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40 Results Found

  • Article
  • Open Access
359 Views
15 Pages

24 November 2025

Plants have the capacity to form adventitious roots (ARs) from detached aerial organs, a process known as de novo root regeneration (DNRR). In Arabidopsis, wounding signals rapidly induce in leaf explants the expression of genes encoding enzymes of a...

  • Review
  • Open Access
4,328 Views
40 Pages

28 June 2025

This review paper addresses the design and testing of ultra-low temperature (ULT) freezers, highlighting their critical functions in various industries, particularly foods, medicine, and research. ULT freezers operating at temperatures of −86 &...

  • Article
  • Open Access
27 Citations
14,239 Views
14 Pages

25 October 2012

The environmental footprint of ultra-low temperature (ULT) freezers as used in bio-repositories, universities and other research organizations is investigated. These freezers, employing the cascade refrigeration system, use between 10 and 20 times th...

  • Feature Paper
  • Article
  • Open Access
6 Citations
8,235 Views
12 Pages

3 February 2023

Gout is one of the most common inflammatory conditions with a growing global prevalence. Individuals with gout are at higher risk of developing chronic conditions, such as diabetes, chronic kidney disease (CKD), and cardiovascular diseases. In this s...

  • Article
  • Open Access
9 Citations
12,384 Views
17 Pages

6 June 2008

Satellite altimeter data from 1993 to 2005 has been used to analyze the seasonal variation and the interannual variability of upper layer thickness (ULT) in the South China Sea (SCS). Base on in-situ measurements, the ULT is defined as the thickness...

  • Article
  • Open Access
1 Citations
2,595 Views
18 Pages

Using Antimicrobial Photodynamic Therapy with Ultrasound Devices and Bioactive Glasses as a Combined Approach for Treating Dentin Caries Lesions

  • João Felipe Besegato,
  • Priscila Borges Gobbo de Melo,
  • Adilson César Abreu Bernardi,
  • Marina Trevelin Souza,
  • Edgar Dutra Zanotto,
  • Vanderlei Salvador Bagnato and
  • Alessandra Nara de Souza Rastelli

17 August 2023

Novel approaches for caries lesion removal and treatment have been proposed. This study evaluates the combined use of an experimental ultrasound, aPDT (antimicrobial photodynamic therapy) and bioactive glasses on the removal, decontamination and remi...

  • Article
  • Open Access
2 Citations
2,466 Views
8 Pages

Prevalence of Patients Receiving Urate-Lowering Medicine in Greenland and Denmark: A Cross-Sectional Case–Control Study

  • Sidsel Dan Hull,
  • Marianne Welzel Andersen,
  • Jessica Bengtsson,
  • Nils Skovgaard,
  • Marie Balslev Backe and
  • Michael Lynge Pedersen

This study estimates the age- and sex-specific prevalence of patients receiving urate-lowering therapy (ULT) in Greenland and compares the results with estimates in Denmark. Characteristics of patients receiving ULT in Greenland were compared to age-...

  • Perspective
  • Open Access
2 Citations
5,247 Views
8 Pages

Can Urate Lowering Therapy Be Stopped in Gout? Rationale and Design of Two Large Randomised Trials

  • Pascal Richette,
  • Marcel Flendrie,
  • Leo A. B. Joosten and
  • Noortje van Herwaarden

Lifelong urate-lowering therapy (ULT) is recommended for gout to prevent flares and urate deposition. However, concerns about its adherence, long-term side effects, and the necessity of continuous treatment after achieving remission raise critical qu...

  • Article
  • Open Access
7 Citations
4,003 Views
25 Pages

The logistics transportation system is critical to the United States economy. Underground Logistics Transportation (ULT) is a class of automated transportation systems in which vehicles carry freight through pipelines and tunnels between terminals. B...

  • Article
  • Open Access
1 Citations
1,298 Views
18 Pages

Gut Microbiota Response to Experimental Acute Cold Stress in Juvenile Yellowfin Tuna (Thunnus albacares)

  • Junhua Huang,
  • Zhengyi Fu,
  • Wei Yu,
  • Bowen Hou,
  • Jinhui Wu,
  • Tao Zhang and
  • Zhenhua Ma

Environmental temperature declines significantly impact the physiological processes of marine organisms, particularly under the cool La Nina conditions, challenging yellowfin tuna (Thunnus albacares) aquaculture. Low temperatures affect fish metaboli...

