923 Results Found

Reducing car dependency requires orchestrated multi-sectoral, multi-policy action in a complex landscape. Thus, development of proposed interventions to reduce car dependency should be informed by systems thinking, complexity science, and socio-techn...

Reducing car dependence is the key to achieving the goal of green and sustainable development. Compared with the existing studies, which mainly focus on administrative areas, this study takes residential areas as the research unit. Four spatial regre...

Chimeric Antigen Receptor (CAR)-T cell immunotherapy revolutionized cancer treatment and consists of the genetic modification of T lymphocytes with a CAR gene, aiming to increase their ability to recognize and kill antigen-specific tumor cells. The d...

We examine the concentration dependence of the Coherent Anti-Stokes Raman Scattering (CARS) signal obtained for gas mixtures at various conditions using the Femtosecond Adaptive Spectroscopic Technique (FAST). We use the CARS signal of the Q-branch v...

The metal surfaces of a car exhibit favorable properties for the passive condensation of atmospheric water. Under certain nocturnal climatic conditions (high relative humidity, weak windspeed, and total nebulosity), dew is often observed on cars, and...

Despite rapid changes in vehicle technology and the expansion of IT-based mobility solutions, travel habits must be changed to address the environmental and health implications of increasing car dependency. A significant amount of research focuses on...

More people than ever before are living in urban settlements, increasing competition for living space, employment, food, water, and energy. Urbanisation poses many challenges, most notably meeting the basic health and well-being needs of inhabitants....

Chimeric antigen receptor T (CAR T)-cell therapy has become a standard treatment option for patients with relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL). Mutations in the PPM1D gene, a frequent driver alteration in clonal hematopoie...

The role of habits in influencing transportation behaviour is acknowledged in many studies. However, most of these analyses draw on a narrow perspective of habits. In this paper, we adopt a reversed perspective regarding the interplay between habits...

For the sake of reducing car dependence, much can be learned from non-car owners about how everyday life can, and cannot, be organized without private car ownership. This study aims to explore carless mobility, including the role of the car, in relat...

Investigating the connections between pedestrian crashes and various urban variables is critical to ameliorate the prediction of pedestrian fatalities, formulate advisories for the stakeholders, and provide an evidence base for policy change to mitig...

Natural Killer (NK) cell-based immunotherapy relies on CD16-mediated Antibody-Dependent Cellular Cytotoxicity (ADCC), yet the ovarian tumor microenvironment (TME) severely compromises this function via Transforming Growth Factor-beta (TGF-β). Th...

The treatment of multiple myeloma (MM) has entered into a new era of immunotherapy. Novel immunotherapies will significantly improve patient outcome via simultaneously targeting malignant plasma cell (PC) and reversing immunocompromised bone marrow (...

The charging demand of electric passenger cars needs to be considered during the planning and operation of the electric power grid, especially at high penetration rates. It is not sufficient to simply quantify these additional loads, but rather time-...

This paper challenges the fact that the absolute freedom for residents to locate themselves wherever they want can lead to sustainable cities. Urban sprawl is the corollary to this freedom. Urban sprawl has become a controversial issue. Lines of thou...

Vehicle air pollution is a significant problem for health and climate change that can be solved by several approaches. The route is one of the many components to be considered. In this work, we propose a statistical analysis of a large FCD database i...

Background/Objectives: Mantle cell lymphoma (MCL) represents a rare B-cell lymphoma subtype with rather high relapse rates. Somatic mutations in the PPM1D gene were shown to be associated with adverse outcomes in patients with diffuse large B-cell ly...

Walkability has increasingly been recognized as an important factor for sustainable urban development that, however, has seldom been investigated in rapid urbanizing cities, especially in the Asian context. This paper assessed walkability in Futian D...

This paper compares bicycling in Washington, DC and Frankfurt am Main, Germany, two car-oriented cities that had adapted their urban transport system to car travel during the 20th century. Our comparative case study shows that both cities have been s...

To make cities more sustainable and livable and to achieve climate targets in transportation, cities around the globe must undergo sustainable transformations. However, disparities in initial conditions pose challenges when trying to implement these...

As car ownership and usage expand globally, understanding the factors that influence the propensity to drive is crucial for promoting sustainable transportation. This literature review examined the factors influencing driving decisions through a syst...

The social cost, as one of the factors determining sustainability of socio-economic development, is strongly dependent upon a number of casualties and mortality in road accidents. The condition of car tires appears to be one of the important factors...

This article examines a simulated collision between a car and a cyclist, assessing the trajectory of the cyclist’s movement after the impact, namely the throwing distances and angles of the cyclist and bicycle. Information about the car and cyc...

The nuclear receptor peroxisome proliferator-activated receptor α (PPARα) is a transcription factor that controls the transcription of genes responsible for fatty acid metabolism. We have recently reported a possible drug–drug inter...

Along with urbanization and economic development, the number of private cars has increased rapidly in recent years in China, which contributes to concerns about traffic congestion, hard parking, energy consumption, and emissions. This study aims to i...

