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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pain Management: Current Challenges and Future Prospects

edited by Gian Marco Petroni

submission deadline 30 Aug 2025 | 2 articles | Viewed by 1982 | Submission Open

Keywords: chronic joint pain; radio frequency ablation; adipose-derived mesenchimal stem cells (ADMScs); intrarticular injection; facet joint injection with ADMScs

(This special issue belongs to the Section Anesthesiology)

Advancements in Cardiac Electrophysiology Through Biomedical Engineering for Abnormality Monitoring and Detection in Clinical Practice

edited by Ilaria Marcantoni and Michela Casella

submission deadline 30 Aug 2025 | 2 articles | Viewed by 1746 | Submission Open

Keywords: electrocardiogram; cardiac electrophysiology; cardiac risk index; cardiac arrhythmias; electrocardiographic alternans; long QT syndrome; heart electrical system anomalies; monitoring of heart electrical system; prevention; biomedical engineering in electrocardiology; cardiac signal processing; cardiac image processing

(This special issue belongs to the Section Cardiology)

Pulmonary Hypertension: Advances in Clinical Diagnosis and Management

edited by Victor F. Tapson

submission deadline 30 Aug 2025 | 2 articles | Viewed by 1710 | Submission Open

Keywords: pulmonary arterial hypertension; pulmonary hypertension; pulmonary vascular disease; chronic thromboembolic pulmonary hypertension; lung disease; left heart disease; functional class; right heart catheterization; prostacyclins; endothelin receptor antagonists; phosphodiesterase inhibitor; soluble guanylate cyclase stimulators; sotatercept

(This special issue belongs to the Section Respiratory Medicine)

Robotic Urological Surgery: Clinical Updates for Better Outcomes

edited by

Shigeo Horie

submission deadline 30 Aug 2025 | 2 articles | Viewed by 1581 | Submission Open

Keywords: robotic urological surgery; clinical outcomes; surgical techniques; surgical navigation; patient-reported outcomes; side effects; incident

(This special issue belongs to the Section Nephrology & Urology)

Orthopedic Trauma Surgery: Current Challenges and Future Perspectives

edited by Paolo Schiavi, Enrico Vaienti and Francesco Pogliacomi

submission deadline 30 Aug 2025 | 1 articles | Viewed by 1257 | Submission Open

Keywords: trauma surgery; politrauma; osteosynthesis; arthroplasty; internal fixation; MIPO; outcome

(This special issue belongs to the Section Orthopedics)

Thrombosis: Latest Advances and Prospects

edited by Manila Gaddh

submission deadline 30 Aug 2025 | 1 articles | Viewed by 1097 | Submission Open

Keywords: thromboembolism; venous thrombosis; arterial thrombosis; anticoagulation

(This special issue belongs to the Section Hematology)

The Role of Bayesian Methods in Clinical Medicine

edited by Nicolas Meyer

submission deadline 30 Aug 2025 | 1 articles | Viewed by 1006 | Submission Open

Keywords: bayesian statistics; clinical trials; epidemiology; clinical epidemiology; decision; diagnostic test; master protocol; review; statistical controversies; adaptive design

(This special issue belongs to the Section Clinical Research Methods)

Orthopedic Trauma in Polytraumatized Patients: Current Management Concepts and Innovations

edited by

Thomas Lustenberger

submission deadline 30 Aug 2025 | 1 articles | Viewed by 868 | Submission Open

Keywords: polytrauma; geriatric polytrauma; fracture management; fracture stabilization; damage control orthopedics; early appropriate care; multidisciplinary approach; innovations; minimally invasive surgery

(This special issue belongs to the Section Orthopedics)

