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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advancing Cancer Research: Molecular Insights, Diagnostic Innovations and Therapeutic Targets

edited by Jue Wang

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3389 | Submission Open

Keywords: cancer; carcinogenesis; molecular pathology; signaling transduction; diagnosis; treatment; prognosis; pathogenesis; precision oncology; biomarker discovery; genomic profiling

(This special issue belongs to the Section Molecular Oncology)

Natural Products and Synthetic Compounds for Drug Development: 3rd Edition

edited by

Guan-Jhong Huang

submission deadline 20 Nov 2025 | 3 articles | Viewed by 3376 | Submission Open

Keywords: reactive oxygen; anti-inflammation; cancer; infectious diseases; liver diseases; lung disease; kidney disease; cardiac disease; neuro disease

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Perspectives in the Diagnosis, Prevention, Treatment, and Vaccination Against Parasitic Diseases

edited by

Bartłomiej Tomasz Ferra

and Anna Lass

submission deadline 20 Nov 2025 | 3 articles | Viewed by 3372 | Submission Open

Keywords: parasitoses; vaccines; diagnostic; epidemiology; prevention; antibodies; cytokines; immune system; treatment; native antigen; recombinant protein; chimeric recombinant protein; multiepitope recombinant protein; pharmaceutical analogues; PCR; molecular techniques

(This special issue belongs to the Section Molecular Microbiology)

Molecular Diagnosis and Latest Treatment for Gastric Cancer

edited by

Petra Hudler

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3299 | Submission Open

Keywords: gastric cancer; biomarkers; genetics; epigenetics; immunotherapy; molecular diagnostics; personalized medicine; predisposition; risk factors

(This special issue belongs to the Section Molecular Oncology)

Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook

edited by Alfredo Cappariello

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3290 | Submission Open

Keywords: mammalian extracellular vesicles; plant-derived extracellular vesicles; bacterial-derived extracellular vesicles; cancer progression; cell migration and invasion; tumor microenvironment; epithelial-to-mesenchymal transition (EMT); drug delivery; diagnostics; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research and Potential Effects of Medicinal Plants

edited by

Guan-Jhong Huang

submission deadline 20 Nov 2025 | 4 articles | Viewed by 3288 | Submission Open

Keywords: medicinal plants; natural products; disease treatment; drug screening; bioassays

(This special issue belongs to the Section Molecular Plant Sciences)

The Effects of Dietary Supplements, Functional Foods and Nutraceuticals in the Immune System

edited by

Kaleta Beata

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3280 | Submission Open

Keywords: dietary supplements; functional foods; immune system; immunomodulation; nutraceuticals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Advances and Perspectives of Lung Disease: 2nd Edition

edited by

Longshuang Huang

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3269 | Submission Open

Keywords: lung disease; inflammation; regeneration; infection; drug discovery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Rheumatoid Arthritis: From Molecular Basis to Therapies

edited by

Gabriella Sármay

submission deadline 20 Nov 2025 | 3 articles | Viewed by 3175 | Submission Open

Keywords: rheumatoid arthritis; autoimmune; intracellular signaling pathways; targeted therapy; inflammation; immunometabolic reprogramming; CD40; CD40 ligand; GM-CSF; PD-1; inhibitors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Plant–Environment Interactions

edited by

Magdalena Pawełkowicz

submission deadline 20 Nov 2025 | 1 articles | Viewed by 3147 | Submission Open

Keywords: vascular biology; floral development; sex expression; fruit development; grafting; source– sink interactions; genetic resources; stress tolerance; molecular breeding; gene regulation; resistance to biotic and abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Genetic Testing in Molecular Pathology and Diagnosis

edited by

Marco Fabiani

submission deadline 20 Nov 2025 | 3 articles | Viewed by 3105 | Submission Open

Keywords: genetic testing; molecular pathology; personalized medicine; genetic diagnostics; disease mechanisms; novel genetic tests; clinical integration; patient management

(This special issue belongs to the Section Molecular Biology)

Pain: From Molecular Basis to Therapy

edited by Samuel J. Lin

submission deadline 20 Nov 2025 | 2 articles | Viewed by 3090 | Submission Open

Keywords: pain mechanisms; molecular signaling; neurotransmitters; ion channels; genetic predisposition; epigenetic regulation; immune– neuron interaction; pharmacological therapy; gene therapy; neuromodulation; regenerative medicine