  • Article
  • Open Access
3 Citations
2,933 Views
13 Pages

31 August 2024

This in vitro study assessed the efficacy of three cleaning methods on lithium disilicate ceramic after the application of different try-in pastes through SEM analysis. Ten rectangular specimens of IPS e.max CAD were prepared using a diamond disc, cr...

  • Review
  • Open Access
15 Citations
4,798 Views
13 Pages

Efficacy of Xanthine Oxidase Inhibitors in Lowering Serum Uric Acid in Chronic Kidney Disease: A Systematic Review and Meta-Analysis

  • Yoojin Lee,
  • Jennifer Hwang,
  • Shaan H. Desai,
  • Xiaobai Li,
  • Christopher Jenkins,
  • Jeffrey B. Kopp,
  • Cheryl A. Winkler and
  • Sung Kweon Cho

27 April 2022

Objective: Current guidelines for gout recommend a treat-to-target approach with serum uric acid (SUA). However, there is little evidence for the dose-dependent effects of urate-lowering therapy (ULT). Herein, we analyzed the reported SUA-lowering ef...

  • Article
  • Open Access
7 Citations
2,997 Views
10 Pages

Atrial Fibrillation Risk and Urate-Lowering Therapy in Patients with Gout: A Cohort Study Using a Clinical Database

  • Ching-Han Liu,
  • Shih-Chung Huang,
  • Chun-Hao Yin,
  • Wei-Chun Huang,
  • Jin-Shuen Chen,
  • Yao-Shen Chen,
  • Su-Ting Gan,
  • Shiow-Jyu Tzou,
  • Ching-Tsai Hsu and
  • Wen-Hwa Wang
  • + 1 author

Individuals of Asian descent are at higher risk for developing hyperuricemia and gout as compared to Western populations. Urate-lowering therapy (ULT) is an effective treatment for hyperuricemia and gout. It was reported that febuxostat, one of the U...

  • Article
  • Open Access
1 Citations
1,528 Views
25 Pages

Thermodynamic Evaluation of Low-GWP A1 Refrigerants for Ultra-Low Temperature Refrigeration Applications

  • Pau Giménez-Prades,
  • Cosmin-Mihai Udroiu,
  • Joaquín Navarro-Esbrí and
  • Adrián Mota-Babiloni

20 August 2025

Slow market development has caused the lack of low-GWP A1 refrigerants for ultra-low temperature (ULT) refrigeration. Consequently, the high-GWP refrigerant R23 (GWP = 14,600) remains widely used within the ULT sector. For this reason, this paper pro...

  • Article
  • Open Access
1,706 Views
11 Pages

Sex Differences in Clinical Features in Gout: A Nationwide Retrospective Cohort Study

  • Hyunsue Do,
  • Kwanyoung Choe,
  • Min Jung Kim,
  • Kichul Shin and
  • Ki Won Moon

24 November 2024

Background: Patients with gout have several coexisting conditions that impact mortality. We analyzed the differences in clinical manifestations among Korean patients with gout and compared the causes of death based on sex using data from the Korean N...

  • Article
  • Open Access
4,084 Views
11 Pages

Cephalometric and Photographic Evaluation of the Nasolabial Angle in Orthodontically Treated Patients: An Observational Cohort Study

  • Silvia Izabella Pop,
  • Eugen Bud,
  • Krisztina Mártha,
  • Izabella Éva Mureșan,
  • Kinga Mária Jánosi,
  • Boglárka Dósa and
  • Bernadette Kerekes-Máthé

Background: The nasolabial angle (NLA) is one of the most critical parameters of the soft tissue profile when orthodontic treatment is required. The primary aim of this prospective cohort study was to compare the differences in the evaluation made on...

