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Innovations in the Clinical Management of Retinal Diseases: Emerging Therapies and Visual Rehabilitation

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 19 December 2025 | Viewed by 335

Special Issue Editor

Dr. Francisco J. Povedano-Montero

E-Mail Website
Guest Editor
Optometry and Vision Department, Complutense University of Madrid, Madrid, Spain
Interests: optometry; neuro-ophthalmic disease; glaucoma; retina; neuroscience
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Retinal diseases, including age-related macular degeneration, diabetic retinopathy, retinal vascular occlusions, and retinitis pigmentosa, remain among the leading causes of vision loss worldwide. In recent years, the development of novel therapies has significantly improved the prognosis of these conditions. Anti-VEGF agents and photodynamic therapy have revolutionized the treatment of macular degeneration and retinal vascular occlusions, while advancements in gene therapies, such as MCO-010, have shown promising results in partially restoring visual function in patients with retinitis pigmentosa.

Retinal vascular occlusions, including both venous and arterial thrombosis, are a major cause of sudden vision loss and require innovative therapeutic approaches. Recent research has explored the role of intravitreal therapies and neuroprotection in improving visual outcomes for these patients.

Additionally, emerging strategies such as optogenetics, retinal implants, and neuroprotective treatments are expanding the available therapeutic options, offering new hope to patients with advanced retinal diseases. In this context, visual rehabilitation and low-vision aids play a crucial role in optimizing the quality of life of affected individuals.

This Special Issue aims to bring together innovative research on the diagnosis, treatment, and rehabilitation of retinal diseases, providing an updated perspective on the latest clinical and scientific advancements in this rapidly evolving field.

Dr. Francisco J. Povedano-Montero
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • retinal diseases
  • macular degeneration
  • maculopathies
  • diabetic retinopathy
  • retinal vascular occlusions
  • retinitis pigmentosa

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Published Papers (1 paper)

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Research

13 pages, 234 KiB  
Article
Patient-Reported Social Impact of Molecularly Confirmed Retinitis Pigmentosa
by Nina Zehe-Lindau, Birgit Lindau, Heidi Stöhr, Bernhard H. F. Weber, Georg Spital and Ulrich Kellner
J. Clin. Med. 2025, 14(9), 3229; https://doi.org/10.3390/jcm14093229 - 6 May 2025
Viewed by 263
Abstract
Objectives: To evaluate the patient-reported impact of retinitis pigmentosa (RP) in a large patient cohort to identify relevant disease-related disadvantages as key aspects for the improvement of ophthalmic and social care. Methods: Consecutive patients with molecularly confirmed RP older than 18 [...] Read more.
Objectives: To evaluate the patient-reported impact of retinitis pigmentosa (RP) in a large patient cohort to identify relevant disease-related disadvantages as key aspects for the improvement of ophthalmic and social care. Methods: Consecutive patients with molecularly confirmed RP older than 18 years of age were identified in two tertiary care centers in Germany. Patients were contacted to participate in an anonymized patient query regarding the impact of RP on their vocational training, professional career, and social, familial, and personal life, as well as their experience with ophthalmologic care. Results: Out of 241 contacted patients, 162 responded (67.2%; 52.5% female, 67.3% younger than 50 years of age). While the impact of RP on vocational training was limited, professional careers were frequently disrupted with early retirement rates of 39.8% (≥40 years of age) to 50% (≥50 years of age). Most respondents felt restricted in their participation in public life (66.3%). One-fifth complained about financial restrictions; however, one-third of this number did not obtain financial help. A negative impact on familial life (21.4%) was less frequently reported compared to personal impairments, especially anxiety (74.5%) and depression (24.2%). Most respondents considered their ophthalmic care as adequate; however, a delayed diagnosis (≥two years: 28.6%) and initial misdiagnosis (24.0%) were frequent. Insufficient psychological support was the major complaint about professional care. Conclusions: RP affects the lives of patients in multiple aspects. Ophthalmic and social care providers should focus on the acceleration of the diagnostic process, as well as easy access to financial assistance and psychological support, as key areas for improvement. Improvements in these areas are expected to reduce challenges for patients. They should have an impact on rehabilitation, participation in public life, and quality of life. Full article
(This article belongs to the Special Issue Innovations in the Clinical Management of Retinal Diseases: Emerging Therapies and Visual Rehabilitation)
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