The ribosome CAR interaction surface behaves as an extension of the decoding center A site and has H-bond interactions with the +1 codon, which is next in line to enter the A site. Through molecular dynamic simulations, we investigated the codon sequ...

Natural killer (NK) cells are cytotoxic lymphocytes that are critical for the innate immune system. Engineering NK cells with chimeric antigen receptors (CARs) allows CAR-NK cells to target tumor antigens more effectively. In this report, we present...

Improving chimeric antigen receptor (CAR)-T cell therapeutic outcomes and expanding its applicability to solid tumors requires further refinement of CAR-T cells. We previously reported that CAR-T cells bearing a herpes virus entry mediator (HVEM)-der...

During the last two decades, the constitutive androstane receptor (CAR; NR1I3) has emerged as a master activator of drug- and xenobiotic-metabolizing enzymes and transporters that govern the clearance of both exogenous and endogenous small molecules....

Concerns about transportation energy consumption and emissions force urban planners and policy makers to pay more attention to the effects of car ownership and use on the environment in China. However, few studies have investigated the relationship b...

Due to the CD1d restricted recognition of altered glycolipids, Vα24-invariant natural killer T (iNKT) cells are excellent tools for cancer immunotherapy with a significantly reduced risk for graft-versus-host disease when applied as off-the she...

The present study focuses on scientific and experimental research on corrosion damage to the bodies of subway cars. The main purpose of the research is to assess the degree of corrosive wear on the main load-bearing metal structures of the subway car...

Chimeric antigen receptor (CAR)-T cells have demonstrated significant clinical potential; however, their strong antitumor activity may cause severe adverse effects. To ensure efficacy and safe CAR-T cell therapy, it is important to understand CAR&rsq...

We consider a queueing network with a finite number of nodes and servers moving between the nodes as a model of car sharing. The arrival process of customers to various nodes is defined by a marked Markovian arrival process. The customer that arrives...

The engineering of T cells through expression of chimeric antigen receptors (CARs) against tumor-associated antigens (TAAs) has shown significant potential for use as an anti-cancer therapeutic. The development of strategies for flexible and modular...

The effect of car cooler mileage and coolant mileage on cooler thermal performance was experimentally investigated. The water–ethylene-glycol-based coolant with mileages of 0 km, 50,000 km, and 100,000 km was circulated in new and used car cool...

The metabolic milieu of solid tumors provides a barrier to chimeric antigen receptor (CAR) T-cell therapies. Excessive lactate or hypoxia suppresses T-cell growth, through mechanisms including NADH buildup and the depletion of oxidized metabolites. N...

Currently, owning a car is a necessity, as it plays a significant role in human transportation for different purposes such as going to work and to the hospital. However, with the current economic challenges, buying expensive cars can be a burden. The...

The paper presented studies on reducing traction energy consumption with a decrease in the weight of an all-metal gondola car. Based on the proposed mathematical criterion, a new form of a blind floor was obtained, which makes it possible to reduce t...

Autonomous car travel planning is increasingly gaining attention from scientists and professionals, who are addressing the integration of autonomous cars into the general urban transportation system. Autonomous car travel planning depends on the tran...

Coxsackievirus B3 (CV-B3) infection causes inflammatory conditions such as viral myocarditis and meningitis, and incidence rates are rising annually. While children are more likely to be affected by severe manifestations, the molecular basis of this...

The constitutive androstane receptor (CAR, NR1I3) is extremely important for the regulation of many physiological processes, especially xenobiotic (drug) metabolism and transporters. CAR differs from steroid hormone receptors in that it can be activa...

Conventional fuels commonly used in cars with combustion engines and the effects of their combustion have a very negative impact on the state of the environment. The combustion of liquid fuels causes the introduction of many thousands of tons of CO₂...

The development of genetic modification techniques has led to a new era in cancer treatments that have been limited to conventional treatments such as chemotherapy. intensive efforts are being performed to develop cancer-targeted therapies to avoid t...

There are known links between the hypothalamic–pituitary–adrenal (HPA) axis and systems responsible for regulating posture. Our aim was to explore directly, for the first time, whether an aspect of circadian HPA axis activity (the cortisol awakening...

The constitutive androstane receptor (CAR) is a critical nuclear receptor in the gene regulation of xenobiotic and endobiotic metabolism. The LanthaScreenTM TR-FRET CAR coactivator assay provides a simple and reliable method to analyze the affinity o...

The paper presents data on the problems of monitoring and diagnosing the technical conditions of critical production facilities, such as torpedo ladle cars, steel ladles. The accidents with critical production facilities, such as torpedo ladle cars,...

Background: The emergence of chimeric antigen receptor T-cell (CAR-T) immunotherapy holds great promise in treating hematologic malignancies. While advancements in CAR design have enhanced therapeutic efficacy, the time-consuming manufacturing proces...

This paper presents research on humidity in a passenger car cabin with the use of supply ventilation without cooling the air. Based on the tests carried out and the humidity balance in the car, a model was developed for changing the humidity in the p...

This paper presents a mixed-method analysis of car ownership in Reykjavik, Iceland, a location with a high motorization level and deeply rooted car culture. We utilize qualitative interviews to understand vehicle possession reasons and elaborate the...