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Search Results (53,131)

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Keywords = accessibility

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18 pages, 639 KiB  
Article
Psychoeducational Classroom Interventions Promoting Inclusion of Special Educational Needs Students in Mainstream Classes: The Case of the BATTIE Program
by Diamanto Filippatou, Anna Gerakin and Georgios Androulakis
Educ. Sci. 2025, 15(8), 958; https://doi.org/10.3390/educsci15080958 (registering DOI) - 25 Jul 2025
Abstract
Inclusive education emphasizes the right of all students, including those with special educational needs and disabilities (SEND), to access equitable learning opportunities in mainstream classrooms. This study presents the implementation and evaluation of a school-based intervention within the BATTIE (Bottleneck Analysis and Teacher [...] Read more.
Inclusive education emphasizes the right of all students, including those with special educational needs and disabilities (SEND), to access equitable learning opportunities in mainstream classrooms. This study presents the implementation and evaluation of a school-based intervention within the BATTIE (Bottleneck Analysis and Teacher Trainings for Inclusive Education) project in Greece, aiming to enhance inclusion through differentiated instruction (DI) and a whole school approach. The intervention was conducted across 26 schools and involved 116 educators and 130 students with SEND. A qualitative methodology was employed, utilizing structured classroom observations, field notes, and semi-structured interviews with teachers. The data were thematically analyzed using NVivo 11. Findings indicated notable improvements in student engagement, academic participation, and classroom collaboration, especially among students with SEND. Teachers reported enhanced professional confidence, better understanding of inclusive strategies, and improved collaboration with special education staff. However, limitations in interdisciplinary cooperation—particularly with school psychologists—were identified. This study concludes that sustained professional development, school-wide collaboration, and differentiated instruction are essential for fostering inclusive practices. It underscores the potential of structured, whole school interventions to improve learning environments for diverse student populations and provides insights for educational policy and practice reform. Full article
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11 pages, 784 KiB  
Article
Application and Outcomes of Minimal-Dose Versus Standard-Dose Radiation in Peripheral Endovascular Intervention (KAR Endovascular Study)
by Subrata Kar and Clifton Espinoza
J. Cardiovasc. Dev. Dis. 2025, 12(8), 284; https://doi.org/10.3390/jcdd12080284 (registering DOI) - 25 Jul 2025
Abstract
Background: Peripheral endovascular intervention (PEVI) is routinely performed using standard-dose radiation (SDR), which is associated with elevated levels of radiation. No study has evaluated the outcomes of minimal-dose radiation (MDR) in PEVI. Methods: We performed a prospective observational study of 184 patients (65 [...] Read more.
Background: Peripheral endovascular intervention (PEVI) is routinely performed using standard-dose radiation (SDR), which is associated with elevated levels of radiation. No study has evaluated the outcomes of minimal-dose radiation (MDR) in PEVI. Methods: We performed a prospective observational study of 184 patients (65 ± 12 years) at an academic medical center from January 2019 to March 2020 (mean follow-up of 3.9 ± 3.6 months) and compared the outcomes of MDR (n = 24, 13.0%) and SDR (n = 160, 87.0%) in PEVI. Primary endpoints included air kerma, dose area product (DAP), fluoroscopy time, and contrast use. Secondary endpoints included all-cause mortality, cardiac mortality, acute myocardial infarction, acute kidney injury, stroke, repeat revascularization, vessel dissection/perforation, major adverse limb event, access site complications, and composite of complications. Results: For MDR (68 ± 10 years, mean follow-up of 4.3 ± 5.2 months), the primary endpoints were significantly less than SDR (65 ± 12 years, mean follow-up of 3.8 ± 3.2 months; p < 0.001). Regarding the secondary endpoints, one vessel dissection occurred using MDR, while 36 total complications occurred with SDR (p = 0.037). Conclusions: PEVI using MDR was safe and efficacious. MDR showed a significant decrement in radiation parameters and fluoroscopy time. Therefore, MDR can serve as an effective alternative for PEVI in acute or critical limb ischemia. Full article
(This article belongs to the Section Acquired Cardiovascular Disease)
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16 pages, 8899 KiB  
Article
DNA Methylation Concurrence, Independent of DNA Methylation Ratios, Is Associated with Chromatin Accessibility and 3D Genome Architecture
by Guian Zhang, Yixian Yang, Dan Cui and Jia Li
Int. J. Mol. Sci. 2025, 26(15), 7199; https://doi.org/10.3390/ijms26157199 - 25 Jul 2025
Abstract
Multiple metrics for read-level DNA methylation pattern analysis have provided new insights into DNA methylation modifications. However, the performance of these metrics and their relationship with DNA methylation ratios in identifying biologically meaningful regions have remained unclear. Here, we systematically benchmarked five read-level [...] Read more.
