The year 2017 was marked by the Food and Drug Administration (FDA) approval of the first two chimeric antigen receptor-T (CAR-T) therapies. The approved indications were for the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL...
For the monitoring of chimeric antigen receptor (CAR) T-cell therapies, antigen-based CAR detection methods are usually applied. However, for each target-antigen, a separate detection system is required. Furthermore, when monitored CAR T-cells in the...
We address the task of classifying car images at multiple levels of detail, ranging from the top-level car type, down to the specific car make, model, and year. We analyze existing datasets for car classification, and identify the CompCars as an exce...
The sharing economy is making its way into our everyday lives. One of its business models, car-sharing, has become highly popular. Can it help us increase our sustainability? Besides emissions and vehicle miles traveled, one key aspect in the assessm...
The adoptive transfer of allogeneic CAR NK cells holds great promise as an anticancer modality due to the relative ease of manufacturing and genetic modification of NK cells, which translates into affordable pricing. Compared to the pronounced effica...
This paper presents a mixed-method analysis of car ownership in Reykjavik, Iceland, a location with a high motorization level and deeply rooted car culture. We utilize qualitative interviews to understand vehicle possession reasons and elaborate the...
Chimeric antigen receptor (CAR)-expressing macrophages (CAR-M) have a great potential to improve cancer therapy, as shown from several recent preclinical studies. However, unlike CAR-T cell therapy, which has been widely studied, the efficacy and lim...
In the era of upcoming European Union regulations limiting the registration of combustion cars from 2035, the development of various types of alternatives to balancing transport is on the agenda of modern cities. One of these types of services includ...
Although Chimeric Antigen Receptor (CAR) T-cells have shown high efficacy in hematologic malignancies, they can cause severe to life-threatening side effects. To address these safety concerns, we have developed adaptor CAR platforms, like the UniCAR...
Car-sharing systems, i.e., short-term car rental services, are solutions indicated as an alternative to individual motorization; they can be used in an increasing number of cities around the world. These services, along with their intensive developme...
For the sake of reducing car dependence, much can be learned from non-car owners about how everyday life can, and cannot, be organized without private car ownership. This study aims to explore carless mobility, including the role of the car, in relat...
Among the many oncology therapies, few have generated as much excitement as CAR-T. The success of CAR therapy would not have been possible without the many discoveries that preceded it, most notably, the Nobel Prize-winning breakthroughs in cellular...
Private car-use is a major contributor of greenhouse gases. Car-sharing is often hypothesised as a potential solution to reduce car-ownership, which can lead to car-sharing users reducing their car-use. However, there is a risk that car-sharing may a...
Acute lymphoblastic leukemia (ALL) and Chronic lymphocytic leukemia (CLL) are the most common leukemias in children and elderly people, respectively. Standard therapies, such as chemotherapy, are only effective in 40% of ALL adult patients with a fiv...
The concept of luxury, considering it a rare and exclusive attribute, is evolving due to technological advances and the increasing influence of consumers in the market. Luxury cars have always symbolized wealth, social status, and sophistication. Rec...
In the last few decades, chimeric antigen receptor (CAR) T-cell therapy has led to a paradigm shift in the treatment of hematological malignancies, including various subtypes of B-cell non-Hodgkin’s lymphoma, B-cell acute lymphoblastic leukemia...
The orientation of objects plays an important role in accurate predictions for the tasks of classification, detection, and trajectory estimation. This is especially important in the automotive domain, where estimating an accurate car orientation can...
Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary treatment for hematological malignancies. However, improvements in CAR T-cell therapies are urgently needed since CAR T cell application is associated with toxicities, exhausti...
Adoptive cell therapies have transformed the treatment landscape for hematologic malignancies. Yet, translation to solid tumors remains constrained by antigen heterogeneity, an immunosuppressive tumor microenvironment (TME), and poor persistence of c...
The article was dedicated to the topic of energy consumption of driving cars equipped with an electric motor. Due to the emerging demands for the excessive use of energy by vehicles (including car-sharing system vehicles), the authors carried out res...
Chimeric antigen receptor (CAR)-T adoptive cell therapy is one of the most promising advanced therapies for the treatment of cancer, with unprecedented outcomes in haematological malignancies. However, it still lacks efficacy in solid tumours, possib...
CAR T cell therapy has revolutionized immunotherapy in the last decade with the successful establishment of chimeric antigen receptor (CAR)-expressing cellular therapies as an alternative treatment in relapsed and refractory CD19-positive leukemias a...
Adoptive cell therapy using chimeric antigen receptor (CAR) technology is one of the most advanced engineering platforms for cancer immunotherapy. CAR-T cells have shown remarkable efficacy in the treatment of hematological malignancies. However, the...
Multiple Myeloma is a hematological neoplasm that, over the recent few years, has benefited from numerous therapeutic options. Among the latter, CAR-T stands out as the most recent and one of the most promising treatments currently available. Despite...
The engineering of T cells through expression of chimeric antigen receptors (CARs) against tumor-associated antigens (TAAs) has shown significant potential for use as an anti-cancer therapeutic. The development of strategies for flexible and modular...