(This special issue belongs to the Section Molecular Neurobiology)

Targeted Therapies and Molecular Methods in Cancer, 3rd Edition

edited by

Julita Kulbacka

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2975 | Submission Open

Keywords: immunotherapy; radiotherapy; methods using facilitated drug delivery such as electroporation; sonoporation; and magnetic fields; nanotechnology and nanocarriers; gene electrotherapy; intelligent predicting methods with AI

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Burn and Wound Healing

edited by

Alisha R. Oropallo

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2954 | Submission Open

Keywords: burn; wound; molecular mechanisms; cell signaling; growth factors; cytokines; extracellular matrix; angiogenesis; healing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

ABC Transporters: Where Are We 45 Years On? (2nd Edition)

edited by

Anthony M George

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2863 | Submission Open

Keywords: nucleotide-binding cassette; transmembrane binding domain; drug resistance; X-ray and cryo-EM structures; molecular dynamics simulations; ABC transporter

(This special issue belongs to the Section Biochemistry)

Recent Advances in Male Reproductive Physiology, Pathophysiology, and Contraception

edited by Gustavo G. Blanco

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2830 | Submission Open

Keywords: spermatogenesis; spermiogenesis; testis; epididymis; sperm function; sperm motility; sperm capacitation; acrosome reaction; male reproduction; male fertility; male infertility; male contraception

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Design of Artificial Receptors Using Virtual Approaches

edited by Houjin Zhang

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2813 | Submission Open

Keywords: artificial receptors; protein design; computational biology; drug targeting; biosensors; tissue engineering; synthetic biology

(This special issue belongs to the Section Molecular Biophysics)

Advances in Molecular Mechanisms of Kidney Disease: Integrating Renal Tumorigenesis

edited by

Michele Marchioni

and

Luigi Schips

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2737 | Submission Open

Keywords: molecular pathogenesis; renal cell carcinoma; genomic profiling; targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Inflammatory Biomarkers in Ischemic Stroke

edited by Hanna Pawluk and

Renata Kołodziejska

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2737 | Submission Open

Keywords: stroke; brain tissue damage; ischemic stroke; inflammatory markers; immune response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Insights into Bone Tissue: Pathologies and Therapeutic Strategies

edited by

Francesca Salamanna

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2698 | Submission Open

Keywords: bone tissue; pathologies; regenerative medicine; biomechanics; diagnostics; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Multi-Omics Analysis and Application of Plant Natural Products (2nd Edition)

edited by

Qiang Zhang

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2688 | Submission Open

Keywords: omics; plant components; bioactivity; signaling; pathway; target; mechanism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Protein Dynamics, Binding and Allostery

edited by

Beatriz Ibarra-Molero

Raquel Godoy-Ruiz

and

Encarnación Medina Carmona

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2682 | Submission Open

Keywords: proteins dynamics; enzyme catalysis; conformational changes; allosteric regulation; signal transduction; neurodegenerative disorders; cancer; computational methods; therapeutic interventions

(This special issue belongs to the Section Biochemistry)

Molecular Research on Sjögren’s Syndrome: From Pathogenesis to Therapy

edited by Alexandru Emil Caraba

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2641 | Submission Open

Keywords: Sjö gren's syndrome; salivary glands; lacrimal glands; T and B cells; macrophage; dendritic cells; salivary gland epithelial cells; inflammatory mediators (cytokines; chemokines; antibodies); intracellular signaling pathways (IFN; TLR; BAFF/BAFF-R; PI3K/Akt/mTOR); atherosclerosis; lymphoma; novel therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research Progress on the Mechanism and Treatment of Cardiomyopathy: Second Edition

edited by

Michael T. Chin

submission deadline 20 Nov 2025 | 3 articles | Viewed by 2638 | Submission Open

Keywords: cardiomyopathy; heart failure; cardiac hypertrophy; dilated cardiomyopathy; restrictive cardiomyopathy; hypertrophic cardiomyopathy; ischemic cardiomyopathy; viral cardiomyopathy; inherited cardiomyopathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Semiconductor Materials

edited by Tarek Hidouri

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2600 | Submission Open

Keywords: optoelectronics; hybrid materials; power devices; III– V materials; advanced characterization; modeling; molecular advances; semiconductors; biophysics