  • Review
  • Open Access
6 Citations
8,066 Views
21 Pages

Gout in China

  • Aichang Ji,
  • Zibin Tian,
  • Yongyong Shi,
  • Riku Takei,
  • Shun-Jen Chang,
  • Ronald M. L. Yip,
  • Huiyong Yin and
  • Changgui Li

Gout is a common inflammatory joint disease in China. In recent years, the prevalence of gout in China has been increasing and the onset age of gout has been trending younger. The common risk factors for gout in China include hyperuricemia, age, sex,...

  • Article
  • Open Access
272 Views
24 Pages

15 January 2026

This study assesses how satellite clock products affect Precise Point Positioning (PPP) for GPS, Galileo, and GPS+Galileo. Multi-GNSS data at 30 s were processed for 12 global IGS stations over one week in 2025, with each day split into eight indepen...

  • Review
  • Open Access
10 Citations
3,341 Views
11 Pages

Imaging modalities such as ultrasonography (US) and dual-energy computed tomography (DECT) have been recognized for their abilities to detect monosodium urate (MSU) crystals. The main described features of gout detected by DECT (tophus) or US (tophus...

  • Review
  • Open Access
48 Citations
14,091 Views
16 Pages

13 September 2021

The relationship between hyperuricemia, gout, and renal disease has been investigated for several years. From the beginning, kidney disease has been considered a complication of gout; however, the viewpoints changed, claiming that hypertension and el...

  • Article
  • Open Access
8 Citations
6,366 Views
13 Pages

Mobile DOAS Observations of Tropospheric NO2 Using an UltraLight Trike and Flux Calculation

  • Daniel-Eduard Constantin,
  • Alexis Merlaud,
  • Mirela Voiculescu,
  • Carmelia Dragomir,
  • Lucian Georgescu,
  • Francois Hendrick,
  • Gaia Pinardi and
  • Michel Van Roozendael

22 April 2017

In this study, we report on airborne Differential Optical Absorption Spectroscopy (DOAS) observations of tropospheric NO2 using an Ultralight Trike (ULT) and associated flux calculations. The instrument onboard the ULT was developed for measuring the...

  • Article
  • Open Access
2 Citations
3,591 Views
13 Pages

20 July 2019

Background: Although gout is accompanied by the substantial burden of kidney disease, there are limited data to assess renal function as a therapeutic target. This study evaluated the importance of implementing a “treat-to-target” approac...

  • Review
  • Open Access
5 Citations
7,023 Views
15 Pages

Asymptomatic Hyperuricemia and the Kidney: Lessons from the URRAH Study

  • Cecilia Barnini,
  • Elisa Russo,
  • Giovanna Leoncini,
  • Maria Carla Ghinatti,
  • Lucia Macciò,
  • Michela Piaggio,
  • Francesca Viazzi and
  • Roberto Pontremoli

2 January 2025

Chronic kidney disease (CKD) is a prevalent global health concern affecting approximately 850 million people worldwide, with a significant and rising mortality rate. CKD often coexists with hyperuricemia (HSUA), which is also increasingly common due...

  • Article
  • Open Access
25 Citations
2,923 Views
10 Pages

Association of Specific Comorbidities with Monosodium Urate Crystal Deposition in Urate-Lowering Therapy-Naive Gout Patients: A Cross-Sectional Dual-Energy Computed Tomography Study

  • Tristan Pascart,
  • André Ramon,
  • Sébastien Ottaviani,
  • Julie Legrand,
  • Vincent Ducoulombier,
  • Eric Houvenagel,
  • Laurène Norberciak,
  • Pascal Richette,
  • Fabio Becce and
  • Jean-François Budzik
  • + 1 author

(1) Background: To determine which factors are associated with the volume of monosodium urate (MSU) crystal deposition quantified by dual-energy computed tomography (DECT) in urate-lowering therapy (ULT)-naive gout patients. (2) Methods: In this mult...

  • Article
  • Open Access
2 Citations
2,086 Views
18 Pages

22 March 2023

The transfer of urban land is an important means for the government to optimize the allocation of resources and promote economic development, and its impact on high-quality economic development (HQED) in the new era is worthy of attention. Based on t...