Multiple metrics for read-level DNA methylation pattern analysis have provided new insights into DNA methylation modifications. However, the performance of these metrics and their relationship with DNA methylation ratios in identifying biologically meaningful regions have remained unclear. Here, we systematically benchmarked five read-level DNA methylation metrics using whole-genome bisulfite sequencing data from 59 individuals across six healthy tissue types and six tumor types. We found that DNA methylation concurrence (MCR) effectively captured tissue-specific features independent of the DNA methylation ratios. Regions that exhibited decreased MCR (MCDRs) in tumors were significantly enriched in promoter and intergenic regions and strongly overlapped with tumor-gained chromatin accessibility sites. The further analysis of histone modifications, including H3K4me3, H3K27ac, and H3K9ac, confirmed that MCDRs marked active gene regulatory elements. Motif enrichment analysis revealed a strong preference for CTCF binding within MCDRs. Additionally, 3D genome analysis supported a model in which MCDRs, independent of DNA methylation ratios, contribute to active gene regulation by facilitating CTCF binding and long-range chromatin interactions. Full article
(This article belongs to the Section Molecular Genetics and Genomics)
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15 pages, 1211 KiB  
Review
Epigenetic Regulation of Neutrophils in ARDS
by Jordan E. Williams, Zannatul Mauya, Virginia Walkup, Shaquria Adderly, Colin Evans and Kiesha Wilson
Cells 2025, 14(15), 1151; https://doi.org/10.3390/cells14151151 - 25 Jul 2025
Abstract
Acute respiratory distress syndrome (ARDS) is an inflammatory pulmonary condition that remains at alarming rates of fatality, with neutrophils playing a vital role in its pathogenesis. Beyond their classical antimicrobial functions, neutrophils contribute to pulmonary injury via the release of reactive oxygen species, [...] Read more.
Acute respiratory distress syndrome (ARDS) is an inflammatory pulmonary condition that remains at alarming rates of fatality, with neutrophils playing a vital role in its pathogenesis. Beyond their classical antimicrobial functions, neutrophils contribute to pulmonary injury via the release of reactive oxygen species, proteolytic enzymes, and neutrophil extracellular traps (NETs). To identify targets for treatment, it was found that epigenetic mechanisms, including histone modifications, hypomethylation, hypermethylation, and non-coding RNAs, regulate neutrophil phenotypic plasticity, survival, and inflammatory potential. It has been identified that neutrophils in ARDS patients exhibit abnormal methylation patterns and are associated with altered gene expression and prolonged neutrophil activation, thereby contributing to sustained inflammation. Histone citrullination, particularly via PAD4, facilitates NETosis, while histone acetylation status modulates chromatin accessibility and inflammatory gene expression. MicroRNAs have also been shown to regulate neutrophil activity, with miR-223 and miR-146a potentially being biomarkers and therapeutic targets. Neutrophil heterogeneity, as evidenced by distinct subsets such as low-density neutrophils (LDNs), varies across ARDS etiologies, including COVID-19. Single-cell RNA sequencing analyses, including the use of trajectory analysis, have revealed transcriptionally distinct neutrophil clusters with differential activation states. These studies support the use of epigenetic inhibitors, including PAD4, HDAC, and DNMT modulators, in therapeutic intervention. While the field has been enlightened with new findings, challenges in translational application remain an issue due to species differences, lack of stratification tools, and heterogeneity in ARDS presentation. This review describes how targeting neutrophil epigenetic regulators could help regulate hyperinflammation, making epigenetic modulation a promising area for precision therapeutics in ARDS. Full article
(This article belongs to the Section Cell Microenvironment)
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15 pages, 411 KiB  
Article
Decoding Treatment Failures in Metastatic Renal Cell Carcinoma: Predictors Across Immunotherapy and Targeted Therapies from a Retrospective Real-World Analysis
by Sorin Saftescu, Vlad-Norin Vornicu, Dorel-Ionel Popovici, Radu-Dumitru Dragomir, Dana-Sonia Nagy, Daniela-Lidia Sandu, Ana Dulan, Șerban-Mircea Negru and Alina-Gabriela Negru
J. Clin. Med. 2025, 14(15), 5271; https://doi.org/10.3390/jcm14155271 - 25 Jul 2025
Abstract
Background: Despite recent advances in the management of metastatic renal cell carcinoma (mRCC), real-world outcomes remain heterogeneous, and early treatment failure is common. Predictive biomarkers for time to treatment failure (TTF) outside clinical trials are poorly characterized. Objective: To identify clinical [...] Read more.
