Therapies for Heart Failure: Clinical Updates and Perspectives

Dear Colleagues,

Although the symptoms of heart failure (HF) have been recognized for decades, there is still disagreement among researchers regarding its clinical presentation and optimal therapeutic strategies. As societies evolve, the signs and symptoms of HF are also adapting, showing considerable variation across populations depending on race, ethnicity, cultural background, lifestyle, and the presence of comorbidities such as cancer or diabetes mellitus.

Clinical manifestations, along with associated comorbidities, significantly influence the progression of HF, compelling clinicians to tailor treatment plans and explore novel therapeutic avenues.

A recent breakthrough in HF management has been the development of new oral glucose-lowering agents, particularly sodium–glucose cotransporter-2 inhibitors (SGLT2i). This drug class has become a cornerstone of HF therapy, with ongoing research continually revealing additional benefits. At every major cardiology conference, innovative diagnostic techniques, clinical strategies for symptom relief, and a spectrum of treatment options—from new pharmacological agents to minimally invasive device implants and advanced cardiac surgery—are being presented and discussed.

This Special Issue will be dedicated to advancing our understanding of the etiology and management of HF. We welcome the submission of original research articles and reviews that align with this aim.

Dr. Cristina Tudoran
Dr. Stela Iurciuc
Prof. Dr. Dragos Cozma
Guest Editors

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