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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Colorectal Cancer: Clinical Practices and Challenges

edited by Muhammad Aziz

submission deadline 20 Jun 2025 | 3 articles | Viewed by 4514 | Submission Open

Keywords: colon cancer; rectal cancer; colonoscopy; diagnosis; management; prevention; innovation; technology; artificial intelligence

(This special issue belongs to the Section Oncology)

New Horizons in Cardiac Surgery: Current Concepts and Innovative Thoughts

edited by Prakash P. Punjabi and Gianluca Lucchese

submission deadline 20 Jun 2025 | 2 articles | Viewed by 3878 | Submission Open

Keywords: minimally invasive; hybrid cardiac surgery; stem cells; mechanical assist device; valve repair

(This special issue belongs to the Section Cardiology)

Advances in Leveraging Big Data for Improving Patient Outcomes in Gastrointestinal and Hepatopancreatobiliary Diseases

edited by Saurabh Chawla

submission deadline 20 Jun 2025 | 2 articles | Viewed by 3768 | Submission Open

Keywords: big data; machine learning; artificial intelligence; gastroenterology; research; hepatopancreatobiliary

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Substance and Behavioral Addictions: Prevention and Diagnosis

edited by

Icro Maremmani

submission deadline 20 Jun 2025 | 2 articles | Viewed by 3560 | Submission Open

Keywords: substance addiction; behavioural addiction; clinical perspectives; prevention strategies; diagnostic protocols; differential diagnosis; psychopathology of addiction; psychopathology as a diagnostic tool; craving behavioural covariates

(This special issue belongs to the Section Mental Health)

New Advances in Extracorporeal Membrane Oxygenation (ECMO)

edited by Camilla L'Acqua

submission deadline 20 Jun 2025 | 4 articles | Viewed by 3493 | Submission Open

Keywords: ECMO; anticoagulation; circuit; global collaboration

(This special issue belongs to the Section Emergency Medicine)

Robotic Bariatric Surgery

edited by

Antonio Vitiello

and Vincenzo Pilone

submission deadline 20 Jun 2025 | 2 articles | Viewed by 2740 | Submission Open

Keywords: bariatric surgery; metabolic surgery; sleeve gastrectomy; bariatrics; general surgery; gastric bypass; robotic surgery; robotics

(This special issue belongs to the Section General Surgery)

New Insights in Ophthalmic Surgery

edited by Irina S. Barequet

submission deadline 20 Jun 2025 | 4 articles | Viewed by 2425 | Submission Open

Keywords: cataract surgery; corneal surgery; refractive surgery; ocular surface reconstruction; anterior segment surgery

(This special issue belongs to the Section Ophthalmology)

Patient Reported Outcomes (PROs) in Inflammatory Bowel Disease (IBD) Around the World

edited by Irina Blumenstein

submission deadline 20 Jun 2025 | 2 articles | Viewed by 2282 | Submission Open

Keywords: inflammatory bowel disease; patient reported outcomes; symptom burden; quality of life; treatment satisfaction

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in Pituitary Adenomas

edited by Brigita Glebauskienė,

Alvita Vilkevičiūtė

and

Rasa Liutkevičienė

submission deadline 20 Jun 2025 | 2 articles | Viewed by 1627 | Submission Open

Keywords: pituitary adenoma; biomarkers; visual functions; recurrence; invasiveness; diagnosis and treatment; clinical insights; development

(This special issue belongs to the Section Clinical Neurology)

Diagnosis and Treatment of Kidney Stones

edited by

Takaaki Inoue

submission deadline 20 Jun 2025 | 2 articles | Viewed by 1466 | Submission Open

Keywords: kidney stones; ureteroscopy; percutaneous nephrolithotomy; novel endourological technology; endourological basic reserch; imaging study of kidney stones; management of complications

(This special issue belongs to the Section Nephrology & Urology)

