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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Spine Surgery: Clinical Advances and Future Directions

edited by

Seung-kook Kim

and Eun-Sang Kim

submission deadline 30 May 2025 | 1 articles | Viewed by 1082 | Submission Open

Keywords: spine surgery; back pain; endoscopic spine surgery; cage implantation; neck pain

(This special issue belongs to the Section Clinical Neurology)

Latest Advances in Glaucoma, Cataract and Refractive Surgery: Expert Views, 2nd Edition

edited by

Jose Angel Fernandez-Vigo

and

Enrique Santos-Bueso

submission deadline 30 May 2025 | 1 articles | Viewed by 898 | Submission Open

Keywords: refractive surgery; glaucoma; cataract; intraocular lenses; diagnostic imaging

(This special issue belongs to the Section Ophthalmology)

Rheumatoid Arthritis: Challenges, Innovations and Outcomes

edited by

Marco Fornaro

submission deadline 30 May 2025 | Viewed by 328 | Submission Open

Keywords: rheumatoid arthritis; pathogenesis; treatments; outcomes; autoimmunity

(This special issue belongs to the Section Immunology)

Aortic Valve Implantation: Recent Advances and Future Prospects

edited by Suvitesh Luthra and Richard Jabbour

submission deadline 30 May 2025 | Viewed by 324 | Submission Open

Keywords: aortic valve replacement; aortic stenosis; paravalvular leak; coronary and structural interventional cardiology; percutaneous coronary artery interventions

(This special issue belongs to the Section Cardiology)

Multiple Sclerosis and Demyelinating Disorders: Past, Present, and Future—2nd Edition

edited by

Nikolaos Grigoriadis

Maria Eleptheria Evangelopoulos

and

Christos Bakirtzis

submission deadline 30 May 2025 | Viewed by 293 | Submission Open

Keywords: multiple sclerosis; disease-modifying therapies; neurodegeneration; neuromyelitis optica; disease monitoring; diagnostic criteria

(This special issue belongs to the Section Clinical Neurology)

Blood Cancer: Current Status and Future Challenges in Acute Myeloid Leukemia (AML)

edited by

Salvatore Perrone

and Massimo Breccia

submission deadline 30 May 2025 | Viewed by 273 | Submission Open

Keywords: acute myeloid leukemia; hematology; leukemia; venetoclax; blood disorders

(This special issue belongs to the Section Hematology)

New Frontiers and Technologies in Spine Surgery

edited by

Enrico Giordan

submission deadline 30 May 2025 | Viewed by 193 | Submission Open

Keywords: spine; technologies; future; surgery; innovations; mini-invasive surgery

(This special issue belongs to the Section Clinical Neurology)

Hospital-Acquired Infections in the Elderly

edited by Nadya Kagansky and Emily Lubart

submission deadline 30 May 2025 | Viewed by 180 | Submission Open

Keywords: hospital-acquired infections (HAIs); elderly patients; infection control; microbial resistance; epidemiology; risk factors; prevention strategies; treatment options; diagnostic accuracy

(This special issue belongs to the Section Epidemiology & Public Health)

Challenges in Fertility Preservation

edited by

Loris Marin

and Guido Ambrosini

submission deadline 30 May 2025 | Viewed by 180 | Submission Open

Keywords: fertility preservation; oocytes cryopreservation; embryo cryopreservation; ovarian tissue transplantation; gonadotoxic therapy

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Multiple Myeloma: Therapeutic and Management Strategies

edited by Terri Parker

submission deadline 30 May 2025 | Viewed by 149 | Submission Open

Keywords: multiple myeloma; frontline treatment; monoclonal antibodies; sequencing of treatment; immunotherapy; CAR T; Bi-specific T cell engagers; toxicity management

(This special issue belongs to the Section Hematology)

Clinical Advancements in Urologic Surgery

edited by Francesco Trama

submission deadline 30 May 2025 | Viewed by 133 | Submission Open

Keywords: urologic oncology; urinary incontinence; endourology; urodynamics; prostate cancer; neurourology; erectile dysfunction

(This special issue belongs to the Section Nephrology & Urology)

Recent Advances in Trauma and Orthopaedic Surgery

edited by Konstantinos Tsikopoulos and

Panagiotis Givissis

submission deadline 31 May 2025 | 8 articles | Viewed by 13067 | Submission Open

Keywords: trauma; orthopaedic surgery; clinical research; orthopaedics; infection orthopaedic

