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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cardiopulmonary Resuscitation—from Research to Clinical Implementation
edited by
submission deadline 31 May 2025 | Viewed by 292 | Submission Open
Keywords: cardiopulmonary resuscitation; cardiac arrest; basic life support; advanced life support; special circumstances; target temperature management; eCPR-ECLS; survival
(This special issue belongs to the Section Emergency Medicine)
The Rebirth of Ventral Skull Base Surgery through Multiportal Approaches: Endonasal, Transorbital, Transmaxillary and Transoral Routes
edited by Matteo de Notaris and Francesco Corrivetti
submission deadline 31 May 2025 | Viewed by 279 | Submission Open
Keywords: skull base surgery; neuroendoscopy; neuroanatomy; multiportal approaches; technical advancements
(This special issue belongs to the Section Clinical Neurology)
Latest Research on Male Infertility submission deadline 31 May 2025 | Viewed by 273 | Submission Open
Keywords: testis; sperm; seminal plasma; spermatogenesis; fertilization; omics; proteomics; oxidative stress; sperm DNA fragmentation; varicocele; male infertility; testicular cancer; infertility management; ART
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Ischemic Stroke: Diagnosis, Treatment, and Management
edited by and Rosario Pascarella
submission deadline 31 May 2025 | Viewed by 260 | Submission Open
Keywords: ischemic stroke; diagnosis; treatment; stroke unit; stroke care; stroke etiology; thrombolysis; EVT; rare causes of stroke; cerebral vein thrombosis
(This special issue belongs to the Section Clinical Neurology)
Oral and Maxillofacial Surgery: Diagnosis, Management and Future Opportunities
edited by
submission deadline 31 May 2025 | Viewed by 257 | Submission Open
Keywords: head and neck oncology; free flaps; oral surgery; malformative surgery; traumatology; endoscopy; preprosthetic surgery; reconstructive surgery; vascular malformations; osteonecrosis
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Endometriosis: Current Insights and Treatments
edited by Mercedes Espada Vaquero
submission deadline 31 May 2025 | Viewed by 253 | Submission Open
Keywords: endometriosis; chronic pelvic pain; pelvic floor dysfunction; hormonal treatment; gynecological surgery; diagnosis; hysteroscopy; infertility
(This special issue belongs to the Section Obstetrics & Gynecology)
What’s New in Cardiomyopathies: Diagnosis, Treatment and Management
edited by
submission deadline 31 May 2025 | Viewed by 247 | Submission Open
Keywords: cardiomyopathies; multimodality imaging; cardiac magnetic resonance; genetic testing; cardiogenetics; genetic cardiovascular disease; rare cardiovascular diseases
(This special issue belongs to the Section Cardiology)
Targeted Diagnosis and Treatment of Maladaptive Developmental Trajectories and Psychopathological Manifestations in Children and Adolescents
edited by , Andrea Baroncelli and Valeria Giostra
submission deadline 31 May 2025 | Viewed by 245 | Submission Open
Keywords: maladaptive developmental trajectories; developmental psychopathology; predictors and correlates of distress in children and adolescents; new forms of social-emotional difficulties and distress; clinical and social interventions and preventions; cognitive; affective; expressive and social improvement of children and adolescents; conduct problems; evidence-based practices; early interventions
(This special issue belongs to the Section Mental Health)
Advances in Knee Surgery and Musculoskeletal Rehabilitation: 2nd Edition submission deadline 31 May 2025 | Viewed by 233 | Submission Open
Keywords: computer-assisted surgical navigation; smart cutting guides; robotic-assisted surgery; fast-track; telemedicine; tele-rehabilitation; virtual reality
(This special issue belongs to the Section Orthopedics)
Diagnostic and Therapeutic Challenges in Infective Endocarditis
