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3,489 Results Found

  • Review
  • Open Access
12 Citations
3,837 Views
9 Pages

From a developmental–relational framework, substance use in women can be understood as relating to early experiences of violence in relationships and across development. This article uses a developmental-relational approach to outline specific...

  • Review
  • Open Access
9 Citations
5,648 Views
14 Pages

Substance use among women is a major public health concern. This review article takes a developmental-relational approach to examine processes through which early relational trauma and violence in relationships may lead to substance use. We examine h...

  • Review
  • Open Access
2 Citations
4,058 Views
14 Pages

Ambivalence towards the Protection of Refugee Children: A Developmental Relational Approach

  • Jeanette A. Lawrence,
  • Agnes E. Dodds,
  • Ida Kaplan and
  • Maria M. Tucci

In this paper we analyze the contemporary ambivalence to child migration identified by Jacqueline Bhabha and propose a developmental relational approach that repositions child refugees as active participants and rights-bearers in society. Ambivalence...

  • Review
  • Open Access
762 Views
12 Pages

ROGDI-Related Disorder Resulting from Disruption of Complex Interactive Neuro-Dental Developmental Networks: A Review and Description of the First Missense Variant

  • Sopio Gverdtsiteli,
  • Trine Bjørg Hammer,
  • Xenia Hermann,
  • Noemi Becser Andersen,
  • David Ros-Pardo,
  • Iñigo Marcos-Alcalde,
  • Paulino Gómez-Puertas,
  • Alan Henry Brook,
  • Asli Silahtaroglu and
  • Zeynep Tümer

14 October 2025

ROGDI-related neurodevelopmental and dental disorder (ROGDI-RD), also known as Kohlschütter–Tönz syndrome (KTZS, MIM #226750), is a rare condition characterized by developmental abnormalities affecting both the central nervous system...

  • Article
  • Open Access
1 Citations
2,062 Views
12 Pages

Health-Related Quality of Life and Behavioral Difficulties in Greek Preschool Children with Developmental Language Disorder

  • Konstantinos Kotsis,
  • Maria Boukouvala,
  • Alexandra Tzotzi,
  • Iouliani Koullourou,
  • Andromachi Mitropoulou,
  • Aspasia Serdari,
  • Vassiliki Siafaka and
  • Thomas Hyphantis

13 February 2024

Developmental language disorder (DLD) has a great impact on language skills as well as on a wide range of functioning areas, such as social and school functioning. In the present study, we aim to explore the Health-Related Quality of Life (HRQoL) of...

  • Article
  • Open Access
1 Citations
836 Views
10 Pages

What Guides Organizations’ Current Dementia-Related Practices Across Four Canadian Provinces?

  • Maria Baranowski,
  • Nancy Jokinen,
  • Leslie Udell,
  • Sandy Stemp,
  • Tracey Berman and
  • Shahin Shooshtari

We conducted a survey to learn what guides current dementia-related practice to support community-dwelling adults with intellectual and developmental disabilities who may be experiencing dementia in Canada. We invited organizations working in health,...

  • Case Report
  • Open Access
1,918 Views
10 Pages

25 September 2024

The ARX mutations encompass a nearly continuous spectrum of neurodevelopmental disorders (NDDs), ranging from lissencephaly to Proud syndrome, as well as infantile spasms without brain malformations, and including both syndromic and non-syndromic int...

  • Article
  • Open Access
3 Citations
2,252 Views
22 Pages

28 November 2023

Declarative and probabilistic feedback-based learning was evaluated in 8–12-year-old school-age children with developmental language disorder (DLD; n = 14) and age-matched children with typical development (TD; n = 15). Children performed a vis...

  • Article
  • Open Access
13 Citations
4,993 Views
9 Pages

Disability-Specific Associations with Child Health and Functioning

  • Ko Ling Chan,
  • Camilla K. M. Lo,
  • Frederick K. Ho and
  • Patrick Ip

This study examined the health profile of children with different types of disabilities and explored the disability-specific associations with various types of health and functioning using a large nonclinical sample of children. A cross-sectional sch...

  • Review
  • Open Access
7 Citations
4,710 Views
15 Pages

4 October 2022

Mutations in the SCN1A gene can cause a variety of phenotypes, ranging from mild forms, such as febrile seizures and generalized epilepsy with febrile seizures plus, to severe, such as Dravet and non-Dravet developmental epileptic encephalopathies. U...

