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257 Results Found

  • Article
  • Open Access
50 Citations
5,667 Views
13 Pages

Safety Studies of Pneumococcal Endolysins Cpl-1 and Pal

  • Marek Harhala,
  • Daniel C. Nelson,
  • Paulina Miernikiewicz,
  • Ryan D. Heselpoth,
  • Beata Brzezicka,
  • Joanna Majewska,
  • Sara B. Linden,
  • Xiaoran Shang,
  • Aleksander Szymczak and
  • Krystyna Dąbrowska
  • + 6 authors

15 November 2018

Bacteriophage-derived endolysins have gained increasing attention as potent antimicrobial agents and numerous publications document the in vivo efficacy of these enzymes in various rodent models. However, little has been documented about their safety...

  • Feature Paper
  • Article
  • Open Access
5 Citations
3,310 Views
8 Pages

27 November 2020

Chiral organic and organometallic luminophores that possess circularly polarized luminescence (CPL) properties in the near-ultraviolet to near-infrared region have several useful applications. However, the CPL properties are subject to inherent facto...

  • Article
  • Open Access
1 Citations
1,342 Views
12 Pages

Chiral Polymers Based on Vinyl[2.2]paracyclophane and Their Application as CPL Emitters

  • Henrik Tappert,
  • Emma V. Puttock,
  • Jhon Sebastian Oviedo Ortiz,
  • Eli Zysman-Colman,
  • Jeanne Crassous and
  • Stefan Bräse

16 April 2025

Chiral molecules are integral to various biological and artificial systems, influencing processes from chemical production to optical activities. In this study, we explore the potential of chiral vinyl[2.2]paracyclophane (vinyl-PCP) as a monomer for...

  • Feature Paper
  • Review
  • Open Access
135 Citations
19,619 Views
20 Pages

Constant Power Loads (CPL) with Microgrids: Problem Definition, Stability Analysis and Compensation Techniques

  • Mohammed Kh. AL-Nussairi,
  • Ramazan Bayindir,
  • Sanjeevikumar Padmanaban,
  • Lucian Mihet-Popa and
  • Pierluigi Siano

19 October 2017

This paper provides a comprehensive review of the major concepts associated with the μgrid, such as constant power load (CPL), incremental negative resistance or impedance (INR/I) and its dynamic behaviours on the μgrid, and power system distribution...

  • Article
  • Open Access
27 Citations
6,461 Views
24 Pages

Sliding Mode Controller and Lyapunov Redesign Controller to Improve Microgrid Stability: A Comparative Analysis with CPL Power Variation

  • Eklas Hossain,
  • Ron Perez,
  • Sanjeevikumar Padmanaban,
  • Lucian Mihet-Popa,
  • Frede Blaabjerg and
  • Vigna K. Ramachandaramurthy

24 November 2017

To mitigate the microgrid instability despite the presence of dense Constant Power Load (CPL) loads in the system, a number of compensation techniques have already been gone through extensive research, proposed, and implemented around the world. In t...

  • Article
  • Open Access
1 Citations
780 Views
22 Pages

RST-Controlled Interleaved Boost Converters for Enhanced Stability in CPL-Dominated DC Microgrids

  • Abdullrahman A. Al-Shammaa,
  • Hassan M. Hussein Farh,
  • Hammed Olabisi Omotoso,
  • AL-Wesabi Ibrahim,
  • Akram M. Abdurraqeeb and
  • Abdulrhman Alshaabani

23 September 2025

Microgrids have emerged as a crucial solution for addressing environmental concerns, such as reducing greenhouse gas emissions and enhancing energy sustainability. By incorporating renewable energy sources like solar and wind, microgrids improve ener...

