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Most Cited

  • Review
  • Open Access
566 Citations
33,453 Views
43 Pages

15 February 2023

Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, fl...

  • Review
  • Open Access
373 Citations
35,250 Views
30 Pages

Emerging Applications of Nanotechnology in Healthcare and Medicine

  • Shiza Malik,
  • Khalid Muhammad and
  • Yasir Waheed

14 September 2023

Knowing the beneficial aspects of nanomedicine, scientists are trying to harness the applications of nanotechnology in diagnosis, treatment, and prevention of diseases. There are also potential uses in designing medical tools and processes for the ne...

  • Review
  • Open Access
329 Citations
28,405 Views
17 Pages

Chitosan-Based Nanoparticles as Effective Drug Delivery Systems—A review

  • Karolina Jafernik,
  • Agata Ładniak,
  • Eliza Blicharska,
  • Katarzyna Czarnek,
  • Halina Ekiert,
  • Agnieszka E. Wiącek and
  • Agnieszka Szopa

18 February 2023

Chitosan-based nanoparticles (chitosan-based nanocomposites; chitosan nanoparticles; ChNPs) are promising materials that are receiving a lot of attention in the last decades. ChNPs have great potential as nanocarriers. They are able to encapsulate dr...

  • Review
  • Open Access
286 Citations
25,620 Views
27 Pages

25 June 2023

Flavonoids represent the main class of plant secondary metabolites and occur in the tissues and organs of various plant species. In plants, flavonoids are involved in many biological processes and in response to various environmental stresses. The co...

  • Review
  • Open Access
281 Citations
35,159 Views
22 Pages

Malondialdehyde as a Potential Oxidative Stress Marker for Allergy-Oriented Diseases: An Update

  • Raffaele Cordiano,
  • Mario Di Gioacchino,
  • Rocco Mangifesta,
  • Claudia Panzera,
  • Sebastiano Gangemi and
  • Paola Lucia Minciullo

9 August 2023

Malondialdehyde (MDA) is a compound that is derived from the peroxidation of polyunsaturated fatty acids. It has been used as a biomarker to measure oxidative stress in various biological samples in patients who are affected by a wide range of diseas...

  • Review
  • Open Access
274 Citations
30,110 Views
16 Pages

Cadmium Toxicity and Health Effects—A Brief Summary

  • Angelika Edyta Charkiewicz,
  • Wioleta Justyna Omeljaniuk,
  • Karolina Nowak,
  • Marzena Garley and
  • Jacek Nikliński

14 September 2023

Cadmium (Cd) is a ductile metal in the form of a blueish or silvery-white powder. It is naturally found in soil (about 0.2 mg/kg), minerals, and water. Cd belongs to the group of toxic, carcinogenic, and stimulating elements. Its biological half-life...

  • Review
  • Open Access
245 Citations
40,483 Views
36 Pages

4 February 2025

The fundamental principle of Fourier Transform Infrared (FTIR) spectroscopy is based on the vibration and rotation of atoms, and it has become a universal and widely used spectral methodology for the detection of internal molecular structures in a di...

  • Review
  • Open Access
241 Citations
56,087 Views
19 Pages

The Bioavailability of Drugs—The Current State of Knowledge

  • Marlena Stielow,
  • Adrianna Witczyńska,
  • Natalia Kubryń,
  • Łukasz Fijałkowski,
  • Jacek Nowaczyk and
  • Alicja Nowaczyk

11 December 2023

Drug bioavailability is a crucial aspect of pharmacology, affecting the effectiveness of drug therapy. Understanding how drugs are absorbed, distributed, metabolized, and eliminated in patients’ bodies is essential to ensure proper and safe tre...

  • Review
  • Open Access
231 Citations
27,717 Views
38 Pages

22 June 2023

The role of nanotechnology is increasingly important in our society. Through it, scientists are acquiring the ability to understand the structure and properties of materials and manipulate them at the scale of atoms and molecules. Nanomaterials are a...

  • Review
  • Open Access
203 Citations
26,301 Views
24 Pages

Bacterial and Fungal Biocontrol Agents for Plant Disease Protection: Journey from Lab to Field, Current Status, Challenges, and Global Perspectives

  • Muhammad Ayaz,
  • Cai-Hong Li,
  • Qurban Ali,
  • Wei Zhao,
  • Yuan-Kai Chi,
  • Muhammad Shafiq,
  • Farman Ali,
  • Xi-Yue Yu,
  • Qing Yu and
  • Wen-Kun Huang
  • + 3 authors

21 September 2023

Plants are constantly exposed to various phytopathogens such as fungi, Oomycetes, nematodes, bacteria, and viruses. These pathogens can significantly reduce the productivity of important crops worldwide, with annual crop yield losses ranging from 20%...

  • Review
  • Open Access
198 Citations
18,289 Views
38 Pages

11 September 2024

The growing presence of diverse pollutants, including heavy metals, organic compounds, pharmaceuticals, and emerging contaminants, poses significant environmental and health risks. Traditional methods for pollutant removal often face limitations in e...

  • Article
  • Open Access
189 Citations
3,736 Views
12 Pages

A New Cd(II)-Based Coordination Polymer for Efficient Photocatalytic Removal of Organic Dyes

  • Juanjuan Zhao,
  • Zhuoyu Dang,
  • Mohd. Muddassir,
  • Saleem Raza,
  • Aiguo Zhong,
  • Xiaoxiong Wang and
  • Juncheng Jin

28 September 2023

Coordination polymers (CPs) are a diverse class of multi-dimensional compounds that show promise as photocatalysts for degrading dyes in polluted water. Herein, a new 1D Cd(II)-based coordination polymer with the formula [Cd(bpyp)(nba)2] (1) (bpyp =...

  • Review
  • Open Access
185 Citations
25,022 Views
19 Pages

Biofilm Formation and Control of Foodborne Pathogenic Bacteria

  • Xiaoli Liu,
  • Huaiying Yao,
  • Xihong Zhao and
  • Chaorong Ge

Biofilms are microbial aggregation membranes that are formed when microorganisms attach to the surfaces of living or nonliving things. Importantly, biofilm properties provide microorganisms with protection against environmental pressures and enhance...

  • Review
  • Open Access
183 Citations
41,915 Views
22 Pages

Advancements in Sustainable Natural Dyes for Textile Applications: A Review

  • Barbara Pizzicato,
  • Severina Pacifico,
  • Diana Cayuela,
  • Gabriela Mijas and
  • Marta Riba-Moliner

8 August 2023

The dyeing and finishing step represents a clear hotspot in the textile supply chain as the wet processing stages require significant amounts of water, energy, and chemicals. In order to tackle environmental issues, natural dyes are gaining attention...

  • Review
  • Open Access
180 Citations
12,274 Views
28 Pages

The current state of heavy metal (HM) environmental pollution problems was considered in the review: the effects of HMs on the vital activity of plants and the functioning of their antioxidant system, including phenolic antioxidants. The latter perfo...

  • Review
  • Open Access
179 Citations
20,658 Views
32 Pages

Quercetin, a Flavonoid with Great Pharmacological Capacity

  • Eber Josue Carrillo-Martinez,
  • Flor Yohana Flores-Hernández,
  • Adriana María Salazar-Montes,
  • Hector Fabián Nario-Chaidez and
  • Luis Daniel Hernández-Ortega

25 February 2024

Quercetin is a flavonoid with a low molecular weight that belongs to the human diet’s phenolic phytochemicals and nonenergy constituents. Quercetin has a potent antioxidant capacity, being able to capture reactive oxygen species (ROS), reactive...

  • Review
  • Open Access
178 Citations
20,716 Views
33 Pages

15 September 2023

In recent years, there has been a growing attempt to manipulate various properties of biodegradable materials to use them as alternatives to their synthetic plastic counterparts. Alginate is a polysaccharide extracted from seaweed or soil bacteria th...

  • Review
  • Open Access
177 Citations
33,862 Views
21 Pages

11 July 2023

Chlorophylls play a crucial role in photosynthesis and are abundantly found in green fruits and vegetables that form an integral part of our diet. Although limited, existing studies suggest that these photosynthetic pigments and their derivatives pos...

  • Review
  • Open Access
175 Citations
15,542 Views
33 Pages

30 March 2023

Nanotechnology (NT) is now firmly established in both the private home and commercial markets. Due to its unique properties, NT has been fully applied within multiple sectors like pharmacy and medicine, as well as industries like chemical, electrical...

  • Review
  • Open Access
175 Citations
18,166 Views
31 Pages

Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review

  • Iram Iqbal,
  • Polrat Wilairatana,
  • Fatima Saqib,
  • Bushra Nasir,
  • Muqeet Wahid,
  • Muhammad Farhaj Latif,
  • Ahmar Iqbal,
  • Rabia Naz and
  • Mohammad S. Mubarak

1 September 2023

Fruits, vegetables, and other food items contain phytochemicals or secondary metabolites which may be considered non-essential nutrients but have medicinal importance. These dietary phytochemicals exhibit chemopreventive and therapeutic effects again...