(This special issue belongs to the Section Orthopedics)

State of the Art—Treatment of Skull Base Diseases (Second Edition)

edited by

Marco Ferrari

submission deadline 31 May 2025 | 6 articles | Viewed by 12219 | Submission Open

Keywords: skull base; cranial base; tumor; cancer; lesion; surgery; adjuvant; neoadjuvant

(This special issue belongs to the Section Clinical Neurology)

Clinical Management of Type 1 Diabetes

edited by Carmen Quirós

submission deadline 31 May 2025 | 6 articles | Viewed by 11238 | Submission Open

Keywords: type 1 diabetes; continuous glucose monitoring; hybrid closed loop; hypoglycemia; physical activity; new onset type 1 diabetes; pre-stage 3 type 1 diabetes; smart insulin pens

(This special issue belongs to the Section Endocrinology & Metabolism)

Evidence-Based Medicine in the Practice of Orthopedics and Trauma Care: Current Status and Future Challenges

edited by Alexander Joeris and Gregory J. Della Rocca

submission deadline 31 May 2025 | 6 articles | Viewed by 10151 | Submission Open

Keywords: evidence-based medicine; patient-reported outcomes; guidelines; trauma care; fracture care; patient engagement; personalized medicine

(This special issue belongs to the Section Orthopedics)

Diagnosis, Treatment, Prevention and Rehabilitation in Osteoporosis

edited by

Gianluca Testa

submission deadline 31 May 2025 | 6 articles | Viewed by 10077 | Submission Open

Keywords: osteoporosis; bone mass density; bone densitometry; osteoporosis drug; diet; bisphosphonates; femoral neck fractures; vertebral fractures; fragility fractures

(This special issue belongs to the Section Orthopedics)

Progress in Diagnosis and Treatment of Primary Immunodeficiencies

edited by

Alexandros Grammatikos

submission deadline 31 May 2025 | 4 articles | Viewed by 9381 | Submission Open

Keywords: primary immunodeficiencies; autoimmune manifestations; PIDs

(This special issue belongs to the Section Immunology)

Advances in Clinical Cardiovascular Magnetic Resonance Imaging

edited by

Antonella Meloni

and

Vincenzo Positano

submission deadline 31 May 2025 | 4 articles | Viewed by 7154 | Submission Open

Keywords: myocardial tissue characterization; quantitative mapping; cardiac function; stress CMR; phase-contrast MRI; cardiac masses; cardiomyopathies; congenital heart diseases; cardiotoxicity; diffusion tensor imaging(DTI); multimodal imaging including CMR; applications of radiomics to CMR image analysis; artificial Intelligence applications to CMR image analysis and CMR data interpretation

(This special issue belongs to the Section Cardiovascular Medicine)

Glomerulonephritis: Current Diagnosis, Treatment and Future Options

edited by Ana I. Ávila and

Montserrat M. Díaz-Encarnación

submission deadline 31 May 2025 | 3 articles | Viewed by 7101 | Submission Open

Keywords: glomerulonephritis; diagnosis; management; drug therapies; treatment

(This special issue belongs to the Section Nephrology & Urology)

Updates in Digestive Diseases and Endoscopy

edited by Hossein Haghbin and Muhammad Aziz

submission deadline 31 May 2025 | 4 articles | Viewed by 6975 | Submission Open

Keywords: colonoscopy; EGD; ERCP; EUS; endoscopic submucosal dissection (ESD); endoscopic mucosal resection (EMR); artificial intelligence; screening colonoscopy; pancreatoscopy; cholangioscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Systemic Autoinflammatory Diseases—Clinical Rheumatic Challenges: 3rd Edition

edited by

Eugen Feist

submission deadline 31 May 2025 | 3 articles | Viewed by 5961 | Submission Open

Keywords: autoinflammation; inflammasome; inflammasomopathies; interferonopathies; relopathies; proteasome-associated syndromes; syndrome of undifferentiated recurrent fever; pro-inflammatory cytokines; biomarkers.

