746 Results Found

The use of self-inducible promoters is a promising strategy to address metabolic imbalances caused by overexpression. However, the low activity of natural self-inducible promoters hinders their widespread application. To overcome this limitation, we...

Background/Objectives: Academic libraries offer a range of activities and initiatives for their students and community users. However, wellbeing, as a concept in academic libraries, is not very well defined and is poorly understood. The objective of...

A library of active genome regulatory elements (putative promoters and enhancers) from MIA PaCa-2 pancreatic adenocarcinoma cells was constructed using a specially designed lentiviral vector and a massive parallel reporter assay (ChIP-lentiMPRA). Chr...

The main components of sandalwood heartwood essential oil are terpenoids, approximately 80% of which are α-santalol and β-santalol. In the synthesis of the main secondary metabolites of sandalwood heartwood, the key gene, santalene synthas...

Cellulosic biomass hydrolysates are rich in glucose and xylose, but most microorganisms, including Komagataella phaffii, are unable to utilize xylose effectively. To address this limitation, we engineered a K. phaffii strain optimized for xylose meta...

5-Methoxyleoligin and leoligin are natural occurring lignans derived from Edelweiss (Leontopodium nivale ssp. alpinum), displaying potent pro-angiogenic and pro-arteriogenic activity. Cholesterol efflux from macrophages is associated with reverse cho...

The key to the successful social inclusion of people recovering from mental illness is mutual understanding with other community members. To promote such social inclusion, the human library approach has been adopted by a group of practitioners based...

Glycolate plays an important role as a platform chemical in both polymeric material and cosmetic industries. However, the microbial production of glycolate often encounters challenges associated with unbalanced metabolic flux, leading to a notably lo...

Cancer is a major health problem. Most of the treatments exhibit systemic toxicity, as they are not targeted or specific to cancerous cells and tumors. Adenoviruses are very promising gene delivery vectors and have immense potential to deliver target...

Interferon (IFN) regulatory factor 3 (IRF3) is the key transcription factor for the induction of IFN and antiviral genes. The absence of antiviral genes in IRF3 deficiency leads to susceptibility to a wide range of viral infections. Previously, we un...

This study aims to examine the state of digital inclusion and digital literacy education in Chinese libraries and provide recommendations for improvement. The background section emphasizes the crucial role of libraries in promoting digital inclusion...

Since the first case of COVID-19 was confirmed in China, social and physical distancing has been promoted worldwide as an effective community mitigation strategy. However, our understanding remains limited regarding how students would resume their ac...

Short-form video platforms have become an important marketing channel for library resources and services. However, such promotions’ actual performance is not as good as expected. This research examined the performance of library marketing on th...

The concept of the ‘teaching library’, which originated in the Anglo-American world, describes all activities of libraries in the field of promoting information, media, and data literacy, as well as other skills in dealing with analog and...

Promoters serve as the switch of gene transcription, playing an important role in regulating gene expression and metabolites production. However, the approach to screening strong constitutive promoters in microorganisms is still limited. In this stud...

Transcription factors play important roles in the growth and development of various tissues in pigs, such as muscle, fat, and bone. A transcription-factor-scale activation library based on the clustered, regularly interspaced, short palindromic repea...

University library spaces play an important role in the learning experience of students. However, the traditional designs for these learning spaces no longer meet the needs of users, and researchers have been turning their attention to university lib...

Participating in collaborative scientific research through citizen science, a component of open science, holds significance for both citizen scientists and professional researchers. Yet, the advantages for those orchestrating citizen science initiati...

Traditional library systems are gradually being replaced by digital libraries. Digital libraries are developing from simple database-based storage and retrieval to knowledge-based implementation. The fuzzy C-means (FCM) clustering algorithm is an exa...

In the Industry 4.0 era, digital transformation is crucial for college libraries aiming to improve reader service quality. The current research proposes various digital transformation initiatives for college libraries but ignores readers’ willi...

Bacterial artificial chromosome (BAC) libraries are extremely valuable for the genome-wide genetic dissection of complex organisms. The Siberian tiger, one of the most well-known wild primitive carnivores in China, is an endangered animal. In order t...

Public libraries provide equitable access to information for all citizens, and they play an important role in preserving and promoting culture, formal education and self-education, and enriching leisure time. Accordingly, there has been an increasing...

The evolution of university libraries from traditional knowledge bases to dynamic, multifunctional learning environments has attracted widespread attention in higher education research. This study, as a scientometric review, focuses on the combinatio...

Background: Journals with high impact factors (IFs) are the “coin of the realm” in many review, tenure, and promotion decisions, ipso facto, IFs influence academic authors’ views of journals and publishers. However, IFs do not evalu...

With rapid urbanization, cities worldwide have sought innovative, sustainable solutions such as smart city initiatives to leverage technology and data to better manage this growth and the challenges it brings. Developing smart cities requires multi-s...