In recent years, the smart car sector has been increasing enormously in the Internet of Things (IoT) market. Furthermore, the number of smart cars seems set to increase over the next few years. This goal will be achieved because the application of re...
Chimeric antigen receptor (CAR) T and CAR NK cell therapies opened new avenues for cancer treatment. Although original successes of CAR T and CAR NK cells for the treatment of hematological malignancies were extraordinary, several obstacles have sinc...
T cells expressing chimeric antigen receptors (CARs) are at the forefront of clinical treatment of cancers. Still, the nanoscale organization of CARs at the interface of CAR-Ts with target cells, which is essential for TCR-mediated T cell activation,...
Background/Objectives: Monoclonal antibody therapies for HER2-positive tumors frequently encounter resistance, requiring alternative treatment strategies. This study investigates the use of natural killer (NK) cells expressing HER2-specific chimeric...
As chimeric antigen receptor (CAR) T cell therapy continues to gain attention as a valuable treatment option against different cancers, strategies to improve its potency and decrease the side effects associated with this therapy have become increasin...
T-cell acute lymphoblastic leukemia (T-ALL) is a hematologic malignancy derived from T cells. Numerous CAR T therapies have been successfully applied to treat hematologic malignancies in the clinic. Nevertheless, there remain several challenges to th...
Multiple myeloma (MM or plasma cell myeloma) is a heterogenous B-cell malignant tumor that typically exhibits a high recurrence rate, resistance to drugs, and molecular diversity of tumor subclones. Given the limited efficacy of standard therapy opti...
Even though autonomous cars have not yet crossed into the mainstream car market, their adoption seems inevitable, but not much is known about the purchasing intention of ACs and potential influences on it. To better understand the influences of vario...
Short-term car rental services called “car-sharing” or “carsharing” are systems that in recent years have been an alternative form of transport by individual car in an increasing number of cities around the world. With the gro...
Cancer is a worldwide health problem. Nevertheless, new technologies in the immunotherapy field have emerged. Chimeric antigen receptor (CAR) technology is a novel biological form to treat cancer; CAR-T cell genetic engineering has positively revolut...
CD8+ T cells and natural killer (NK) cells eliminate target cells through the release of lytic granules and Fas ligand (FasL)-induced target cell apoptosis. The introduction of chimeric antigen receptor (CAR) makes these two types of cells selective...
Regulatory T cells are critical for maintaining immune tolerance. Recent studies have confirmed their therapeutic suppressive potential to modulate immune responses in organ transplant and autoimmune diseases. However, the unknown and nonspecific ant...
Car-sharing systems, i.e., automatic, short-time car rentals, are among the solutions of the new mobility concept, which in recent years has gained popularity around the world. With the growing interest in services in society, their demands for the s...
T cells that are genetically engineered to express chimeric antigen receptor (CAR) have a strong potential to eliminate tumor cells, yet the CAR-T cells may also induce severe side effects due to an excessive immune response. Although optimization of...
Damages of different kinds that can be inflicted to a parked car. Among them, loosening of the car wheel bolts is difficult to detect during normal use of the car and is at the same time very dangerous to the health and life of the driver. Moreover,...
Carotenoid biosynthesis in the fungus Fusarium fujikuroi is regulated by environmental factors, with light being the main stimulating signal. The CarS RING-finger protein plays an important role in the downregulation of structural genes of the carote...
The pervasive application of chimeric antigen receptor (CAR)-based cellular therapies in the treatment of oncological diseases has long been recognized. However, CAR T cells can target and eliminate autoreactive cells in autoimmune and immune-mediate...
The Reverse Chimeric Antigen Receptor (RevCAR) system is an adapter CAR T cell technology that allows the precise tuning of T cell activity and, thus, improved safety management. RevCAR T cells recognize and eradicate tumor cells via a bispecific ada...
Adoptive cell immunotherapy (ACT) is a vibrant field of cancer treatment that began progressive development in the 1980s. One of the most prominent and promising examples is chimeric antigen receptor (CAR) T-cell immunotherapy for the treatment of B-...
With the rising popularity of the Advanced Driver Assistance System (ADAS), there is an increasing demand for more human-like car-following performance. In this paper, we consider the role of heterogeneity in car-following behavior within car-followi...
Peer-to-peer car-sharing systems are an evolving branch of urban mobility, aligning with global trends focused on sustainable development and reducing congestion in cities. A research gap has been identified concerning the specific vehicle attributes...
Immunotherapy with chimeric antigen receptor-engineered T cells (CAR-T) has revolutionized the treatment landscape of relapsed/refractory B-cell malignancies. Nonetheless, the use of autologous T cells has certain limitations, including the variable...
Currently, owning a car is a necessity, as it plays a significant role in human transportation for different purposes such as going to work and to the hospital. However, with the current economic challenges, buying expensive cars can be a burden. The...
Chimeric antigen receptor (CAR)-modified T cell therapy has been rapidly developing in recent years, ultimately revolutionizing immunotherapeutic strategies and providing significant anti-tumor potency, mainly in treating hematological neoplasms. How...
To improve the efficacy and safety of chimeric antigen receptor (CAR)-expressing T cell therapeutics through enhanced CAR design, we analysed CAR structural factors that affect CAR-T cell function. We studied the effects of disulphide bonding at cyst...
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