(This special issue belongs to the Section Materials Science)

Tissue Engineering Related Biomaterials: Progress and Challenges

edited by

Mihaela Violeta Ghica

Lacramioara Popa

and Cristina Elena Dinu-Pirvu

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2557 | Submission Open

Keywords: biomaterials; tissue engineering; scaffold materials; regenerative medicine; cell– material interactions; tissue regeneration; bioactive materials; nanotechnology in tissue engineering; electrospinning; 3D printing; biodegradable materials; growth factors

(This special issue belongs to the Section Materials Science)

New Insights in Artificial Intelligence for Drug Design and Target Discovery

edited by

Yanjing Wang

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2534 | Submission Open

Keywords: pre-trained language models; generative models; drug prediction; binding site prediction; peptides; multi-omics; deep learning; QSAR modeling; molecular dynamics (MD) simulations

(This special issue belongs to the Section Molecular Pharmacology)

MicroRNA (miRNA) Technology in Cancer

edited by

Duncan Ayers

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2500 | Submission Open

Keywords: miRNA; microRNA; cancer; oncology; drug delivery; technology; non-coding RNA

(This special issue belongs to the Section Molecular Oncology)

Therapeutic Potential of Antioxidants in the Prevention of Human Diseases, 2nd Edition

edited by

Kota V. Ramana

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2478 | Submission Open

Keywords: antioxidants; vitamins; inflammation; cancer; neurological complications; diabetes; flavonoids; natural compounds; cancer; infections; COVID-19

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biological Hallmarks and Therapeutic Strategies in Cancer

edited by Ramesh Kumar

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2470 | Submission Open

Keywords: hallmarks of cancer; cancer progression; chemotherapy; tumorigenesis; oncogenic signaling

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Nanoparticles in Molecular Biology: Second Edition

edited by

Maciej Monedeiro-Milanowski

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2463 | Submission Open

Keywords: nanoparticles; nanomedicine; biomolecules; nanoparticle– cell interactions; organic– inorganic hybrid; cytotoxic potential

(This special issue belongs to the Section Molecular Nanoscience)

Peptides and Peptidomimetics for Targeting Protein-Protein Interactions

edited by

Giacomo Rossino

and

Pasquale Linciano

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2442 | Submission Open

Keywords: protein– protein interactions; peptide– protein interactions; interactome; proteomics; peptides; modified peptides; peptidomimetics; molecular glues; drug discovery; medicinal chemistry; rule of five; biophysical assays; molecular modelling; cancer; neurodegenerative diseases; orphan diseases; antimicrobial resistance; PROTAC

(This special issue belongs to the Section Biochemistry)

New Cellular and Molecular Insights into Glaucoma

edited by

Meritxell López-Gallardo

and

José A. Fernández-Albarral

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2413 | Submission Open

Keywords: neuroinflammation; microglia; macroglia; retinal ganglion cells; therapeutical approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Synapse Dynamics: From Molecular Mechanisms to Functional Plasticity

edited by

Maria Bykhovskaia

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2347 | Submission Open

Keywords: synaptic plasticiy; neuronal transmitters; molecular dynamics; neuronal networks; dendritic spines; synapse formation; synaptic vesicles; active zones; axonal transport

(This special issue belongs to the Section Molecular Neurobiology)

Phytohormone Signaling and Crosstalk in Regulation of Plant Growth and Environmental Stress Responses: 2nd Edition

edited by

Lam-Son Phan Tran

and Mohammad G. Mostofa

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2340 | Submission Open

Keywords: plant hormones; hormonal crosstalk; signal transduction; stress signaling; root system architecture; shoot branching; leaf development; phytohormone-responsive factors; transcriptional regulators; gene expression; plant physiology; senescence; plant plasticity; regulatory mechanisms; hormone homeostasis; stress adaptation/acclimatization

(This special issue belongs to the Section Molecular Plant Sciences)

Computational Approaches for Protein Design

edited by Livija Jakaite and

Mahesh Narayan

submission deadline 20 Nov 2025 | 3 articles | Viewed by 2318 | Submission Open

Keywords: computational protein design; molecular structure prediction; deep learning; protein structure and function prediction

(This special issue belongs to the Section Molecular Biophysics)

