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204 Results Found

  • Review
  • Open Access
37 Citations
10,714 Views
18 Pages

Vaccinia Virus: From Crude Smallpox Vaccines to Elaborate Viral Vector Vaccine Design

  • Onur Kaynarcalidan,
  • Sara Moreno Mascaraque and
  • Ingo Drexler

26 November 2021

Various vaccinia virus (VACV) strains were applied during the smallpox vaccination campaign to eradicate the variola virus worldwide. After the eradication of smallpox, VACV gained popularity as a viral vector thanks to increasing innovations in gene...

  • Article
  • Open Access
1,605 Views
16 Pages

Deciphering the Genetic Architecture of Staphylococcus warneri Prophage vB_G30_01: A Comprehensive Molecular Analysis

  • Fangxiong Pu,
  • Ning Zhang,
  • Jiahe Pang,
  • Nan Zeng,
  • Faryal Babar Baloch,
  • Zijing Li and
  • Bingxue Li

19 October 2024

The current knowledge of Staphylococcus warneri phages is limited, with few genomes sequenced and characterized. In this study, a prophage, vB_G30_01, isolated from Staphylococcus warneri G30 was characterized and evaluated for its lysogenic host ran...

  • Article
  • Open Access
2 Citations
2,984 Views
18 Pages

19 September 2022

Paracoccus marginatus (Hemiptera: Pseudococcidae) is an invasive pest with a diverse host range, strong diffusion, and high fecundity. It has been observed that P. marginatus feeding on Carica papaya have a higher survival rate, fecundity, and longer...

  • Article
  • Open Access
11 Citations
3,795 Views
20 Pages

Tailoring the Host Range of Ackermannviridae Bacteriophages through Chimeric Tailspike Proteins

  • Jose Gil,
  • John Paulson,
  • Matthew Brown,
  • Henriett Zahn,
  • Minh M. Nguyen,
  • Marcia Eisenberg and
  • Stephen Erickson

19 January 2023

Host range is a major determinant in the industrial utility of a bacteriophage. A model host range permits broad recognition across serovars of a target bacterium while avoiding cross-reactivity with commensal microbiota. Searching for a naturally oc...

  • Article
  • Open Access
2 Citations
1,861 Views
31 Pages

Ecological Strategies for Resource Use by Three Bromoviruses in Anthropic and Wild Plant Communities

  • Bisola Babalola,
  • Aurora Fraile,
  • Fernando García-Arenal and
  • Michael McLeish

21 August 2023

Ecological strategies for resource utilisation are important features of pathogens, yet have been overshadowed by stronger interest in genetic mechanisms underlying disease emergence. The purpose of this study is to ask whether host range and transmi...

  • Article
  • Open Access
8 Citations
3,193 Views
18 Pages

The Genetic Basis of Gene Expression Divergence in Antennae of Two Closely Related Moth Species, Helicoverpa armigera and Helicoverpa assulta

  • Ping-Ping Guo,
  • Guo-Cheng Li,
  • Jun-Feng Dong,
  • Xin-Lin Gong,
  • Lingyu Wang,
  • Ke Yang,
  • Jun Yang,
  • Ling-Qiao Huang and
  • Chen-Zhu Wang

2 September 2022

The closely related species Helicoverpa armigera (H. armigera) and Helicoverpa assulta (H. assulta) have different host plant ranges and share two principal components of sex pheromones but with reversed ratios. The antennae are the main olfactory or...

  • Article
  • Open Access
2 Citations
1,750 Views
15 Pages

Pangenome-Wide Association Study in the Chlamydiaceae Family Reveals Key Evolutionary Aspects of Their Relationship with Their Hosts

  • Rosalba Salgado-Morales,
  • Karla Barba-Xochipa,
  • Fernando Martínez-Ocampo,
  • Edgar Dantán-González,
  • Armando Hernández-Mendoza,
  • Manuel Quiterio-Trenado,
  • Magdalena Rodríguez-Santiago and
  • Abraham Rivera-Ramírez

26 November 2024

The Chlamydiaceae are a family of obligate intracellular bacteria known for their unique biphasic developmental cycle. Chlamydial are associated with various host organisms, including humans, and have been proposed as emerging pathogens. Genomic stud...