  • Article
  • Open Access
19 Citations
5,874 Views
26 Pages

Participation in community activities contributes to child development and health-related quality of life (HRQOL), but restricted participation has been reported in children with disabilities. Occupational performance coaching (OPC) is an interventio...

  • Article
  • Open Access
1 Citations
1,322 Views
20 Pages

Neural Correlates of Telicity in Spanish-Speaking Children with and without Developmental Language Disorder

  • Mabel Urrutia,
  • Soraya Sanhueza,
  • Hipólito Marrero,
  • Esteban J. Pino and
  • María Troncoso-Seguel

14 August 2024

Background: It is broadly acknowledged that children with Developmental Language Disorder (DLD) show verb-related limitations. While most previous studies have focused on tense, the mastery of lexical aspect—particularly telicity—has not...

  • Article
  • Open Access
4 Citations
4,443 Views
22 Pages

Children with developmental language disorder (DLD) demonstrate deficits in executive functioning; however, the specific components of executive functioning that are affected in this population are not well understood. This study evaluated set shifti...

  • Article
  • Open Access
14 Citations
3,654 Views
14 Pages

29 September 2021

Most of the current empirical evidence regarding the relationship between health-related fitness and level of motor performance is based on children from high-income countries. Yet, children from low-resource areas may have fewer opportunities to dev...

  • Article
  • Open Access
411 Views
19 Pages

Atypical Resting-State and Task-Evoked EEG Signatures in Children with Developmental Language Disorder

  • Aimin Liang,
  • Zhijun Cui,
  • Yang Shi,
  • Chunyan Qu,
  • Zhuang Wei,
  • Hanxiao Wang,
  • Xu Zhang,
  • Xiaolin Ning,
  • Xin Ni and
  • Jiancheng Fang

Developmental Language Disorder (DLD) is associated with abnormalities in both intrinsic resting-state brain networks and task-evoked neural responses, yet direct electrophysiological evidence linking these levels remains limited. This study examined...

  • Article
  • Open Access
5 Citations
2,607 Views
21 Pages

30 August 2023

Language acquisition depends on the ability to process and learn probabilistic information, often through the integration of performance feedback. Children with developmental language disorder (DLD) have demonstrated weaknesses in both probabilistic...

  • Article
  • Open Access
6 Citations
3,765 Views
18 Pages

We examined whether children with developmental language disorder (DLD) differed from their peers with typical development (TD) in the degree to which they encode information about a talker’s mouth shape into long-term phonemic representations. Child...

  • Review
  • Open Access
104 Citations
10,556 Views
23 Pages

26 September 2016

Bisphenol A (BPA), used in polycarbonate plastics and epoxy resins, has a widespread exposure to humans. BPA is of concern for developmental exposure resulting in immunomodulation and disease development due to its ability to cross the placental barr...

  • Article
  • Open Access
16 Citations
4,472 Views
14 Pages

Effect of Interleukin-7 on In Vitro Maturation of Porcine Cumulus-Oocyte Complexes and Subsequent Developmental Potential after Parthenogenetic Activation

  • Dongjin Oh,
  • Joohyeong Lee,
  • Eunhye Kim,
  • Seon-Ung Hwang,
  • Junchul-David Yoon,
  • Lian Cai,
  • Mirae Kim,
  • Gahye Kim,
  • Hyerin Choi and
  • Sang-Hwan Hyun

8 March 2021

Interleukin-7 (IL-7) is a cytokine essential for cell development, proliferation and survival. However, its role in oocyte maturation is largely unknown. To investigate the effects of IL-7 on the in vitro maturation (IVM) of porcine oocytes, we analy...

  • Review
  • Open Access
2 Citations
2,872 Views
9 Pages

2 November 2020

The sexual abuse crisis that has rocked the Catholic Church in recent decades has resulted in one major unintended casualty: creating a skeptical distance in the relationship between adult leaders and youth. This article provides a short history of t...

  • Article
  • Open Access
3 Citations
3,937 Views
18 Pages

This study aims to assess program quality and developmental outcomes of a youth volleyball project in one of the regional states in Ethiopia, and further examine variations between groups across gender and project site zones. We applied a cross-secti...

  • Article
  • Open Access
9 Citations
6,583 Views
19 Pages

21 November 2023

Recent studies have demonstrated dose-responses of the cannabis plant to supply of macronutrients. However, further development of precision nutrition requires a high-resolution understanding of temporal trends of plant requirements for nutrients thr...

