences in how athletes appraise and manage uncertainty. The study provides an exploratory foundation for future research integrating IU within sport contexts and underscores the importance of addressing both subjective and performance-related aspects of uncertainty in sport psychology. Full article

Artificial intelligence (AI) systems and tools are increasingly reshaping educational practices. This study examines perspectives shared in student-focused online communities on AI’s impact on education, comparing those of computer science (CS) and business students through an analysis of Reddit posts. Using natural language processing (NLP), sentiment analysis, and Latent Dirichlet Allocation (LDA) topic modeling, we analyzed 1108 posts collected from six subreddits. Results reveal distinct thematic focuses: CS students emphasize technical aspects, including programming efficiency, coding assistance, and concerns about job displacement, while business students focus on decision-making enhancement, financial analysis applications, and operational efficiency. Sentiment analysis indicates that the Business/Finance-oriented corpus is slightly more positive than the CS-oriented corpus (51.9% vs. 50.1% positive). The CS-oriented corpus also contains a higher proportion of negative posts (36.0% vs. 33.2%). These differences reflect discipline-specific epistemological frameworks shaping AI perception. The findings provide educators with guidelines for developing tailored AI integration strategies that address discipline-specific concerns and opportunities. This study contributes to understanding how academic background influences perceptions of AI in education, offering insights for curriculum design and policy development. Full article

Due to their unique structures, intriguing electronic properties, and potential applications across various fields, Janus materials have attracted extensive attention from the science community. However, the thermal transport properties of Janus systems are less known so far, especially regarding lattice thermal conductivity (LTC). In this work, we establish an accurate machine learning potential by which the phonon Boltzmann transport equation can be iteratively solved to readily predict the LTC of Janus WXY (X, Y = S, Se, Te) monolayers. It is found that the LTC for all three systems decreases monotonically with increasing temperature. Among them, the WTeSe monolayer exhibits the lowest LTC, which can be traced back to the competition between the contributions of phonon group velocity and relaxation time. Interestingly, we demonstrate that the effect of four phonon scattering plays an important role in accurately determining the LTC of these Janus monolayers. Our work also provides an alternative way of effectively predicting the LTC of systems with low symmetry and/or large size. Full article

Living Labs offer immersive learning in Higher Education Institutions (HEIs), yet their core nature and value for competency development remain underexplored, particularly from the perspective of lab leaders. To address the knowledge gap, this study examines the perspectives of lab leaders on the potential of living labs as dynamic learning settings. Specifically, it explores two dimensions: (1) how living labs structure learning processes, and (2) the influence of collaboration with societal partners on learning outcomes, framed by the Quadruple Helix Model (academia, industry, government, and community). The study adopts a qualitative research design via semi-structured interviews with seven laboratory leaders across five well-established living labs in Finnish Universities of Applied Sciences. Interview transcripts were analyzed using Julius.ai and in vivo coding to identify and categorize themes. The respondents highlighted that in their experience, combining physical and digital settings often facilitates experiential, reflective, and innovative learning while equipping students with practical skills and competencies that improve their employability. Furthermore, the respondents reported that engagement with stakeholders fosters co-creation and well-rounded innovation. These collaborations also help ensure that the living labs can effectively sustain their operation, offering students the opportunities to engage in globally relevant issues such as digital transformation. Nonetheless, obstacles include resource limitations, maintaining enduring teamwork, and adjusting to rapid technological changes. The paper concludes that living labs serve as supplementary instruments and their adoption can help match academic learning curricula and practices with industry needs, while also enhancing student learning in preparation for the world of work. Full article

Accurately identifying urban functional zones and revealing their spatial interaction characteristics is crucial for understanding urban operational mechanisms and optimizing spatial layouts. Addressing the limitations of traditional research in simultaneously capturing static functional attributes and dynamic resident travel behaviors, this study takes the central urban area of Lhasa as the research object, integrating ride-hailing trajectory data with Point of Interest (POI) data to conduct research on urban functional zone identification and spatial interaction characteristics. First, Thiessen polygons were used to quantify the spatial influence range of POIs, and an address matching algorithm was employed to associate ride-hailing origins and destinations (ODs) with POIs. A weighted land use intensity index was constructed, and functional zones were precisely identified using information entropy and K-Means clustering. Secondly, with basic research units as nodes and OD flows as edges, a directed weighted spatial interaction network was constructed. Complex-network indicators and the Infomap community detection algorithm were utilized to analyze network characteristics, node importance, and community interaction patterns. The results show that: (1) The functional mixing degree in the study area exhibits a pattern of “highly composite core, relatively differentiated periphery.” Eight functional zone types, including commercial–residential mixed, science–education–culture, and transportation service zones, were ultimately identified. Residential areas form the base, while the core area features multi-functional agglomeration. (2) The spatial interaction network exhibits typical small-world effects, while its degree distribution is better characterized by a lognormal distribution rather than a power law. Node importance is dominated by betweenness centrality, with Lhasa Station, the Potala Palace, and core commercial areas constituting key hubs. (3) The network can be divided into four functionally coupled communities: the core multi-functional area, the western industry–residence integrated area, the eastern science–education-dominated area, and the southern transportation hub area, forming a “core leading, two wings supporting” center–subcenter spatial organization pattern. This study verifies the effectiveness of integrating trajectory and POI data for identifying urban functional zones and provides a new perspective for understanding the spatial structure and planning of plateau cities. Full article