Background: Despite recent advances in the management of metastatic renal cell carcinoma (mRCC), real-world outcomes remain heterogeneous, and early treatment failure is common. Predictive biomarkers for time to treatment failure (TTF) outside clinical trials are poorly characterized. Objective: To identify clinical and laboratory predictors associated with early treatment failure in a real-world cohort of mRCC patients treated with immune checkpoint inhibitors (ICIs), tyrosine kinase inhibitors (TKIs), or combination regimens. Methods: We conducted a retrospective, single-center analysis of patients with metastatic non-urothelial RCC treated between 2018 and 2023. Cox proportional hazards regression was used to evaluate the association between baseline biological parameters and TTF for each treatment regimen. Results: Among 137 patients receiving first-line therapy, 50 received Ipilimumab + Nivolumab, 49 Sunitinib, and 17 Avelumab + Axitinib. For Ipilimumab + Nivolumab, elevated AST was significantly associated with shorter TTF. For Avelumab + Axitinib, shorter TTF was associated with lymph node metastases, low lymphocyte count, low creatinine, low BMI, and low hemoglobin. For Cabozantinib in subsequent lines, a higher platelet count, ALT, and presence of liver metastases were associated with shorter TTF. No statistically significant predictors were found for Nivolumab used in the second-line setting. Conclusions: Routine, accessible biomarkers such as AST, hemoglobin, lymphocyte count, and creatinine may serve as predictors of treatment failure in specific therapeutic contexts. These findings support risk-adapted strategies and individualized monitoring in real-world clinical practice, though further validation in larger cohorts is warranted. Full article
(This article belongs to the Special Issue Advances and Perspectives in Cancer Diagnostics and Treatment)
11 pages, 235 KiB  
Article
Pivotal Studies for Drugs About to Be Launched for Rare Diseases: Will They Better Support Health Technology Assessment and Market Access than in the Past?
by Claudio Jommi, Marzia Bonfanti, Melissa Guardigni, Andrea Aiello, Andrea Marcellusi, Pier Luigi Canonico, Fulvio Luccini and Chiara Lucchetti
J. Mark. Access Health Policy 2025, 13(3), 37; https://doi.org/10.3390/jmahp13030037 - 25 Jul 2025
Abstract
The designs of clinical trials of drugs for rare diseases are challenged by health technology assessment organisations and payers. Phase II pivotal studies, single-arm or open-label designs, the extensive use of non-final endpoints, and the limited use of patient-reported outcomes (PROs) are the [...] Read more.
The designs of clinical trials of drugs for rare diseases are challenged by health technology assessment organisations and payers. Phase II pivotal studies, single-arm or open-label designs, the extensive use of non-final endpoints, and the limited use of patient-reported outcomes (PROs) are the main points of contention. The evidence on the actual design of these trials is limited, but corroborates the concerns of the above. Our aim is to scrutinise whether the design of pivotal studies of drugs for rare diseases to be launched into the Italian market by 2026 present similar issues. The drugs and the relevant pivotal studies were retrieved from Biomedtracker and US and European clinical trial databases. We identified 154 new drugs for rare diseases. Single-arm designs account for 36% of trials. Almost 50% of randomised control trials (RCTs) are designed using an active comparator and 61% are double-blinded. Primary endpoints are mostly (82%) surrogate. A total of 59% of studies include PROs. Our findings were partially expected (e.g., extensive use of surrogate endpoints) and partially not (e.g., RCTs and an active comparator), considering previous studies on the same topic. Having more head-to-head studies may reduce uncertainty concerning evidence at market launch, but different issues persist, including the still limited role of PROs. Full article
30 pages, 1691 KiB  
Article
Controlling Industrial Robotic Arms Using Gyroscopic and Gesture Inputs from a Smartwatch
by Carmen-Cristiana Cazacu, Mihail Hanga, Florina Chiscop, Dragos-Alexandru Cazacu and Costel Emil Cotet
Appl. Sci. 2025, 15(15), 8297; https://doi.org/10.3390/app15158297 - 25 Jul 2025
Abstract
This paper presents a novel interface that leverages a smartwatch for controlling industrial robotic arms. By harnessing the gyroscope and advanced gesture recognition capabilities of the smartwatch, our solution facilitates intuitive, real-time manipulation that caters to users ranging from novices to seasoned professionals. [...] Read more.