(This special issue belongs to the Section Immunology)

Clinical Echocardiography: Advances and Practice Updates

edited by

Andrea Sonaglioni

and

Gian Luigi Nicolosi

submission deadline 31 May 2025 | 4 articles | Viewed by 5478 | Submission Open

Keywords: echocardiography; M-mode echocardiography; 2D echocardiography; tissue Doppler imaging (TDI); speckle tracking echocardiography; 3D echocardiography; cardiovascular; cardiology; ischemic and non-ischemic cardiomyopathy; diastolic dysfunction; pulmonary hypertension; coronary artery disease; heart failure; vascular disease; structural heart disease; systemic disease; cardiac tumors; cardiac function; atrial fibrillation; myocardial infarction; cardiology imaging; diagnosis; treatment

(This special issue belongs to the Section Cardiology)

Post-COVID Symptoms and Causes, 3rd Edition

edited by

Domingo Palacios-Ceña

and

César Fernández-de-las-Peñas

submission deadline 31 May 2025 | 4 articles | Viewed by 4655 | Submission Open

Keywords: COVID-19; symptoms; long-COVID; pain; function; fatigue; dyspnea; public health

(This special issue belongs to the Section Infectious Diseases)

New Insights into Cardiovascular and Minimally Invasive Cardiac Surgery

edited by Parwis Massoudy and Hilmar C. Dörge

submission deadline 31 May 2025 | 3 articles | Viewed by 3763 | Submission Open

Keywords: coronary artery bypass grafting; aortic valve surgery; mitral valve surgery; aortic surgery; minimally invasive cardiac surgery

(This special issue belongs to the Section Cardiology)

Musculoskeletal Diagnosis and Treatment: Connecting Gaps to Enhance Patient Care

edited by

Gali Dar

submission deadline 31 May 2025 | 3 articles | Viewed by 3684 | Submission Open

Keywords: musculoskeletal; back pain; neck pain; knee; shoulder; diagnosis; physiotherapy

(This special issue belongs to the Section Orthopedics)

New Insights into Melanoma and Non-Melanoma Skin Cancers

edited by

Andrea Carugno

submission deadline 31 May 2025 | 3 articles | Viewed by 3609 | Submission Open

Keywords: melanoma; non-melanoma skin cancers (nmsc); basal cell carcinoma (bcc); squamous cell carcinoma (scc); actinic keratosis (ak); prevention and early detection; genetic; artificial intelligence; telemedicine; immunotherapy and targeted therapy

(This special issue belongs to the Section Dermatology)

Innovation in Shoulder Surgery: Navigating the Future with New Technologies

edited by Francesco Franceschi, Angelo Baldari and Antonio Caldaria

submission deadline 31 May 2025 | 4 articles | Viewed by 3220 | Submission Open

Keywords: shoulder biomechanics; arthroscopic shoulder surgery; shoulder arthroplasty; revision shoulder arthroplasty; aug-mented reality; machine learning; artificial intelligence

(This special issue belongs to the Section Orthopedics)

Preventive, Diagnostic and Therapeutic Strategies for Abdominal Surgery Complications (Second Edition)

edited by

Orestis Ioannidis

submission deadline 31 May 2025 | 3 articles | Viewed by 3178 | Submission Open

Keywords: complications; diagnosis; treatment; management; morbidity; abdomen; abdominal surgery; outcome; postoperative

(This special issue belongs to the Section General Surgery)

Neurovascular Diseases: Clinical Advances and Challenges

edited by

Roberto Colasanti

, Silky Chotai, Alessandro Di Rienzo and Joham Choque-Velasquez

submission deadline 31 May 2025 | 4 articles | Viewed by 3113 | Submission Open

Keywords: neurovascular diseases; ischemic stroke; hemorrhagic stroke; aneurysms; vascular malformations; diagnostic imaging; minimally invasive approaches; surgical techniques; endovascular interventions; treatment algorithms

(This special issue belongs to the Section Clinical Neurology)

The Association Between Sleep Disorders and Metabolic and Mental Health

edited by

Filip Franciszek Karuga

Piotr Bialasiewicz

and

Marcin Sochal

submission deadline 31 May 2025 | 3 articles | Viewed by 3112 | Submission Open

Keywords: sleep medicine; sleep apnea; hypoxia; metabolism; mental health; women’ s health

(This special issue belongs to the Section Mental Health)

Maxillo-Facial Surgery: New Insights and Technologies in Head and Neck

edited by Federica Ruggiero

submission deadline 31 May 2025 | 5 articles | Viewed by 3006 | Submission Open

Keywords: oral and maxilla-facial surgery; orthognathic surgery; cranio-facial surgery; head and neck surgery; augmented reality; navigation; finite element modeling; virtual surgical planning; patient-specific implants