  • Article
  • Open Access
686 Views
27 Pages

3 October 2025

Biobanks rely on ultra-low-temperature (ULT) storage for irreplaceable specimens, where precise 3D temperature field reconstruction is critical to preserve integrity. This is the first study to apply geostatistical methods to ULT field reconstruction...

  • Review
  • Open Access
6 Citations
9,582 Views
14 Pages

Ultrasound Features in Gout: An Overview

  • Cristina Dorina Pârvănescu,
  • Andreea Lili Bărbulescu,
  • Cristina Elena Biță,
  • Ștefan Cristian Dinescu,
  • Beatrice Andreea Trașcǎ,
  • Sineta Cristina Firulescu and
  • Florentin Ananu Vreju

The accurate diagnosis of gout frequently constitutes a challenge in clinical practice, as it bears a close resemblance to other rheumatologic conditions. An undelayed diagnosis and an early therapeutic intervention using uric acid lowering therapy (...

  • Article
  • Open Access
19 Citations
3,690 Views
29 Pages

22 April 2021

Ulva lactuca has been used to remove many toxic substances from industrial wastewater. In the present study we tried to optimize the efficiency of U. lactuca as an adsorbent of methylene blue (MB) in aqueous solution. U. lactuca was chemically treate...

  • Article
  • Open Access
663 Views
17 Pages

Effect of Metakaolin and Biosilica on the Mechanical Properties of Cementitious Mortars

  • Marine Kalantaryan,
  • Nelli Muradyan,
  • Avetik Arzumanyan,
  • Yeghvard Melikyan,
  • David Laroze,
  • Manuk Barseghyan and
  • Yeghiazar Vardanyan

27 October 2025

The growing demand for sustainable construction materials has intensified efforts to reduce the environmental impact of Portland cement. This study investigates the effect of partial substitution of cement with metakaolin (MK, 5–15 wt.%) and bi...

  • Review
  • Open Access
22 Citations
15,392 Views
31 Pages

Ultra-Low-Temperature Refrigeration Systems: A Review and Performance Comparison of Refrigerants and Configurations

  • Muhammad Zahid Saeed,
  • Luca Contiero,
  • Stefanie Blust,
  • Yosr Allouche,
  • Armin Hafner and
  • Trygve Magne Eikevik

26 October 2023

During the last decade, many industrial and medical applications have shown a requirement for low-temperature-cooling usage (from −40 to −80 °C), which cannot be efficiently obtained via the conventional refrigeration systems usually...

  • Article
  • Open Access
6 Citations
3,625 Views
10 Pages

Relationship between Selected Cephalometric Parameters, Nasolabial Angle and Its Components in Adolescent Females

  • Mikołaj Gołębiowski,
  • Agnieszka Świątkowska,
  • Przemysław Pastuszak and
  • Mansur Rahnama

Nasolabial angle is commonly used to assess the soft tissue profile of the subnasal region. The aim of this retrospective study was to evaluate the relationship between the nasolabial angle, the inclination of the lower border of the nose and upper l...

  • Perspective
  • Open Access
5,490 Views
7 Pages

Treat to Target in Gout Management: A Critical Reappraisal of Current Strategies

  • Anusha Moses,
  • Martijn Oude Voshaar,
  • Mart van de Laar and
  • Tim L. Th. Jansen

Gout management strategies remain a topic of debate, particularly regarding the efficacy of treat-to-target (T2T) and treat-to-avoid-symptoms (T2S) approaches. T2T, endorsed by major rheumatology societies, involves systematic serum urate (sUA) monit...

  • Article
  • Open Access
32 Citations
5,032 Views
19 Pages

16S rRNA of Mucosal Colon Microbiome and CCL2 Circulating Levels Are Potential Biomarkers in Colorectal Cancer

  • Carmela Nardelli,
  • Ilaria Granata,
  • Marcella Nunziato,
  • Mario Setaro,
  • Fortunata Carbone,
  • Claudio Zulli,
  • Vincenzo Pilone,
  • Ettore Domenico Capoluongo,
  • Giovanni Domenico De Palma and
  • Lucia Sacchetti
  • + 3 authors

4 October 2021

Colorectal cancer (CRC) is one of the most common malignancies in the Western world and intestinal dysbiosis might contribute to its pathogenesis. The mucosal colon microbiome and C-C motif chemokine 2 (CCL2) were investigated in 20 healthy controls...