Alcohol-Related Liver Disease: Diagnosis, Treatment, and Management

edited by

Adrian Boicean

and

Cristian Ichim

submission deadline 30 Aug 2025 | 1 articles | Viewed by 626 | Submission Open

Keywords: alcohol-related liver disease; gut– liver axis; hepatic fibrosis; liver cirrhosis; micro-RNA; inflammatory pathways; liver transplantation; steatohepatitis; fecal microbiota transplantation in liver cirrhosis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Clinical Insights into Exercise, Obesity, and Diabetes

edited by

Hugo Louro

Nuno M. Pimenta

, Ana Conceição and

Luis Leitão

submission deadline 30 Aug 2025 | Viewed by 522 | Submission Open

Keywords: diabetes; obesity; physical activity; exercise prescription; physically active learning; tissue oxidation; exercise physiology; physically active senior centres

(This special issue belongs to the Section Sports Medicine)

Current and Emerging Treatment Options in Atrial Fibrillation: 2nd Edition

edited by

Marco Valerio Mariani

submission deadline 30 Aug 2025 | Viewed by 245 | Submission Open

Keywords: atrial fibrillation; left atrial appendage closure; ablation techniques; personalized medicine in AF treatment; cardioversion methods

(This special issue belongs to the Section Cardiology)

Cardiac Anesthesia: Current Research and Future Prospects

edited by

Fabio Sangalli

and Lorenzo Stephan Cesare Grazioli

submission deadline 30 Aug 2025 | Viewed by 233 | Submission Open

Keywords: cardiac anesthesia; cardiac surgery; echocardiography; interventional cardiology; anesthesia; cardiology

(This special issue belongs to the Section Anesthesiology)

Recent Developments of Radiotherapy in Oncology

edited by Rosario Mazzola and

Priscilla Guglielmo

submission deadline 30 Aug 2025 | Viewed by 178 | Submission Open

Keywords: radiotherapy; image-guided radiotherapy; adaptive radiotherapy; treatment planning; radiation oncology; immunotherapy synergy

(This special issue belongs to the Section Oncology)

Kidney Failure: Diagnosis and Treatment of Acute and Chronic Conditions

edited by Nikolina Basic-Jukic

submission deadline 31 Aug 2025 | 13 articles | Viewed by 23910 | Submission Open

Keywords: kidney failure; renal dysfunction; hyponatremia; peritoneal dialysis; hemodialysis; renal transplantation; immunoadsorption; plasma exchange

(This special issue belongs to the Section Nephrology & Urology)

Acute Ischemic Stroke: Current Status and Future Challenges

edited by

Lucio D'Anna

submission deadline 31 Aug 2025 | 11 articles | Viewed by 20936 | Submission Open

Keywords: acute ischemic stroke; atrial fibrillation; endovascular thrombectomy; intravenous thrombolysis; direct oral anticoagulants

(This special issue belongs to the Section Clinical Neurology)

Clinical Management of Pregnancy-Related Complications: 2nd Edition

edited by

Panagiotis Peitsidis

, Stephanos Zervoudis and

Panagiotis Tsikouras

submission deadline 31 Aug 2025 | 4 articles | Viewed by 17691 | Submission Open

Keywords: diabetes; hypertension; post-partum hemorrhage; preterm labor; infection; cancer

(This special issue belongs to the Section Obstetrics & Gynecology)

Cardiometabolic Disease and Atherosclerosis: Epidemiology, Prevention, Diagnosis, and Clinical Treatment

edited by

Evangelos Oikonomou

and Konstantinos Mourouzis

submission deadline 31 Aug 2025 | 9 articles | Viewed by 14216 | Submission Open

Keywords: atherosclerosis; obesity; cardiometabolic disease; prevention; diabetes mellitus; endothelium; arteriosclerosis; coronary artery disease

(This special issue belongs to the Section Cardiology)

New Challenges and Perspectives in Polycystic Ovary Syndrome

edited by

Jim Parker

submission deadline 31 Aug 2025 | 4 articles | Viewed by 12602 | Submission Open

Keywords: polycystic ovary syndrome; evolutionary origins; developmental origins; pathogenesis; pathophysiology; microbiome; pregnancy complications; lifestyle

(This special issue belongs to the Section Obstetrics & Gynecology)