  • Article
  • Open Access
4 Citations
2,997 Views
17 Pages

Ophiocordyceps sinensis Berk. is a fungal parasite that parasitizes the larvae of Hepialidae and is used as a traditional Chinese medicine. However, it is not clear how O. sinensis infects its host. The encoding gene haplotype diversity and predicted...

  • Article
  • Open Access
23 Citations
3,724 Views
15 Pages

Molecular Insights into Bacteriophage Evolution toward Its Host

  • Marina de Leeuw,
  • Maayan Baron,
  • Oshrit Ben David and
  • Ariel Kushmaro

6 October 2020

Bacteriophages (phages), viruses that infect bacteria, are considered to be highly host-specific. To add to the knowledge about the evolution and development of bacteriophage speciation toward its host, we conducted a 21-day experiment with the broad...

  • Article
  • Open Access
515 Views
19 Pages

5 December 2025

Plutella xylostella, a major pest of cruciferous vegetables, depends predominantly on chemoreception to locate host plants. Legs are crucial in insect chemical perception, particularly during close-range and contact chemoreception. However, the molec...

  • Article
  • Open Access
5 Citations
4,731 Views
18 Pages

The Association of Waminoa with Reef Corals in Singapore and Its Impact on Putative Immune- and Stress-Response Genes

  • Giorgia Maggioni,
  • Danwei Huang,
  • Davide Maggioni,
  • Sudhanshi S. Jain,
  • Randolph Z. B. Quek,
  • Rosa Celia Poquita-Du,
  • Simone Montano,
  • Enrico Montalbetti and
  • Davide Seveso

15 April 2022

Waminoa spp. are acoel flatworms mainly found as ectosymbionts on scleractinian corals. Although Waminoa could potentially represent a threat to their hosts, not enough information is available yet regarding their ecology and effect on the coral. Her...

  • Article
  • Open Access
1 Citations
3,230 Views
14 Pages

Genomic Comparisons of Alphacoronaviruses and Betacoronaviruses from Korean Bats

  • Van Thi Lo,
  • Sun Woo Yoon,
  • Yong Gun Choi,
  • Dae Gwin Jeong and
  • Hye Kwon Kim

25 June 2022

Coronaviruses are well known as a diverse family of viruses that affect a wide range of hosts. Since the outbreak of severe acute respiratory syndrome, a variety of bat-associated coronaviruses have been identified in many countries. However, they do...

  • Article
  • Open Access
2 Citations
2,438 Views
17 Pages

Genetic Loci of Plant Pathogenic Dickeya solani IPO 2222 Expressed in Contact with Weed-Host Bittersweet Nightshade (Solanum dulcamara L.) Plants

  • Robert Czajkowski,
  • Dorota M. Krzyżanowska,
  • Daryna Sokolova,
  • Łukasz Rąbalski,
  • Maciej Kosiński,
  • Sylwia Jafra and
  • Aleksandra Królicka

28 February 2024

Dickeya solani, belonging to the Soft Rot Pectobacteriaceae, are aggressive necrotrophs, exhibiting both a wide geographic distribution and a wide host range that includes many angiosperm orders, both dicot and monocot plants, cultivated under all cl...

  • Feature Paper
  • Article
  • Open Access
3 Citations
3,559 Views
17 Pages

Gene Expression Space Shapes the Bioprocess Trade-Offs among Titer, Yield and Productivity

  • Fernando N. Santos-Navarro,
  • Yadira Boada,
  • Alejandro Vignoni and
  • Jesús Picó

24 June 2021

Optimal gene expression is central for the development of both bacterial expression systems for heterologous protein production, and microbial cell factories for industrial metabolite production. Our goal is to fulfill industry-level overproduction d...

  • Article
  • Open Access
4 Citations
3,233 Views
12 Pages

Comparative Analysis of Microbiome Metagenomics in Reintroduced Wild Horses and Resident Asiatic Wild Asses in the Gobi Desert Steppe

  • Liping Tang,
  • Yunyun Gao,
  • Liping Yan,
  • Huiping Jia,
  • Hongjun Chu,
  • Xinping Ma,
  • Lun He,
  • Xiaoting Wang,
  • Kai Li and
  • Dong Zhang
  • + 1 author

The gut microbiome offers important ecological benefits to the host; however, our understanding of the functional microbiome in relation to wildlife adaptation, especially for translocated endangered species, is lagging. In this study, we adopted a c...