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Recent Developments in Mitral Valve Repair

edited by Pasquale Totaro

submission deadline 31 May 2025 | 1 articles | Viewed by 2714 | Submission Open

Keywords: mitral valve repair; minimally invasive mitral valve surgery; robotic surgery; mitral regurgitation; transcatheter mitral valve replacement

(This special issue belongs to the Section Cardiology)

Hip Diseases: From Joint Preservation to Hip Arthroplasty Revision

edited by Christoph Böhler

submission deadline 31 May 2025 | 4 articles | Viewed by 2441 | Submission Open

Keywords: hip preservation surgery; pelvic osteotomies; hip arthroscopy; total hip replacement; THA revision ar-throplasty; pelvic discontinuity; pelvic fracture management; periprosthetic fractures; robotic surgery; peripros-thetic joint infection

(This special issue belongs to the Section Orthopedics)

Sports Injury Treatment: Innovations in Pain Management, Recovery, and Performance Optimization

edited by Antonio P. Veloso and Javad Sarvestan

submission deadline 31 May 2025 | 2 articles | Viewed by 2357 | Submission Open

Keywords: sports injury treatment; pain management; recovery optimization; performance enhancement; advanced rehabilitation; injury prevention; biomechanics; neuromechanics; novel pain relief modalities; performance recovery strategies; wearable technology

(This special issue belongs to the Section Sports Medicine)

Gynecological Cancers—Surgical Management, Prognosis, and Quality of Life: 2nd Edition

edited by

Valentina Elisabetta Bounous

submission deadline 31 May 2025 | 3 articles | Viewed by 2098 | Submission Open

Keywords: gynecological cancers; endometrial cancer; ovarian cancer; cervical cancer; vulvar cancer; vaginal cancer; breast cancer; surgery; radiotherapy; systemic treatment; quality of life

(This special issue belongs to the Section Obstetrics & Gynecology)

Advanced Techniques for the Treatment of Complex Coronary Artery Disease: 2nd Edition

edited by Simone Calcagno

submission deadline 31 May 2025 | 2 articles | Viewed by 2033 | Submission Open

Keywords: coronary calcified lesion; IVUS; OCT; intravascular lithotripsy; bifurcation coronary lesions; left main; chronic total occlusions; multivessel disease; STEMI; NSTEMI

(This special issue belongs to the Section Cardiovascular Medicine)

Recent Advances in Spine Tumor Diagnosis and Treatment

edited by Jae Hwan Cho

submission deadline 31 May 2025 | 2 articles | Viewed by 1939 | Submission Open

Keywords: spine tumor; spinal metastasis; pathologic fracture; cord compression; separation surgery; radiotherapy; interdisciplinary collaboration; surgeon’ s role; medical oncologist; radiologic oncologist; psychological aspects; pain management; innovative approaches; patient outcomes; diagnostic advancements

(This special issue belongs to the Section Clinical Neurology)

Understanding Syncope: Multidisciplinary Approaches to Diagnosis and Management

edited by

Isabel Rocha

and Laranjo Sergio

submission deadline 31 May 2025 | 2 articles | Viewed by 1878 | Submission Open

Keywords: syncope; diagnostic strategies; prognostication; treatment options; quality of life; wearable devices; artificial intelligence; autonomic dysfunction; orthostatic hypotension; POTS (postural orthostatic tachycardia syndrome)

(This special issue belongs to the Section Cardiovascular Medicine)

Cardiac Arrhythmias: Recent Advances in Underlying Mechanisms, Diagnostic Options and Therapeutic Approaches

edited by Elisabeth M.J.P. Mouws and

Natasja de Groot

submission deadline 31 May 2025 | 2 articles | Viewed by 1711 | Submission Open

Keywords: cardiac arrhythmia; atrial fibrillation; congenital heart disease; underlying mechanisms; therapeutic options

(This special issue belongs to the Section Cardiology)

Recent Developments and Emerging Trends of Echocardiography in Cardiac Disease

edited by Petri Gudmundsson

submission deadline 31 May 2025 | 1 articles | Viewed by 1506 | Submission Open

Keywords: echocardiography development; artificial intelligence (AI) integration; real-time 3D and 4D imaging; portable and handheld devices; contrast-enhanced imaging; tissue characterization; integration with other modalities; quantitative analysis; tele-echocardiography

(This special issue belongs to the Section Cardiology)

