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Clinical Advances in the Pharmacotherapy of Diabetes

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 20 June 2026 | Viewed by 470

Special Issue Editors


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Guest Editor
Department of Clinical Pharmacy, School of Pharmacy, University of California San Francisco (UCSF), San Francisco, CA, USA
Interests: clinical pharmacy; pharmacotherapy; diabetes; type 2 diabetes; statins; cholesterol; lipids; atherosclerosis; insulin resistance; glucose metabolism; metabolism; risk prediction; cardiovascular epidemiology

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Guest Editor
Department of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University (WSU), Spokane, WA, USA
Interests: diabetes; diabetic kidney disease; chronic kidney disease; diabetes complications; pharmacotherapy
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Guest Editor Assistant
Department of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University (WSU), Spokane, WA, USA
Interests: clinical pharmacy; pharmacotherapy; diabetes management

Special Issue Information

Dear Colleagues,

Therapies and clinical paradigms for the management of diabetes and diabetes-related complications have evolved dramatically in recent years. Evolving evidence from dedicated cardiovascular and kidney outcome trials has rapidly transformed the standard of care management of type 2 diabetes from a traditional “glucocentric” approach to a contemporary comprehensive approach that prioritizes organ protection and achievement and maintenance of weight management goals. The market has also seen a rapid expansion of newly approved pharmacotherapies and diabetes technologies, offering more options than ever for clinicians to tailor their therapeutic approach to the individualized needs of people living with diabetes. This Special Issue, “Clinical Advances in the Pharmacotherapy of Diabetes,” will be featured in the Journal of Clinical Medicine, with Prof. J. Watanabe, Prof. J. Neumiller, and Prof. C. Frazier as Guest Editors.

In this Special Issue, we focus on recent advances in the treatment and management of diabetes and diabetes-related complications and conditions.

Topics of interest include, but are not limited to, the following:

  • New and emerging therapies for the treatment of type 2 diabetes;
  • Use of therapies and ongoing research on type 1 diabetes delay and prevention;
  • Applied use of diabetes technologies (e.g., CGM, AID) in general and special populations and settings;
  • Novel paradigms and care models to optimize guideline-directed care;
  • Prevention and treatment of diabetes-related complications;
  • Real-world effectiveness and safety;
  • Pharmacoepidemiology and pharmacovigilance studies;
  • Agents for the treatment of diabetes and related conditions in the developmental pipeline (e.g., new and novel insulins, incretin-based therapies);
  • Evaluations of adherence, persistence, discontinuation, and concordant effects on outcomes;
  • Economic and humanistic evaluations of new diabetes treatments.

Based on your publication record and expertise in this field, we would like to invite you to contribute a paper to this Special Issue; we welcome the submission of research articles and reviews.  Original research studies should be appropriately powered for meaningful inference to be concluded. We would additionally appreciate it if you could share this opportunity with any colleagues who may be interested in contributing their work to this Special Issue.

We look forward to receiving your contributions.

Please feel free to reach out with any questions.

Prof. Dr. Jonathan Watanabe
Dr. Joshua J. Neumiller
Guest Editors

Dr. Cheyenne Frazier
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetes
  • microvascular complications
  • macrovascular complications
  • diabetes technology
  • pharmacoepidemiology
  • care delivery
  • novel therapies

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Published Papers (1 paper)

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15 pages, 1766 KB  
Systematic Review
The Effect of Semaglutide on Pancreatic β-Cell Function in Adults with Type 2 Diabetes: A Systematic Review and Meta-Analysis
by Omar Abusedera, Jana Sherif, Malak Smida and Salim Fredericks
J. Clin. Med. 2025, 14(24), 8734; https://doi.org/10.3390/jcm14248734 - 10 Dec 2025
Viewed by 378
Abstract
Background/Objectives: Type 2 diabetes mellitus (T2DM) is characterized by progressive β-cell dysfunction and insulin resistance. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may enhance β-cell function. Semaglutide, a long-acting GLP-1 RA, improves glycemic control and weight, but its direct effects on β-cell function remain [...] Read more.
Background/Objectives: Type 2 diabetes mellitus (T2DM) is characterized by progressive β-cell dysfunction and insulin resistance. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may enhance β-cell function. Semaglutide, a long-acting GLP-1 RA, improves glycemic control and weight, but its direct effects on β-cell function remain uncertain. Methods: This systematic review and meta-analysis followed PRISMA guidelines and was registered in PROSPERO (CRD420251034071). PubMed, Embase, and Scopus were searched through April 2025 for randomized controlled trials evaluating semaglutide’s effects on β-cell function in adults with T2DM. Primary outcomes included HOMA-B, HOMA-IR, and the proinsulin/insulin ratio; secondary outcomes included insulin secretion rate, insulinogenic index, and C-peptide. Two reviewers independently performed data extraction and risk-of-bias assessment using the Cochrane RoB 1 tool. Random-effects models were used for pooling. Certainty of evidence was evaluated using GRADE. Results: Sixteen trials (n = 6591) met inclusion criteria, with nine included in the meta-analysis. Semaglutide improved β-cell function (HOMA-B log ratio of means 1.50, 95% confidence interval [CI]: 1.25–1.80) and reduced insulin resistance (HOMA-IR ratio 0.82, 95% CI: 0.73–0.94) compared with placebo or active comparators. The pooled treatment ratio for proinsulin/insulin was 0.70 (95% CI: 0.63–0.79). However, risk of bias was generally high due to open-label designs, and certainty of evidence for all primary outcomes was rated very low. Conclusions: Semaglutide appears to improve β-cell function and insulin sensitivity in adults with T2DM, but conclusions remain uncertain given the very low certainty of evidence and substantial heterogeneity. High-quality trials with standardized β-cell outcomes are needed to confirm these findings. Full article
(This article belongs to the Special Issue Clinical Advances in the Pharmacotherapy of Diabetes)
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