Cardiovascular Imaging: Opportunities and Challenges in Clinical Application: 3rd Edition

edited by

Kana Fujikura

and Panagiota Christia

submission deadline 20 Jun 2025 | 2 articles | Viewed by 1435 | Submission Open

Keywords: echocardiography; cardiovascular magnetic resonance imaging; cardiovascular computed tomography imaging; nuclear cardiology imaging; stress test with imaging; multimodality cardiovascular imaging; cardiomyopathy; coronary artery disease; microvascular disease; valvular heart disease

(This special issue belongs to the Section Cardiology)

Clinical Management of Burns: Past, Present and Future

edited by Lior Rosenberg

submission deadline 20 Jun 2025 | 1 articles | Viewed by 1407 | Submission Open

Keywords: history of burn care; burn care infection; inflammation; burn wound care and closure; debridement; traditional Chinese burn care; traditional Indian (Ayurveda) burn care; burn mass casualty incidents (BMCIs); surge capacity; burn pain control; pruritus; burn scar treatment

(This special issue belongs to the Section General Surgery)

Latest Advances in Orthodontics

edited by

Giuseppina Laganà

submission deadline 20 Jun 2025 | 1 articles | Viewed by 497 | Submission Open

Keywords: digital treatment planning; clear aligners; skeletal anchorage; OSAS; artificial intelligence

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Influence of the Environment on Ocular Diseases

edited by

Anat Galor

submission deadline 20 Jun 2025 | Viewed by 252 | Submission Open

Keywords: air pollution and eye health; climate change and ocular diseases; UV radiation and eye diseases; urbanization; lifestyle; and ocular health; occupational and environmental exposures; public health perspectives

(This special issue belongs to the Section Ophthalmology)

Advances in Trauma Care and Emergency Medicine

edited by

Lothar Andreas Schwarte

Patrick Schober

and

Georgios F. Giannakopoulos

submission deadline 20 Jun 2025 | Viewed by 197 | Submission Open

Keywords: trauma; trauma care; emergency medicine; pre-hospital; emergency room; intensive care unit

(This special issue belongs to the Section Emergency Medicine)

Innovative Treatment and Management Strategies for Inflammatory Bowel Disease

edited by Syed Adeel Hassan and

Neeraj Kapur

submission deadline 20 Jun 2025 | Viewed by 189 | Submission Open

Keywords: Crohn’ s disease; ulcerative colitis; efficacy; safety; nutrition; surgery; biomarkers

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Challenging the Gold Standard: Minimally Invasive Solutions Aim to Redefine Efficacy and Safety in Benign Prostatic Hyperplasia Treatment

edited by

Rosario Leonardi

and Alessandro Calarco

submission deadline 20 Jun 2025 | Viewed by 172 | Submission Open

Keywords: minimally invasive surgery; BPH; benign prostatic hyperplasia; benign prostatic obstruction; vaporesection; laser

(This special issue belongs to the Section Nephrology & Urology)

Transformative Research in Hydrocephalus: Clinical Advances

edited by Afroditi D. Lalou, Zofia Helena Czosnyka and Marek Czosnyka

submission deadline 20 Jun 2025 | Viewed by 148 | Submission Open

Keywords: cerebrospinal fluid dynamics; CSF shunt; intracranial pressure monitoring; telemetric ICP; hydrocephalus pathophysiology; neuroimaging; paediatric hydrocephalus; adult hydrocephalus; translational neuroscience

(This special issue belongs to the Section Clinical Neurology)

Symptoms and Treatment of Parkinson’s Disease

edited by

Christos Koros

and Nikolaos Papagiannakis

submission deadline 24 Jun 2025 | 4 articles | Viewed by 4817 | Submission Open

Keywords: Parkinson’ s disease; non-motor symptoms; clinical progression; cognitive assessment; genetics; remote monitoring; biomarkers; personalized medicine; device-aided treatments; disease-modifying therapies

(This special issue belongs to the Section Clinical Neurology)

Clinical Treatment and Management of Rheumatic Diseases, Autoinflammatory Diseases, and Autoimmune Disorders

edited by Merav Lidar and

Abdulla Watad

submission deadline 24 Jun 2025 | 2 articles | Viewed by 2252 | Submission Open

Keywords: rheumatic diseases; autoinflammatory diseases; autoimmune disorders; rheumatoid arthritis; diagnosis