edited by Lorenzo Bertolino
submission deadline 31 May 2025 | Viewed by 231 | Submission Open
Keywords: infective endocarditis; complications; diagnostic challenges; therapeutic approach; epidemiology; clinical correlates
(This special issue belongs to the Section Cardiology)
Rhinosinusitis and Nasal Polyposis: Patophysiology, Diagnosis and Treatment
edited by Gianluca Fadda and Giovanni Cavallo
submission deadline 31 May 2025 | Viewed by 227 | Submission Open
Keywords: chronic rhinosinusitis; nasal polyposis; upper airway disorders; endoscopic sinus surgery; sinonasal imaging
(This special issue belongs to the Section Otolaryngology)
Advances and Future Directions in Percutaneous Coronary Intervention (PCI)
edited by Daniele Giacoppo and Antonio Greco
submission deadline 31 May 2025 | Viewed by 217 | Submission Open
Keywords: drug-eluting stents; drug-coated balloons; bioresorbable vascular scaffolds; antiplatelet therapy; intravascular ultrasound; optical coherence tomography; quantitative flow ratio; complete revascularization
(This special issue belongs to the Section Cardiology)
Clinical Updates on Rheumatoid Arthritis: 2nd Edition
edited by Francesca Bandinelli
submission deadline 31 May 2025 | Viewed by 216 | Submission Open
Keywords: rheumatoid arthritis; rheumatology; treatment; diagnosis; biomarkers; rheumatic disease
(This special issue belongs to the Section Immunology)
Research and Applications in Clinical Pharmacy Based on Pharmacokinetics
edited by
submission deadline 31 May 2025 | Viewed by 209 | Submission Open
Keywords: pharmacokinetics; clinical pharmacy; personalized medicine; drug therapy management; therapeutic drug monitoring
(This special issue belongs to the Section Pharmacology)
Current Advances and Future Perspectives of Laparoscopic Surgery submission deadline 31 May 2025 | Viewed by 208 | Submission Open
Keywords: abdominal surgery; general surgery; emergency laparoscopic surgery; colorectal surgery; advance laparoscopic surgery; hernia surgery; surgical oncology; bariatric surgery; adrenal surgery; mini-invasive surgery
(This special issue belongs to the Section General Surgery)
Advances in Fertility Preservation
edited by Dunja Maria Baston-Büst
submission deadline 31 May 2025 | Viewed by 186 | Submission Open
Keywords: fertility preservation; gonadotoxic treatment; chemotherapy; transgender; cryopreservation; ejaculate; testicular tissue; mature oocytes; immature oocytes; ovarian tissue; ovarian cortex
(This special issue belongs to the Section Obstetrics & Gynecology)
Treatment and Prognosis of Spinal Surgery
edited by Andy Ton and Shane Shahrestani
submission deadline 31 May 2025 | Viewed by 178 | Submission Open
Keywords: spinal surgery; minimally invasive surgery (MIS); robotic-assisted surgery; patient-reported outcomes (PROs); postoper-ative outcomes; predictive analytics; radiographic predictors; endoscopic; disk arthroplasty; single position surgery
(This special issue belongs to the Section Clinical Neurology)
Emerging Treatment Options in Aortic Valve Disease and Aortic Stenosis
edited by Borut Geršak and Robert Phillip Gallegos
submission deadline 31 May 2025 | Viewed by 173 | Submission Open
Keywords: aortic stenosis; minimally invasive surgery; transcatheter aortic valve replacement; surgical treatment; diagnostic strategies; re-operation/redo AVR; calcified root; valve in valve
(This special issue belongs to the Section Cardiology)
New Perspectives of Gastric Cancer: Current Treatment and Management
edited by Mindaugas Kiudelis
submission deadline 31 May 2025 | Viewed by 168 | Submission Open
Keywords: gastric cancer; neoadjuvant chemotherapy; peritoneal metastasis; HIPEC; treatment; management
(This special issue belongs to the Section Oncology)
Revascularization Strategies in Peripheral Artery Disease and Chronic Limb-Threatening Ischemia: Current Standards and Future Perspectives submission deadline 5 Jun 2025 | 2 articles | Viewed by 1919 | Submission Open