  • Article
  • Open Access
5 Citations
3,863 Views
29 Pages

Comparative Study of Control Strategies for Stabilization and Performance Improvement of DC Microgrids with a CPL Connected

  • Isaías V. de Bessa,
  • Renan L. P. de Medeiros,
  • Iury Bessa,
  • Florindo A. C. Ayres Junior,
  • Alessandra R. de Menezes,
  • Gustavo M. Torres and
  • João Edgar Chaves Filho

25 May 2020

The DC microgrid system is composed by converters that operate like feeders and loads. Among these loads, we highlight the constant power loads (CPLs) that may cause instability in the microgrid, observed in the form of undesired oscillations due to...

  • Article
  • Open Access
13 Citations
2,440 Views
15 Pages

Adaptive Sensorless PI+Passivity-Based Control of a Boost Converter Supplying an Unknown CPL

  • Sebastián Riffo,
  • Walter Gil-González,
  • Oscar Danilo Montoya,
  • Carlos Restrepo and
  • Javier Muñoz

17 November 2022

This paper presents an adaptive control to stabilize the output voltage of a DC–DC boost converter that feeds an unknown constant power load (CPL). The proposed controller employs passivity-based control (PBC), which assigns a desired system en...

  • Article
  • Open Access
2 Citations
1,419 Views
14 Pages

26 December 2024

The substituent effect has a significant influence on the optical properties of spectral shape, width, and wavelength, and the intensities of the maximum peaks of emission (EMI) and circularly polarized luminescence (CPL). In this work, we conducted...

  • Article
  • Open Access
8 Citations
2,925 Views
13 Pages

25 September 2023

Malware is a significant threat to the field of cyber security. There is a wide variety of malware, which can be programmed to threaten computer security by exploiting various networks, operating systems, software and physical security vulnerabilitie...

  • Article
  • Open Access
4 Citations
2,891 Views
19 Pages

24 October 2019

Microgrids are versatile systems for integration of renewable energy sources and non-conventional storage devices. Sliding Mode techniques grant excellent features of robustness controlling power conditioning systems, making them highly suitable for...

  • Review
  • Open Access
29 Citations
5,736 Views
13 Pages

28 October 2020

Circularly polarized luminescence (CPL) has attracted significant attention in the fields of chiral photonic science and optoelectronic materials science. In a CPL-emitting system, a chiral luminophore derived from chiral molecules is usually essenti...

  • Review
  • Open Access
14 Citations
4,319 Views
25 Pages

27 January 2023

Microgrids have arisen as an alternate solution to the problem of power generation in distributed energy. Compared to ac microgrids, dc microgrids (DC MGs) are superior in terms of system efficiency, power quality, affordability, and ease of control....

  • Article
  • Open Access
1 Citations
1,493 Views
20 Pages

9 July 2024

This paper presents two control design strategies for voltage regulation in a single inductor dual-output DC-DC buck converter system. Based on a nominal multiple input multiple output plant model and performance requirements, both a Linear Quadratic...

  • Review
  • Open Access
7 Citations
2,868 Views
16 Pages

27 July 2024

Circularly polarized luminescence (CPL) materials have been widely used in the fields of bioimaging, optoelectronic devices, and optical communications. The supramolecular interaction, involving harnessing non-covalent interactions between host and g...

  • Feature Paper
  • Review
  • Open Access
3 Citations
1,812 Views
14 Pages

17 September 2023

Light that rotates in a circular spiral when viewed from the front is known as circularly polarized luminescence (CPL), and can be divided into two types, namely, left- and right-rotating light. To emit both left- and right-rotating CPLs, two types o...

  • Article
  • Open Access
4 Citations
2,652 Views
13 Pages

11 September 2019

In DC microgrid (DC-MG), the loads connected with converters under strict control are considered as CPLs (constant power loads). When the voltage of CPLs decreases, the current increases and the negative impedance characteristic of CPLs cause instabi...

  • Article
  • Open Access
9 Citations
6,607 Views
13 Pages

8 April 2022

Different lipase assays have variable reported diagnostic accuracies for acute pancreatitis (AP) in dogs. The aims of this retrospective study were to evaluate optimal cutoffs for 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6′-methylresorufin)...

  • Article
  • Open Access
17 Citations
3,377 Views
15 Pages

RST Digital Robust Control for DC/DC Buck Converter Feeding Constant Power Load

  • Akram M. Abdurraqeeb,
  • Abdullrahman A. Al-Shamma’a,
  • Abdulaziz Alkuhayli,
  • Abdullah M. Noman and
  • Khaled E. Addoweesh

23 May 2022

The instability of DC microgrids is the most prominent problem that limits the expansion of their use, and one of the most important causes of instability is constant power load CPLs. In this paper, a robust RST digital feedback controller is propose...

  • Article
  • Open Access
1 Citations
3,387 Views
14 Pages

1 July 2018

As an important interface converter, the three-phase voltage-source rectifier (VSR) connects the grid to DC-input converters. The constant power load (CPL) characteristic of the converter-load often causes large-signal stability problems. In order to...

  • Article
  • Open Access

28 January 2026

To address the issue of negative damping instability easily induced by DC/DC converters under constant power load (CPL) in DC microgrids and to enhance the control robustness of the system under uncertainties such as parameter perturbations, this pap...

  • Article
  • Open Access
4 Citations
2,250 Views
17 Pages

Fibroblast Growth Factor Receptor Inhibitors Decrease Proliferation of Melanoma Cell Lines and Their Activity Is Modulated by Vitamin D

  • Anna Piotrowska,
  • Joanna I. Nowak,
  • Justyna M. Wierzbicka,
  • Paweł Domżalski,
  • Monika Górska-Arcisz,
  • Rafał Sądej,
  • Delfina Popiel,
  • Maciej Wieczorek and
  • Michał A. Żmijewski

21 February 2024

Regardless of the unprecedented progress in malignant melanoma treatment strategies and clinical outcomes of patients during the last twelve years, this skin cancer remains the most lethal one. We have previously documented that vitamin D and its low...

  • Article
  • Open Access
4 Citations
2,392 Views
21 Pages

20 February 2023

In islanded AC microgrids, negative impedance characteristics of AC constant power loads (AC CPLs) easily introduce large signal instability to the system, while energy storage systems sometimes compensate for the dynamic characteristics of AC CPLs,...

  • Article
  • Open Access
7 Citations
2,755 Views
19 Pages

7 September 2022

Islanded DC microgrids composed of distributed generators (DGs), constant power loads (CPLs), parallel converters, batteries and supercapacitors (SCs) are typical nonlinear systems, and guaranteeing large-signal stability is a key issue. In this pape...

  • Article
  • Open Access
5 Citations
3,361 Views
17 Pages

A Stability Preserving Criterion for the Management of DC Microgrids Supplied by a Floating Bus

  • Daniele Bosich,
  • Andrea Vicenzutti,
  • Samuele Grillo and
  • Giorgio Sulligoi

1 November 2018

Direct current (DC) distribution is one of the most important enabling technologies for the future development of microgrids, due to the ease of interfacing DC components (e.g., batteries, photovoltaic systems, and native DC loads) to the grid. In th...

  • Proceeding Paper
  • Open Access
306 Views
8 Pages

Chiral DPP Thin Films: Unlocking Circularly Polarized Light for Next-Gen Optoelectronics

  • Alessia Arrigoni,
  • Simone Molinaro,
  • Federico Turco,
  • Eleonora Sofia Cama,
  • Chiara Botta,
  • Umberto Giovanella,
  • Benedetta Maria Squeo and
  • Mariacecilia Pasini

13 November 2025

We report the synthesis and characterization of the two enantiomeric forms of a thienyl-substituted diketopyrrolopyrrole (DPP) derivative bearing chiral alkyl chains. Thin films were prepared either by spin-coating and drop-casting and analyzed by UV...

  • Article
  • Open Access
901 Views
17 Pages

This article proposes a nonlinear control strategy to address the voltage instability issue caused by the boost converter with an uncertain constant power load (CPL). This strategy combines a passivity-based controller (PBC) with a virtual DC motor c...

  • Article
  • Open Access
4 Citations
2,744 Views
10 Pages

25 April 2022

Au nanocluster (AuNCs)-based luminescent functional materials have attracted the interest of researchers owing to their small size, tractable surface modification, phosphorescence lifetime and biocompatibility. However, the poor luminescence quantum...

  • Feature Paper
  • Article
  • Open Access
12 Citations
6,648 Views
13 Pages

17 July 2020

Bulk, solventless anionic ring-opening polymerization (AROP) of ε-caprolactam (CPL) with high yields, without side products and with short reaction times, initiated by caprolactamate-carbamoylcaprolactam initiating systems belong to green pol...

  • Communication
  • Open Access
2,193 Views
7 Pages

9 October 2024

Mesenchymal stem cells (MSCs) have significant anti-inflammatory properties and are beneficial in rodent models of pancreatitis. The safety and efficacy of MSCs is unknown in dogs with acute pancreatitis (AP). Dogs with AP who were treated with MSCs...

  • Article
  • Open Access
37 Citations
1,933 Views
13 Pages

On the Evidence of Dynamical Dark Energy

  • Qing Gao,
  • Zhiqian Peng,
  • Shengqing Gao and
  • Yungui Gong

31 December 2024

To elucidate the robustness of the baryon acoustic oscillation (BAO) data measured by the dark energy spectroscopic instrument (DESI) in capturing the dynamical behavior of dark energy, we assess the model dependence of the evidence for dynamical dar...

  • Article
  • Open Access
2 Citations
1,698 Views
24 Pages

Islanded hybrid AC/DC microgrids lack support for a large grid, and the negative incremental impedance of constant power loads (CPLs) aggravates the poor anti-disturbance capability of the system. When a single-phase ground fault (SPGF) occurs, the a...

  • Article
  • Open Access
724 Views
17 Pages

17 June 2025

Hybrid energy storage systems (HESSs), with superior transient response characteristics compared to conventional battery (BAT) systems, have emerged as an effective solution for power balance. However, the high penetration of constant power loads (CP...

  • Article
  • Open Access
1 Citations
1,868 Views
20 Pages

5 December 2022

Large disturbances frequently happen in isolated AC/DC Hybrid Microgrids. Unfortunately, constant power loads (CPLs) with negative impedance characteristics are equivalent to positive feedback, resulting in an increase in large disturbances. The syst...

  • Article
  • Open Access
5 Citations
3,751 Views
18 Pages

Confocal Blood Flow Videomicroscopy of Thrombus Formation over Human Arteries and Local Targeting of P2X7

  • Patrizia Marchese,
  • Maria Lombardi,
  • Maria Elena Mantione,
  • Domenico Baccellieri,
  • David Ferrara,
  • Roberto Chiesa,
  • Ottavio Alfieri and
  • Chiara Foglieni

Atherothrombosis exposes vascular components to blood. Currently, new antithrombotic therapies are emerging. Herein we investigated thrombogenesis of human arteries with/without atherosclerosis, and the interaction of coagulation and vascular compone...

  • Article
  • Open Access
4 Citations
1,896 Views
15 Pages

Stability Analysis of Buck Converter Based on Passivity-Based Stability Criterion

  • Yajing Zhang,
  • Jinyao Si,
  • Xiu-Teng Wang,
  • Jianguo Li and
  • Hongyan Zhao

21 February 2024

Recently, the stability of DC microgrids has attracted increasing attention. The traditional stability analysis method cannot not meet the requirements for the complexity and bidirectional energy flow of the system. In this paper, a passivity-based s...

  • Article
  • Open Access
49 Citations
10,171 Views
14 Pages

13 March 2012

The CAPRICE (CPC)-like MYB gene family encodes R3-type MYB transcription factors in Arabidopsis. There are six additional CPC-like MYB sequences in the Arabidopsis genome, including TRYPTICHON (TRY), ENHANCER OF TRY AND CPC1 and 2 (ETC1 and ETC2), EN...

