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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Personalized Diagnosis and Treatment for Intracranial Aneurysm
edited by Nina Zobenica Moore and Mark D. Bain
submission deadline 30 Jun 2025 | 2 articles | Viewed by 1386 | Submission Open
Keywords: cerebral aneurysms; personalized medicine; predictive modeling; simulation imaging; subarachnoid hemorrhage; Intracranial Aneurysm
(This special issue belongs to the Section Clinical Neurology)
Advances in Aortic Surgery
edited by and Joseph Touma
submission deadline 30 Jun 2025 | 2 articles | Viewed by 1272 | Submission Open
Keywords: aortic surgery; aortic disease; aortic valve surgery; endovascular treatment; aortic imaging techniques; aortic aneurysm; acute aortic syndrome
(This special issue belongs to the Section Vascular Medicine)
Advancements in Spinal Oncology: The Current Landscape
edited by Aladine Elsamadicy and
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1259 | Submission Open
Keywords: spinal oncology; patient outcomes; primary bone tumor; spine metastases; intradural tumors
(This special issue belongs to the Section Clinical Neurology)
Targeted Treatment of Oral Cancer
edited by and Claudia Malheiros Coutinho-Camillo
submission deadline 30 Jun 2025 | 1 articles | Viewed by 1240 | Submission Open
Keywords: precision medicine; immunotherapy; targeted drugs; combination therapy; tumor immune evasion; clinical trials
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Allergen-Specific Immunotherapy (AIT) for Allergic Diseases of the Respiratory Tract and Food Allergies
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 937 | Submission Open
Keywords: allergy; allergic rhinitis; allergic conjunctivitis; allergic asthma; food allergy; peptide immunotherapy; allergoids; SLIT; SCIT; OIT
(This special issue belongs to the Section Immunology)
Diagnosis, Treatment and Comorbidities in Chronic Obstructive Pulmonary Disease (COPD): 2nd Edition
edited by Juan Luis Rodriguez Hermosa, José Luis Álvarez-Sala Walther and Myriam Calle Rubio
submission deadline 30 Jun 2025 | 1 articles | Viewed by 780 | Submission Open
Keywords: COPD; diagnosis; comorbidities; respiratory rehabilitation; inhaled therapy; biological therapies
(This special issue belongs to the Section Respiratory Medicine)
Current Concept and Emerging Treatments of Coronary Artery Disease (CAD)
edited by Simone Fezzi and Roberto Scarsini
submission deadline 30 Jun 2025 | 1 articles | Viewed by 748 | Submission Open
Keywords: coronary physiology; intracoronary imaging; imaging-derived computational physiology; drug-coated balloon and bioresorbable scaffolds; virtual PCI; artificial intelligence
(This special issue belongs to the Section Cardiovascular Medicine)
The State of Breast Reconstruction: From Surgical Methods to Patient-Reported Outcomes
edited by Geoffroy C. Sisk
submission deadline 30 Jun 2025 | 1 articles | Viewed by 742 | Submission Open
Keywords: breast reconstruction; implant based; autologous tissue; oncoplastic; breast cancer reconstruction; patient-reported outcomes; acellular dermal matrix; prepectoral; lymphedema; microsurgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Multiple Sclerosis: Clinical Advances in Diagnosis and Treatment
edited by
submission deadline 30 Jun 2025 | 1 articles | Viewed by 709 | Submission Open
Keywords: relapse-remitting multiple sclerosis; progressive multiple sclerosis; immunomodulatory treatments; cognitive impairment; personalized medicine in multiple sclerosis
(This special issue belongs to the Section Clinical Neurology)
Selected Papers from the 4th International Conference on Inflammation and Infection Imaging submission deadline 30 Jun 2025 | 2 articles | Viewed by 687 | Submission Open
Keywords: infection imaging; inflammation imaging; imaging tumor micro-environment; bacteria imaging; new radiopharmaceuticals
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Clinical Epidemiology of Skin Diseases: 3rd Edition
edited by Simone Garcovich and
submission deadline 30 Jun 2025 | 1 articles | Viewed by 550 | Submission Open
Keywords: dermatology and trends; skin diseases and diagnosis; skin diseases and epidemiology; skin neoplasms and diagnosis; skin neoplasms and epidemiology; prevalence; mortality trends; prevention and control; noncommunicable diseases and therapy
(This special issue belongs to the Section Dermatology)
Inflammatory Bowel Disease: From Diagnosis to Treatment—2nd Edition
edited by Laura Maria Minordi and Daniela Pugliese
submission deadline 30 Jun 2025 | 1 articles | Viewed by 509 | Submission Open