Advances in Child Neurology

edited by

Giuseppina Sgandurra

and

Marco Carotenuto

submission deadline 31 Aug 2025 | 6 articles | Viewed by 11842 | Submission Open

Keywords: pediatric neurological disorders; pediatric sleep disorders; pediatric epilepsy; autoimmune encephalitis; pediatric acute-onset neuropsychiatric syndrome (PANS); pediatric headaches; RASopathies; neurogenetic disorders; developmental coordination disorder (DCD); pedaitric neurological rehabilitation; AI application for diagnosis and therapeutic management of pediatric neurological diseases

(This special issue belongs to the Section Clinical Pediatrics)

New Diagnostic and Therapeutic Trends in Sepsis and Septic Shock

edited by

and

submission deadline 31 Aug 2025 | 4 articles | Viewed by 9903 | Submission Open

Keywords: sepsis; septic shock; diagnostics; therapeutics; biomarkers; critical care

(This special issue belongs to the Section Hematology)

Chronic Obstructive Pulmonary Disease (COPD): Treatment and Management

edited by

Maurizio Marvisi

and Alfredo Chetta

submission deadline 31 Aug 2025 | 7 articles | Viewed by 9242 | Submission Open

Keywords: COPD; treatable traits; precision medicine; COPD comorbidities; COPD mortality

(This special issue belongs to the Section Respiratory Medicine)

Blood Disorders: Diagnosis, Management, and Future Opportunities

edited by

Cristina Panuzzo

and

Barbara Pergolizzi

submission deadline 31 Aug 2025 | 3 articles | Viewed by 8153 | Submission Open

Keywords: blood disorders; biomarkers; personalized medicine; diagnosis; NGS; metabolomics; digital droplet PCR (ddPCR)

(This special issue belongs to the Section Hematology)

Cerebrovascular Disease: Symptoms, Diagnosis and Current Treatment

edited by Alba Scerrati and Giorgio Mantovani

submission deadline 31 Aug 2025 | 5 articles | Viewed by 7931 | Submission Open

Keywords: ischemic stroke; cerebral aneurysms; cerebral vascular malformation; cerebral venous disease; cerebral venous thrombosis

(This special issue belongs to the Section Clinical Neurology)

Pediatric Critical Care: Clinical Recognition, Management, and Outcomes

edited by Janet Hume

submission deadline 31 Aug 2025 | 5 articles | Viewed by 7612 | Submission Open

Keywords: pediatric critical care medicine; sepsis; pediatric acute respiratory distress syndrome; mechanical ventilation; renal replacement therapy; chronic critical illness; post-intensive care syndrome

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Advancements in Kidney Transplantation

edited by Louise Benning

submission deadline 31 Aug 2025 | 6 articles | Viewed by 6126 | Submission Open

Keywords: kidney transplantation; immunosuppression; immune monitoring; biomarkers; rejection; machine perfusion; graft survival

(This special issue belongs to the Section Nephrology & Urology)

Advances in the Prevention, Management, and Rehabilitation of Sports Injuries

edited by

Mutsuaki Edama

submission deadline 31 Aug 2025 | 3 articles | Viewed by 5821 | Submission Open

Keywords: prevention; rehabilitation; physical therapy; clinical anatomy; exercise; ultrasonography; foot and ankle; tendon; musculoskeletal; female athlete

(This special issue belongs to the Section Sports Medicine)

The Future of Inflammatory Biomarkers: Challenges and Clinical Integration

edited by

Sabina Galiniak

and

Marek Biesiadecki

submission deadline 31 Aug 2025 | 3 articles | Viewed by 5184 | Submission Open

Keywords: inflammatory marker; inflammation; biomarker; cancers; rheumatoid arthritis; inflammatory bowel disease; respiratory diseases

(This special issue belongs to the Section Immunology)

Clinical Advancements in Retinal Diseases

edited by

Anna Bryl

and

Malgorzata Mrugacz

submission deadline 31 Aug 2025 | 2 articles | Viewed by 3662 | Submission Open

Keywords: retinal diseases; treatment of retinal diseases; diagnostics of retinal diseases; retinal imaging; retinal surgeries

