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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Anterior Cruciate Ligament (ACL): Innovations in Clinical Management
edited by Xaver Feichtinger, and Georg Brandl
submission deadline 25 May 2025 | 3 articles | Viewed by 3286 | Submission Open
Keywords: ACL; graft choice; ACL repair; ALL; tibial slope
(This special issue belongs to the Section Orthopedics)
New Insights into Augmentative Therapy for Parkinson’s Disease
edited by Adam Thrasher
submission deadline 25 May 2025 | 2 articles | Viewed by 2528 | Submission Open
Keywords: Parkinson’ s Disease; postural instability; locomotion; physical therapy; neuromodulation; augmentative therapies
(This special issue belongs to the Section Clinical Neurology)
A Multi-Faceted Approach to Urinary Incontinence and Other Pelvic Floor Dysfunction—from Prevention to Therapy submission deadline 25 May 2025 | 2 articles | Viewed by 2398 | Submission Open
Keywords: urinary incontinence; pelvic floor dysfunction; urinary and fecal incontinence; pelvic organs prolapse; pelvic pain; pelvic floor disorders
(This special issue belongs to the Section Nephrology & Urology)
Thoracic Surgery: Recent Developments and Future Challenges
edited by and Lucio Cagini
submission deadline 25 May 2025 | 1 articles | Viewed by 2172 | Submission Open
Keywords: VATS; RATS; ERAS; sublobar resection; minimally invasive thoracic surgery; target therapy; nodule localization
(This special issue belongs to the Section Respiratory Medicine)
New Clinical Advances in Chronic Asthma
edited by Vitaliano Nicola Quaranta
submission deadline 25 May 2025 | 2 articles | Viewed by 2058 | Submission Open
Keywords: chronic asthma; breathlessness; coughing; inhaled corticosteroids (ICS); long-acting beta-agonists (LABAs); personalized treatment; chronic rhinosinusitis; nasal polyps; bronchiectasis; endotypes; oral corticosteroids
(This special issue belongs to the Section Respiratory Medicine)
New Challenges of Cardiovascular Diseases: From Clinical to Preclinical Research
edited by and Jorge Rodriguez Capitan
submission deadline 25 May 2025 | 2 articles | Viewed by 2057 | Submission Open
Keywords: cardiovascular diseases; cardiovascular prevention; risk factors; population aging; public health; medical innovation; personalized treatments; precision medicine
(This special issue belongs to the Section Cardiovascular Medicine)
Chronic Lung Conditions: Integrative Approaches to Long-Term Care submission deadline 25 May 2025 | 2 articles | Viewed by 1924 | Submission Open
Keywords: chronic lung conditions: chronic non-infectious lung disease and post-respiratory infectious syndromes; including TB sequelae; TB MDR; post-COVID-19; and bronchiectasis; long-term care; integrative approach; multidisciplinary; multimorbidity; outcomes
(This special issue belongs to the Section Respiratory Medicine)
Endometriosis: Clinical Challenges and Prognosis submission deadline 25 May 2025 | 1 articles | Viewed by 1704 | Submission Open
Keywords: endometriosis; therapy; rehabilitation; psychology; diagnostics; ultrasound imaging; metabolomics; prognosis
(This special issue belongs to the Section Obstetrics & Gynecology)
Assessing Strategies and Challenges in Heart Failure: An Update
edited by
submission deadline 25 May 2025 | 1 articles | Viewed by 1492 | Submission Open
Keywords: cardiac MR; coronary microvascular dysfunction; diagnosis; endothelial function; heart failure; myocardial metabolism; prognosis
(This special issue belongs to the Section Cardiology)
Recent Advances in Intracranial Aneurysm Treatment
edited by Victor Volovici
submission deadline 25 May 2025 | 1 articles | Viewed by 1185 | Submission Open
Keywords: intracranial aneurysm; cerebrovascular disease; microneurosurgery; endovascular treatment; subarachnoid hemorrhage
(This special issue belongs to the Section Clinical Neurology)
Vascular Surgery: Current Advances and Future Directions
edited by Giovanni Coppi
submission deadline 25 May 2025 | 2 articles | Viewed by 998 | Submission Open
Keywords: stroke; carotid artery stenosis; carotid artery stenting; carotid endarterectomy; occlusion
(This special issue belongs to the Section General Surgery)
Trends in Minimally Invasive Urological Surgery: Robot and Beyond
edited by Riccardo Giuseppe Bertolo and Alessandro Antonelli
submission deadline 25 May 2025 | 1 articles | Viewed by 881 | Submission Open
Keywords: minimally invasive surgery; robotic surgery; urology; innovation; surgical technology; patient outcomes; surgical robotics; laparoscopic surgery; artificial intelligence; augmented reality
(This special issue belongs to the Section Nephrology & Urology)
Arthritis: From Diagnosis to Treatment