Keywords: Crohn’ s disease; ulcerative colitis; imaging; endoscopy; complications; advanced therapies; surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Neurosurgery: Current Challenges and New Perspectives
edited by Adip G. Bhargav, Paul J. Camarata and Jean-Luc K. Kabangu
submission deadline 30 Jun 2025 | Viewed by 447 | Submission Open
Keywords: neurosurgery; brain tumor; neuromodulation; epilepsy; cerebrovascular; DEI; spine surgery
(This special issue belongs to the Section Clinical Neurology)
Augmented and Artificial Intelligence in Ophthalmology
edited by Tina Felfeli, Edsel B. Ing, David Jose Mathew and Michael Balas
submission deadline 30 Jun 2025 | Viewed by 367 | Submission Open
Keywords: artificial intelligence; ophthalmology; eye health; vision; teleophthalmology
(This special issue belongs to the Section Ophthalmology)
Innovations and Challenges in Cardiovascular Surgery
edited by Marc Leon
submission deadline 30 Jun 2025 | Viewed by 268 | Submission Open
Keywords: cardiovascular surgery; minimally invasive surgery; robotic surgery; hybrid; 3D printing; artificial intelligence; mechanical circulatory support; heart transplantation; valve disease; aortic dissection; ischemic heart disease; heart failure
(This special issue belongs to the Section Cardiovascular Medicine)
Recent Advances in the Pathogenesis and Management of Metabolic Syndrome
edited by and Sridevi Devaraj
submission deadline 30 Jun 2025 | Viewed by 223 | Submission Open
Keywords: metabolic syndrome; inflammation; oxidative stress; microbiome dysbiosis; metabolomics; epigenetics/genetics
(This special issue belongs to the Section Endocrinology & Metabolism)
Rehabilitation and Conservative Approaches of Orthopaedic and Sports Medicine Injuries
edited by and Berardo di Matteo
submission deadline 30 Jun 2025 | Viewed by 213 | Submission Open
Keywords: rehabilitation; sport medicine; conservative treatment; interventional physiatry; sport injuries
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Updates on Acute Kidney Disease
edited by
submission deadline 30 Jun 2025 | Viewed by 211 | Submission Open
Keywords: acute kidney injury; septic shock and acute kidney injury; surgical acute kidney injury; biomarkers; acute kidney injury-to-chronic kidney disease transition; continuous renal replacement therapy; blood purification; kidney damage
(This special issue belongs to the Section Nephrology & Urology)
New Insights into Corneal Disease and Transplantation
edited by
submission deadline 30 Jun 2025 | Viewed by 204 | Submission Open
Keywords: lamellar keratoplasty; DSAEK; DMEK; DALK; keratoconus; corneal dystrophies; bullous keratopathy; corneal infection; anterior segment-OCT
(This special issue belongs to the Section Ophthalmology)
Clinical Updates on Prenatal Diagnosis
edited by Valentina D'Ambrosio
submission deadline 30 Jun 2025 | Viewed by 174 | Submission Open
Keywords: fetal anomalies; twin pregnancy; fetal therapy; prenatal genetic testing; genome sequencies
(This special issue belongs to the Section Obstetrics & Gynecology)
From GERD to Esophageal Carcinoma: Caring for Patients with Esophageal Disease
edited by Ghulam Abbas
submission deadline 30 Jun 2025 | Viewed by 139 | Submission Open
Keywords: gastroesophageal reflux— diagnosis; epidemiology; therapy; surgery; hiatal hernia— etiology; surgery; barrett esophagus— diagnosis; therapy; surgery; esophageal neoplasm— surgery; therapy; radiotherapy; drug therapy; esophagectomy; robotic surgical procedures
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Novel Diagnostic and Therapeutic Approaches to Urologic Oncology
edited by , Bogdan Florin Geavlete and
submission deadline 30 Jun 2025 | Viewed by 127 | Submission Open
Keywords: diagnosis; therapy; up-to-date; uro-oncologic pathology
(This special issue belongs to the Section Oncology)
Recent Advancements in Nuclear Medicine and Radiology
edited by Adriaan A. Lammertsma
submission deadline 1 Jul 2025 | 6 articles | Viewed by 7945 | Submission Open
Keywords: PET; SPECT; CT; MRI; AI; image analysis; kinetic analysis
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Advances in Asthma: 2nd Edition submission deadline 1 Jul 2025 | 4 articles | Viewed by 6185 | Submission Open
Keywords: bronchial asthma; biologic inflammation; asthma; management
(This special issue belongs to the Section Respiratory Medicine)
Neuroendocrine Tumors: Challenges and Future Perspectives (Second Edition) submission deadline 5 Jul 2025 | 4 articles | Viewed by 3924 | Submission Open
Keywords: neuroendocrine tumors; clinical challenges; innovative biomarkers; novel agents; personalized oncology
