Next Article in Journal
eDNA Increases the Detectability of Ranavirus Infection in an Alpine Amphibian Population
Next Article in Special Issue
H-1 Parvovirus as a Cancer-Killing Agent: Past, Present, and Future
Previous Article in Journal
Bafilomycin A1 and U18666A Efficiently Impair ZIKV Infection
Previous Article in Special Issue
Equine Parvovirus-Hepatitis Frequently Detectable in Commercial Equine Serum Pools
Open AccessArticle

An Ancient Lineage of Highly Divergent Parvoviruses Infects both Vertebrate and Invertebrate Hosts

1
McKnight Brain Institute and Department of Biochemistry and Molecular Biology, University of Florida, 1149 Newell Dr, Gainesville, FL 32610, USA
2
Virology Research Center, School of Medicine of Ribeirão Preto of the University of São Paulo, Ribeirão Preto, Brazil
3
Medical Research Council-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow G61 1QH, UK
*
Authors to whom correspondence should be addressed.
Viruses 2019, 11(6), 525; https://doi.org/10.3390/v11060525
Received: 17 April 2019 / Revised: 3 June 2019 / Accepted: 5 June 2019 / Published: 6 June 2019
(This article belongs to the Special Issue New Insights into Parvovirus Research)
Chapparvoviruses (ChPVs) comprise a divergent, recently identified group of parvoviruses (family Parvoviridae), associated with nephropathy in immunocompromised laboratory mice and with prevalence in deep sequencing results of livestock showing diarrhea. Here, we investigate the biological and evolutionary characteristics of ChPVs via comparative in silico analyses, incorporating sequences derived from endogenous parvoviral elements (EPVs) as well as exogenous parvoviruses. We show that ChPVs are an ancient lineage within the Parvoviridae, clustering separately from members of both currently established subfamilies. Consistent with this, they exhibit a number of characteristic features, including several putative auxiliary protein-encoding genes, and capsid proteins with no sequence-level homology to those of other parvoviruses. Homology modeling indicates the absence of a β-A strand, normally part of the luminal side of the parvoviral capsid protein core. Our findings demonstrate that the ChPV lineage infects an exceptionally broad range of host species, including both vertebrates and invertebrates. Furthermore, we observe that ChPVs found in fish are more closely related to those from invertebrates than they are to those of amniote vertebrates. This suggests that transmission between distantly related host species may have occurred in the past and that the Parvoviridae family can no longer be divided based on host affiliation. View Full-Text
Keywords: chapparvovirus; parvovirus evolution; endogenous viral elements; Parvoviridae; densovirus; homology modeling; new viruses chapparvovirus; parvovirus evolution; endogenous viral elements; Parvoviridae; densovirus; homology modeling; new viruses
Show Figures

Figure 1

MDPI and ACS Style

Pénzes, J.J.; de Souza, W.M.; Agbandje-McKenna, M.; Gifford, R.J. An Ancient Lineage of Highly Divergent Parvoviruses Infects both Vertebrate and Invertebrate Hosts. Viruses 2019, 11, 525.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop