Molecular Advances and Views in Triple-Negative Breast Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 336
Special Issue Editor
Interests: breast cancer; hormone receptors; triple negative; HER-2/neu; pregnancy-associated breast cancer; gene mutations
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Triple-negative breast cancer (TNBC) remains one of the most challenging subtypes of breast malignancies, accounting for approximately 15–20% of all breast cancers and disproportionately affecting younger women and certain ethnic groups. Characterized by the absence of estrogen receptor, progesterone receptor, and HER2 amplification, TNBC lacks the benefit of established targeted therapies, such as endocrine or HER2-directed treatment. Historically, cytotoxic chemotherapy has represented the cornerstone of management. However, recent molecular discoveries and translational advances are reshaping the therapeutic landscape.
Advances in genomic and transcriptomic profiling have highlighted the heterogeneity of TNBC. Subclassification into basal-like, mesenchymal, immunomodulatory, and luminal androgen receptor (LAR) subtypes has provided a molecular framework to understand differential biology and therapeutic vulnerabilities. This stratification not only guides biomarker discovery but also paves the way for approaches involving precision medicine.
For this Special Issue, we welcome original research articles and reviews.
Aim: The aim of this editorial is to highlight recent molecular insights into triple-negative breast cancer (TNBC), underscore how these advances are reshaping therapeutic strategies, and provide perspectives on future directions in research and clinical management.
Research areas may include (but are not limited to) the following: emerging therapeutic targets; biomarker development and precision oncology; and future perspectives.
We look forward to receiving your contributions.
Dr. Ioannis Boutas
Guest Editor
Manuscript Submission Information
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Keywords
- breast cancer
- molecular biology
- personalized medicine
- triple-negative breast cancer
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