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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Skin Cancer: From Diagnosis to Personalized Treatment

edited by

Anthony J. Dixon

submission deadline 31 Jan 2026 | Viewed by 138 | Submission Open

Keywords: immunotherapy; neoadjuvant; melanoma; cutaneous sarcoma; merkel cel tumor; risk assessment; combination therapy; surgery

(This special issue belongs to the Section Dermatology)

Exercise, Injury and Rehabilitation: Integrated Perspectives in Sports Medicine

edited by

Cíntia França

and

Élvio Gouveia

submission deadline 3 Feb 2026 | 2 articles | Viewed by 7415 | Submission Open

Keywords: sports medicine; biomechanics; injury prevention; exercise physiology; sports performance; load management; exercise prescription; return to play; recovery

(This special issue belongs to the Section Sports Medicine)

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) as a Global but Not Liver-Limited Health Challenge—from Disease Pathogenesis to Therapeutic Targets

edited by

Beata Kasztelan-Szczerbinska

and Halina Cichoż-Lach

submission deadline 5 Feb 2026 | 4 articles | Viewed by 11048 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); non-alcoholic fatty liver disease (NAFLD); hepatic steatosis; multiorgan metabolic interactions; liver-related morbidity; liver-related mortality; lipid metabolism; cardiovascular metabolic complications; metabolic dysfunction-related cancer

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Advances and Clinical Outcomes of Cardiothoracic Surgery

edited by Hee-Jung Kim and

Seung-Hyun Lee

submission deadline 5 Feb 2026 | Viewed by 254 | Submission Open

Keywords: cardiac surgery; coronary artery bypass grafting; heart valve surgery; aortic intervention; materials; precision medicine; artificial intelligence

(This special issue belongs to the Section General Surgery)

Physical Therapy in Neurorehabilitation: Innovations, Challenges and Opportunities

edited by

Daphne Bakalidou

Maria Gabriella Ceravolo

and

Pinelopi Vlotinou

submission deadline 6 Feb 2026 | Viewed by 184 | Submission Open

Keywords: neurorehabilitation; physical activity; neurocognitive rehabilitation; neurogenic bladder; fatigue; sexual dysfunction; accessibility

(This special issue belongs to the Section Clinical Neurology)

Current Trends and Future Directions in Prosthetic and Implant Dentistry in the Digital Era, 3rd Edition

edited by

Adolfo Di Fiore

and

Giulia Brunello

submission deadline 10 Feb 2026 | 6 articles | Viewed by 18854 | Submission Open

Keywords: 3D printing; additive manufacturing; milling technologies; CAD/CAM; digital implant planning; digital workflow; facial scanners; computer-guided implant surgery; intraoral scanners; digital design and fabrication of dental prostheses

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Updates and Perspectives of Implant Dentistry

edited by

Renzo Guarnieri

and

Rodolfo Reda

submission deadline 10 Feb 2026 | 4 articles | Viewed by 14489 | Submission Open

Keywords: osseointegration; soft tissue integration; peri-implant diseases

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Infectious Disease Epidemiology: Current Updates and Perspectives

edited by

Agata Skrzat-Klapaczynska

and

Justyna Dominika Kowalska

submission deadline 10 Feb 2026 | 3 articles | Viewed by 7858 | Submission Open

Keywords: infection prevention and control; infectious diseases epidemiology; public health; novel treatments

(This special issue belongs to the Section Infectious Diseases)

The Journey of Hearing and Hearing-Related Disorders over Time—2nd Edition

edited by

Winfried Schlee

and

Jorge Piano Simões

submission deadline 10 Feb 2026 | 4 articles | Viewed by 6871 | Submission Open

Keywords: hearing; hearing journey; hearing-related disorders; tinnitus; hyperacusis; digital phenotyping; big data

(This special issue belongs to the Section Otolaryngology)

Plastic and Reconstructive Surgery: Cutting-Edge Expert Perspective

edited by

Roberto Cuomo

and

Ishith Seth

submission deadline 10 Feb 2026 | 1 articles | Viewed by 2903 | Submission Open

Keywords: plastic and reconstructive surgery; new perspectives; regeneration; microsurgery; oncoplastic; post bariatric; breast implant

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Current Challenges and Advancements in Lateral Skull Base Surgery

edited by Alessia Rubini

submission deadline 10 Feb 2026 | 2 articles | Viewed by 2734 | Submission Open

Keywords: lateral skull base; neurotology; jugular foramen; cerebellopontine angle; petrous apex; inner ear; acoustic neuroma; jugular paraganglioma; transtemporal approaches; infratemporal approaches

(This special issue belongs to the Section Otolaryngology)

Application of Anticoagulation and Antiplatelet Therapy

edited by

Rossella Marcucci

and

Martina Berteotti

submission deadline 10 Feb 2026 | 2 articles | Viewed by 1961 | Submission Open

Keywords: antiplatelets; anticoagulants; atherothrombosis; coronary artery disease; peripheral artery disease; cerebral artery disease; vitamin K antagonists; direct oral anticoagulants; clopidogrel; aspirin; ticagrelor; prasugrel

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Advances in Pediatric Critical Care Medicine

edited by

Lama Elbahlawan

submission deadline 10 Feb 2026 | 2 articles | Viewed by 1854 | Submission Open

Keywords: acute renal failure; acute respiratory failure; pediatric oncology; pediatric ICU; pediatric critical care medicine; multi-organ dysfunction

(This special issue belongs to the Section Clinical Pediatrics)

Advancements and Future Directions in Clinical Psychosis

edited by

Marco Colizzi

and

Alessandra Martinelli

submission deadline 10 Feb 2026 | 2 articles | Viewed by 1614 | Submission Open

Keywords: clinical psychosis; schizophrenia spectrum disorders; early detection of psychosis; treatment-resistant psychosis; long-term outcomes; personalized psychiatry; digital mental health; AI in psychiatry; neurocognitive interventions; psychosocial therapies; translational psychiatry; interdisciplinary mental health; psychosis clinical trials; innova-tive diagnostic tools

(This special issue belongs to the Section Mental Health)

Management of Congenital Heart Disease (CHD)

edited by Sarah Nordmeyer and Marie Schafstedde

submission deadline 10 Feb 2026 | 2 articles | Viewed by 1469 | Submission Open

Keywords: congenital heart disease; imaging; diagnostics; surgical innovations; minimally invasive interventions

(This special issue belongs to the Section Cardiovascular Medicine)

Hearing Disorders: Diagnosis, Management, and Future Opportunities: 4th Edition

edited by

George K. Psillas

submission deadline 10 Feb 2026 | 2 articles | Viewed by 863 | Submission Open

Keywords: middle ear surgery; otosclerosis; sensorineural hearing loss; sudden hearing; cochlear implant

(This special issue belongs to the Section Otolaryngology)

Clinical Advances in Spine Disorders—2nd Edition

edited by

Sokol Trungu

and

Luca Ricciardi

submission deadline 10 Feb 2026 | 1 articles | Viewed by 521 | Submission Open

Keywords: spine disorders; lumbar spine surgery; minimally invasive surgery; spine surgery; microneurosurgery

(This special issue belongs to the Section Clinical Neurology)

Minimally Invasive Approaches to Urolithiasis and Upper Urinary Tract Transitional Cell Carcinoma: Current Evidence

edited by

Massimiliano Creta

submission deadline 10 Feb 2026 | Viewed by 304 | Submission Open

Keywords: extracorporeal shock wave lithotripsy; lasers; percutaneous lithotripsy; robotic surgery; ureteroscopy; urolithiasis

(This special issue belongs to the Section Nephrology & Urology)

Recent Concepts in Ovarian Cancer: Epidemiology, Diagnosis, Treatment and Quality of Life

edited by Giulia Scotto and

Giorgio Valabrega

submission deadline 10 Feb 2026 | Viewed by 163 | Submission Open

Keywords: ovarian cancer; quality of life; multidisciplinary care; personalized medicine; PARP inhibitors

(This special issue belongs to the Section Oncology)

Clinical Advances in Pain Management

edited by Jamal Hasoon and Omar Viswanath

submission deadline 13 Feb 2026 | 11 articles | Viewed by 22845 | Submission Open

Keywords: postoperative pain; acute pain; chronic pain; nociceptive; analgesia; analgesics; interventional pain procedures

(This special issue belongs to the Section Anesthesiology)

Systemic Lupus Erythematosus: Current Trends and Therapeutic Innovations

edited by Giuseppe Barilaro

submission deadline 15 Feb 2026 | 4 articles | Viewed by 5378 | Submission Open

Keywords: systemic lupus erythematosus; autoantibodies; biomarkers; therapeutic drugs; lupus nephritis; quality of life; new treatment strategies

(This special issue belongs to the Section Immunology & Rheumatology)

Periodontal Diseases and Systemic Health: Pathogenesis, Prevention and Management

edited by

Saverio Cosola

submission deadline 15 Feb 2026 | 3 articles | Viewed by 5324 | Submission Open

Keywords: periodontitis; dental implants; systemic inflammation; diabetes and periodontal disease; cardiovascular implications; pregnancy and oral health; host immune responses; preventive dentistry; implant-prosthetic rehabilitation

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Pancreatic Disorder, Pancreatitis, and Pancreatic Cancer: Interconnections, Clinical Challenges, and Therapeutic Advances

edited by

Cristian George Ţieranu

and

Adrian Saftoiu

submission deadline 15 Feb 2026 | 1 articles | Viewed by 3721 | Submission Open

Keywords: pancreatic disorder; pancreatitis; pancreatic cancer; translational research; diagnosis; treatment

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Cardiac Electrophysiology: Focus on Clinical Practice

edited by

Andreas Müssigbrodt

submission deadline 15 Feb 2026 | 4 articles | Viewed by 3640 | Submission Open

Keywords: cardiomyopathy; arrhythmia; heart rhythm; atrial fibrillation; ventricular tachycardia; sudden cardiac death; mapping; ablation; pulsed field ablation (PFA); device; pacemaker; left bundle branch area pacing (LBBAP); conduction system pacing (CSP); implantable cardioverter-defibrillator (ICD); leadless pacing; extraction

(This special issue belongs to the Section Cardiology)

New Insight into Pain and Chronic Pain Management

edited by

Eung Don Kim

submission deadline 15 Feb 2026 | 2 articles | Viewed by 3073 | Submission Open

Keywords: chronic pain; pain management; pharmacological treatment; non-pharmacological interventions; neuromodula-tion; multidisciplinary approaches; personalized medicine; quality of life

(This special issue belongs to the Section Clinical Rehabilitation)

Bariatric Surgery: Challenges and Future Trends

edited by Hugo Santos-Sousa

submission deadline 15 Feb 2026 | 2 articles | Viewed by 2815 | Submission Open

Keywords: obesity; metabolic and bariatric surgery; sleeve gastrectomy; metabolic syndrome; novel surgical procedures; Nissen-sleeve fundoplication; Roux-en-Y gastric bypass distalization; single-anastomosis procedures

(This special issue belongs to the Section General Surgery)

Current Concepts and Updates in Eye Diseases

edited by Wiktor Stopyra,

Joanna Konopińska

and Anna Machalinska

submission deadline 15 Feb 2026 | 2 articles | Viewed by 2713 | Submission Open

Keywords: corneal disease; glaucoma; cataract; uveitis; ocular oncology; retinal disorder; ocular treatment; eye surgery; ocular diagnostics

(This special issue belongs to the Section Ophthalmology)

Drug-Related Problems: Clinical Pharmacy and Safety of Pharmacotherapy

edited by

Mariola Drozd

and

Jakub Pawlikowski

submission deadline 15 Feb 2026 | 2 articles | Viewed by 2563 | Submission Open

Keywords: adverse drug reaction; drug-related problems; drug formulation technology; safety of pharmacotherapy; clinical pharmacy; pharmaceutical care; pharmacology

(This special issue belongs to the Section Pharmacology)

Catheter Ablation of Cardiac Arrhythmias: Current Updates and Perspectives: 2nd Edition

edited by

Shaojie Chen

submission deadline 15 Feb 2026 | 1 articles | Viewed by 2297 | Submission Open

Keywords: ablation; arrhythmia; electrophysiology; atrial fibrillation; atrial flutter; atrial tachycardia; mapping; supraventricular tachycardia; ventricular arrhythmia

(This special issue belongs to the Section Cardiology)

New Insights in Neonatal Intensive Care

edited by

Benjamim Ficial

Leonardo Gottin

and Martina Ciarcià

submission deadline 15 Feb 2026 | 2 articles | Viewed by 2078 | Submission Open

Keywords: neonatal intensive care; neonatal diseases; critically ill infants; premature infants; neonatal care; intensive care medicine

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Perspectives in Amyotrophic Lateral Sclerosis: Diagnosis, Management and Future Opportunities

edited by

Matthias Boentert

submission deadline 15 Feb 2026 | 1 articles | Viewed by 768 | Submission Open

Keywords: amyotrophic lateral sclerosis; early diagnosis; neuroimaging; biomarkers; treatment

(This special issue belongs to the Section Clinical Neurology)

Clinical Diagnosis and Surgical Strategies Update on Ear Disorders: 2nd Edition

edited by

Eleonora M.C. Trecca

and

Andrea Albera

submission deadline 15 Feb 2026 | 1 articles | Viewed by 762 | Submission Open

Keywords: middle ear; inner ear; endoscopic ear surgery; cholesteatoma; Meniè re’ s disease; hearing loss; robotic surgery; oto-sclerosis

(This special issue belongs to the Section Otolaryngology)

Advances in Traumatic Brain Injury: Causes and Recovery

edited by Antonio Bonora

submission deadline 15 Feb 2026 | 1 articles | Viewed by 722 | Submission Open

Keywords: mild traumatic brain injury; TBI; brain injuries; neuroimaging; rehabilitation

(This special issue belongs to the Section Brain Injury)

Recent Advances in Refractive Surgery and Intraocular Lens Implantation

edited by Antonio Leccisotti

submission deadline 15 Feb 2026 | Viewed by 246 | Submission Open

Keywords: refractive surgery; intraocular lens implantation; keratectomy; cornea; ocular surgery; optical coherence tomography; laser surgery; KLEx (keratorefractive lenticule extraction); femtolasik

(This special issue belongs to the Section Ophthalmology)

Kidney Transplantation: Current Challenges and Future Perspectives: 2nd Edition

edited by Alberto Piana and Angelo Territo

submission deadline 15 Feb 2026 | Viewed by 226 | Submission Open

Keywords: kidney transplantation; urologic cancers; organ preservation; surgical challenges; donor selection; long-term outcomes; complications; post-transplant care; technology

(This special issue belongs to the Section Nephrology & Urology)

State of the Art in Bladder Cancer: Diagnostics and Treatment Strategies

edited by

Angelo Porreca

submission deadline 15 Feb 2026 | Viewed by 158 | Submission Open

Keywords: bladder cancer; photodynamic diagnosis (PDD); bladder-sparing strategies; robotic-assisted surgery; single-port robotic cystectomy; older patients; immunotherapy; intravesical therapy; bladder preservation; minimally invasive urology; advanced bladder cancer; diagnostic innovation

(This special issue belongs to the Section Nephrology & Urology)

Eosinophilic Esophagitis: Clinical Advances in Diagnosis, Treatment, and Monitoring

edited by Pierfrancesco Visaggi, Edoardo Vincenzo Savarino and

Nicola De Bortoli

submission deadline 18 Feb 2026 | 4 articles | Viewed by 8525 | Submission Open

Keywords: eosinophilic esophagitis (EoE); diagnosis ; treatment ; monitoring; disease assessment; precision medicine

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Endocrine Malignancies: Current Surgical Therapeutic Approaches: 2nd Edition

edited by

Mariarita Tarallo

Enrico Fiori

and Marco Bononi

submission deadline 18 Feb 2026 | 4 articles | Viewed by 6747 | Submission Open

Keywords: endocrine malignancies; thyroid cancer; adrenocortical cancer; parathyroid; men

(This special issue belongs to the Section Endocrinology & Metabolism)

Sepsis: Current Updates and Perspectives

edited by

Ecaterina Scarlatescu

submission deadline 20 Feb 2026 | 10 articles | Viewed by 26504 | Submission Open

Keywords: sepsis biomarkers; diagnostic tools; cytokines; inflammation; infection; antibiotherapy; blood purification; novel therapies

(This special issue belongs to the Section Intensive Care)

Recent Developments in Gynecological Endocrinology

edited by

Błażej Męczekalski

submission deadline 20 Feb 2026 | 8 articles | Viewed by 25865 | Submission Open

Keywords: amenorrhea; puberty; PCOS; premature ovarian insufficiency; endometriosis; infertility; pregnancy; hormones; menopause

(This special issue belongs to the Section Obstetrics & Gynecology)

Traumatic Brain Injury: Emergency Management, Prevention of Secondary Injury, and Rehabilitation

edited by

Katja E. Wartenberg

and Lori Shutter

submission deadline 20 Feb 2026 | 7 articles | Viewed by 24666 | Submission Open

Keywords: traumatic brain injury; neuromonitoring; neurocritical care; neurorehabilitation; secondary injury; outcome; prognostication

(This special issue belongs to the Section Brain Injury)

Sexually Transmitted Infections as a Challenge of Modern Society: Old Problems and Modern Solutions

edited by Mauro Zaccarelli and

Alessandra Latini

submission deadline 20 Feb 2026 | 7 articles | Viewed by 21575 | Submission Open

Keywords: sexually transmitted infections (STIs); human papilloma virus (HPV); syphilis; gonorrhea; chlamydia trachomatis; HIV infection; PrEP; chemsex

(This special issue belongs to the Section Infectious Diseases)

Endodontic and Periodontal Medicine: Systemic Implications of Oral Infections

edited by

Juan J. Segura-Egea

and

Daniel Cabanillas-Balsera

submission deadline 20 Feb 2026 | 10 articles | Viewed by 20427 | Submission Open

Keywords: dentistry; endodontics; apical periodontitis; endodontic medicine; periodontal disease; periodontal medicine; pulpitis; systemic diseases; root canal treatment

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Blood Disorders: Diagnosis, Management, and Future Opportunities

edited by

Cristina Panuzzo

and

Barbara Pergolizzi

submission deadline 20 Feb 2026 | 5 articles | Viewed by 17221 | Submission Open

Keywords: blood disorders; biomarkers; personalized medicine; diagnosis; NGS; metabolomics; digital droplet PCR (ddPCR)

(This special issue belongs to the Section Hematology)

Pediatric Critical Care: Clinical Recognition, Management, and Outcomes

edited by Janet Hume

submission deadline 20 Feb 2026 | 6 articles | Viewed by 16020 | Submission Open

Keywords: pediatric critical care medicine; sepsis; pediatric acute respiratory distress syndrome; mechanical ventilation; renal replacement therapy; chronic critical illness; post-intensive care syndrome

(This special issue belongs to the Section Clinical Pediatrics)

Cystic Fibrosis: Diagnosis and Treatment

edited by Corrado Tagliati and Gian Marco Giuseppetti

submission deadline 20 Feb 2026 | 6 articles | Viewed by 15664 | Submission Open

Keywords: cystic fibrosis; diagnosis; treatment; management

(This special issue belongs to the Section Respiratory Medicine)

Preeclampsia and Other Pregnancy Complications: Early Intervention, Diagnosis and Management

edited by

Kornelia Zaręba

Aneta Słabuszewska-Jóźwiak

and Mohamed Ahmed Mostafa Aboellail

submission deadline 20 Feb 2026 | 5 articles | Viewed by 14408 | Submission Open

Keywords: preeclampsia; pregnancy complications; early intervention; diagnosis of pregnancy complications; management of pregnancy complications; sexual dysfunctions in pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Orthopedic Surgery: Recent Advances and Prospects

edited by Mitchell K. Ng

submission deadline 20 Feb 2026 | 4 articles | Viewed by 12224 | Submission Open

Keywords: orthopedic surgery; clinical updates; joint reconstruction; spine surgery; trauma; elective surgery; peri-operative management

(This special issue belongs to the Section Orthopedics)

Management of Pituitary Tumors: Current and Future Treatment Options—2nd Edition

edited by

Amit Akirov

submission deadline 20 Feb 2026 | 6 articles | Viewed by 11992 | Submission Open

Keywords: pituitary; cushing syndrome; acromegaly; prolactinoma; non-functioning pituitary adenoma; hypopituitarism; hypophysitis

(This special issue belongs to the Section Endocrinology & Metabolism)

Neuroendocrine Tumors: Challenges and Future Perspectives (Second Edition)

edited by

Anna La Salvia

and

Giuseppe Lamberti

submission deadline 20 Feb 2026 | 6 articles | Viewed by 11432 | Submission Open

Keywords: neuroendocrine tumors; clinical challenges; innovative biomarkers; novel agents; personalized oncology

(This special issue belongs to the Section Oncology)

Displaying special issue 51-100 on page 2 of 32.

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