  • Article
  • Open Access
11 Citations
3,404 Views
15 Pages

Identification of Co-Expressed Genes Related to Theacrine Synthesis in Tea Flowers at Different Developmental Stages

  • Xiaomin Chen,
  • Shuxian Shao,
  • Ruxing Yang,
  • Mengya Gu,
  • Pengjie Wang,
  • Feng Zhao and
  • Naixing Ye

13 December 2021

Jiaocheng kucha is the first reported tea germplasm resource which contains theacrine founded in Fujian Province. Currently, the anabolic mechanism of theacrine within tea leaves is clear, but there are few studies focused on its flowers. In order to...

  • Article
  • Open Access
29 Citations
4,720 Views
12 Pages

Arsenic is carcinogenic and teratogenic. In addition, it is also a developmental neurotoxicant. Little is known however about the effect of arsenic exposure during brain development on social behavior. This study aimed to detect the effect of develop...

  • Review
  • Open Access
145 Citations
19,563 Views
19 Pages

A Narrative Review of Motor Competence in Children and Adolescents: What We Know and What We Need to Find Out

  • Luís Lopes,
  • Rute Santos,
  • Manuel Coelho-e-Silva,
  • Catherine Draper,
  • Jorge Mota,
  • Boris Jidovtseff,
  • Cain Clark,
  • Mirko Schmidt,
  • Philip Morgan and
  • César Agostinis-Sobrinho
  • + 46 authors

Lack of physical activity is a global public health problem causing not only morbidity and premature mortality, but it is also a major economic burden worldwide. One of the cornerstones of a physically active lifestyle is Motor Competence (MC). MC is...

  • Article
  • Open Access
8 Citations
3,962 Views
10 Pages

(1) Background—the magnocellular hypothesis proposes that impaired development of the visual timing systems in the brain that are mediated by magnocellular (M-) neurons is a major cause of dyslexia. Their function can now be assessed quite easi...

  • Article
  • Open Access
10 Citations
11,219 Views
16 Pages

In common with most, if not all, papers in this special issue, I will argue that understanding the nature of developmental change and individual differences in intelligence requires a theory of the mechanisms underlying both factors. Insofar as these...

  • Article
  • Open Access
16 Citations
3,384 Views
19 Pages

11 October 2021

Methylmercury (MeHg) is a ubiquitous pollutant shown to cause developmental neurotoxicity, even at low levels. However, there is still a large gap in our understanding of the mechanisms linking early-life exposure to life-long behavioural impairments...

  • Article
  • Open Access
18 Citations
4,737 Views
15 Pages

Plasma-Activated Water Modulates Root Hair Cell Density via Root Developmental Genes in Arabidopsis thaliana L.

  • Dong Hyeun Ka,
  • Ryza Aditya Priatama,
  • Joo Young Park,
  • Soon Ju Park,
  • Seong Bong Kim,
  • In Ah Lee and
  • Young Koung Lee

3 March 2021

Low-temperature atmospheric pressure plasma technology has been used in agriculture and plant science by direct and indirect treatment of bio-samples. However, the cellular and molecular mechanisms affected by plasma-activated water (PAW) are largely...

  • Article
  • Open Access
62 Citations
8,593 Views
18 Pages

23 September 2016

Previous studies have shown that germin-like proteins (GLPs) are present ubiquitously in rice and Arabidopsis. However, the understanding regarding their role in development and abiotic/biotic stress resistance remains limited. In the present study,...

  • Review
  • Open Access
12 Citations
4,537 Views
15 Pages

20 August 2023

CASK-related disorders are a form of rare X-linked neurological diseases and most of the patients are females. They are characterized by several symptoms, including microcephaly with pontine and cerebellar hypoplasia (MICPCH), epilepsy, congenital ny...

  • Article
  • Open Access
7 Citations
3,583 Views
11 Pages

A Child’s Perception of Their Developmental Difficulties in Relation to Their Adult Assessment. Analysis of the INPP Questionnaire

  • Alina Demiy,
  • Agata Kalemba,
  • Maria Lorent,
  • Anna Pecuch,
  • Ewelina Wolańska,
  • Marlena Telenga and
  • Ewa Z. Gieysztor

5 October 2020

This study involved a comparison of the perception of developmental difficulties in a child by the parents, the teacher, and through the child’s self-assessment. Based on the Institute for Neuro-Psychological Psychology (INPP) questionnaire acc...