(This special issue belongs to the Section Ophthalmology)

Management of Pituitary Tumors: Current and Future Treatment Options—2nd Edition

edited by

Amit Akirov

submission deadline 31 Aug 2025 | 4 articles | Viewed by 3496 | Submission Open

Keywords: pituitary; cushing syndrome; acromegaly; prolactinoma; non-functioning pituitary adenoma; hypopituitarism; hypophysitis

(This special issue belongs to the Section Endocrinology & Metabolism)

Updates on Brain Tumors: Diagnosis and Treatment

edited by Jigisha P. Thakkar and

Rimas V Lukas

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2817 | Submission Open

Keywords: primary brain tumors; glioblastoma; IDH mutant glioma; meningioma; brain metastases; leptomeningeal disease

(This special issue belongs to the Section Clinical Neurology)

Novel Insights into the Prevention and Treatment of Contact Dermatitis

edited by

Cara Bieck

, Christoph Skudlik, Swen Malte John and

Albert Nienhaus

submission deadline 31 Aug 2025 | 1 articles | Viewed by 2253 | Submission Open

Keywords: allergic; allergy; contact dermatitis; irritant; occupation; prevention; sensitization; skin; therapy; treatment

(This special issue belongs to the Section Dermatology)

Current and Emerging Treatment Options in Skull Base Surgery and Neuro-Oncology

edited by Antonio Meola and Leonello Tacconi

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2192 | Submission Open

Keywords: skull base; neuro-oncology; brain tumor; artificial intelligence; radiosurgery; targeted therapy; neuro endoscopy

(This special issue belongs to the Section Clinical Neurology)

Novel Therapeutic Targets with Inflammatory Bowel Diseases

edited by Konstantinos H. Katsanos and Fotios S. Fousekis

submission deadline 31 Aug 2025 | 2 articles | Viewed by 2180 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; colorectal; intestinal bowel disease; mucosal im-munology; molecular endoscopy; fibrosis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Recent Developments in Hearing and Balance Disorders: 2nd Edition

edited by

Juan Carlos Amor-Dorado

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1974 | Submission Open

Keywords: ear; otology; audiology; hearing disorders; deafness; hearing loss; autoimmunity; ENT; inflammation; vertigo; imbalance

(This special issue belongs to the Section Otolaryngology)

Acute Kidney Events in Intensive Care Patients

edited by Kada Klouche

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1940 | Submission Open

Keywords: acute kidney events; ICU; critically ill; RRT; outcome; acute kidney disease; chronic kidney disease; bi-omarkers

(This special issue belongs to the Section Intensive Care)

Spinal Rehabilitation for Health and Performance: A Collection of Case Reports and Series

edited by

Deed E. Harrison

Douglas F. Lightstone

, Curtis Fedorchuk and

Joseph Betz

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1858 | Submission Open

Keywords: spinal rehabilitation; cervical; thoracic; lumbar; sacrum; pelvis; radiography; case report; case series; sagittal balance; coronal balance; spinal alignment; spinal posture; spinal deformity; patient-reported outcomes

(This special issue belongs to the Section Clinical Rehabilitation)

Advances in Plastic and Reconstructive and Aesthetic Surgery of Face, Breast and Body

edited by

Valentin Haug

submission deadline 31 Aug 2025 | 2 articles | Viewed by 1673 | Submission Open

Keywords: reconstructive surgery; academic plastic surgery; research; social media in plastic surgery; breast surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Novel Developments on Diagnostics and Treatment of Knee Instability and Osteoarthritis

edited by Jacek B. Kowalczewski and Marcin Tyrakowski

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1599 | Submission Open

Keywords: knee instability; degenerative disease; knee osteoarthritis; arthroplasty; periprosthetic joint infection

(This special issue belongs to the Section Orthopedics)