This paper presents a novel interface that leverages a smartwatch for controlling industrial robotic arms. By harnessing the gyroscope and advanced gesture recognition capabilities of the smartwatch, our solution facilitates intuitive, real-time manipulation that caters to users ranging from novices to seasoned professionals. A dedicated application is implemented to aggregate sensor data via an open-source library, providing a streamlined alternative to conventional control systems. The experimental setup consists of a smartwatch equipped with a data collection application, a robotic arm, and a communication module programmed in Python. Our aim is to evaluate the practicality and effectiveness of smartwatch-based control in a real-world industrial context. The experimental results indicate that this approach significantly enhances accessibility while concurrently minimizing the complexity typically associated with automation systems. Full article
34 pages, 3155 KiB  
Review
Suicide Prevention Measures at High-Risk Locations: A Goal-Directed Motivation Perspective
by Laura Joyner, Jay-Marie Mackenzie, Andy Willis, Penny Phillips, Bethany Cliffe, Ian Marsh, Elizabeth Pettersen, Keith Hawton and Lisa Marzano
Behav. Sci. 2025, 15(8), 1009; https://doi.org/10.3390/bs15081009 - 25 Jul 2025
Abstract
Understanding the effectiveness of suicide prevention measures for high-risk locations can often be challenging as many rely, at least to some degree, on psychological processes (e.g., engaging with help-seeking behaviours). Establishing how these measures may influence decision-making during a suicide attempt could be [...] Read more.
Understanding the effectiveness of suicide prevention measures for high-risk locations can often be challenging as many rely, at least to some degree, on psychological processes (e.g., engaging with help-seeking behaviours). Establishing how these measures may influence decision-making during a suicide attempt could be helpful for understanding how and when they may be most effective at preventing deaths. In the present work, we consider how suicide prevention measures may influence “goal pursuit” as it unfolds. Drawing on findings from across the suicide prevention literature, we apply the descriptive framework outlined in GOAL Architecture to consider how different measures may shape perceptions of “distance”, “time”, and “rate of progress” and, in turn, could influence levels of motivational drive associated with specific acts (e.g., “accessing means for suicide”). This is discussed in relation to real-time decisions around accessing means for suicide, avoiding intervention by a third party, and engaging in help-seeking behaviours. As well as the psychological processes that could encourage or prevent an individual from disengaging from a suicide attempt, we also consider potential risks and the influence of person-level factors. Full article
(This article belongs to the Special Issue Suicidal Behaviors: Prevention, Intervention and Postvention)
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18 pages, 379 KiB  
Article
Literacy or Useless Knowledge? Associations Between Health Literacy and Lifestyle Among Adolescents
by Bernadett Varga, Gábor Pál Stromájer, Dóra Heizler, Melinda Csima and Tímea Stromájer-Rácz
Children 2025, 12(8), 978; https://doi.org/10.3390/children12080978 - 25 Jul 2025
Abstract
Background/Objectives: Health literacy plays a fundamental role in adolescents’ health-related decisions and behaviors. The aim of our study was to assess the level of health literacy among 16–17-year-old students in Southern Hungary and to examine the associations between sociodemographic characteristics and health behaviors. [...] Read more.