(This special issue belongs to the Section Oncology)
Selected Papers from the 2nd International Electronic Conference on Clinical Medicine
edited by and
submission deadline 5 Jul 2025 | Viewed by 528 | Submission Open
Keywords: cardiology; gastroenterology & hepatopancreatobiliary medicine; epidemiology & public health; AI & telemedicine; immunology; mental health; oncology & hematology; dermatology
Skin Cancer: Prevention, Diagnosis and Treatment
edited by Athanassios A. Kyrgidis and
submission deadline 10 Jul 2025 | 4 articles | Viewed by 12451 | Submission Open
Keywords: skin cancer; melanoma; squamous cell carcinoma; basal cell carcinoma; clinical biomarkers; dermoscopy; quality of life
(This special issue belongs to the Section Dermatology)
Clinical Updates on Cardiac and Vascular Toxicities from Antineoplastic Drugs and Beyond
edited by
submission deadline 10 Jul 2025 | 5 articles | Viewed by 9066 | Submission Open
Keywords: cardiotoxicity; vascular toxicity; cardio-oncology; immune checkpoint inhibitors; anthracyclines; tyrosine kinase inhibitors; HER2; proteasome inhibitors; platinum; antimetabolites; microtubule inhibitors
(This special issue belongs to the Section Cardiovascular Medicine)
Heart Disease and Chronic Inflammatory Conditions: New Insights
edited by Ofer Kobo and Gilad Margolis
submission deadline 10 Jul 2025 | 3 articles | Viewed by 6671 | Submission Open
Keywords: heart diseases; chronic inflammatory; rheumatoid arthritis; cardiovascular disease; inflammatory bowel disease
(This special issue belongs to the Section Cardiology)
New Insights into Abdominal Surgery
edited by Pietro Fransvea
submission deadline 10 Jul 2025 | 2 articles | Viewed by 2843 | Submission Open
Keywords: acute care surgery; trauma; minimally invasive emergency surgery; artificial intelligence; outcome prediction
(This special issue belongs to the Section General Surgery)
Current and Emerging Therapies for Rheumatoid Arthritis
edited by
submission deadline 10 Jul 2025 | 1 articles | Viewed by 1839 | Submission Open
Keywords: DMARDs (disease-modifying anti-rheumatic drugs); boDMARDs (biological DMARDs); bsDMARDs (biosimilar DMARDs); csDMARDs (conventional synthetic DMARDs); rheumatoid arthritis; tsDMARDs (targeted synthetic DMARDs)
(This special issue belongs to the Section Immunology)
Clinical Therapeutic Advances in Bone Fractures
edited by Simon Hackl and Eva Simone Steinhausen
submission deadline 10 Jul 2025 | 1 articles | Viewed by 1341 | Submission Open
Keywords: stem cells; biomechanics; fracture fixation; orthobiologics; rehabilitation; personalized medicine; 3D printing; im-plant coating; nonunion; fracture-related infection
(This special issue belongs to the Section Orthopedics)
Heart Failure and Coronary Artery Diseases: Cardiovascular Complications and Comorbidities submission deadline 10 Jul 2025 | 1 articles | Viewed by 901 | Submission Open
Keywords: heart failure; acute myocardial infarction; coronary artery diseases; cardiac imaging; biomarkers; artificial intelligence
(This special issue belongs to the Section Cardiovascular Medicine)
Recent Advances and Challenges in Cardiothoracic Surgery
edited by Marco Anile and Vannucci Jacopo
submission deadline 10 Jul 2025 | Viewed by 501 | Submission Open
Keywords: minimally invasive thoracic surgery; RATS; uniportal VATS; lung transplantation; VATS for arrhythmias; new technologies; radiomics; STAS
(This special issue belongs to the Section Cardiology)
Advances in Burn Management
edited by Juan P. Barret
submission deadline 15 Jul 2025 | 6 articles | Viewed by 8501 | Submission Open
Keywords: burns; wound healing; immune response; stem cells  ; burn surgery  ; rehabilitation  ; PROMs; PREMs
(This special issue belongs to the Section General Surgery)
Cardiac Imaging: Current Applications and Future Perspectives
edited by Anna Baritussio and Isabella Leo
submission deadline 15 Jul 2025 | 7 articles | Viewed by 7317 | Submission Open
Keywords: cardiac imaging; echocardiography; cardiac CT; cardiac MRI; nuclear imaging; artificial intelligence
(This special issue belongs to the Section Cardiology)
Clinical Application of Biomarkers in Cancers
edited by
submission deadline 15 Jul 2025 | 3 articles | Viewed by 4981 | Submission Open
Keywords: cancer biomarkers; early detection; personalized therapy; biomarker validation; advanced technologies; clinical implementation
(This special issue belongs to the Section Clinical Laboratory Medicine)
Advances in Rheumatology: From Bench to Bedside
edited by
submission deadline 15 Jul 2025 | 2 articles | Viewed by 2928 | Submission Open
