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Innovations in Psychosis and Schizophrenia: New Findings and Implications

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Mental Health".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 825

Special Issue Editor


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Guest Editor
Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy
Interests: psychological assessment; mental illness; clinical psychiatry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Schizophrenia spectrum disorders (SSDs) are severe mental disorders that cause positive and negative symptoms and often lead to impaired cognitive performance, poor real-world functional outcomes, reduced quality of life, high levels of internalized stigma, low levels of life engagement, and increased mortality. They also represent a leading cause of disability worldwide and account for a substantial proportion of the use and costs of mental health services.

Considering the impact of SSDs, providing novel and further insight into their psychopathology, neurobiology, assessment, and treatment could provide valuable knowledge not only from a scientific perspective but also in clinical settings.

The present Special Issue focuses on novel findings regarding SSDs and psychosis and will publish research on psychopathology; new outcome measures and patient-reported outcomes; molecular neurobiology and neuroimaging; pharmacological treatments and psychosocial interventions; and novel conceptual insights.

Original research, systematic reviews, meta-analyses, and narrative reviews are all of interest.

Dr. Gabriele Nibbio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • schizophrenia
  • psychosis
  • psychopathology
  • neurobiology
  • assessment
  • pharmacological treatment
  • psychosocial interventions

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Published Papers (1 paper)

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Research

16 pages, 302 KB  
Article
Prognostic Value of FasL, BDNF, and IL-1β as Predictors of Therapeutic Response in Schizophrenia
by Zofia Szymona-Kuciewicz, Maja Owe-Larsson, Marta Flis, Hanna Karakula-Juchnowicz, Barbara Zdzisinska, Ewa Dudzinska, Ewa M. Urbanska and Kinga Szymona
J. Clin. Med. 2025, 14(18), 6417; https://doi.org/10.3390/jcm14186417 - 11 Sep 2025
Viewed by 586
Abstract
Background/Objectives: Pro-inflammatory, neurotrophic, and proapoptotic factors affect the course of schizophrenia; however, their impact on the clinical response during relapse is not well recognized. A member of TNF family, Fas ligand (FasL), participates in apoptosis, but its connection with treatment-resistant schizophrenia is [...] Read more.
Background/Objectives: Pro-inflammatory, neurotrophic, and proapoptotic factors affect the course of schizophrenia; however, their impact on the clinical response during relapse is not well recognized. A member of TNF family, Fas ligand (FasL), participates in apoptosis, but its connection with treatment-resistant schizophrenia is unknown. Methods: For this preliminary exploratory study, 53 patients with schizophrenia relapse and 45 healthy subjects were enrolled. Pro-inflammatory interleukin IL-1β, brain-derived neurotrophic factor (BDNF), FasL levels, and clinical evaluations (PANSS, SANS, SAPS) were studied at admission, after a 4-week therapy, and at remission. Results: In the clozapine-treated therapy-resistant group, IL-1β correlated negatively with clinical improvement (admission, 4-week treatment). In patients not treated with clozapine, IL-1β correlated negatively with disease duration (admission). A negative correlation occurred between FasL and clinical improvement in general symptoms (admission, 4-week treatment), FasL and leukocyte count (admission), and IL-1β and BDNF levels (4-week treatment). In the clozapine-treated group, the negative correlation between FasL levels and the leukocyte count was absent. Conclusions: The severity of psychopathology in patients with schizophrenia seems to correlate with higher IL-1β and lower BDNF. The novelty of our findings is the observation that higher FasL is negatively associated with the degree of clinical improvement. Thus, a decline of FasL during treatment may be proposed as a predictor of clinical recovery. With caution, we suggest that clozapine use may be linked to a protective effect against FasL signaling and the alleviation of apoptotic processes. Full article
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