Background/Objectives: Health literacy plays a fundamental role in adolescents’ health-related decisions and behaviors. The aim of our study was to assess the level of health literacy among 16–17-year-old students in Southern Hungary and to examine the associations between sociodemographic characteristics and health behaviors. Methods: This cross-sectional quantitative study was conducted in the autumn of 2024 in Baranya and Somogy counties. A total of 133 students completed a self-administered questionnaire including sociodemographic variables and health behaviors. Health literacy was measured using the validated HELMA-H instrument. Statistical analysis included chi-square tests, t-tests, and ANOVA (p < 0.05). Results: Overall, 62.7% of the students demonstrated adequate, while 37.3% demonstrated inadequate levels of health literacy. No significant association was found between overall health literacy and sociodemographic variables; however, partial associations were observed on specific subscales. Boys reported better access to health information (p = 0.037), while children of mothers with higher educational attainment scored better in comprehension (p = 0.042) and appraisal (p = 0.036). In the case of the numeracy subscale, children of mothers with the lowest educational level showed significantly better results (p = 0.006). Students with higher health literacy levels were less likely to smoke or consume caffeine; however, a reverse trend was observed regarding alcohol consumption. Physical activity showed a positive association with healthier behaviors (p < 0.05). Discussion: The use of digital technologies, interactive learning strategies, and the involvement of family members—especially mothers—may support the development of health-conscious decision-making in adolescents. Consequently, health education programs should focus not only on knowledge transfer but also on fostering critical thinking and decision-making skills. Full article
(This article belongs to the Section Global Pediatric Health)
24 pages, 4310 KiB  
Article
A Privacy Preserving Attribute-Based Access Control Model for the Tokenization of Mineral Resources via Blockchain
by Padmini Nemala, Ben Chen and Hui Cui
Appl. Sci. 2025, 15(15), 8290; https://doi.org/10.3390/app15158290 - 25 Jul 2025
Abstract
The blockchain technology is transforming the mining industry by enabling mineral reserve tokenization, improving security, transparency, and traceability. However, controlling access to sensitive mining data remains a challenge. Existing access control models, such as role-based access control, are too rigid because they assign [...] Read more.
The blockchain technology is transforming the mining industry by enabling mineral reserve tokenization, improving security, transparency, and traceability. However, controlling access to sensitive mining data remains a challenge. Existing access control models, such as role-based access control, are too rigid because they assign permissions based on predefined roles rather than real-world conditions like mining licenses, regulatory approvals, or investment status. To address this, this paper explores an attribute-based access control model for blockchain-based mineral tokenization systems. ABAC allows access permissions to be granted dynamically based on multiple attributes rather than fixed roles, making it more adaptable to the mining industry. This paper presents a high-level system design that integrates ABAC with the blockchain using smart contracts to manage access policies and ensure compliance. The proposed model is designed for permissioned blockchain platforms, where access control decisions can be automated and securely recorded. A comparative analysis between ABAC and RBAC highlights how ABAC provides greater flexibility, security, and privacy for mining operations. By introducing ABAC in blockchain-based mineral reserve tokenization, this paper contributes to a more efficient and secure way of managing data access in the mining industry, ensuring that only authorized stakeholders can interact with tokenized mineral assets. Full article
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23 pages, 1120 KiB  
Review
Visual Field Examinations for Retinal Diseases: A Narrative Review
by Ko Eun Kim and Seong Joon Ahn
J. Clin. Med. 2025, 14(15), 5266; https://doi.org/10.3390/jcm14155266 - 25 Jul 2025
Abstract
Visual field (VF) testing remains a cornerstone in assessing retinal function by measuring how well different parts of the retina detect light. It is essential for early detection, monitoring, and management of many retinal diseases. By mapping retinal sensitivity, VF exams can reveal [...] Read more.
Visual field (VF) testing remains a cornerstone in assessing retinal function by measuring how well different parts of the retina detect light. It is essential for early detection, monitoring, and management of many retinal diseases. By mapping retinal sensitivity, VF exams can reveal functional loss before structural changes become visible. This review summarizes how VF testing is applied across key conditions: hydroxychloroquine (HCQ) retinopathy, age-related macular degeneration (AMD), diabetic retinopathy (DR) and macular edema (DME), and inherited disorders including inherited dystrophies such as retinitis pigmentosa (RP). Traditional methods like the Goldmann kinetic perimetry and simple tools such as the Amsler grid help identify large or central VF defects. Automated perimetry (e.g., Humphrey Field Analyzer) provides detailed, quantitative data critical for detecting subtle paracentral scotomas in HCQ retinopathy and central vision loss in AMD. Frequency-doubling technology (FDT) reveals early neural deficits in DR before blood vessel changes appear. Microperimetry offers precise, localized sensitivity maps for macular diseases. Despite its value, VF testing faces challenges including patient fatigue, variability in responses, and interpretation of unreliable results. Recent advances in artificial intelligence, virtual reality perimetry, and home-based perimetry systems are improving test accuracy, accessibility, and patient engagement. Integrating VF exams with these emerging technologies promises more personalized care, earlier intervention, and better long-term outcomes for patients with retinal disease. Full article
(This article belongs to the Special Issue New Advances in Retinal Diseases)
17 pages, 805 KiB  
Article
Use of Instagram as an Educational Strategy for Learning Animal Reproduction
by Carlos C. Pérez-Marín
Vet. Sci. 2025, 12(8), 698; https://doi.org/10.3390/vetsci12080698 - 25 Jul 2025
Abstract
The present study explores the use of Instagram as an innovative strategy in the teaching–learning process in the context of animal reproduction topics. In the current era, with digital technology and social media transforming how information is accessed and consumed, it is essential [...] Read more.