  • Article
  • Open Access
4 Citations
5,998 Views
34 Pages

Design, Synthesis, and Development of pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3Kδ Inhibitors: Part I—Indole Derivatives

  • Mariola Stypik,
  • Marcin Zagozda,
  • Stanisław Michałek,
  • Barbara Dymek,
  • Daria Zdżalik-Bielecka,
  • Maciej Dziachan,
  • Nina Orłowska,
  • Paweł Gunerka,
  • Paweł Turowski and
  • Maciej Wieczorek
  • + 13 authors

Phosphoinositide 3-kinase δ (PI3Kδ), a member of the class I PI3K family, is an essential signaling biomolecule that regulates the differentiation, proliferation, migration, and survival of immune cells. The overactivity of this protein c...

  • Article
  • Open Access
2 Citations
2,614 Views
17 Pages

Ectopic Expression of JcCPL1, 2, and 4 Affects Epidermal Cell Differentiation, Anthocyanin Biosynthesis and Leaf Senescence in Arabidopsis thaliana

  • Yanbo Chen,
  • Pingzhi Wu,
  • Chao Zhang,
  • Yali Guo,
  • Bingbing Liao,
  • Yaping Chen,
  • Meiru Li,
  • Guojiang Wu,
  • Yaqin Wang and
  • Huawu Jiang

9 February 2022

The CAPRICE (CPC)-like (CPL) genes belong to a single-repeat R3 MYB family, whose roles in physic nut (Jatropha curcas L.), an important energy plant, remain unclear. In this study, we identified a total of six CPL genes (JcCPL16) in physic nu...

  • Article
  • Open Access
9 Citations
2,964 Views
17 Pages

Improved Adaptive Hamiltonian Control Law for Constant Power Load Stability Issue in DC Microgrid: Case Study for Multiphase Interleaved Fuel Cell Boost Converter

  • Phatiphat Thounthong,
  • Pongsiri Mungporn,
  • Babak Nahid-Mobarakeh,
  • Nicu Bizon,
  • Serge Pierfederici and
  • Damien Guilbert

20 July 2021

The cascaded connection of power converters in a DC microgrid may cause instabilities. Indeed, power converters operating as external loads exhibit constant power load (CPL) behaviors. In this study, the design of the feedback controller of a multi–c...

  • Article
  • Open Access
9 Citations
2,232 Views
14 Pages

Research on Flexible Virtual Inertia Control Method Based on the Small Signal Model of DC Microgrid

  • Shengyang Lu,
  • Tongwei Yu,
  • Huiwen Liu,
  • Wuyang Zhang,
  • Yuqiu Sui,
  • Junyou Yang,
  • Li Zhang,
  • Jiaxu Zhou and
  • Haixin Wang

9 November 2022

Renewable energy is usually connected to the DC micro-grid by a large number of power electronic devices, which have the advantages of a fast system response, but the disadvantage to reduce the inertia of the system, which makes the stability of the...

  • Article
  • Open Access
2 Citations
2,790 Views
18 Pages

Development of a Formulation and In Vitro Evaluation of a Pulmonary Drug Delivery System for a Novel Janus Kinase (JAK) Inhibitor, CPL409116

  • Aleksandra Rzewińska,
  • Jakub Szlęk,
  • Damian Dąbrowski,
  • Ewelina Juszczyk,
  • Katarzyna Mróz,
  • Heikki Räikkönen,
  • Mia Siven,
  • Maciej Wieczorek and
  • Przemysław Dorożyński

The pursuit of targeted therapies for cytokine-dependent diseases has led to the discovery of Janus kinase (JAK) inhibitors, a promising class of drugs. Among them, CPL409116, a selective dual JAK and rho-associated protein kinase inhibitor (ROCK), h...

