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Article

An Avocado Extract Enriched in Mannoheptulose Prevents the Negative Effects of a High-Fat Diet in Mice

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Department of Psychology, Towson University, 8000 York Road, Towson, MD 21252, USA
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Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, IN 47907, USA
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Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Skip Bertman Drive, Baton Rouge, LA 70803, USA
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Pennington Biomedical Research Center, Louisiana State University, 5600 Perkins Road, Baton Rouge, LA 70808, USA
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GeroScience, Inc., 19895 Southern Hills, Baton Rouge, LA 70809, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Federico Carbone
Nutrients 2022, 14(1), 155; https://doi.org/10.3390/nu14010155
Received: 17 November 2021 / Revised: 22 December 2021 / Accepted: 26 December 2021 / Published: 29 December 2021
(This article belongs to the Section Nutrition and Obesity)
Beginning at 16 weeks of age and continuing for 44 weeks, male C57BL/6J were fed either a control (CON) diet; a high-fat (HF) diet (60% unsaturated); or the HF diet containing an extract of unripe avocados (AvX) enriched in the 7-carbon sugar mannoheptulose (MH), designed to act as a glycolytic inhibitor (HF + MH). Compared to the CON diet, mice on the HF diet exhibited higher body weights; body fat; blood lipids; and leptin with reduced adiponectin levels, insulin sensitivity, VO2max, and falls from a rotarod. Mice on the HF + MH diet were completely protected against these changes in the absence of significant diet effects on food intake. Compared to the CON diet, oxidative stress was also increased by the HF diet indicated by higher levels of total reactive oxygen species, superoxide, and peroxynitrite measured in liver samples by electron paramagnetic resonance spectroscopy, whereas the HF + MH diet attenuated these changes. Compared to the CON, the HF diet increased signaling in the mechanistic target of the rapamycin (mTOR) pathway, and the addition of the MH-enriched AvX to this diet attenuated these changes. Beyond generating further interest in the health benefits of avocados, these results draw further new attention to the effects of this rare sugar, MH, as a botanical intervention for preventing obesity. View Full-Text
Keywords: rare sugar; obesity; glycolysis; metabolism; insulin; adipokines; oxidative stress; mTOR rare sugar; obesity; glycolysis; metabolism; insulin; adipokines; oxidative stress; mTOR
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MDPI and ACS Style

Pistell, P.J.; Utsuki, T.; Francis, J.; Ebenezer, P.J.; Terrebonne, J.; Roth, G.S.; Ingram, D.K. An Avocado Extract Enriched in Mannoheptulose Prevents the Negative Effects of a High-Fat Diet in Mice. Nutrients 2022, 14, 155. https://doi.org/10.3390/nu14010155

AMA Style

Pistell PJ, Utsuki T, Francis J, Ebenezer PJ, Terrebonne J, Roth GS, Ingram DK. An Avocado Extract Enriched in Mannoheptulose Prevents the Negative Effects of a High-Fat Diet in Mice. Nutrients. 2022; 14(1):155. https://doi.org/10.3390/nu14010155

Chicago/Turabian Style

Pistell, Paul J., Tadanobu Utsuki, Joseph Francis, Philip J. Ebenezer, Jennifer Terrebonne, George S. Roth, and Donald K. Ingram. 2022. "An Avocado Extract Enriched in Mannoheptulose Prevents the Negative Effects of a High-Fat Diet in Mice" Nutrients 14, no. 1: 155. https://doi.org/10.3390/nu14010155

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