Keywords: peripheral arterial disease (PAD); chronic limb-threatening ischemia (CLTI); below the knee; atherosclerosis; endovascular intervention; endovascular therapies; image-guided therapies
(This special issue belongs to the Section Vascular Medicine)
Comprehensive Approaches in Plastic and Reconstructive Surgery
edited by Michael Alfertshofer
submission deadline 7 Jun 2025 | 2 articles | Viewed by 1318 | Submission Open
Keywords: plastic surgery; reconstructive surgery; regenerative medicine; advanced surgical planning; trauma reconstruction; patient-specific solutions; multidisciplinary care
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Technological Advances, Innovative Applications, and New Clinical Benefits of Computed Tomography submission deadline 10 Jun 2025 | 3 articles | Viewed by 5242 | Submission Open
Keywords: computed tomography (CT); spectral CT; dual-energy CT; dual-source spectral CT; dual-layer spectral CT; pho-ton-counting CT; photon-counting detector CT; spectral photon-counting CT; artificial intelligence; radiomics
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Kidney Transplantation and Rehabilitation: Current Updates and Perspectives
edited by Zoltán Sándor
submission deadline 10 Jun 2025 | 2 articles | Viewed by 3275 | Submission Open
Keywords: chronic kidney disease; kidney transplantation; transplant rehabilitation; transplant care; physical therapy; occupational therapy; intervention; recovery; quality of life; aftercare
(This special issue belongs to the Section Nephrology & Urology)
Clinical Updates on Knee and Hip Arthroplasty
edited by Amarildo Smakaj and Elena Gasbarra
submission deadline 10 Jun 2025 | 2 articles | Viewed by 1346 | Submission Open
Keywords: knee arthroplasty; hip arthroplasty; total joint replacement; minimally invasive arthroplasty; implant durability; postoperative rehabilitation; revision arthroplasty; prosthesis-related complications; periprosthetic joint infection; implant loosening
(This special issue belongs to the Section Orthopedics)
New Techniques and Breakthroughs in Head and Neck Surgery
edited by Giuseppe Consorti, Paolo Balercia, and
submission deadline 10 Jun 2025 | 1 articles | Viewed by 1217 | Submission Open
Keywords: head and neck surgery; minimally invasive procedures; robotic-assisted surgery; precision medicine; reconstructive surgery; immunotherapy; emerging therapies; custom- made; virtual surgical plane; oral cancer
(This special issue belongs to the Section General Surgery)
Recent Advances in Inflammatory and Infectious Skin Diseases (Second Edition)
edited by , Astrid Herzum and Paolo Romita
submission deadline 10 Jun 2025 | 2 articles | Viewed by 1102 | Submission Open
Keywords: atopic dermatitis; eczematous diseases; inflammatory skin diseases; chronic skin diseases; human herpesvirus; roseola syphilitica; psoriasis
(This special issue belongs to the Section Dermatology)
Clinical and Surgical Insights on Lung Cancer Treatment
edited by and Marco Schiavon
submission deadline 10 Jun 2025 | 1 articles | Viewed by 449 | Submission Open
Keywords: lung cancer; surgery; minimally invasive surgery; immunotherapy; clinical trials; robotic surgery; diagnosis; multimodal treatment; outcomes; targeted therapy
(This special issue belongs to the Section Respiratory Medicine)
Inflammatory Bowel Disease (IBD): Clinical Diagnosis and Treatment
edited by Moisés Tolentino B. Da Silva and Isabel Silva
submission deadline 12 Jun 2025 | 10 articles | Viewed by 15664 | Submission Open
Keywords: gastrointestinal disorders; intestinal inflammation; intestinal bowel disease; nutrition; physical exercise; cancer; enteric nervous system; vagus nerve
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances, New Technologies and Optimization of Reverse Shoulder Arthroplasty submission deadline 15 Jun 2025 | 10 articles | Viewed by 13161 | Submission Open