  • Article
  • Open Access
2 Citations
2,764 Views
17 Pages

Tuning the Biological Activity of PI3Kδ Inhibitor by the Introduction of a Fluorine Atom Using the Computational Workflow

  • Wojciech Pietruś,
  • Mariola Stypik,
  • Marcin Zagozda,
  • Martyna Banach,
  • Lidia Gurba-Bryśkiewicz,
  • Wioleta Maruszak,
  • Arkadiusz Leniak,
  • Rafał Kurczab,
  • Zbigniew Ochal and
  • Maciej Wieczorek
  • + 1 author

17 April 2023

As a member of the class I PI3K family, phosphoinositide 3-kinase δ (PI3Kδ) is an important signaling biomolecule that controls immune cell differentiation, proliferation, migration, and survival. It also represents a potential and promis...

  • Article
  • Open Access
9 Citations
4,509 Views
35 Pages

Design, Synthesis, and Development of Pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3Kδ Inhibitors: Part II—Benzimidazole Derivatives

  • Mariola Stypik,
  • Stanisław Michałek,
  • Nina Orłowska,
  • Marcin Zagozda,
  • Maciej Dziachan,
  • Martyna Banach,
  • Paweł Turowski,
  • Paweł Gunerka,
  • Daria Zdżalik-Bielecka and
  • Maciej Wieczorek
  • + 13 authors

Phosphoinositide 3-kinase (PI3K) is the family of lipid kinases participating in vital cellular processes such as cell proliferation, growth, migration, or cytokines production. Due to the high expression of these proteins in many human cells and the...

  • Article
  • Open Access
30 Citations
3,560 Views
63 Pages

13 August 2021

We present a detailed and pedagogical analysis of recent cosmological data, including CMB, BAO, SnIa and the recent local measurement of H0. We thus obtain constraints on the parameters of these standard dark energy parameterizations, including ΛCDM,...

  • Article
  • Open Access
2 Citations
1,910 Views
15 Pages

14 December 2022

Dual-stage cascaded dc systems are some of the most widely applied power interfaces in dc distributed power systems. However, in some practical situations, these systems might be unstable, especially if they incorporate tightly regulated load convert...

  • Article
  • Open Access
23 Citations
3,822 Views
25 Pages

15 November 2020

DC microgrid applications include electric vehicle systems, shipboard power systems, and More Electric Aircraft (MEA), which produce power at a low voltage level. Rapid developments in hydrogen fuel cell (FC) energy have extended the applications of...

  • Article
  • Open Access
1 Citations
2,979 Views
14 Pages

Chiral Binaphthalene Building Blocks for Self-Assembled Nanoscale CPL Emitters

  • Yu-Yu Hsieh,
  • Jing-Jong Shyue,
  • Yu-Chiang Chao,
  • Ken-Tsung Wong and
  • Dario M. Bassani

11 April 2023

The introduction of biuret hydrogen-bonding sites onto chiral binaphthalene-based chromophores was investigated as a route to sub-micron-sized, vesicle-like aggregates endowed with chiroptical properties. The synthesis was conducted from the correspo...

  • Article
  • Open Access
2 Citations
1,898 Views
14 Pages

31 October 2023

This article introduces a novel approach to voltage regulation in a DC/DC boost converter. The approach leverages two advanced control techniques, including learning-based nonlinear control. By combining the backstepping (BSC) algorithm with artifici...

  • Article
  • Open Access
13 Citations
3,938 Views
23 Pages

Implementation of QbD Approach to the Development of Chromatographic Methods for the Determination of Complete Impurity Profile of Substance on the Preclinical and Clinical Step of Drug Discovery Studies

  • Lidia Gurba-Bryśkiewicz,
  • Urszula Dawid,
  • Damian A. Smuga,
  • Wioleta Maruszak,
  • Monika Delis,
  • Krzysztof Szymczak,
  • Bartosz Stypik,
  • Aleksandra Moroz,
  • Aleksandra Błocka and
  • Maciej Wieczorek
  • + 2 authors

14 September 2022

The purpose of this work was to demonstrate the use of the AQbD with the DOE approach to the methodical step-by-step development of a UHPLC method for the quantitative determination of the impurity profile of new CPL409116 substance (JAK/ROCK inhibit...

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