Keywords: autoimmune disease; inflammation pathophysiology; novel therapeutic strategies; translational medicine; bench to bedside (B2B); disease biomarkers
(This special issue belongs to the Section Immunology)
Peripheral Nerves: Imaging, Electrophysiology and Surgical Techniques
edited by , Aniello Iovino and Vito Stifano
submission deadline 15 Jul 2025 | 2 articles | Viewed by 2183 | Submission Open
Keywords: MRI; MSK imaging; soft-tissue tumors; DTI; neuropathies; inflammatory neuropathies; nerve entrapment; motor neuron disease; neurophysiology; MSK ultrasound; peripheral nerve tumor; nerve entrapment; nerve reconstruction
(This special issue belongs to the Section Clinical Neurology)
Current Trends and Prospects of Critical Emergency Medicine
edited by Quincy K. Tran
submission deadline 15 Jul 2025 | 2 articles | Viewed by 850 | Submission Open
Keywords: critically ill patients; critical care; resuscitation; emergency medicine; trends; prospects; outcomes
(This special issue belongs to the Section Emergency Medicine)
Pulmonary Embolism—Current and Novel Approaches
edited by Roy Beigel and Shlomi Matetzky
submission deadline 15 Jul 2025 | 1 articles | Viewed by 657 | Submission Open
Keywords: pulmonary embolism; treatment; coagulation; venous thrombosis; thrombolysis; anticoagulation; risk stratification
(This special issue belongs to the Section Respiratory Medicine)
Pediatric Urology: How to Adapt Current Knowledge to the New Era
edited by Simona Gerocarni Nappo and
submission deadline 15 Jul 2025 | Viewed by 257 | Submission Open
Keywords: pediatric urology; telemedicine; telesurgery; artificial intelligence; 3D-models; congenital urinary diseases; pediatric oncology
(This special issue belongs to the Section Clinical Pediatrics)
Medicine and Exercise for Wellbeing: Effective Diagnosis and Non-Pharmacological Treatment in Chronic Conditions and Pain
edited by
submission deadline 16 Jul 2025 | 3 articles | Viewed by 3445 | Submission Open
Keywords: chronic pain; physical exercise; diagnosis; chronic conditions; pain management
(This special issue belongs to the Section Sports Medicine)
Keratoconus: Current Status and Prospects
edited by and Isabel Lema
submission deadline 16 Jul 2025 | 3 articles | Viewed by 1804 | Submission Open
Keywords: keratoconus; prevention; diagnostic; biomarker discovery; genetics; exposome; treatment; personalized medicine; major challenges; technological advances
(This special issue belongs to the Section Ophthalmology)
New Insights into Acute Care and Emergency Surgery
edited by Jacob Chen and Avi Benov
submission deadline 17 Jul 2025 | 6 articles | Viewed by 9722 | Submission Open
Keywords: trauma surgery; emergency surgery; acute care; anesthesia; ICU
(This special issue belongs to the Section General Surgery)
Stress, Rhythms Dysregulation and Bipolar Spectrum submission deadline 20 Jul 2025 | 15 articles | Viewed by 25344 | Submission Open
Keywords: bipolar spectrum; neo-Kraepelinian tradition; dimensional approach; social rhythms; chronobiological rhythms
(This special issue belongs to the Section Mental Health)
Clinical Updates in Physiotherapy for Musculoskeletal Disorders submission deadline 20 Jul 2025 | 6 articles | Viewed by 7999 | Submission Open
Keywords: musculoskeletal disorders; physiotherapy interventions; lifestyle; psychoneuroimmunology; chronic pain; inflammation; physical therapy
(This special issue belongs to the Section Clinical Rehabilitation)
New Insights into Infectious Skin and Mucosal Diseases
edited by , and Astrid Herzum
submission deadline 20 Jul 2025 | 4 articles | Viewed by 6160 | Submission Open
Keywords: exanthem; latent viruses; infectious diseases; skin eruptions; sexually transmitted infections
(This special issue belongs to the Section Dermatology)
Multidisciplinarity in Thoraco-Pulmonary Diseases: Every Generation Needs a New Revolution. Insights from the XXII SIET National Meeting
edited by Federico Raveglia, and
submission deadline 20 Jul 2025 | 6 articles | Viewed by 5935 | Submission Open
Keywords: lung cancer; interventional endoscopy; upper airway reconstruction; robotic diagnosis; robotic surgery
(This special issue belongs to the Section Respiratory Medicine)
Advances in the Surgical Management of Gynecological Malignancies
edited by Laurentiu Pirtea and Răzvan Ştefan Ilina
submission deadline 20 Jul 2025 | 2 articles | Viewed by 5189 | Submission Open
Keywords: minimally invasive surgery; laparoscopy surgery; robotic-assisted surgery; gynecological malignancies
(This special issue belongs to the Section Obstetrics & Gynecology)
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