  • Article
  • Open Access
54 Citations
7,841 Views
16 Pages

A Novel Roseosiphophage Isolated from the Oligotrophic South China Sea

  • Yunlan Yang,
  • Lanlan Cai,
  • Ruijie Ma,
  • Yongle Xu,
  • Yigang Tong,
  • Yong Huang,
  • Nianzhi Jiao and
  • Rui Zhang

15 May 2017

The Roseobacter clade is abundant and widespread in marine environments and plays an important role in oceanic biogeochemical cycling. In this present study, a lytic siphophage (labeled vB_DshS-R5C) infecting the strain type of Dinoroseobacter shibae...

  • Article
  • Open Access
9 Citations
4,845 Views
22 Pages

A System Based-Approach to Examine Cytokine Response in Poxvirus-Infected Macrophages

  • Pui-San Wong,
  • Richard Sutejo,
  • Hui Chen,
  • Sock-Hoon Ng,
  • Richard J. Sugrue and
  • Boon-Huan Tan

5 December 2018

The poxviruses are large, linear, double-stranded DNA viruses about 130 to 230 kbp, that have an animal origin and evolved to infect a wide host range. Variola virus (VARV), the causative agent of smallpox, is a poxvirus that infects only humans, but...

  • Article
  • Open Access
26 Citations
4,511 Views
18 Pages

13 February 2021

The Yersinia bacteriophages fPS-2, fPS-65, and fPS-90, isolated from pig stools, have long contractile tails and elongated heads, and they belong to genus Tequatroviruses in the order Caudovirales. The phages exhibited relatively wide host ranges amo...

  • Article
  • Open Access
17 Citations
4,971 Views
23 Pages

Comparative Genomics: Insights on the Pathogenicity and Lifestyle of Rhizoctonia solani

  • Nurhani Mat Razali,
  • Siti Norvahida Hisham,
  • Ilakiya Sharanee Kumar,
  • Rohit Nandan Shukla,
  • Melvin Lee,
  • Mohd Faizal Abu Bakar and
  • Kalaivani Nadarajah

22 February 2021

Proper management of agricultural disease is important to ensure sustainable food security. Staple food crops like rice, wheat, cereals, and other cash crops hold great export value for countries. Ensuring proper supply is critical; hence any biotic...

  • Article
  • Open Access
49 Citations
9,752 Views
16 Pages

Genetic Characterization of a Recombinant Myxoma Virus in the Iberian Hare (Lepus granatensis)

  • Ana Águeda-Pinto,
  • Ana Lemos de Matos,
  • Mário Abrantes,
  • Simona Kraberger,
  • Maria A. Risalde,
  • Christian Gortázar,
  • Grant McFadden,
  • Arvind Varsani and
  • Pedro J. Esteves

7 June 2019

Myxomatosis is a lethal disease in wild European and domestic rabbits (Oryctolagus cuniculus), which is caused by a Myxoma virus (MYXV) infection—a leporipoxvirus that is found naturally in some Sylvilagus rabbit species in South America and Ca...

  • Review
  • Open Access
1 Citations
1,898 Views
24 Pages

Genetic Testing in Periodontitis: A Narrative Review on Current Applications, Limitations, and Future Perspectives

  • Clarissa Modafferi,
  • Cristina Grippaudo,
  • Andrea Corvaglia,
  • Vittoria Cristi,
  • Mariacristina Amato,
  • Pietro Rigotti,
  • Alessandro Polizzi and
  • Gaetano Isola

1 November 2025

Background: Periodontitis is a multifactorial inflammatory disease with a complex interplay between microbial, environmental, and host-related factors. Among host factors, genetic susceptibility plays a significant role in influencing both disease on...

  • Article
  • Open Access
1 Citations
2,690 Views
12 Pages

The Diversity of Wolbachia across the Turtle Ants (Formicidae: Cephalotes spp.)

  • Corey Reese,
  • Leland C. Graber,
  • Manuela O. Ramalho and
  • Corrie S. Moreau

13 February 2024

Wolbachia is a widespread and well-known bacterium that can induce a wide range of changes within its host. Ants specifically harbor a great deal of Wolbachia diversity and are useful systems to study endosymbiosis. The turtle ants (Cephalotes) are a...