  • Article
  • Open Access
5 Citations
2,728 Views
13 Pages

Simple Application and Adherence to Gout Guidelines Enables Disease Control: An Observational Study in French Referral Centres

  • Charlotte Jauffret,
  • Sébastien Ottaviani,
  • Augustin Latourte,
  • Hang-Korng Ea,
  • Sahara Graf,
  • Frédéric Lioté,
  • Thomas Bardin,
  • Pascal Richette and
  • Tristan Pascart

28 September 2022

Background: In a context of therapeutic inertia, the French Society of Rheumatology (SFR) published its first recommendations on gout in 2020, which were deliberately simple and concise. The objectives of the study were to determine the profile of pa...

  • Article
  • Open Access
24 Citations
6,435 Views
14 Pages

Establishment and Validation of Predictive Model of Tophus in Gout Patients

  • Tianyi Lei,
  • Jianwei Guo,
  • Peng Wang,
  • Zeng Zhang,
  • Shaowei Niu,
  • Quanbo Zhang and
  • Yufeng Qing

22 February 2023

(1) Background: A tophus is a clinical manifestation of advanced gout, and in some patients could lead to joint deformities, fractures, and even serious complications in unusual sites. Therefore, to explore the factors related to the occurrence of to...

  • Article
  • Open Access
6 Citations
4,729 Views
9 Pages

Prevalence and Influence of Gout in Patients with Advanced Chronic Kidney Disease: Findings of a Large Retrospective Chart Review

  • Leonard Stern,
  • Richard J. Johnson,
  • Payam Shakouri,
  • Amod Athavale,
  • Lissa Padnick-Silver,
  • Brian LaMoreaux,
  • Brad A. Marder and
  • Sreedhar Mandayam

Gout patients have higher mortality, heavier comorbidity burden, and lower quality of life than non-gout patients, but information is sparse on how gout affects advanced CKD patients. This study examined the prevalence and potential health impacts in...

  • Article
  • Open Access
1 Citations
3,349 Views
15 Pages

We assessed changes in vascular inflammation and monosodium urate (MSU)-coded deposits after administration of Pegloticase in the vasculature of tophaceous gout patients using 18F-fluorodeoxyglucose (18F-FDG) Positron emission tomography/computed tom...

  • Review
  • Open Access
23 Citations
9,641 Views
16 Pages

31 August 2022

Gout is a metabolic disorder, and one of the most common inflammatory arthritic conditions, caused by elevated serum urate (SU). Gout is globally rising, partly due to global dietary changes and the growing older adult population. Gout was known to a...

  • Article
  • Open Access
3 Citations
4,618 Views
20 Pages

Targeting Hyperuricemia and NLRP3 Inflammasome in Gouty Arthritis: A Preclinical Evaluation of Allopurinol and Disulfiram Combination Therapy

  • Yahya I. Asiri,
  • Manimekalai Pichaivel,
  • Selva Prasanthi Parameshwaran,
  • Krishnaraju Venkatesan,
  • Saud Alqahtani,
  • Taha Alqahtani,
  • Rehab Ahmed,
  • Hassabelrasoul Elfadil,
  • Mahmoud Elodemi and
  • Premalatha Paulsamy
  • + 2 authors

Background/Objectives: Gouty arthritis (GA) is a chronic inflammatory condition characterized by hyperuricemia and NLRP3 inflammasome activation, leading to joint damage and systemic inflammation. Although allopurinol (ALP), a xanthine oxidase inhibi...

  • Review
  • Open Access
12 Citations
9,907 Views
18 Pages

Pharmacogenetic Perspective for Optimal Gout Management

  • Khalifa Y. Alrajeh and
  • Youssef M. Roman

Pharmacogenetics (PGx) is an emerging field of pharmacology focusing on how gene variations affect the patient’s response to treatment. Pharmacogenetics is a promising tool to optimize the selection and dosing of medications, including urate-lo...