(This special issue belongs to the Section Immunology)

Clinical Advances in Minimally Invasive Spinal Treatment

edited by

Akihiko Hiyama

Haruki Funao

and

Masayuki Ishihara

submission deadline 25 Jun 2025 | 9 articles | Viewed by 17424 | Submission Open

Keywords: minimally invasive spine treatment; percutaneous pedicle screw; robotic-guided spine surgery; intraoperative image guidance; lateral position surgery; full endoscopic spine surgery; augmented reality (AR); virtual reality (VR)

(This special issue belongs to the Section Orthopedics)

Cardiac Electrophysiology and Catheter Ablation of Different Arrhythmias

edited by

Hussam Ali

and Antonio Frontera

submission deadline 25 Jun 2025 | 10 articles | Viewed by 14308 | Submission Open

Keywords: cardiac electrophysiology; cardiac arrhythmias; atrial fibrillation; catheter ablation

(This special issue belongs to the Section Cardiology)

Advances in Diagnosis and Treatment of Amyloidosis

edited by Michael Rosenzweig

submission deadline 25 Jun 2025 | 7 articles | Viewed by 11521 | Submission Open

Keywords: amyloidosis; transthyretin (TTR); autologous stem cell transplantation (ASCT); chemotherapy; immunotherapy; cardiomyopathy; nephropathy; neuropathy

(This special issue belongs to the Section Cardiology)

Endocrine Disorders in Children

edited by

Juan Pedro López-Siguero

submission deadline 25 Jun 2025 | 6 articles | Viewed by 8560 | Submission Open

Keywords: endocrinology; pediatrics; hormones; genetics; growth; nutrition; development; adolescence; prevention

(This special issue belongs to the Section Clinical Pediatrics)

Advances in Spine Disease Research

edited by

Sebastian Głowiński

submission deadline 25 Jun 2025 | 7 articles | Viewed by 7421 | Submission Open

Keywords: spine diseases; low back pain; neck back pain; spinal biomechanics; spine deformity

(This special issue belongs to the Section Orthopedics)

Skin Diseases: From Diagnosis to Treatment

edited by

Anna Colagrande

submission deadline 25 Jun 2025 | 4 articles | Viewed by 4704 | Submission Open

Keywords: skin; melanoma; NMSC; CTCL; mesenchymal

(This special issue belongs to the Section Dermatology)

The “Orthogeriatric Fracture Syndrome”—Issues and Perspectives

edited by

Johannes Dominik Bastian

submission deadline 25 Jun 2025 | 4 articles | Viewed by 4511 | Submission Open

Keywords: geriatric trauma; fragility fracture; orthogeriatric; co-management; assessment; integrated care; osteoporosis; sarcopenia; frailty; gait disturbance; fall; rehabilitation; prehabilitation; prevention; ehealth; digitalization

(This special issue belongs to the Section Orthopedics)

Clinical Perspectives on Atrial Fibrillation

edited by Lukasz Kuzma

submission deadline 25 Jun 2025 | 3 articles | Viewed by 4303 | Submission Open

Keywords: atrial fibrillation; structural heart disease; interventional rhythm therapy; cardiac arrhythmia; electrocardiogram

(This special issue belongs to the Section Cardiology)

Thyroid Cancer: Clinical Diagnosis and Treatment

edited by Alfred A. Simental

submission deadline 25 Jun 2025 | 4 articles | Viewed by 3700 | Submission Open

Keywords: thyroid nodule; thyroid ultrasound; radiofrequency ablation; molecular analysis; thyroid surgery

(This special issue belongs to the Section Oncology)

Sports Injury: Clinical Prevention and Treatment

edited by

Carlos Lago-Fuentes

, Susana Pulgar and

Nuno Leite

submission deadline 25 Jun 2025 | 3 articles | Viewed by 3443 | Submission Open

Keywords: injury prevention; team sports; talent identification; biobanding; injury burden; muscle injury; PHV

(This special issue belongs to the Section Sports Medicine)

