8 May 2019
Background: Spinal muscular atrophy type 1 (SMA1) is a devastating genetic disease for which gene-replacement therapy may bring substantial survival and quality of life benefits. Objective: This study investigated the cost-effectiveness of onasemnog...
Classical cryptographic standards such as RSA and ECC face existential threats from the advent of quantum computing, necessitating an urgent transition to quantum-resistant post-quantum cryptographic (PQC) algorithms. This article presents a cross-pl...
Parallel implementations of algorithms are usually compared with single-core CPU performance. The advantage of multicore vector processors decreases the performance gap between GPU and CPU computation, as shown in many recent pieces of research. With...
Currently, cryptographic hash functions are widely used in various applications, including message authentication codes, cryptographic random generators, digital signatures, key derivation functions, and post-quantum algorithms. Notably, they play a...
Cytosolic phospholipase A2α (cPLA2α) is the rate-limiting enzyme in releasing arachidonic acid and biosynthesis of its derivative eicosanoids. Thus, the catalytic activity of cPLA2α plays an important role in cellular metabolism in...
In order to cope with the massive scale of traffic and reduce the memory overhead of traffic statistics, the traffic statistics method based on the Sketch algorithm has become a research hotspot for traffic statistics. This paper studies the problem...
For classified and sensitive electronic documents within the scope of enterprises and organizations, in order to standardize and strengthen the confidentiality management of enterprises and meet the actual needs of secret text classification, a docum...
Mathematical expression evaluation is a critical component in high-performance software systems. Traditional state-dependent algorithms resist Single Instruction, Multiple Data vectorization, while managed runtime environments introduce Garbage Colle...
With the development of synthetic aperture radar (SAR) technologies in recent years, the huge amount of remote sensing data brings challenges for real-time imaging processing. Therefore, high performance computing (HPC) methods have been presented to...
COVID-19 vaccines remain essential for pandemic control, but antibody responses wane, and viral variants emerge. Affordable platforms enabling local manufacturing are important for equitable vaccine access in low- and middle-income countries (LMICs)....
Remote sensing data has known an explosive growth in the past decade. This has led to the need for efficient dimensionality reduction techniques, mathematical procedures that transform the high-dimensional data into a meaningful, reduced representati...
We investigate in this paper the behaviors of the Riemann solvers (Roe and Harten-Lax-van Leer-Contact (HLLC) schemes) and the Riemann-solver-free method (central-upwind scheme) regarding their accuracy and efficiency for solving the 2D shallow water...
Background/Objectives: Obesity is a growing problem in the feline population worldwide. An extract of unripe avocado (AvX) has been shown to attenuate gains in body weight and body fat in mice fed a high-fat diet. The aim of this study was to evaluat...
As a regulator of cellular inflammation and proliferation, cytosolic phospholipase A2 α (cPLA2α) is a promising therapeutic target for psoriasis; indeed, the cPLA2α inhibitor AVX001 has shown efficacy against plaque psoriasis in a p...
This paper presents high-performance Advanced Vector Extensions 512 (AVX-512) implementations of two Korean standard cryptographic algorithms: the Lightweight Secure Hash (LSH) function and Lightweight Encryption Algorithm–Galois/Counter Mode (...
Thread-level and data-level parallel architectures have become the design of choice in many of today’s energy-efficient computing systems. However, these architectures put substantially higher requirements on the memory subsystem than scalar architec...
Chronic kidney disease (CKD) is a significant global health burden and a leading cause of death in the United States. Chronic inflammation contributes to fibrosis and CKD progression. Here, we present evidence that a key pro-inflammatory group IVA ph...
Beginning at 16 weeks of age and continuing for 44 weeks, male C57BL/6J were fed either a control (CON) diet; a high-fat (HF) diet (60% unsaturated); or the HF diet containing an extract of unripe avocados (AvX) enriched in the 7-carbon sugar mannohe...
AR-15512 (formerly known as AVX-012 and WS-12) is a TRPM8 receptor agonist currently in phase 2b clinical trials for the treatment of dry eye. This bioactive compound with menthol-like cooling activity has three stereogenic centers, and its final str...
The generation of energy-efficient parallel scientific codes became very important in the time of carbon footprint reduction. In this paper, we briefly present our latest particle-in-cell code with the results of a numerical simulation of plasma dyna...
The paper presents a new hydrodynamical code, OMPEGAS, for the 3D simulation of astrophysical flows on shared memory architectures. It provides a numerical method for solving the three-dimensional equations of the gravitational hydrodynamics based on...
This paper proposes a post-quantum secure key agreement protocol tailored for vehicular networks (V2X), addressing the dual challenges of quantum resistance and lightweight deployment. The hybrid scheme integrates two lattice-based Key Encapsulation...
A problem has been noted regarding the admixture of fuel to a low viscosity lubricant in hybrid electric vehicles (HEVs). This is very detrimental to the wear and tear of engine operating components. In this study, the operating conditions of HEVs we...
Background: Unripe avocados (Persea americana) are naturally enriched in mannoheptulose (MH), which is a candidate caloric restriction mimetic. Objectives: To evaluate the effects of a diet supplement made from unripe avocado on glucose tolerance, an...
As Mobile Communication and Internet Systems (MCIS) have rapidly developed, security issues related to MCIS have become increasingly important. Therefore, the development and research of security technologies for mobile communication and internet sys...
28 February 2021
Background: Recent cost-utility analysis (CUA) models for onasemnogene abeparvovec (Zolgensma®, formerly AVXS-101) in spinal muscular atrophy type 1 (SMA1) differ on key assumptions and results. Objective: To compare the manufacturer’s proprietary C...
As systems migrate toward post-quantum readiness, symmetric keys are kept longer and protect larger data volumes, a regime in which keystream security beyond the birthday bound matters. The dominant block–cipher counter mode, AES-CTR (Advanced...
Cucumber is a vegetable crop of economic importance in Mexico. In 2023, fresh or frozen cucumber and pickle international sales reached USD 783M, placing Mexico in second rank among countries with the highest currency inflow in the world. This crop i...