  • Review
  • Open Access
173 Citations
20,080 Views
46 Pages

10 March 2023

Polyphenols are an important component of plant-derived food with a wide spectrum of beneficial effects on human health. For many years, they have aroused great interest, especially due to their antioxidant properties, which are used in the preventio...

  • Review
  • Open Access
170 Citations
9,666 Views
31 Pages

Biosynthesis of Gold and Silver Nanoparticles Using Phytochemical Compounds

  • Ade Zuhrotun,
  • Dede Jihan Oktaviani and
  • Aliya Nur Hasanah

Gold and silver nanoparticles are nanoparticles that have been widely used in various fields and have shown good benefits. The method of nanoparticle biosynthesis utilizing plant extracts, also known as green synthesis, has become a promising method...

  • Review
  • Open Access
170 Citations
30,630 Views
15 Pages

14 July 2023

Medicinal mushrooms, e.g., Lion’s Mane (Hericium erinaceus (Bull.) Pers.), Reishi (Ganoderma lucidum (Curtis) P. Karst.), Chaga (Inonotus obliquus (Ach. ex Pers.) Pilát), Cordyceps (Ophiocordyceps sinensis (Berk.) G.H. Sung, J.M. Sung, H...

  • Review
  • Open Access
157 Citations
17,217 Views
26 Pages

The Classification, Molecular Structure and Biological Biosynthesis of Flavonoids, and Their Roles in Biotic and Abiotic Stresses

  • Wei-Bing Zhuang,
  • Yu-Hang Li,
  • Xiao-Chun Shu,
  • Yu-Ting Pu,
  • Xiao-Jing Wang,
  • Tao Wang and
  • Zhong Wang

20 April 2023

With the climate constantly changing, plants suffer more frequently from various abiotic and biotic stresses. However, they have evolved biosynthetic machinery to survive in stressful environmental conditions. Flavonoids are involved in a variety of...

  • Review
  • Open Access
148 Citations
18,886 Views
38 Pages

Peptides as Therapeutic Agents: Challenges and Opportunities in the Green Transition Era

  • Giacomo Rossino,
  • Emanuela Marchese,
  • Giovanni Galli,
  • Francesca Verde,
  • Matteo Finizio,
  • Massimo Serra,
  • Pasquale Linciano and
  • Simona Collina

19 October 2023

Peptides are at the cutting edge of contemporary research for new potent, selective, and safe therapeutical agents. Their rise has reshaped the pharmaceutical landscape, providing solutions to challenges that traditional small molecules often cannot...

  • Review
  • Open Access
148 Citations
32,577 Views
46 Pages

Carbon Quantum Dots: Properties, Preparation, and Applications

  • Jichuan Kong,
  • Yihui Wei,
  • Feng Zhou,
  • Liting Shi,
  • Shuangjie Zhao,
  • Mengyun Wan and
  • Xiangfeng Zhang

26 April 2024

Carbon quantum dots are a novel form of carbon material. They offer numerous benefits including particle size adjustability, light resistance, ease of functionalization, low toxicity, excellent biocompatibility, and high-water solubility, as well as...

  • Review
  • Open Access
146 Citations
19,138 Views
31 Pages

Therapeutic Effects of Coumarins with Different Substitution Patterns

  • Virginia Flores-Morales,
  • Ana P. Villasana-Ruíz,
  • Idalia Garza-Veloz,
  • Samantha González-Delgado and
  • Margarita L. Martinez-Fierro

The use of derivatives of natural and synthetic origin has gained attention because of their therapeutic effects against human diseases. Coumarins are one of the most common organic molecules and are used in medicine for their pharmacological and bio...

  • Review
  • Open Access
146 Citations
69,099 Views
28 Pages

Skin Pigmentation Types, Causes and Treatment—A Review

  • Amin Mahmood Thawabteh,
  • Alaa Jibreen,
  • Donia Karaman,
  • Alà Thawabteh and
  • Rafik Karaman

18 June 2023

Human skin pigmentation and melanin synthesis are incredibly variable, and are impacted by genetics, UV exposure, and some drugs. Patients’ physical appearance, psychological health, and social functioning are all impacted by a sizable number o...

  • Review
  • Open Access
145 Citations
16,712 Views
24 Pages

Radioactive Wastewater Treatment Technologies: A Review

  • Hailing Ma,
  • Minghai Shen,
  • Yao Tong and
  • Xiao Wang

17 February 2023

With the wide application of nuclear energy, the problem of radioactive pollution has attracted worldwide attention, and the research on the treatment of radioactive wastewater is imminent. How to treat radioactive wastewater deeply and efficiently h...