  • Article
  • Open Access
6 Citations
3,025 Views
16 Pages

Recent years have seen the classification and reclassification of many viruses related to the model enterobacterial phage P2. Here, we report the identification of a prophage (Smhb1) that infects Salinivibrio kushneri BNH isolated from a Namib Desert...

  • Review
  • Open Access
26 Citations
5,633 Views
14 Pages

29 October 2019

Phytotoxins, secondary metabolites toxic to plants and produced by fungi, are believed to play an important role in disease development by targeting host cellular machineries and/or interfering with host immune responses. The Ascochyta blight disease...

  • Article
  • Open Access
4 Citations
4,092 Views
18 Pages

Cappable-Seq Reveals Specific Patterns of Metabolism and Virulence for Salmonella Typhimurium Intracellular Survival within Acanthamoeba castellanii

  • Alexander S. Balkin,
  • Andrey O. Plotnikov,
  • Natalia E. Gogoleva,
  • Yuri V. Gogolev,
  • Kirill N. Demchenko and
  • Sergey V. Cherkasov

23 August 2021

The bacterial pathogen Salmonella enterica, which causes enteritis, has a broad host range and extensive environmental longevity. In water and soil, Salmonella interacts with protozoa and multiplies inside their phagosomes. Although this relationship...

  • Article
  • Open Access
955 Views
18 Pages

Campylobacter hepaticus Transcriptomics Identified Genes Involved in Spotty Liver Disease (SLD) Pathogenesis

  • Varsha Bommineni,
  • Lekshmi K. Edison,
  • Chaitanya Gottapu,
  • Gary D. Butcher and
  • Subhashinie Kariyawasam

17 October 2025

Campylobacter hepaticus is the etiological agent of Spotty Liver Disease (SLD), a newly emerging bacterial disease of laying hens resulting in significant mortality and production losses primarily in free-range systems. Although its economic impact c...

  • Article
  • Open Access
29 Citations
4,202 Views
20 Pages

15 November 2019

Edwardsiella tarda is a Gram-negative bacterial pathogen with a broad host range, including fish, reptiles, and mammals. One prominent virulence feature of E. tarda is its ability to survive and replicate in host phagocytes, but the relevant molecula...

  • Article
  • Open Access
8 Citations
3,766 Views
14 Pages

Insights into the Gryllus bimaculatus Immune-Related Transcriptomic Profiling to Combat Naturally Invading Pathogens

  • Abid Hussain,
  • Muhammad Waqar Ali,
  • Ahmed Mohammed AlJabr and
  • Saad Naser AL-Kahtani

18 October 2020

Natural pathogen pressure is an important factor that shapes the host immune defense mechanism. The current study primarily aimed to explore the molecular basis of the natural immune defense mechanism of a sporadic pest, Gryllus bimaculatus, during s...

  • Review
  • Open Access
9 Citations
4,954 Views
15 Pages

Blaze a New Trail: Plant Virus Xylem Exploitation

  • Yong-Duo Sun,
  • Arianna Spellman-Kruse and
  • Svetlana Y. Folimonova

Viruses are trailblazers in hijacking host systems for their own needs. Plant viruses have been shown to exploit alternative avenues of translocation within a host, including a challenging route through the xylem, to expand their niche and establish...

  • Review
  • Open Access
82 Citations
8,272 Views
13 Pages

miRNA Mediated Regulation and Interaction between Plants and Pathogens

  • Xiaoqian Yang,
  • Lichun Zhang,
  • Yuzhang Yang,
  • Markus Schmid and
  • Yanwei Wang

Plants have evolved diverse molecular mechanisms that enable them to respond to a wide range of pathogens. It has become clear that microRNAs, a class of short single-stranded RNA molecules that regulate gene expression at the transcriptional or post...

  • Article
  • Open Access
5 Citations
2,706 Views
14 Pages

10 May 2023

Parasitic wasps are abundant and diverse Hymenoptera insects that lay their eggs inside or on the external surface of the host and inject venom into the host to create a more favorable environment for the larvae to survive and regulate the host&rsquo...

  • Article
  • Open Access
14 Citations
2,392 Views
11 Pages

7 September 2023

Flavescence dorée (FD) is the most important phytoplasma-associated disease of the grapevine yellows complex in Europe. Recent studies highlighted a great genetic diversity within FD phytoplasma (FDp) strains and demonstrated that their diffus...