The present study explores the use of Instagram as an innovative strategy in the teaching–learning process in the context of animal reproduction topics. In the current era, with digital technology and social media transforming how information is accessed and consumed, it is essential for teachers to adapt and harness the potential of these tools for educational purposes. This article delves into the need for teachers to stay updated with current trends and the importance of promoting digital competences among teachers. This research aims to provide insights into the benefits of integrating social media into the educational landscape. Students of Veterinary Science degrees, Master’s degrees in Equine Sport Medicine as well as vocational education and training (VET) were involved in this study. An Instagram account named “UCOREPRO” was created for educational use, and it was openly available to all users. Instagram usage metrics were consistently tracked. A voluntary survey comprising 35 questions was conducted to collect feedback regarding the educational use of smartphone technology, social media habits and the UCOREPRO Instagram account. The integration of Instagram as an educational tool was positively received by veterinary students. Survey data revealed that 92.3% of respondents found the content engaging, with 79.5% reporting improved understanding of the subject and 71.8% acquiring new knowledge. Students suggested improvements such as more frequent posting and inclusion of academic incentives. Concerns about privacy and digital distraction were present but did not outweigh the perceived benefits. The use of short videos and microlearning strategies proved particularly effective in capturing students’ attention. Overall, Instagram was found to be a promising platform to enhance motivation, engagement, and informal learning in veterinary education, provided that thoughtful integration and clear educational objectives are maintained. In general, students expressed positive opinions about the initiative, and suggested some ways in which it could be improved as an educational tool. Full article
27 pages, 47905 KiB  
Article
FDS-Based Study on Fire Spread and Control in Modern Brick-Timber Architectural Heritage: A Case Study of Faculty House at a University in Changsha
by Simian Liu, Gaocheng Liang, Lei Shi, Ming Luo and Meizhen Long
Sustainability 2025, 17(15), 6773; https://doi.org/10.3390/su17156773 - 25 Jul 2025
Abstract
The modern Chinese architectural heritage combines sturdy Western materials with delicate Chinese styling, mainly adopting brick-timber structural systems that are highly vulnerable to fire damage. The study assesses the fire spread characteristics of the First Faculty House, a 20th-century architectural heritage located at [...] Read more.
The modern Chinese architectural heritage combines sturdy Western materials with delicate Chinese styling, mainly adopting brick-timber structural systems that are highly vulnerable to fire damage. The study assesses the fire spread characteristics of the First Faculty House, a 20th-century architectural heritage located at a university in China. The assessment is carried out by analyzing building materials, structural configuration, and fire load. By using FDS (Fire Dynamics Simulator (PyroSim version 2022)) and SketchUp software (version 2023) for architectural reconstruction and fire spread simulation, explores preventive measures to reduce fire risks. The result show that the total fire load of the building amounts to 1,976,246 MJ. After ignition, flashover occurs at 700 s, accompanied by a sharp increase in the heat release rate (HRR). The peak ceiling temperature reaches 750 °C. The roof trusses have critical structural weaknesses when approaching flashover conditions, indicating a high potential for collapse. Three targeted fire protection strategies are proposed in line with the heritage conservation principle of minimal visual and functional intervention: fire sprinkler systems, fire retardant coating, and fire barrier. Simulations of different strategies demonstrate their effectiveness in mitigating fire spread in elongated architectural heritages with enclosed ceiling-level ignition points. The efficacy hierarchy follows: fire sprinkler system > fire retardant coating > fire barrier. Additionally, because of chimney effect, for fire sources located above the ceiling and other hidden locations need to be warned in a timely manner to prevent the thermal plume from invading other sides of the ceiling through the access hole. This research can serve as a reference framework for other Modern Chinese Architectural Heritage to develop appropriate fire mitigation strategies and to provide a methodology for sustainable development of the Chinese architectural heritage. Full article
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12 pages, 205 KiB  
Project Report
The A.BA.CO. Project and Efforts to Optimize Access to the Sounds of Learning
by Eva Orzan, Valeria Gambacorta and Giampietro Ricci
Audiol. Res. 2025, 15(4), 92; https://doi.org/10.3390/audiolres15040092 - 25 Jul 2025
Abstract
Background/Objectives: Despite its significant impact on learning, classroom acoustics and students’ hearing difficulties are often overlooked compared with more visible issues like lighting. Hearing loss—frequently underestimated and invisible—affects both students and teachers, potentially leading to fatigue, reduced participation, and academic challenges. The [...] Read more.