Emergency Ultrasound: State of the Art and Perspectives

edited by

Yale Tung-Chen

and

Gonzalo Garcia Casasola

submission deadline 25 Jun 2025 | 2 articles | Viewed by 3194 | Submission Open

Keywords: point-of-care ultrasound; emergency ultrasound; focus cardiac ultrasound; lung ultrasound; shock; venous thromboembolic disease; systemic venous congestion; resuscitation; polytrauma

(This special issue belongs to the Section Emergency Medicine)

Neurocritical Care: Clinical Advances and Practice Updates

edited by Ali Seifi

submission deadline 25 Jun 2025 | 4 articles | Viewed by 3001 | Submission Open

Keywords: traumatic brain injury (TBI); intracerebral hemorrhage (ICH); neurocritical care practice; neurocritical care artificial intelligence; medical device and technology innovation in neurocritical care; stroke management; subarachnoid hemorrhage (SAH); status epilepticus

(This special issue belongs to the Section Clinical Neurology)

New Technologies and Translational Approach for an Early Diagnosis of Bipolar Spectrum and Hyperactive and Novelty Seeking Profiles

edited by

Massimo Tusconi

, Serdar Dursun and

Germano Orru

submission deadline 25 Jun 2025 | 3 articles | Viewed by 2772 | Submission Open

Keywords: psychiatry; mental health; bipolar disorders; mood; biomarkers; new technology; BD

(This special issue belongs to the Section Mental Health)

Evidence-Based Clinical Management of Orthopaedic Trauma: 25 Years in Retrospect, and a Forecast of 25 Years to Come

edited by Dirk Stengel and

Paul Alfred Grützner

submission deadline 25 Jun 2025 | 3 articles | Viewed by 2624 | Submission Open

Keywords: evidence-based medicine; orthopaedic surgery; clinical trials; systematic reviews; patient outcomes; multiple trauma; artificial intelligence; injuries

(This special issue belongs to the Section Orthopedics)

Recent Advances in Diagnosis and Treatment of Vestibular Disorders—2nd Edition

edited by

Angel Ramos-Macias

and

Nicolas Perez-Fernandez

submission deadline 25 Jun 2025 | 2 articles | Viewed by 2227 | Submission Open

Keywords: dizziness; vertigo; vestibulo-ocular reflex; Mé niere’ s disease; nystagmus; positional vertigo; vestibular implant

(This special issue belongs to the Section Otolaryngology)

State of the Art in Hand Surgery

edited by Leszek Romanowski and

Piotr Czarnecki

submission deadline 25 Jun 2025 | 2 articles | Viewed by 1957 | Submission Open

Keywords: hand surgery; nerve surgery; state-of-the-art; hand therapy; tendons; thumb arthritis; hand fractures

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Clinical Guidelines in Critical Care Medicine

edited by

Ana Vujaklija Brajković

Andrej Markota

and Daniela Bandic-Pavlovic

submission deadline 25 Jun 2025 | 2 articles | Viewed by 1914 | Submission Open

Keywords: critical illness; immunocompromised host; biomarkers; thrombocytopenia; blood coagulation disorders; multiple trauma; diagnostic imaging

(This special issue belongs to the Section Intensive Care)

State of the Art: Application of Ultrasound Imaging in Tumor Diagnosis

edited by

Alfonso Reginelli

and Anna Russo

submission deadline 25 Jun 2025 | 1 articles | Viewed by 1903 | Submission Open

Keywords: ultrasonography; high-frequency ultrasound; CEUS; renal cell carcinoma; Bi-RADS; Ti-RADS; O-RADS; Li-RADS

(This special issue belongs to the Section Oncology)

Advances in the Prevention, Diagnosis, and Rehabilitation of Sports Injuries

edited by Kevin Laudner

submission deadline 25 Jun 2025 | 1 articles | Viewed by 1697 | Submission Open

Keywords: orthopedics; prevention; rehabilitation; management; sports injuries

(This special issue belongs to the Section Sports Medicine)