  • Article
  • Open Access
23 Citations
4,574 Views
22 Pages

Behavioral and Physiological Plasticity Provides Insights into Molecular Based Adaptation Mechanism to Strain Shift in Spodoptera frugiperda

  • Muhammad Hafeez,
  • Xiaowei Li,
  • Farman Ullah,
  • Zhijun Zhang,
  • Jinming Zhang,
  • Jun Huang,
  • Muhammad Musa Khan,
  • Limin Chen,
  • Xiaoyun Ren and
  • Yaobin Lu
  • + 3 authors

24 September 2021

How herbivorous insects adapt to host plants is a key question in ecological and evolutionary biology. The fall armyworm, (FAW) Spodoptera frugiperda (J.E. Smith), although polyphagous and a major pest on various crops, has been reported to have a ri...

  • Article
  • Open Access
3 Citations
2,173 Views
14 Pages

Expressions of a wide range of cytoprotective counter-defense genes are mainly regulated by the Keap1-Nrf2-ARE signaling pathway in response to oxidative stress from xenobiotics. Gossypol is the major antiherbivore secondary metabolite of cotton, but...

  • Article
  • Open Access
12 Citations
2,878 Views
12 Pages

24 April 2023

Bactrocera dorsalis (Hendel) (Diptera: Tephritidae) is one of the broad host ranges and economically-important insect pests in tropical and subtropical areas. A wide range of hosts means they have strong adaptation ability to changes in dietary macro...

  • Article
  • Open Access
8 Citations
3,600 Views
17 Pages

Xylella fastidiosa is a xylem-limited bacterium phylogenetically related to the xanthomonads, with an unusually large and diversified range of plant hosts. To ascertain the origin of its peculiarities, its pan-genome was scanned to identify the genes...

  • Review
  • Open Access
14 Citations
5,060 Views
22 Pages

Unbridled Integrons: A Matter of Host Factors

  • Egill Richard,
  • Baptiste Darracq,
  • Céline Loot and
  • Didier Mazel

8 March 2022

Integrons are powerful recombination systems found in bacteria, which act as platforms capable of capturing, stockpiling, excising and reordering mobile elements called cassettes. These dynamic genetic machineries confer a very high potential of adap...

  • Article
  • Open Access
73 Citations
6,790 Views
21 Pages

An Ancient Lineage of Highly Divergent Parvoviruses Infects both Vertebrate and Invertebrate Hosts

  • Judit J. Pénzes,
  • William Marciel de Souza,
  • Mavis Agbandje-McKenna and
  • Robert J. Gifford

6 June 2019

Chapparvoviruses (ChPVs) comprise a divergent, recently identified group of parvoviruses (family Parvoviridae), associated with nephropathy in immunocompromised laboratory mice and with prevalence in deep sequencing results of livestock showing diarr...

  • Review
  • Open Access
17 Citations
10,735 Views
28 Pages

24 September 2024

Fusarium oxysporum is one of the most economically important plant fungal pathogens, causing devastating Fusarium wilt diseases on a diverse range of hosts, including many key crop plants. Consequently, F. oxysporum has been the subject of extensive...

  • Article
  • Open Access
4 Citations
2,782 Views
19 Pages

Shiga toxin-producing Escherichia coli (STEC) infections have increased in humans, animals, and the food industry, with ready-to-eat (RTE) food products being particularly susceptible to contamination. The prevalence of multidrug-resistant strains ha...

  • Article
  • Open Access
1,019 Views
18 Pages

Unlocking the Potential of vB_EfaS_LOK1: A Newly Isolated Bacteriophage Against Enterococcus faecalis

  • Laura Marcela Plata Suarez,
  • Salvador Del Valle Balbuena,
  • Isamar Leticia Becerra Mejía,
  • Alejandra Aidee Loera Piedra,
  • Cristina Domínguez Espinoza,
  • Arantxa Monserrat Ángeles González,
  • Araceli Contreras Rodríguez,
  • Alejandra Aquino Andrade,
  • Sergio Francisco Martínez Díaz and
  • Ma. Guadalupe Aguilera Arreola

Phage therapy has emerged as a promising alternative for combating infections caused by drug-resistant pathogens. Among these, Enterococcus faecalis remains a significant public health concern due to its persistence in clinical settings and frequent...