edited by Andrea Di Matteo and
submission deadline 25 May 2025 | Viewed by 287 | Submission Open
Keywords: rheumatoid arthritis; psoriatic arthritis; imaging; ultrasound; DMARDs; differential diagnosis; difficult to treat rheumatoid arthritis; prevention
(This special issue belongs to the Section Immunology)
Challenges and Future Trends in Bariatric Surgery
edited by Maurizio L. de Luca and Amanda Belluzzi
submission deadline 25 May 2025 | Viewed by 276 | Submission Open
Keywords: metabolic and bariatric surgery; SADI-S; LSG; RYGB; SASI; OAGB; complications after MBS; long-term outcomes; malnutrition
(This special issue belongs to the Section General Surgery)
Innovations in Clinical Artificial Intelligence: Image Analysis, Prediction, and Treatment Optimization
edited by Shahriar Faghani
submission deadline 25 May 2025 | Viewed by 232 | Submission Open
Keywords: artificial intelligence; clinical practice; prediction; diagnosis; treatment
Clinical Updates on Prosthodontics
edited by and Carla Fons-Badal
submission deadline 25 May 2025 | Viewed by 227 | Submission Open
Keywords: dental prosthesis; dental implants; gingival treatment; gingival aesthetics; gingival treatment; dental aesthetics; dental ceramics; BOPT; surgical periodontal treatment
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Modern Blood Banking and Transfusion in Clinical Practice: Second Edition
edited by
submission deadline 25 May 2025 | Viewed by 226 | Submission Open
Keywords: blood transfusion therapy; patient blood management; restrictive transfusion; cell therapy; platelet transfusion
(This special issue belongs to the Section Hematology)
Clinical Application of Left Ventricular Assist Devices
edited by Themistokles Chamogeorgakis
submission deadline 25 May 2025 | Viewed by 195 | Submission Open
Keywords: ventricular assist device; LVAD; RVAD; heart failure; right ventricular failure; continuous flow pump; volume displacement pump; centrifugal pump; magnetically levitated pump; survival
(This special issue belongs to the Section Cardiology)
Clinical Advances in Obesity and Bariatric Surgery
edited by Valentin Mocanu and Jerry Dang
submission deadline 27 May 2025 | 9 articles | Viewed by 15225 | Submission Open
Keywords: obesity; bariatric surgery; metabolic surgery; anti-obesity medications; obesity treatment
(This special issue belongs to the Section Endocrinology & Metabolism)
Oral Hygiene: Updates and Clinical Progress
edited by
submission deadline 28 May 2025 | 6 articles | Viewed by 4675 | Submission Open
Keywords: periodontal disease; dental caries; plaque control; oral hygiene practices; gingivitis; dental prophylaxis; oral health education
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
New Trends in Mechanical Ventilation
edited by
submission deadline 28 May 2025 | 1 articles | Viewed by 3131 | Submission Open
Keywords: positive pressure ventilation; negative pressure ventilation; constant flow ventilation; PEEP; lung recruitment; obesity; laparoscopy; ARDS; atelectasis; total lung compliance
(This special issue belongs to the Section Anesthesiology)
Neuro-Oncology: Diagnosis and Treatment
edited by Shunsuke Shibao
submission deadline 28 May 2025 | 2 articles | Viewed by 2063 | Submission Open
Keywords: neuro-oncology; genetic diagnostics; biomarker-based diagnostics; AI-based image diagnosis; preoperative simulation; augmented reality (AR); virtual reality (VR); endoscopic surgery; minimally invasive surgery; skull base surgery
(This special issue belongs to the Section Clinical Neurology)
Advances in the Diagnosis and Management of Age-Related Macular Degeneration: 2nd Edition
edited by Tsutomu Yasukawa
submission deadline 28 May 2025 | 4 articles | Viewed by 1954 | Submission Open
Keywords: age-related macular degeneration; angiography; antivascular endothelial growth factor therapy; choroidal neovascularization; geographic atrophy; multimodal imaging; ophthalmology; optical coherence tomography; photodynamic therapy; retinal pigment epithelium
(This special issue belongs to the Section Ophthalmology)
Recent Developments and Emerging Trends in Aortic Surgery
edited by Daniele Linardi
submission deadline 28 May 2025 | 1 articles | Viewed by 1695 | Submission Open
Keywords: aortic aneurysm; aortic dissection; endovascular repair; minimally invasive approaches; thoracic aorta; abdominal aorta; aortic valve-sparing surgery; aortic stent grafts
(This special issue belongs to the Section Vascular Medicine)
New Advances in Myasthenia Gravis
edited by Shingo Konno
submission deadline 29 May 2025 | 2 articles | Viewed by 775 | Submission Open
Keywords: myasthenia gravis; clinical trials; translational research; drug repurposing; biological markers; experimental autoimmune myasthenia gravis
(This special issue belongs to the Section Clinical Neurology)
New Advances in the Management of Voice Disorders submission deadline 30 May 2025 | 12 articles | Viewed by 22590 | Submission Open
Keywords: voice disorder; voice treatment/therapy; voice assessment/measures; laryngology; phonosurgery; voice/dysphonia; larynx
(This special issue belongs to the Section Otolaryngology)
Dry Eye Disease: Risk Factors, Diagnosis, Treatment and Prevention Measures
edited by and Jennifer P. Craig
submission deadline 30 May 2025 | 13 articles | Viewed by 21050 | Submission Open
Keywords: dry eye disease; meibomian gland dysfunction; epidemiology; diagnosis; management; risk factors
(This special issue belongs to the Section Ophthalmology)
Management of Heart Failure
edited by , and Dragos Cozma
submission deadline 30 May 2025 | 3 articles | Viewed by 19064 | Submission Open
Keywords: heart failure; revascularization; device implantation; resynchronization therapy; implantable cardiac defibrillator; contractility modulation; mitra-clip; telemedicine
(This special issue belongs to the Section Cardiology)
Kidney Transplantation: Current Challenges and Future Perspectives
edited by Alberto Piana and Angelo Territo
submission deadline 30 May 2025 | 11 articles | Viewed by 16416 | Submission Open
Keywords: kidney transplantation; urologic cancers; organ preservation; surgical challenges; donor selection; long-term out-comes; complications; post-transplant care; technology
(This special issue belongs to the Section Nephrology & Urology)
Recent Advances in Endocrine Surgery
edited by
submission deadline 30 May 2025 | 5 articles | Viewed by 8413 | Submission Open
Keywords: endocrine surgery; thyroid; thyroid cancer; parathyroid; parathyroidectomy; adrenal glands; disorders of hepatobiliary and gastrointestinal tract
(This special issue belongs to the Section General Surgery)
Pruritus and Psyche: An Update on Clinical Management
edited by Simon M. Mueller and Antonios Kolios
submission deadline 30 May 2025 | 6 articles | Viewed by 7680 | Submission Open
Keywords: pruritus; itching; psyche; psychodermatology; psychopharmacology; modern treatment; burden of disease; depression; anxiety; stress; delusional infestation; skin– brain axis
(This special issue belongs to the Section Dermatology)
Trends in Plastic and Reconstructive Surgery
edited by Eduardo D. Rodriguez, Carter J. Boyd and Oriana D. Cohen
submission deadline 30 May 2025 | 2 articles | Viewed by 5316 | Submission Open
Keywords: plastic surgery; innovation; breast surgery; microsurgery; craniofacial surgery; hand surgery; body contouring
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Urological Oncology: New Insights into Diagnosis and Treatment
edited by Aldo Brassetti
submission deadline 30 May 2025 | 3 articles | Viewed by 5314 | Submission Open
Keywords: minimally invasive surgical procedures; robotic surgical procedures; laparoscopy; augmented reality; prostatectomy; nephrectomy; cystectomy; diagnosis; immunotherapy; chemotherapy
(This special issue belongs to the Section Nephrology & Urology)
Clinical Management of Palliative Medicine submission deadline 30 May 2025 | 4 articles | Viewed by 5133 | Submission Open
Keywords: advance care planning; death; ethics; hospice care; pain management; palliative care; psychosocial functioning
(This special issue belongs to the Section Oncology)
Gastrointestinal Endoscopy: Recent Developments and Emerging Trends
edited by and Nico Pagano
submission deadline 30 May 2025 | 3 articles | Viewed by 4425 | Submission Open
Keywords: interventional ultrasonography; endoscopy; gastrointestinal endoscopy; NET; pancreatic cancer; EUS; endo-hepatology; ERCP
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advancements in Cornea Transplantation
edited by Giulia Coco and Davide Romano
submission deadline 30 May 2025 | 5 articles | Viewed by 4183 | Submission Open
Keywords: corneal transplant; keratoplasty; DMEK; DSAEK; PK; cornea
(This special issue belongs to the Section Ophthalmology)
Perinatal Mental Health Management submission deadline 30 May 2025 | 3 articles | Viewed by 3753 | Submission Open
Keywords: perinatal mental health; child mental health; problem behavior; cognitive development therapy; hyperactivity
(This special issue belongs to the Section Mental Health)
Pelvic Organ Prolapse: Current Progress and Clinical Challenges
edited by and Cosimo De Nunzio
submission deadline 30 May 2025 | 3 articles | Viewed by 3749 | Submission Open
Keywords: pelvic organ prolapse (POP); postmenopausal; urinary dysfunction; minimally invasive surgery; laparoscopic surgery; robotic surgery; surgical mesh
(This special issue belongs to the Section Obstetrics & Gynecology)