Background/Objectives: Despite its significant impact on learning, classroom acoustics and students’ hearing difficulties are often overlooked compared with more visible issues like lighting. Hearing loss—frequently underestimated and invisible—affects both students and teachers, potentially leading to fatigue, reduced participation, and academic challenges. The A.BA.CO. project in Italy was developed to address these issues by promoting improved classroom design, technological solutions, and better auditory communication accessibility in schools. Objective: This article presents the A.BA.CO. project, offering context and an overview of the preliminary analyses conducted by its multidisciplinary team. The goal is to share insights and propose organizational frameworks, technical solutions, and best practices concerning the hearing, communication, and auditory learning challenges experienced by students with hearing impairments. Results: The A.BA.CO. team’s analyses identified key barriers to inclusion for students with (or without) hearing impairments, such as poor classroom acoustics, excessive noise, and suboptimal seating arrangements. The project underscores the importance of improved acoustic environments and the integration of assistive technologies, including speech-to-text systems. The findings highlight the need for interdisciplinary collaboration to design accessible and inclusive educational settings for all learners. Conclusions: Embedding educational audiology within school systems—alongside enhancements in classroom acoustics and the use of assistive technologies and other technological solutions—is essential to ensure that all students, regardless of hearing ability, have equitable access to learning and full participation in educational life. Full article
14 pages, 3187 KiB  
Article
Characterizations of Electrospun PVDF-Based Mixed Matrix Membranes with Nanomaterial Additives
by Haya Taleb, Venkatesh Gopal, Sofian Kanan, Raed Hashaikeh, Nidal Hilal and Naif Darwish
Nanomaterials 2025, 15(15), 1151; https://doi.org/10.3390/nano15151151 - 25 Jul 2025
Abstract
Water scarcity poses a formidable challenge around the world, especially in arid regions where limited availability of freshwater resources threatens both human well-being and ecosystem sustainability. Membrane-based desalination technologies offer a viable solution to address this issue by providing access to clean water. [...] Read more.
Water scarcity poses a formidable challenge around the world, especially in arid regions where limited availability of freshwater resources threatens both human well-being and ecosystem sustainability. Membrane-based desalination technologies offer a viable solution to address this issue by providing access to clean water. This work ultimately aims to develop a novel permselective polymeric membrane material to be employed in an electrochemical desalination system. This part of the study addresses the optimization, preparation, and characterization of a polyvinylidene difluoride (PVDF) polymeric membrane using the electrospinning technique. The membranes produced in this work were fabricated under specific operational, environmental, and material parameters. Five different additives and nano-additives, i.e., graphene oxide (GO), carbon nanotubes (CNTs), zinc oxide (ZnO), activated carbon (AC), and a zeolitic imidazolate metal–organic framework (ZIF-8), were used to modify the functionality and selectivity of the prepared PVDF membranes. Each membrane was synthesized at two different levels of additive composition, i.e., 0.18 wt.% and 0.45 wt.% of the entire PVDF polymeric solution. The physiochemical properties of the prepared membranes were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), zeta potential, contact angle, conductivity, porosity, and pore size distribution. Based on findings of this study, PVDF/GO membrane exhibited superior results, with an electrical conductivity of 5.611 mS/cm, an average pore size of 2.086 µm, and a surface charge of −38.33 mV. Full article
(This article belongs to the Section Synthesis, Interfaces and Nanostructures)
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