Innovations in Maxillofacial Surgery

edited by

Carlos Navarro-Cuéllar

José Luis Cebríán-Carretero

and Ignacio Navarro Cuéllar

submission deadline 25 Jun 2025 | 3 articles | Viewed by 1453 | Submission Open

Keywords: orthognathic surgery; sleep apnea; 3D technologies; regenerative medicine; reconstructive surgery; facial trauma; minimally invasive surgery; oncology

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Perspectives on Acute Coronary Syndrome

edited by

Marius Rus

and

Massimo Mancone

submission deadline 25 Jun 2025 | 2 articles | Viewed by 1339 | Submission Open

Keywords: acute coronary syndrome; ischemic heart disease; multidisciplinary approach; interventional cardiology; new research lines; diagnosis and risk stratification; biomarkers; reperfusion strategies

(This special issue belongs to the Section Cardiovascular Medicine)

Autism Spectrum Disorder: Diagnosis, Treatment, and Management

edited by

Marios Adamou

submission deadline 25 Jun 2025 | 1 articles | Viewed by 956 | Submission Open

Keywords: adult autism (including autism spectrum disorders); neurodevelopmental disorders; clinical diagnostics; digital diagnostics; artificial intelligence; multimodal treatments

(This special issue belongs to the Section Mental Health)

Clinical Advances of Adolescent Idiopathic Scoliosis: Current Status and Prospects

edited by Maria Chiara Maccarone and

Stefano Masiero

submission deadline 25 Jun 2025 | 1 articles | Viewed by 866 | Submission Open

Keywords: adolescent idiopathic scoliosis; treatment; non-invasive therapies; surgery; neurophisiology; imaging; motion analysis; personalized medicine

(This special issue belongs to the Section Orthopedics)

Clinical Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease

edited by Hirsh D. Trivedi

submission deadline 25 Jun 2025 | 1 articles | Viewed by 838 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease; MASLD; non-alcoholic fatty liver disease; NAFLD; liver disease; liver fibrosis; metabolic syndrome

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Microsurgery: Current and Future Challenges

edited by

Matthias Aitzetmüller-Klietz

submission deadline 25 Jun 2025 | 2 articles | Viewed by 815 | Submission Open

Keywords: microsurgery; reconstruction; reconstructive surgery; breast reconstruction; extremity reconstruction

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Novel Advanced Imaging in Cardiology: Current Status and Future Directions

edited by

Moshe Rav-Acha

and

Arik Wolak

submission deadline 25 Jun 2025 | 1 articles | Viewed by 757 | Submission Open

Keywords: cardiac imaging; cardiac magnetic resonance; echocardiography; computed tomography; trans-thoracic echocardiography global longitudinal strain (GLS) analyses; radiomics

(This special issue belongs to the Section Cardiovascular Medicine)

Unruptured Intracranial Aneurysms: From Diagnosis to Treatment

edited by

Stefano Maria Priola

Gianluca Scalia

Giuseppe Emmanuele Umana

and

Vishal K. Chavda

submission deadline 25 Jun 2025 | Viewed by 358 | Submission Open

Keywords: aneurysms; DSA; clipping; coiling; stenting; vasospasm

(This special issue belongs to the Section Clinical Neurology)

Cardiac Electrophysiology: Clinical Advances and Practice Updates—2nd Edition

edited by

Ibrahim Marai

submission deadline 25 Jun 2025 | Viewed by 300 | Submission Open

Keywords: cardiac arrhythmias; cardiac implantable electronic device; catheter ablation; sudden cardiac death; lead extraction; atrial fibrillation; ventricular tachycardia; defibrillator therapy

(This special issue belongs to the Section Cardiology)

Pulmonary Embolism: Clinical Advances and Future Opportunities

edited by James Horowitz

submission deadline 25 Jun 2025 | Viewed by 294 | Submission Open

Keywords: pulmonary embolism; risk stratification; pulmonary embolism response teams; high risk PE; massive PE; intermediate risk PE; sub massive PE; catheter directed thrombolysis; catheter thrombectomy; catheter directed embolectomy; extra corporeal membrane oxygenation

(This special issue belongs to the Section Respiratory Medicine)

Headache: Updates on the Assessment, Diagnosis and Treatment

edited by

Ernesto Anarte-Lazo

and