  • Review
  • Open Access
135 Citations
16,417 Views
18 Pages

Phytochemical Properties, Extraction, and Pharmacological Benefits of Naringin: A Review

  • VS Shilpa,
  • Rafeeya Shams,
  • Kshirod Kumar Dash,
  • Vinay Kumar Pandey,
  • Aamir Hussain Dar,
  • Shaikh Ayaz Mukarram,
  • Endre Harsányi and
  • Béla Kovács

25 July 2023

This review describes the various innovative approaches implemented for naringin extraction as well as the recent developments in the field. Naringin was assessed in terms of its structure, chemical composition, and potential food sources. How naring...

  • Review
  • Open Access
129 Citations
14,770 Views
18 Pages

An Overview on Carbon Quantum Dots Optical and Chemical Features

  • Marco Giuseppe Giordano,
  • Giulia Seganti,
  • Mattia Bartoli and
  • Alberto Tagliaferro

19 March 2023

Carbon quantum dots are the materials of a new era with astonishing properties such as high photoluminescence, chemical tuneability and high biocompatibility. Since their discovery, carbon quantum dots have been described as nanometric high-fluoresce...

  • Review
  • Open Access
128 Citations
31,742 Views
25 Pages

29 February 2024

Zeolites, a group of minerals with unique properties, have been known for more than 250 years. However, it was the development of methods for hydrothermal synthesis of zeolites and their large-scale industrial applications (oil processing, agricultur...

  • Review
  • Open Access
127 Citations
8,988 Views
20 Pages

Cancer Nanomedicine: Emerging Strategies and Therapeutic Potentials

  • Manman Xu,
  • Xinpu Han,
  • Hongtai Xiong,
  • Yijie Gao,
  • Bowen Xu,
  • Guanghui Zhu and
  • Jie Li

30 June 2023

Cancer continues to pose a severe threat to global health, making pursuing effective treatments more critical than ever. Traditional therapies, although pivotal in managing cancer, encounter considerable challenges, including drug resistance, poor dr...

  • Review
  • Open Access
127 Citations
12,321 Views
16 Pages

Pharmacological Effects of Astragaloside IV: A Review

  • Yutong Liang,
  • Biqiong Chen,
  • Di Liang,
  • Xiaoxiao Quan,
  • Ruolan Gu,
  • Zhiyun Meng,
  • Hui Gan,
  • Zhuona Wu,
  • Yunbo Sun and
  • Guifang Dou
  • + 1 author

18 August 2023

Astragaloside IV (AS-IV) is one of the main active components extracted from the Chinese medicinal herb Astragali and serves as a marker for assessing the herb’s quality. AS-IV is a tetracyclic triterpenoid saponin in the form of lanolin ester...

  • Review
  • Open Access
127 Citations
12,325 Views
25 Pages

Biosynthesis of Nanoparticles from Various Biological Sources and Its Biomedical Applications

  • Gopalu Karunakaran,
  • Kattakgoundar Govindaraj Sudha,
  • Saheb Ali and
  • Eun-Bum Cho

In the last few decades, the broad scope of nanomedicine has played an important role in the global healthcare industry. Biological acquisition methods to obtain nanoparticles (NPs) offer a low-cost, non-toxic, and environmentally friendly approach....

  • Review
  • Open Access
126 Citations
9,331 Views
15 Pages

Copper and Copper-Based Nanoparticles in Medicine—Perspectives and Challenges

  • Marta J. Woźniak-Budych,
  • Katarzyna Staszak and
  • Maciej Staszak

18 September 2023

Nanotechnology has ushered in a new era of medical innovation, offering unique solutions to longstanding healthcare challenges. Among nanomaterials, copper and copper oxide nanoparticles stand out as promising candidates for a multitude of medical ap...

  • Review
  • Open Access
125 Citations
23,879 Views
16 Pages

21 April 2023

Insecticides play a critical role in controlling the spread of insect-borne diseases and preserving crop health. These chemical substances are specifically formulated to kill or manage insect populations. Over the years, various types of insecticides...

  • Essay
  • Open Access
124 Citations
3,136 Views
14 Pages

18 October 2023

This paper reports the synthesis of a novel quaternary surfactant containing a hydroxyethyl group (PFPE-C) and the surface properties of its aqueous solution (investigated by comparisons with two structurally similar chemicals, dodecyl-(2-hydroxyethy...

