The terminal nucleotidyltransferases TUT4 and TUT7 (TUT4/7) regulate miRNA and mRNA stability by 3′ end uridylation. In humans, TUT4/7 polyuridylates both mRNA and pre-miRNA, leading to degradation by the U-specific exonuclease DIS3L2. We inves...
African trypanosomiasis occurs in 36 countries in sub-Saharan Africa with 10,000 reported cases annually. No definitive remedy is currently available and if left untreated, the disease becomes fatal. Structural and biochemical studies of trypanosomal...
Was tut sich am Lehrstuhl Zürich in Bezug auf Forschung? Die Forschung geniesst in Zürich einen hohen Stellenwert
Quantifying training variables of a physical exercise modality is essential for an appropriate dosage. In training with elastic bands, time under tension (TUT) and force represent the duration and intensity of this force-training modality. The aims o...
Terminal nucleotidyltransferases (TENTs) could generate a ‘mixed tail’ or ‘U-rich tail’ consisting of different nucleotides at the 3′ end of RNA by non-templated nucleotide addition to protect or degrade cellular messeng...
Nowadays, location-enabled mobile phones are becoming more and more widespread. Various players in the mobile business forecast that, in the future, a significant part of total wireless revenue will come from Location-Based Services (LBS). An LBS sys...
During the COVID-19 pandemic, educational mobile games may play a significant role to facilitate students’ learning. Several studies have indicated that these games using mobile phones may improve students’ learning motivation and effectiveness when...
(1) Background: Several tools have been proposed to measure elastic band tension and time under tension (TUT) during elastic band exercise performance. However, current methods are often indirect, non-objective, or expensive. The Elastic Force Evalua...
Die Praxisassistenz ist für Fachärztinnen und -ärzte Allgemeine Innere Medizin mit Ziel Hausarztmedizin sowie für Kinder- und Jugendmediziner mit Ziel Grundversorgung unerlässlich. Den künftigen Hausärzten stehen zudem in der Curriculum- Weiterbildun...
Es tut sich etwas in der Hausarztmedizin [...]
Wer tut was in den Versorgungsmodellen der Zukunft? [...]
The aim of the study was to determine the effect of step load in hypoxia on the effectiveness of preoperative rehabilitation (PR) and hormone levels based on a case study. Introduction: We assessed the impact of variables such as rate of movement and...
8 April 2020
Background: The aim of the present study was to evaluate the effects of post-activation performance enhancement (PAPE) on resistance training volume during the bench press exercise (BP). The study included 12 healthy strength-trained males (age 25.2...
Background: Adiponectin is an adipokine with insulin-sensitizing, anti-inflammatory, and cytoprotective properties that also plays a key role in metabolic adaptation to exercise. Although its regulation after resistance exercise has been extensively...
Purpose: Tympanostomy tubes are essential for middle ear ventilation, but conventional long-term tubes carry high perforation rates (12–22%). This study evaluated the Tympanostomy U-Tube (TUT), a novel silicone-based tube designed to minimize p...
Von der Moderation des Workshops mit Gallus Heeb [...]
The purpose of this study was threefold: (a) to analyze differences in mean force, impulse, mean concentric and eccentric velocity, and peak concentric velocity across six repetitions of the flywheel deadlift exercise, with a particular focus on the...
Wieviel Intervention tut gut? Wieviel Labor braucht es für die Therapieentscheide? In einem praxisorientierten und interaktiven Seminar wurde mit den Teilnehmern anhand eines Falles das Vorgehen bei schmerzhaften Rückenbeschwerden besprochen
Er steht jeden Tag in der Praxis Und tut liebevoll, was er soll. Und wenn auch sein Herz – weich wie Wachs is’ Steht er auf, denn das Mass ist jetzt voll[...]
Um die zunehmende Antibiotika-Resistenzentwicklung zu bremsen, hat ein Team des Berner Insti tuts für Hausarztmedizin (BIHAM), unterstützt vom BAG, Informations- und Konsultationshilfsmit tel zur partizipativen Entscheidungsfindung in der Grundversor...
