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Ultrasound-Guided Biopsy of Gynecologic Tumors: Technique and Clinical Application

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 30 December 2025 | Viewed by 84

Special Issue Editors


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Guest Editor
Department of Obstetrics and Gynecology, University Hospital of Larissa, 41110 Larissa, Greece
Interests: gynecological oncology; gynecological surgery; biomarkers in obstetrics and gynecology

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Guest Editor
Department of Obstetrics and Gynaecology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece
Interests: cervical cancer; gynecological oncology; gynecological surgery
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Special Issue Information

Dear Colleagues,

The ultrasound-guided biopsy of gynecological tumors represents an accurate and safe diagnostic technique that is widely used in the pathological evaluation of ovarian, uterine, and pelvic masses and can accurately improve diagnostic rates. Ultrasound-guided needle biopsy refers to the ultrasound-guided insertion of a needle into a lesion and then the removal of some of the lesion tissue, followed by pathological and laboratory analyses to determine the nature of the relevant lesion tissue and how to treat it. This technique is mainly employed to determine the nature of unclear disease, such as whether a tumor is benign or malignant and whether there is inflammation. Its application range is very wide, and it has strong clinical practical value. For this Special Issue, we welcome the submission of papers related to ultrasound-guided biopsy in gynecological tumors.

Dr. Athina A. Samara
Prof. Dr. Alexandros Daponte
Guest Editors

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Keywords

  • ultrasound-guided biopsy
  • gynecologic tumors
  • ovarian cancer
  • biopsy technique
  • precision diagnosis
  • endometrial lesions

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Published Papers (1 paper)

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Review

16 pages, 1755 KiB  
Review
Decoding the Link Between Talcum Powder and Ovarian Cancer: A Comprehensive Review
by Sophia Tsokkou, Alkis Matsas, Ioannis Konstantinidis, Eleni Stamoula, Sofoklis Stavros, Evaggelia Karopoulou, Anastasios Potiris and Theodore Troupis
J. Clin. Med. 2025, 14(16), 5746; https://doi.org/10.3390/jcm14165746 - 14 Aug 2025
Abstract
Ovarian cancer (OC) is a highly lethal gynecologic malignancy, frequently diagnosed at advanced stages due to its silent onset and nonspecific clinical presentation. The use of talc-containing powders in the genital area has long been suspected to contribute to the development of OC [...] Read more.
Ovarian cancer (OC) is a highly lethal gynecologic malignancy, frequently diagnosed at advanced stages due to its silent onset and nonspecific clinical presentation. The use of talc-containing powders in the genital area has long been suspected to contribute to the development of OC through inflammatory and irritative pathways; however, the association remains controversial. This scoping review aims to decode the link between talc powder exposure and ovarian cancer by synthesizing findings from epidemiologic studies, public awareness surveys, and laboratory investigations. Epidemiologic analyses reveal that the use of genital powders is associated with a, modestly, 30–32% increase in the risk of OC, with similar risk patterns observed across racial subgroups. In contrast, studies on uterine cancer yield largely null associations after adjusting for confounders. Awareness surveys consistently report that only about 23% of respondents recognize talc use as a risk factor. Laboratory studies demonstrate that the dominant class of talc particles in commercially available powders—characterized by an aspect ratio of 1–3.9 and an area of 1–400 μm2—is nearly identical to those retrieved from pelvic tissues in OC patients, supporting the hypothesis of migration via retrograde and lymphatic pathways. The collective evidence supports the biological plausibility that talc from genital powders can migrate to pelvic tissues and potentially foster oncogenic inflammation. Further methodologically rigorous prospective and mechanistic studies are warranted to clarify the causal relationship and inform targeted public health and regulatory interventions. Full article
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