  • Article
  • Open Access
15 Citations
6,563 Views
17 Pages

Sleep-Related Declarative Memory Consolidation in Children and Adolescents with Developmental Dyslexia

  • Flaminia Reda,
  • Maurizio Gorgoni,
  • Aurora D'Atri,
  • Serena Scarpelli,
  • Matteo Carpi,
  • Erica Di Cola,
  • Deny Menghini,
  • Stefano Vicari,
  • Giacomo Stella and
  • Luigi De Gennaro

Sleep has a crucial role in memory processes, and maturational changes in sleep electrophysiology are involved in cognitive development. Albeit both sleep and memory alterations have been observed in Developmental Dyslexia (DD), their relation in thi...

  • Article
  • Open Access
6 Citations
3,631 Views
21 Pages

Differential Coloration, Pigment Biosynthesis-Related Gene Expression, and Accumulation According to Developmental Stage in the ‘Enbu’ Apple

  • Van Giap Do,
  • Seonae Kim,
  • Youngsuk Lee,
  • Sangjin Yang,
  • Jeong-Hee Kim,
  • Nay Myo Win,
  • Young-Soon Kwon,
  • Juhyeon Park and
  • Jong-Taek Park

25 September 2023

Coloration, a major factor contributing to apple quality, attracts consumer attraction, thereby increasing the sale of fruits in the market. Among the fruit pigments, anthocyanins and carotenoids are the most important pigments that impart coloration...

  • Article
  • Open Access
9 Citations
2,564 Views
14 Pages

Exploration of the Feasibility of Remote Assessment of Functioning in Children and Adolescents with Developmental Disabilities: Parents’ Perspectives and Related Contextual Factors

  • Beatriz Helena Brugnaro,
  • Fabiana Nascimento Vieira,
  • Gesica Fernandes,
  • Olaf Kraus de Camargo,
  • Laís Fumincelli,
  • Ana Carolina de Campos,
  • Silvia Letícia Pavão and
  • Nelci Adriana Cicuto Ferreira Rocha

The COVID-19 pandemic interrupted face-to-face health services, leveraging telehealth strategies. The aim of this cross-sectional study was to investigate, from a parent’s perspective, the feasibility of a remote assessment of functioning in ch...

  • Article
  • Open Access
831 Views
16 Pages

31 October 2025

The paper presents the issue of acquired and secondary auditory processing disorder (APD) in children and adolescents in the Polish population. The authors analyzed a group of individuals with APD and younger children who were at risk based on a deta...

  • Article
  • Open Access
5 Citations
2,738 Views
10 Pages

Developmental Exposure to Endocrine Disrupter DDT Interferes with Age-Related Involution of Thymus

  • Nataliya V. Yaglova,
  • Sergey S. Obernikhin,
  • Elina S. Tsomartova,
  • Valentin V. Yaglov,
  • Svetlana V. Nazimova,
  • Dibakhan A. Tsomartova,
  • Ekaterina P. Timokhina,
  • Elizaveta V. Chereshneva,
  • Marina Y. Ivanova and
  • Olga V. Payushina

The impact of endocrine-disrupting chemicals on the development and involution of the immune system is a possible reason for the increased incidence of disorders associated with inappropriate immune function. The thymus is a lymphoid and also an endo...

  • Article
  • Open Access
4,278 Views
14 Pages

Children with developmental coordination disorder (DCD) have motor difficulties that interfere with their daily functions. The extent to which DCD affects children in Hong Kong has not been established. In this study, we aimed to estimate the prevale...

  • Article
  • Open Access
6 Citations
8,183 Views
19 Pages

Alcohol Triggers the Accumulation of Oxidatively Damaged Proteins in Neuronal Cells and Tissues

  • Anusha W. Mudyanselage,
  • Buddhika C. Wijamunige,
  • Artur Kocoń,
  • Ricky Turner,
  • Denise McLean,
  • Benito Morentin,
  • Luis F. Callado and
  • Wayne G. Carter

Alcohol is toxic to neurons and can trigger alcohol-related brain damage, neuronal loss, and cognitive decline. Neuronal cells may be vulnerable to alcohol toxicity and damage from oxidative stress after differentiation. To consider this further, the...