New Challenges in Maternal-Fetal Medicine

edited by Marzena Laskowska

submission deadline 31 May 2025 | 1 articles | Viewed by 1496 | Submission Open

Keywords: thrombocytopenia in pregnancy; multiple pregnancies; placental abruption; DIC; sepsis; chorioamnionitis; cholestasis; postpartum hemorrhage; emergency cervical cerclage; problems in pregnancy and labor; pregnancy complications; spina bifida; fetal well-being evaluation

(This special issue belongs to the Section Obstetrics & Gynecology)

Cystic Fibrosis: Novel Strategies of Diagnosis and Treatments

edited by

Michal Gur

and

Lea Bentur

submission deadline 31 May 2025 | 2 articles | Viewed by 1490 | Submission Open

Keywords: cystic fibrosis; CFTR modulators; stop mutations; gene therapy; mRNA therapy; novel therapies; rare pathogens

(This special issue belongs to the Section Respiratory Medicine)

Systemic Vasculitis: Advancement in Pathogenesis, Clinical Features, Management and Therapeutic Strategies

edited by

Giulia Cassone

submission deadline 31 May 2025 | 2 articles | Viewed by 1457 | Submission Open

Keywords: immune-mediated systemic vasculitis; etiology; epidemiology; therapy; diagnosis; classification; risk factors; genetics; management

(This special issue belongs to the Section Vascular Medicine)

Transcatheter Aortic Valve Replacement in the Clinical Management of Heart Valve Disease

edited by

Masahiko Asami

submission deadline 31 May 2025 | 1 articles | Viewed by 1436 | Submission Open

Keywords: transcatheter aortic valve implantation; transcatheter aortic valve replacement; preprocedural imaging assessments; valve-in-valve procedure; alternative approaches; cerebral embolic protection devices; challenging anatomy; artificial intelligence

(This special issue belongs to the Section Cardiology)

Cardiac Arrhythmias: Current Status and Future Directions

edited by

Jackson J. Liang

submission deadline 31 May 2025 | 1 articles | Viewed by 1358 | Submission Open

Keywords: ventricular tachycardia; atrial fibrillation; catheter ablation; novel therapies; complex arrhythmias

(This special issue belongs to the Section Cardiology)

Quality of Life in Patients with Hydrocephalus

edited by Susan Noell and

Leonidas Trakolis

submission deadline 31 May 2025 | 1 articles | Viewed by 1279 | Submission Open

Keywords: pediatric hydrocephalus; adult hydrocephalus; normal pressure hydrocephalus; long-term outcome; management; quality of life; chronic disability; cognitive disorder

(This special issue belongs to the Section Clinical Neurology)

Clinical Updates on Heart Failure and Cardiac Transplantation

edited by Jasper Iske, Fabio Ius and Felix Hennig

submission deadline 31 May 2025 | 1 articles | Viewed by 1108 | Submission Open

Keywords: heart transplantation; organ allocation; organ preservation; ex vivo heart perfusion; machine perfusion; NMP; preservation protocols; organ procurement; transplant protocol; heart transplant rejection

(This special issue belongs to the Section Cardiovascular Medicine)

Novel Insights into the Diagnosis and Management of Inflammatory Bowel Disease (IBD)

edited by

Alina Ioana Tantau

submission deadline 31 May 2025 | 1 articles | Viewed by 659 | Submission Open

Keywords: inflammatory bowel disease; non-invasive biomarkers; abdominal ultrasonography; colonoscopy; biologic therapy; small molecules; mucosal healing; brain-gut axis; dysbiosis; colorectal dysplasia

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Surgical Wound Infections and Management

edited by Sharon Henry and

Marcelo A. F. Ribeiro Jr.

submission deadline 31 May 2025 | 2 articles | Viewed by 486 | Submission Open

Keywords: surgical wound infections; epidemiology; incidence; risk factors; prophylactic antibiotics; antiseptic techniques; patient outcomes; complications; postoperative care; vulnerable populations; burn wound infection; antimicrobials; bioengineered materials for wounds and infections

(This special issue belongs to the Section Clinical Rehabilitation)

Current Status and Future Directions in Cardiac Surgery

edited by Marie-Elisabeth Stelzmüller and Randolph H.L. Wong

submission deadline 31 May 2025 | Viewed by 399 | Submission Open

Keywords: innovations; AI; minimally invasive; endoscopic; novel technologies in electrophysiology; hybrid procedures; inno-vative approaches in cardiac surgery and patient care

(This special issue belongs to the Section Cardiology)

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