Keywords: reverse total shoulder arthroplasty; cuff tear arthropathy; osteoarthritis; proximal humeral fracture sequelae; revision; long-term outcome; implant design; biomechanics
(This special issue belongs to the Section Orthopedics)
Clinical Diagnosis and Surgical Strategies Update on Ear Disorders submission deadline 15 Jun 2025 | 7 articles | Viewed by 9125 | Submission Open
Keywords: middle ear; inner ear; endoscopic ear surgery; cholesteatoma; Meniè re’ s disease; hearing loss; robotic surgery; otosclerosis
(This special issue belongs to the Section Otolaryngology)
Pathogenesis, Diagnosis, and Management of Upper Gastrointestinal Disease
edited by
submission deadline 15 Jun 2025 | 3 articles | Viewed by 5305 | Submission Open
Keywords: esophagus; stomach; duodenum; DGBI; FGIDs; Helicobacter; eosinophilic esophagitis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Research Progress in Osseointegrated Oral Implants submission deadline 15 Jun 2025 | 4 articles | Viewed by 5296 | Submission Open
Keywords: dental implants; peri-implantitis; osseointegration; guided surgery; navigation surgery; robotic surgery; implant surface; implant stability
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
New Advances in Cardiorenal Syndrome: 2nd Edition submission deadline 15 Jun 2025 | 3 articles | Viewed by 5232 | Submission Open
Keywords: cardiorenal syndrome; outcome; hyperkalemia; acute kidney injury; chronic kidney disease; chronic heart failure
(This special issue belongs to the Section Cardiology)
Clinical Advances in Cardiovascular Interventions
edited by
submission deadline 15 Jun 2025 | 5 articles | Viewed by 4525 | Submission Open
Keywords: coronary artery disease; myocardial infarction; cardiovascular imaging; microvascular disease; heart failure; atrial fibrillation; ventricular arrhythmias; cardiac implantable electronic device; valvular heart disease and treatment; peripheral arterial disease
(This special issue belongs to the Section Cardiology)
Physical Activity, Exercise and Health: Clinical Management and Research submission deadline 15 Jun 2025 | 3 articles | Viewed by 2615 | Submission Open
Keywords: physical activity; exercise; exercise physiology; exercise prescription; aging; women’ s health; chronic disease
(This special issue belongs to the Section Epidemiology & Public Health)
Retinal Diseases: Recent Advances in Diagnosis and Treatment
edited by Dario Giorgio and Dario Pasquale Mucciolo
submission deadline 15 Jun 2025 | 2 articles | Viewed by 1836 | Submission Open
Keywords: retinal diseases; retinal degeneration; macular degeneration; OCT; retinal imaging
(This special issue belongs to the Section Ophthalmology)
Evolving Therapies in Metastatic Prostate Cancer
edited by Joseph Renzulli and Soum D. Lokeshwar
submission deadline 15 Jun 2025 | 1 articles | Viewed by 924 | Submission Open
Keywords: prostate cancer; metastatic prostate cancer; metastatic disease; therapies; men’ s health
(This special issue belongs to the Section Oncology)
Multimodal Ophthalmic Imaging and Therapeutic Advances in Retinal Diseases: Real-World Insights and Clinical Outcomes
edited by Stefano Mercuri and Fabrizio Giansanti
submission deadline 15 Jun 2025 | 1 articles | Viewed by 726 | Submission Open
Keywords: surgical retina; medical retina; imaging; multimodal imaging; uveitis; OCT
(This special issue belongs to the Section Ophthalmology)
Clinical Updates on Metabolic and Bariatric Surgery
edited by Maria-Jose Barahona
submission deadline 15 Jun 2025 | Viewed by 206 | Submission Open
Keywords: obesity; bariatric surgery; metabolic surgery; weight loss; obesity treatment; metabolic disorders
(This special issue belongs to the Section General Surgery)
New Advances in Extracorporeal Life Support (ECLS)
edited by Robertas Stasys Samalavičius, and
submission deadline 18 Jun 2025 | 1 articles | Viewed by 1936 | Submission Open