  • Article
  • Open Access
122 Citations
8,529 Views
17 Pages

Green Synthesis of Silver Nanoparticles from Allium cepa L. Peel Extract, Their Antioxidant, Antipathogenic, and Anticholinesterase Activity

  • Mehmet Fırat Baran,
  • Cumali Keskin,
  • Ayşe Baran,
  • Abdulkerim Hatipoğlu,
  • Mahmut Yildiztekin,
  • Selçuk Küçükaydin,
  • Kadri Kurt,
  • Hülya Hoşgören,
  • Md. Moklesur Rahman Sarker and
  • Aziz Eftekhari
  • + 3 authors

The present work deals with the green synthesis and characterization of silver nanoparticles (AgNPs) using Allium cepa (yellowish peel) and the evaluation of its antimicrobial, antioxidant, and anticholinesterase activities. For the synthesis of AgNP...

  • Review
  • Open Access
122 Citations
46,810 Views
38 Pages

19 December 2023

Citric acid finds broad applications in various industrial sectors, such as the pharmaceutical, food, chemical, and cosmetic industries. The bioproduction of citric acid uses various microorganisms, but the most commonly employed ones are filamentous...

  • Review
  • Open Access
119 Citations
11,904 Views
16 Pages

27 March 2023

Chitosan (CS), a biopolymer derived from chitin, is known for strong antifungal activity while being biodegradable, biocompatible, and non-toxic. Because of its characteristic it has been widely used in control of fungal pathogens. Antifungal activit...

  • Review
  • Open Access
119 Citations
15,644 Views
15 Pages

23 February 2023

The anti-inflammatory drug ibuprofen is considered to be an emerging contaminant because of its presence in different environments (from water bodies to soils) at concentrations with adverse effects on aquatic organisms due to cytotoxic and genotoxic...

  • Review
  • Open Access
119 Citations
8,982 Views
17 Pages

Structural Modification and Biological Activity of Polysaccharides

  • Ting Zhao,
  • Min Yang,
  • Lina Ma,
  • Xinglong Liu,
  • Qiteng Ding,
  • Guodong Chai,
  • Yang Lu,
  • Hewei Wei,
  • Shuai Zhang and
  • Chuanbo Ding

14 July 2023

Natural polysaccharides are macromolecular substances with a wide range of biological activities. The structural modification of polysaccharides by chemical means can enhance their biological activity. This paper reviews the latest research reports o...

  • Review
  • Open Access
116 Citations
18,015 Views
21 Pages

15 February 2023

This review provides a report on the properties and recent advances in the application of chitosan and chitosan-based materials in cosmetics. Chitosan is a polysaccharide that can be obtained from chitin via the deacetylation process. Chitin most com...

  • Review
  • Open Access
115 Citations
36,766 Views
83 Pages

A Comprehensive Review of Nanoparticles: From Classification to Application and Toxicity

  • Furkan Eker,
  • Hatice Duman,
  • Emir Akdaşçi,
  • Ecem Bolat,
  • Sümeyye Sarıtaş,
  • Sercan Karav and
  • Anna Maria Witkowska

25 July 2024

Nanoparticles are structures that possess unique properties with high surface area-to-volume ratio. Their small size, up to 100 nm, and potential for surface modifications have enabled their use in a wide range of applications. Various factors influe...

  • Review
  • Open Access
114 Citations
22,578 Views
35 Pages

Plant-Derived Terpenoids: A Plethora of Bioactive Compounds with Several Health Functions and Industrial Applications—A Comprehensive Overview

  • José S. Câmara,
  • Rosa Perestrelo,
  • Rui Ferreira,
  • Cristina V. Berenguer,
  • Jorge A. M. Pereira and
  • Paula C. Castilho

15 August 2024

Terpenoids are a large class of natural secondary plant metabolites which are highly diverse in structure, formed from isoprene units (C-5), associated with a wide range of biological properties, including antioxidant, antimicrobial, anti-inflammator...

  • Review
  • Open Access
113 Citations
23,373 Views
26 Pages

1 September 2023

With population and economic development increasing worldwide, the public is increasingly concerned with the health benefits and nutritional properties of vegetable oils (VOs). In this review, the chemical composition and health-promoting benefits of...

  • Article
  • Open Access
111 Citations
10,710 Views
10 Pages

Antioxidant Activities of Essential Oils and Their Major Components in Scavenging Free Radicals, Inhibiting Lipid Oxidation and Reducing Cellular Oxidative Stress

  • Xiaohua Chen,
  • Shufeng Shang,
  • Fei Yan,
  • Hai Jiang,
  • Guanjie Zhao,
  • Shan Tian,
  • Rui Chen,
  • Dejing Chen and
  • Yafeng Dang

Antioxidant activities of five essential oils (cinnamon, thyme, clove, lavender and peppermint oils) and their major components (eugenol, thymol, linalool, and menthol) were evaluated on scavenging DPPH (2,2-diphenyl-1 picrylhydrazyl) free radicals,...

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Molecules - ISSN 1420-3049