Aortic Pathologies: Aneurysm, Atherosclerosis and More
edited by Alexander Gombert and Panagiotis Doukas
submission deadline 30 May 2025 | 4 articles | Viewed by 3449 | Submission Open
Keywords: aorta; aortic aneurysm; thoracoabdominal aortic aneurysm; fenestrated endovascular aortic repair (FEVAR); branched endovascular aortic repair (BEVAR); spinal cord ischemia; coral reef aorta; surgery; endovascular aortic surgery
(This special issue belongs to the Section Cardiovascular Medicine)
Personalized Risk Stratification with Diagnostic and Prognostic Relevance for Coronary Artery Disease: New Challenges and Opportunities in a New Era submission deadline 30 May 2025 | 3 articles | Viewed by 3327 | Submission Open
Keywords: coronary artery disease; cardiovascular prevention; risk stratification; cardiovascular pathology
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Advances in Spine Disorders submission deadline 30 May 2025 | 3 articles | Viewed by 2909 | Submission Open
Keywords: spine disorders; lumbar spine surgery; minimally invasive surgery; spine surgery; microneurosurgery
(This special issue belongs to the Section Clinical Neurology)
Coronary Heart Disease: Causes, Diagnosis and Management
edited by
submission deadline 30 May 2025 | 2 articles | Viewed by 2347 | Submission Open
Keywords: coronary heart disease; coronary revascularization; coronary artery disease; ischemic heart disease; atherosclerosis
(This special issue belongs to the Section Cardiology)
Current Perspectives on the Management of Atrial Fibrillation
edited by Narut Prasitlumkum and Nithi Tokavanich
submission deadline 30 May 2025 | 1 articles | Viewed by 2027 | Submission Open
Keywords: atrial fibrillation; management; AF ablation; anticoagulation; left atrial appendage ligation/occlusion; same-day discharge
(This special issue belongs to the Section Cardiology)
Challenges in Diagnosis and Treatment of Gynecological Malignancies in Young Adults
edited by , Dimitrios Haidopoulos and
submission deadline 30 May 2025 | 1 articles | Viewed by 1885 | Submission Open
Keywords: gynecological cancers; young adults; young women; fertility; personalized care
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Utility of Optical Coherence Tomography in Ophthalmology: 2nd Edition submission deadline 30 May 2025 | 1 articles | Viewed by 1567 | Submission Open
Keywords: optical coherence tomography; ophthalmology; intraoperative OCT; en face OCT; wide-field OCT; retinal diseases; glaucoma; cornea; strabismus; cataract
(This special issue belongs to the Section Ophthalmology)
Current State of Breast Reconstruction
edited by
submission deadline 30 May 2025 | 1 articles | Viewed by 1403 | Submission Open
Keywords: breast reconstruction; silicone implant; autologous tissue; acellular dermal matrix; seroma; outcome; complication; patient satisfaction
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Mitral and Tricuspid Valve Disease and Imaging Techniques—2nd Edition
edited by and Annalisa Pasquini
submission deadline 30 May 2025 | 2 articles | Viewed by 1315 | Submission Open
Keywords: imaging in valvular heart disease; mitral valve disease; tricuspid valve disease; computed tomography; echocardiography; transesophageal echocardiography; cardiac magnetic resonance imaging; cardiac surgery; structural interventional cardiology; multi-modality imaging
(This special issue belongs to the Section Cardiovascular Medicine)
Breast Reconstruction: The Current Environment and Future Directions
edited by Chris A. Campbell
submission deadline 30 May 2025 | 2 articles | Viewed by 1230 | Submission Open
Keywords: breast reconstruction; plastic surgery; microsurgery; trunk and extremity reconstruction; cancer resection; head and neck reconstruction
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Personalized Therapy and Clinical Advances for Congenital Heart Disease submission deadline 30 May 2025 | 1 articles | Viewed by 1194 | Submission Open
Keywords: congenital heart disease; genetics; inheritance; biochemical; behavioral; lifestyle; artificial intelligence
(This special issue belongs to the Section Cardiology)
Neural Application of Artificial Intelligence in Clinical Neuroscience
edited by Saurabh J. Singhal
submission deadline 30 May 2025 | 1 articles | Viewed by 1124 | Submission Open
Keywords: artificial intelligence (AI); clinical neuroscience; neuroimaging; brain– computer interfaces (BCIs); neuroprosthetics; EEG/EMG analysis; robotic surgery; deep brain stimulation (DBS); drug discovery; telemedicine; neurorehabilitation; stroke detection; Alzheimer’ s disease; brain tumors; seizure prediction
(This special issue belongs to the Section Clinical Neurology)
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