Critical health literacy enables individuals to use cognitive and social resources for informed action on the wider determinants of health. Promoting critical health literacy early in the life-course may contribute to improved health outcomes in the...

In recent years, due to the advantages of high construction efficiency and less environmental pollution, prefabricated housing has been of increasing interest and vigorously promoted. However at present, most prefabricated houses simply pursue an inc...

The paper sought to examine the role of collaboration in sustaining citizen science activities and projects in academic libraries. The study applied a quantitative approach and a survey design to assess knowledge and understanding of citizen science...

The indoor environmental quality of a library greatly affects the comfort and productivity of its users while preserving the materials. Despite the high energy consumption of HVACs in libraries, achieving acceptable thermal conditions, acceptable aco...

Inspired by the many reported successful applications of DNA-encoded chemical libraries in drug discovery projects with protein targets, we decided to apply this platform to nucleic acid targets. We used a 120-billion-compound set of 33 distinct DNA-...

This research examines the utilization of Web-Based Library and Information Services (WBLIS) in academic libraries. Digital technology promotes the use of WBLIS, including during the COVID-19 pandemic. Few Malaysian studies have investigated utilizat...

Enzymatic oligonucleotide synthesis is used for the development of functional oligonucleotides selected by in vitro selection. Expanding available sugar modifications for in vitro selection helps the functional oligonucleotides to be used as therapeu...

A promoter is a small region of a DNA sequence that responds to various transcription factors, which initiates a particular gene expression. The promoter-engineered biosensor can activate or repress gene expression through a transcription factor reco...

Background/Objective: Immunomodulators play a critical role in regulating immune responses, with immunostimulatory agents enhancing cancer therapy by activating immune cells such as T cells. While immune checkpoint inhibitors (ICIs) targeting PD-1 an...

Foxl2 is an evolutionarily conserved female sex gene, which is specifically expressed in the ovary and mainly involved in oogenesis and ovarian function maintenance. However, little is known about the mechanism that regulates Foxl2 specific expressio...

Synthetic DNA barcodes are double-stranded DNA molecules designed to carry recoverable information, information that can be used to represent and track objects and organisms. DNA barcodes offer robust, sensitive detection using standard amplification...

Various articles suggest that artificial intelligence (AI) in libraries can enhance the learning experience, promote lifelong learning, and strengthen digital literacy. However, it is unclear if practicing librarians agree with these benefits. Malays...

Many integrated gene clusters beyond a single genetic element are commonly trapped as the result of promoter traps in (meta)genomic DNA libraries. Generally, a single element, which is mainly the promoter, is deduced from the resulting gene clusters...

In tropical rubber-growing regions, Corynespora leaf fall disease stands as a predominant and economically significant threat to rubber trees. The toxin protein encoded by the cas5 gene is the main pathogenic factor of Corynespora cassiicola. To iden...

Follicle-stimulating hormone (FSH) regulates ovarian follicle development through specific gene expression programs. Granulosa cells (GCs) are somatic cells surrounding the oocytes, secreting gonadotropins to regulate ovulation and promote follicular...

This article examines the structure and functions of the plant synthetic promoters frequently used to precisely regulate complex regulatory routes. It details the composition of native promoters and their interacting proteins to provide a better unde...

Most out-of-the-box institutional repository systems do not provide the workflows and metadata features required for research data. Consequently, many libraries now support two institutional repository systems—one for publications, and one for...

Currently, university students are facing high levels of stress and negativity. Creating a campus learning environment that promotes students’ physical and mental health and well-being has become a key focus of current research. There is now a...

With the increasing number of public buildings worldwide, their energy consumption has garnered significant attention. This study aims to promote building energy efficiency and emission reduction by exploring the application of Building-Integrated Ph...

Background: Food waste is a significant global issue with environmental, social, and economic consequences. In 2022, approximately 1.05 billion tons of food were wasted worldwide, with 220 million tons lost during the production and processing stages...

Skeletal muscle myogenesis hinges on gene regulation, meticulously orchestrated by molecular mechanisms. While the roles of transcription factors and non-coding RNAs in myogenesis are widely known, the contribution of RNA-binding proteins (RBPs) has...

Background: The aging global population presents significant challenges for healthcare systems. Technology-assisted interventions have emerged as promising tools to enhance independence and well-being among elderly individuals. Objective: The aim of...

The contradiction between urban construction and sustainable development has led to an increasing demand for urban underground space (UUS). The value evaluation of urban underground space (UUSVE) is of great significance in promoting the rational dev...

Cell adhesion molecule L1 is a cell surface glycoprotein that promotes neuronal cell migration, fosters regeneration after spinal cord injury and ameliorates the consequences of neuronal degeneration in mouse and zebrafish models. Counter-indicative...

The Life Cycle Assessment (LCA) methodology is often used to check the environmental suitability of hydrogen energy systems, usually involving comparative studies. However, these comparative studies are typically affected by inconsistent methodologic...