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JCM
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Clinical Diagnosis and Management of Erectile Dysfunction
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Clinical Diagnosis and Management of Erectile Dysfunction

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Reproductive Medicine & Andrology".

Deadline for manuscript submissions: 15 June 2026 | Viewed by 587

Special Issue Editors

Dr. Maurizio De Rocco Ponce

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Guest Editor
Andrology Department, Fundació Puigvert, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Universitat Autònoma de Barcelona, 08041 Barcelona, Spain
Interests: male sexual dysfunction; male infertility; hypogonadism; diabetes; obesity; endocrinology
Dr. Giuseppe Grande

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Guest Editor
Unit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, Padova, Italy
Interests: reproductive endocrinology; male infertility; andrology; hypogonadism; proteomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Erectile dysfunction (ED) is one of the most prevalent male sexual health disorders worldwide, affecting quality of life, relationships, and overall well-being. Despite the availability of numerous therapeutic options, the optimal management of ED remains a challenge due to its multifactorial etiology. Moreover, advances in diagnostic techniques and the development of novel treatment modalities—from pharmacological agents and regenerative medicine to surgical innovations—have significantly expanded our understanding and management options.

This Special Issue, “Clinical Diagnosis and Management of Erectile Dysfunction”, aims to provide a comprehensive overview of current approaches and emerging trends in the diagnosis and treatment of ED. We welcome submissions of original research articles, clinical studies, and systematic reviews, such as patient stratification, guideline-based management, surgical and minimally invasive interventions, psychosexual therapy, and innovations in regenerative and personalized medicine.

We look forward to receiving your valuable contributions to foster scientific exchange and advance clinical care in this evolving field.

Dr. Maurizio De Rocco Ponce
Dr. Giuseppe Grande
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • erectile dysfunction
  • clinical management
  • cardiovascular disease
  • penile prosthesis
  • personalized medicine
  • hipogonadism

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Published Papers (1 paper)

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Research

16 pages, 763 KB  
Article
Association Between Parameters of Penile Doppler Ultrasound and Cardiovascular Risk in Patients with Erectile Dysfunction: A Single-Center Retrospective Study
by Andrea Graziani, Andrea Delbarba, Matteo Nardin, Nicola Caretta, Pierfrancesco Palego, Giuseppe Grande, Andrea Di Nisio, Carlo Cappelli and Alberto Ferlin
J. Clin. Med. 2026, 15(7), 2722; https://doi.org/10.3390/jcm15072722 - 3 Apr 2026
Viewed by 386
Abstract
Background: Erectile dysfunction (ED) is increasingly recognized as an early manifestation of systemic vascular disease and might represent a window for cardiovascular risk assessment. Dynamic penile colour Doppler ultrasound (PCDU) provides quantitative arterial and venous parameters that could reflect subclinical vascular impairment. [...] Read more.
Background: Erectile dysfunction (ED) is increasingly recognized as an early manifestation of systemic vascular disease and might represent a window for cardiovascular risk assessment. Dynamic penile colour Doppler ultrasound (PCDU) provides quantitative arterial and venous parameters that could reflect subclinical vascular impairment. We investigated the association between PCDU parameters and estimated cardiovascular risk in men with ED. Methods: In this single-center retrospective observational study, 275 men undergoing PCDU for ED were evaluated. Clinical characteristics, biochemical data, and QRISK3 10-year cardiovascular risk scores were collected. Mean peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistive index (RI) were analyzed. Correlation analyses, logistic regression using a QRISK3 ≥ 10% threshold, linear regression models, age-stratified analyses, and receiver operating characteristic (ROC) curve analyses were performed. Results: Patients with impaired PSV (<35 cm/s) were older and exhibited higher QRISK3 scores and a greater prevalence of diabetes mellitus and previous cardiovascular events. Mean PSV was inversely correlated with QRISK3 (r = −0.203, p < 0.01) and was associated with higher cardiovascular risk categories in unadjusted logistic regression (β = −0.016, p = 0.048), but not after adjustment for age and diabetes mellitus. ROC analysis showed modest discrimination of increased cardiovascular risk (AUC = 0.60). The addition of PSV to a model including age and diabetes resulted in minimal improvement in discrimination (AUC 0.966 vs. 0.968). Age-stratified analysis demonstrated a significant association between lower PSV and higher cardiovascular risk only in patients ≤60 years. A progressive increase in QRISK3 was observed according to the number of abnormal Doppler parameters (p = 0.013). Conclusions: PCDU parameters reflect the overall cardiovascular risk burden in men with ED. Although not independent predictors beyond traditional risk factors, penile Doppler abnormalities might identify a vascular phenotype associated with higher estimated cardiovascular risk, particularly in younger individuals. These findings support the role of comprehensive vascular assessment in selected patients with ED. Full article
(This article belongs to the Special Issue Clinical Diagnosis and Management of Erectile Dysfunction)
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