  • Article
  • Open Access
3,191 Views
16 Pages

Spatial Accuracy and Variability in Dart Throwing in Children with Developmental Coordination Disorder and the Relationship with Ball Skill Items

  • Faiçal Farhat,
  • Achraf Ammar,
  • Nourhen Mezghani,
  • Mohamed Moncef Kammoun,
  • Khaled Trabelsi,
  • Haitham Jahrami,
  • Adnene Gharbi,
  • Lassad Sallemi,
  • Haithem Rebai and
  • Bouwien Smits-Engelsman
  • + 1 author

The present study aimed to examine precision and variability in dart throwing performance and the relationships between these outcomes and bouncing, throwing and catching tasks in children with and without DCD. Children between the ages of 8 and 10 y...

  • Article
  • Open Access
3 Citations
2,463 Views
14 Pages

The hazardous pest known as rice leaf roller (Marasmia ruralis Wlk.) (Lepidoptera: Pyralidae), which undermines rice (Oryza sativa L.) output globally, folds the leaves of the rice plant. Protein elicitors are thought to be biological elements that c...

  • Article
  • Open Access
38 Citations
4,210 Views
13 Pages

14 August 2019

Hypertension can originate from early-life exposure to oxidative stress. As reported, dimethyl fumarate (DMF) activates nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and protects against oxidative stress damage. We examined whether mater...

  • Brief Report
  • Open Access
9 Citations
3,969 Views
17 Pages

The Proteasome Lid Triggers COP9 Signalosome Activity during the Transition of Saccharomyces cerevisiae Cells into Quiescence

  • Laylan Bramasole,
  • Abhishek Sinha,
  • Dana Harshuk,
  • Angela Cirigliano,
  • Gurevich Sylvia,
  • Zanlin Yu,
  • Rinat Lift Carmeli,
  • Michael H. Glickman,
  • Teresa Rinaldi and
  • Elah Pick

4 September 2019

The class of Cullin–RING E3 ligases (CRLs) selectively ubiquitinate a large portion of proteins targeted for proteolysis by the 26S proteasome. Before degradation, ubiquitin molecules are removed from their conjugated proteins by deubiquitinating enz...

  • Review
  • Open Access
7 Citations
11,363 Views
23 Pages

8 March 2022

Strategically timed trauma- and attachment-informed psychotherapy to address underlying emotional wounds, paired with ketamine administered in precision-calibrated doses to ensure high-entropy brain states, may be key to improving the quality and dur...

  • Review
  • Open Access
2 Citations
7,788 Views
17 Pages

Pediatric Chronic Kidney Disease: Mind the Gap Between Reality and Expectations

  • Chien-Ning Hsu,
  • Pei-Chen Lu,
  • Wei-Ting Liao and
  • You-Lin Tain

Pediatric chronic kidney disease (CKD) is a growing concern that often originates early in life, yet significant challenges remain in translating clinical guidelines into real-world practice. World Kidney Day 2025 highlights the importance of early d...

  • Review
  • Open Access
7 Citations
3,440 Views
17 Pages

17 April 2023

Cerebral cavernous malformations (CCMs) are abnormally dilated intracranial capillaries that form cerebrovascular lesions with a high risk of hemorrhagic stroke. Recently, several somatic “activating” gain-of-function (GOF) point mutation...

  • Article
  • Open Access
11 Citations
2,431 Views
15 Pages

9 November 2023

Most catastrophic injuries in Thoroughbred racehorses involve the fetlock. There is no description of comparative imaging in Thoroughbreds entering racehorse training. The aim was to describe MRI, CT and radiographic findings in the metacarpophalange...

  • Article
  • Open Access
10 Citations
3,822 Views
18 Pages

CRIPTO and miR-371a-3p Are Serum Biomarkers of Testicular Germ Cell Tumors and Are Detected in Seminal Plasma from Azoospermic Males

  • Cassy M. Spiller,
  • João Lobo,
  • Willem P. A. Boellaard,
  • Ad J. M. Gillis,
  • Josephine Bowles and
  • Leendert H. J. Looijenga

23 March 2020

miR-371a-3p is currently the most informative reported biomarker for germ cell tumors (GCTs). Another developmental-related biomarker, CRIPTO, is involved in the regulation of pluripotency and germ cell fate commitment. We aimed to assess the value o...

  • Article
  • Open Access
33 Citations
5,351 Views
25 Pages

Spodoptera frugiperda is a worldwide generalist pest with remarkable adaptations to environments and stresses, including developmental stage-related behavioral and physiological adaptations, such as diverse feeding preferences, mate seeking, and pest...

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