Effects of Ionizing Radiation in Cancer Radiotherapy: 2nd Edition

edited by

François Chevalier

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2301 | Submission Open

Keywords: non-targeted effects; radiation-induced bystander effect; abscopal effect; genomic instability; low dose effects; radioprotection; circulating biomarkers; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of microRNA in Human Diseases: 3rd Edition

edited by

Andrey Turchinovich

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2282 | Submission Open

Keywords: microRNA (miRNA); non-coding RNAs; human diseases; cancer; fatty liver; cardiovascular diseases; neurological diseases; viral infection

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Computational Design and Therapeutic Applications of Peptide-Based Drugs

edited by

Shayon Bhattacharya

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2282 | Submission Open

Keywords: peptide drug design; in silico drug discovery; peptide– protein interactions; therapeutic peptides

(This special issue belongs to the Section Molecular Biology)

Colorectal Cancer: From Pathophysiology to Novel Therapies

edited by

Fabio Gelsomino

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2251 | Submission Open

Keywords: colorectal cancer; immunotherapy; targeted therapy; biomarkers; multidisciplinary management; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Germ Cell Research

edited by

Sheng-Hsiang Li

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2235 | Submission Open

Keywords: spermatogenesis; sperm capacitation; oogenesis; oocyte maturation; cumulus cells; fertilization; gene expression; biomarkers; exosomes; infertility

(This special issue belongs to the Section Molecular Biology)

Synthesis and Application of Chiral Ligands and Heterocycles in Pharmacological Studies

edited by

István Szatmári

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2214 | Submission Open

Keywords: nonracemic amino acids; enantioselective synthesis; chiral catalysis; enantiopure bioconjugates; electron-rich hydroxyquinoline; indole; β -carboline; bioactive compounds

(This special issue belongs to the Section Molecular Pharmacology)

Progress in New Agents to Treat Breast Cancer

edited by Eileen Brantley

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2176 | Submission Open

Keywords: breast cancer; chemotherapeutic agents; DNA-alkylating drugs; anthracyclines; antimetabolites; taxanes

(This special issue belongs to the Section Molecular Oncology)

The Role of Omics in Cancer Diagnosis and Treatment

edited by Xiaohu Tang

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2169 | Submission Open

Keywords: cancer; heterogeneity; omics; biomarker; therapeutic targets; drug resistance; molecular profile; algorithm

(This special issue belongs to the Section Molecular Oncology)

Whole-Cell System and Synthetic Biology, 2nd Edition

edited by

Jingjing Tian

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2136 | Submission Open

Keywords: synthesis biology; molecular biology; functional nucleic acids; biosensor; CRISPR-Cas; directed evolution; whole-cell system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Breakthroughs in Cardiac Tissue Remodeling: From Mechanisms to Therapeutics

edited by

Antonio Lax

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2112 | Submission Open

Keywords: myocardial infarction; heart failure; adverse remodeling; cardiac fibrosis; cardiomyopathy; cardiotoxicity; ventricular remodeling; cardiac dysfunction; biomarkers; cardiac regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Precision Medicine During Surgery and Postoperative Care

edited by Lukas Andereggen and Markus M. Luedi

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2069 | Submission Open

Keywords: genomics & pharmacogenomics; molecular mechanisms of anesthesia; perioperative biomarkers; perioperative care; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Fruit Tree Physiology, Breeding and Genetic Research

edited by Jiangping Mao

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2039 | Submission Open

Keywords: fruit tree; genetic breeding; fruit tree physiology; gene functional identification

(This special issue belongs to the Section Molecular Plant Sciences)

Sarcomas: From Molecular Insights to Personalized Therapies

edited by

Hye Jin You

submission deadline 20 Nov 2025 | 1 articles | Viewed by 2023 | Submission Open

Keywords: soft tissue sarcoma; biomarkers; molecular mechanisms; experimental models; clinical factors associated with sarcoma development

(This special issue belongs to the Section Molecular Oncology)

Research on Intracellular Signal Transduction Systems

edited by

Takaya Satoh

submission deadline 20 Nov 2025 | 2 articles | Viewed by 2021 | Submission Open

Keywords: signal transduction; receptor; G protein; kinase; second messenger; gene expression; cytoskeleton; human disease

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 1101-1150 on page 23 of 70.

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