The worst performance rule (WPR) is a robust empirical finding reflecting that people’s worst task performance shows numerically stronger correlations with cognitive ability than their average or best performance. However, recent meta-analytic...
The aim of this study was to determine the effect of a step load periodisation protocol for the rehabilitation of the anterior cruciate ligament (ACL) based on the variables of both the tempo of movement and time under tension (TUT) in normobaric hyp...
The score-based diffusion model has made significant progress in the field of computer vision, surpassing the performance of generative models, such as variational autoencoders, and has been extended to applications such as speech enhancement and rec...
Objective: This study designed experiments to explore the effects of ischemic preconditioning (IPC) intervention with different cycling periods on the upper limb strength performance of college male bodybuilding athletes. Methods: Ten bodybuilding at...
Die Universität Witten-Herdecke ist im Medizinstudium von Anfang an neue Wege gegangen und tut dies immer noch. Seit 2013 ist Professor Andreas Soennichsen neuer Leiter des Instituts für Allgemeinmedizin. Er hatte vor Jahren in Salzburg das innovativ...
Background: Warm-up strategies are essential for optimizing strength-training performance. Traditional warm-ups improve neuromuscular readiness, whereas post-activation potentiation (PAP) has been proposed to acutely enhance muscular output. This ran...
Chromosomal rearrangements involving the KMT2A gene occur frequently in acute lymphoblastic leukaemia (ALL). KMT2A-rearranged ALL (KMT2Ar ALL) has poor long-term survival rates and is the most common ALL subtype in infants less than 1 year of age. KM...
In welchen Fällen ist unsere Begeisterung für das Neue gerechtfertigt? Welche Neuigkeiten sind auch wirklich ein Fortschritt? Eine Beurteilung tut in jedem Falle not. Statine, Säurehemmer und orale Antidiabetika wurden in diesem Artikel unter die Lup...
To address the interdependence of local time-frequency information in audio scene recognition, a segment-based time-frequency feature fusion method based on cross-attention is proposed. Since audio scene recognition is highly sensitive to individual...
Membrane technology has been widely used in industrial CO2 capturing, gas purification and gas separation, arousing attention due to its advantages of high efficiency, energy saving and environmental protection. In the context of reducing global carb...
A setup for testing transformers under load through low power converter is presented in this paper. This setup is used for testing power transformers as it allows to verify their performance under operating conditions regarding aspects such as heatin...
Acoustic scene classification (ASC) tries to inference information about the environment using audio segments. The inter-class similarity is a significant issue in ASC as acoustic scenes with different labels may sound quite similar. In this paper, t...
Crack segmentation in cluttered scenes with slender and irregular patterns remains difficult, and practical systems must balance accuracy and efficiency. We present CONTI-CrackNet, which is a lightweight visual state-space network that integrates a M...
Background: The Jinwu pig is a novel breed created by crossbreeding Jinhua and Duroc pigs, displaying superior meat quality, strong adaptability to coarse feed, high production performance, and a rapid growth rate. However, research on its reproducti...
While open-set recognition algorithms have been extensively explored in computer vision, their application to environmental sound analysis remains understudied. To address this gap, this study investigates how to effectively recognize unknown sound c...
Location-based services (LBS) have gained increasing importance in our everyday lives and serve as the foundation for many smartphone applications. Whereas Global Navigation Satellite Systems (GNSS) enable reliable position estimation outdoors, there...
24 March 2020
Sustained tobacco use after cancer diagnosis decreases treatment effectiveness while increasing treatment side effects, primary cancer recurrence, and the occurrence of secondary cancers. Delivering tobacco use treatment to fewer patients due to inef...
Lodging reduces rice yield, but increasing lodging resistance (LR) usually limits yield potential. Stem strength and leaf type are major traits related to LR and yield, respectively. Hence, understanding the genetic basis of stem strength and leaf ty...
Indoor localization finds wide-ranging applications in user navigation and intelligent building systems. Nevertheless, signal interference within complex indoor environments and challenges regarding localization generalization in multi-building and m...
Background: The tempo of resistance exercises is known to influence performance outcomes, yet its specific effects on post-activation performance enhancement (PAPE) remain unclear. This study aimed to investigate the effects of fast versus slow repet...