Colorectal Surgery: Innovative Techniques and Enhanced Patient Outcomes

edited by Filippo Carannante and Leandro Siragusa

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1260 | Submission Open

Keywords: colorectal surgery; minimally invasive techniques; artificial intelligence; perioperative patient management; translational research in coloproctology

(This special issue belongs to the Section General Surgery)

Clinical Applications of Endoscopic Technology in Gastroenterology

edited by

Naim Abu-Freha

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1150 | Submission Open

Keywords: gastroscopy; colonoscopy; sedation; polyps; early detection; endoscopic submucosal dissection; mucosal resection; artificial intelligence in endoscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Innovations in Bariatric and Minimally Invasive Gastrointestinal Surgery

edited by Jerry Dang and Juan Barajas-Gamboa

submission deadline 31 Aug 2025 | 1 articles | Viewed by 1024 | Submission Open

Keywords: bariatric surgery; laparoscopic surgery; endoscopic techniques; gut microbiome; metabolic outcomes; minimally invasive surgery; artificial intelligence in surgery; robotic surgery; surgical innovation; precision medicine; perioperative care; virtual reality surgery; surgical planning; clinical outcomes; surgical technology; endoluminal surgery; patient safety

(This special issue belongs to the Section General Surgery)

Advances in Diagnosis and Therapeutic Strategies for Uveal Melanoma

edited by Yong Qin

submission deadline 31 Aug 2025 | 1 articles | Viewed by 978 | Submission Open

Keywords: uveal melanoma; immunotherapy; targeted therapy; biomarker; disease management; drug development; drug resistance

(This special issue belongs to the Section Ophthalmology)

Robot-Assisted Surgery: Current Trends and Future Perspectives

edited by

Francisco Miguel Sanchez-Margallo

and

Juan Alberto Sánchez-Margallo

submission deadline 31 Aug 2025 | 1 articles | Viewed by 835 | Submission Open

Keywords: robot-assisted surgery; surgical robotics; artificial intelligence in surgery; augmented reality; surgical ergonomics; minimally invasive surgery; haptic feedback

(This special issue belongs to the Section General Surgery)

Advancements in Ovarian Cancer Management: From Early Detection to Precision Therapies

edited by

Alexandros Laios

submission deadline 31 Aug 2025 | 1 articles | Viewed by 828 | Submission Open

(This special issue belongs to the Section Obstetrics & Gynecology)

New Insights into Critical Care

edited by Francesca Rubulotta and

Luigi La Via

submission deadline 31 Aug 2025 | Viewed by 815 | Submission Open

Keywords: critical care; gender medicine; artificial intelligence; mechanical ventilation; robotic anesthesia; Kepler Intubator; closed-loop anesthesia; diagnostic innovations; treatment advances; DEI

(This special issue belongs to the Section Emergency Medicine)

Obesity Surgery—State of the Art

edited by Anna Casajoana

submission deadline 31 Aug 2025 | 1 articles | Viewed by 713 | Submission Open

Keywords: obesity; bariatric surgery; metabolic surgery; diabetes mellitus type 2; GLP-1

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

New Insights in Neonatal Intensive Care

edited by

Benjamim Ficial

Leonardo Gottin

and Martina Ciarcià

submission deadline 31 Aug 2025 | Viewed by 648 | Submission Open

Keywords: neonatal intensive care; neonatal diseases; critically ill infants; premature infants; neonatal care; intensive care medicine

(This special issue belongs to the Section Clinical Pediatrics)

The Use of Artificial Intelligence in Cardiovascular Medicine

edited by

Stefano Palermi

submission deadline 31 Aug 2025 | Viewed by 239 | Submission Open

Keywords: artificial intelligence; cardiovascular medicine; ECG analysis; machine learning; imaging in cardiology; personalized medicine; arrhythmia detection; AI ethics in healthcare; clinical validation of AI tools; cardiovascular risk assessment

(This special issue belongs to the Section Cardiovascular Medicine)

Advances in Neurological Rehabilitation: Innovations and Clinical Insights

edited by