Keywords: extracorporeal life support (ECLS); extracorporeal membrane oxygenation (ECMO); innovations in ECLS; respiratory failure; cardiogenic shock; eCPR
(This special issue belongs to the Section Emergency Medicine)
Management of Dyslipidaemias: Enhancing Lipid Modification to Reduce Cardiovascular Risk
edited by and Etienne Khoury
submission deadline 20 Jun 2025 | 9 articles | Viewed by 22086 | Submission Open
Keywords: cardiovascular disease; dyslipidemia; lipoprotein remnant; emerging lipid-lowering therapies; rare and severe causes of atherogenic lipid disorders; cardiovascular risk-related biomarkers; drug safety and efficacy
(This special issue belongs to the Section Cardiovascular Medicine)
Geriatric Fracture: Current Treatment and Future Options
edited by Detlef Van der Velde and Henk Jan Schuijt
submission deadline 20 Jun 2025 | 7 articles | Viewed by 13248 | Submission Open
Keywords: geriatric trauma; trauma surgery; orthopedic surgery; fractures; frailty; osteoporosis; older adult medicine
(This special issue belongs to the Section Orthopedics)
New Insights into Head and Neck Surgery
edited by
submission deadline 20 Jun 2025 | 8 articles | Viewed by 10734 | Submission Open
Keywords: otorhinolaryngology; head and neck surgery; ear surgery; sinonasal surgery; skull base surgery; salivary gland surgery; thyroid gland surgery; head and neck cancer surgery
(This special issue belongs to the Section General Surgery)
Advancements in Total Joint Arthroplasty: Innovations, Outcomes and Challenges
edited by Hendrik Kohlhof
submission deadline 20 Jun 2025 | 10 articles | Viewed by 10454 | Submission Open
Keywords: knee and hip replacements; joint replacement; biomechanics; revision arthroplasty; orthogeriatrics and perioperative management
(This special issue belongs to the Section Orthopedics)
Update on Prenatal Diagnosis and Maternal Fetal Medicine: 2nd Edition submission deadline 20 Jun 2025 | 5 articles | Viewed by 8530 | Submission Open
Keywords: hemolytic disease; maternofetal medicine; congenital heart disease; fetal therapy; spina bifida
(This special issue belongs to the Section Obstetrics & Gynecology)
Current Challenges and Opportunities in Oto-Rhino-Laryngological Surgery
edited by Leonardo Franz, , Cosimo De Filippis and
submission deadline 20 Jun 2025 | 4 articles | Viewed by 6968 | Submission Open
Keywords: otolaryngology; surgery; otology; skull-base; head and neck; laryngology; rhinology
(This special issue belongs to the Section Otolaryngology)
Advances and Updates in Hand Surgery
edited by Sebastien Durand and Wassim Raffoul
submission deadline 20 Jun 2025 | 5 articles | Viewed by 6634 | Submission Open
Keywords: hand surgery; walant technique; 3D imaging; hand ultrasonography; artificial intelligence
(This special issue belongs to the Section Orthopedics)
New Insights into Suicide and Mental Health Conditions
edited by Cory R. Weissman and Zafiris Daskalakis
submission deadline 20 Jun 2025 | 6 articles | Viewed by 6616 | Submission Open
Keywords: suicide prevention; clinical trial design; pharmacological interventions; brain stimulation; novel interventions
(This special issue belongs to the Section Mental Health)
Latest Developments in Minimally Invasive Spinal Treatment—2nd Edition
edited by
submission deadline 20 Jun 2025 | 5 articles | Viewed by 5078 | Submission Open
Keywords: minimally invasive spine surgery; spinal fusion; discectomy; endoscopic; spinal deformity surgery; robotic spine surgery; neuronavigation
(This special issue belongs to the Section Clinical Neurology)
Surgical Treatment and Postoperative Recovery of Heart and Lung Disease
edited by
submission deadline 20 Jun 2025 | 4 articles | Viewed by 4575 | Submission Open
Keywords: heart and lung disease; complications; frailty; rehabilitation; atrial fibrillation; infections
(This special issue belongs to the Section Cardiovascular Medicine)
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