  • Article
  • Open Access
24 Citations
6,389 Views
21 Pages

Co-Circulation and Excretion Dynamics of Diverse Rubula- and Related Viruses in Egyptian Rousette Bats from South Africa

  • Marinda Mortlock,
  • Muriel Dietrich,
  • Jacqueline Weyer,
  • Janusz T. Paweska and
  • Wanda Markotter

8 January 2019

The Egyptian rousette bat (Rousettus aegyptiacus) has previously been implicated as the natural host of a zoonotic rubulavirus; however, its association with rubulaviruses has been studied to a limited extent. Urine, spleen, and other organs collecte...

  • Article
  • Open Access
1 Citations
2,212 Views
12 Pages

Comparative Genome Analysis of Canine Frederiksenia canicola Isolates

  • Marianna Domán,
  • Krisztina Pintér,
  • Boglárka Dóra Pollák,
  • Ágnes Pintér,
  • Enikő Wehmann,
  • Miklós Tenk and
  • Tibor Magyar

22 December 2024

Background/Objectives: The One Health approach is crucial for managing and controlling the spread of antimicrobial resistance. Frederiksenia canicola is a recently identified bacterial species that seems to be a component of the oral microbiota of do...

  • Article
  • Open Access
31 Citations
4,307 Views
18 Pages

30 September 2021

Candida albicans is a commensal fungus of humans but can cause infections, particularly in immunocompromised individuals, ranging from superficial to life-threatening systemic infections. The cell wall is the outermost layer of C. albicans that inter...

  • Article
  • Open Access
3 Citations
1,958 Views
15 Pages

A Novel Bacteriophage Targeting mcr-9 Enterobacter kobei with Potential Application in Fresh Leafy Greens

  • Alberto Pintor-Cora,
  • Andrea Carpintero,
  • Ángel Alegría,
  • Apostolos Giannis,
  • Teresa-María Lopez-Díaz,
  • Jesús A. Santos and
  • Jose M. Rodríguez-Calleja

The presence of opportunistic pathogens, such as the Enterobacter cloacae complex (ECC), in fresh vegetables poses a significant health risk, particularly amid the ongoing antibiotic resistance crisis. Traditional chemical decontamination methods are...

  • Article
  • Open Access
23 Citations
4,899 Views
20 Pages

Heritability of Oral Microbiota and Immune Responses to Oral Bacteria

  • Anders Esberg,
  • Simon Haworth,
  • Ralf Kuja-Halkola,
  • Patrik K.E. Magnusson and
  • Ingegerd Johansson

Maintaining a symbiotic oral microbiota is essential for oral and dental health, and host genetic factors may affect the composition or function of the oral microbiota through a range of possible mechanisms, including immune pathways. The study inclu...

  • Review
  • Open Access
12 Citations
4,988 Views
16 Pages

19 May 2020

Many fungal pathogens carry accessory regions in their genome, which are not required for vegetative fitness. Often, although not always, these regions occur as relatively small chromosomes in different species. Such mini chromosomes appear to be a t...

  • Review
  • Open Access
84 Citations
12,468 Views
21 Pages

Biotechnological Advances in Resveratrol Production and its Chemical Diversity

  • Samir Bahadur Thapa,
  • Ramesh Prasad Pandey,
  • Yong Il Park and
  • Jae Kyung Sohng

15 July 2019

The very well-known bioactive natural product, resveratrol (3,5,4′-trihydroxystilbene), is a highly studied secondary metabolite produced by several plants, particularly grapes, passion fruit, white tea, and berries. It is in high demand not on...

  • Article
  • Open Access
4 Citations
3,068 Views
15 Pages

9 June 2021

Trichuris spp. is a widespread nematode which parasitizes a wide range of mammalian hosts including rodents, the most diverse mammalian order. However, genetic data on rodent whipworms are still scarce, with only one published whole genome (Trichuris...

  • Article
  • Open Access
18 Citations
6,800 Views
15 Pages

21 July 2015

In this study, we used a culture-independent method based on library construction and sequencing to analyze the genetic diversity of the cellulase and hemicellulase genes of the bacterial community resident in the hindgut of Holotrichia parallela lar...

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