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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Protein and Protein Interactions
edited by Wu Xu
submission deadline 20 Jan 2026 | 3 articles | Viewed by 5631 | Submission Open
Keywords: protein and protein interactions; ligand and protein interactions; computational method; geometry-based; energy-based; conformational changes; binding site prediction; structural biology; computational biology and bioinformatics
(This special issue belongs to the Section Molecular Biology)
Diagnosis and Monitoring of Kidney Disease: From Biology to Biomarkers submission deadline 20 Jan 2026 | 3 articles | Viewed by 5581 | Submission Open
Keywords: chronic kidney disease (CKD); end-stage renal disease; CKD biomarkers; CKD progression; metabolomics; molecular pathways; biomolecules; CKD anemia; cardiovascular disease risk; CKD-related disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Trends in Experimental Models for Cancer Research submission deadline 20 Jan 2026 | 3 articles | Viewed by 5516 | Submission Open
Keywords: experimental models; cancer research; cell culture; animal models; organoids; computational models
(This special issue belongs to the Section Molecular Oncology)
Biochemical and Molecular Aspects of Bioremediation of Soils with Organic Pollutants by Microorganisms
edited by
submission deadline 20 Jan 2026 | 5 articles | Viewed by 5340 | Submission Open
Keywords: bioremediation; soil pollution; organic pollutants; microorganisms; microbial communities; gene expression; enzyme degradation; molecular tools; indigenous soil microorganisms; contaminated soils
(This special issue belongs to the Section Molecular Microbiology)
Molecular Biomarkers in Cancers: Advances and Challenges, 2nd Edition submission deadline 20 Jan 2026 | 3 articles | Viewed by 5117 | Submission Open
Keywords: cancer; cancer staging; diagnostic tools; novel biomarkers; proteomics; molecular markers; metabolic profiling; prognostic value
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Editorial Board Members’ Collection Series: Cardiovascular Diseases submission deadline 20 Jan 2026 | 3 articles | Viewed by 5101 | Submission Open
Keywords: cardiovascular disease; metabolism; cardiometabolic risk; coronary artery disease; CVD
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Perspective of Precision Medicine Revolutionizing Kidney Disease submission deadline 20 Jan 2026 | 1 articles | Viewed by 4995 | Submission Open
Keywords: personalized medicine; kidney diseases; genomics; biomarkers; therapeutics; proteomics; metabolomics; machine learning
(This special issue belongs to the Section Molecular Informatics)
Recent Advances in Electrochemical-Related Materials
edited by Celia García-Hernandez
submission deadline 20 Jan 2026 | 4 articles | Viewed by 4968 | Submission Open
Keywords: novel electrochemical devices; advanced micro- and nanomaterials for electrochemical applications; batteries; fuel and photoelectrochemical cells; electrochemical sensors and biosensors; new advances in supercapacitors; electrochemical electrolyzers; advanced electrochemical materials for environmental applications
(This special issue belongs to the Section Materials Science)
Renin-Angiotensin System in Health and Diseases
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 4962 | Submission Open
Keywords: coronavirus disease 2019 (COVID-19); SARS-CoV-2; RAAS; spike protein; angiotensin; ACE2; clinical study; basic experiments
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms Involved in Sperm Development, Maturation, and Fertilization (3rd Edition)
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 4877 | Submission Open
Keywords: sperm physiology; seminal plasma; extracellular vesicles; reproduction; spermatogenesis; capacitation; fertility
(This special issue belongs to the Section Molecular Biology)
Molecular Research Landscape of Pulmonary Arterial Hypertension
edited by Cármen Brás-Silva
submission deadline 20 Jan 2026 | 2 articles | Viewed by 4330 | Submission Open
Keywords: pulmonary arterial hypertension; right ventricle; right heart failure; molecular mechanisms; vascular disease; translational research; therapy
(This special issue belongs to the Section Molecular Biology)
Molecular Studies of Natural Compounds and Plant Extracts—3rd Edition
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 4291 | Submission Open
Keywords: bioactive substances; plant chemistry; polysaccharides; flavonoids; alkaloids; saponins; terpenes; phenolic acids; volatile oils; antioxidant/anti-inflammatory/anti-cancer; blood pressure lowering; blood sugar lowering; antibacterial; antiviral; antiallergic
(This special issue belongs to the Section Biochemistry)
Melanin and Other Pigments: Function, Synthesis and Characterization
edited by Koen P. Vercruysse
submission deadline 20 Jan 2026 | 3 articles | Viewed by 4022 | Submission Open
Keywords: melanin; eumelanin; pheomelanin; allomelanin; catechol; indole; phenol
(This special issue belongs to the Section Biochemistry)
New Insights into Satellite DNAs submission deadline 20 Jan 2026 | 2 articles | Viewed by 3894 | Submission Open
Keywords: satellite DNA; satellitome; satellite DNA organization; satellite DNA evolution; satellite DNA origin; satellite DNA transcription; satellite DNA function; satellite DNA regulation; satellite RNA; heterochromatin; centromere; telomere; gene regulation; cancer; biomarkers; epigenetics; next-generation sequencing (NGS); nanopore sequencing; PacBio sequencing
(This special issue belongs to the Section Molecular Biology)
Advanced Electrode and Electrolyte Materials: Molecular Scale Design, Synthesis, Mechanisms and Applications
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 3846 | Submission Open
Keywords: cathode; anode; electrolyte; synthesis; electrochemistry; rechargeable batteries; lithium-ion batteries; all-solid-state lithium metal batteries
(This special issue belongs to the Section Materials Science)
Oxidative Stress in Human Diseases
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 3500 | Submission Open
Keywords: inflammation; oxidative stress; free radicals; proteins; lipids; DNA damage; biomarkers
(This special issue belongs to the Section Biochemistry)
Cell and Molecular Perspectives in Breast Cancer
edited by Seungbaek Lee
submission deadline 20 Jan 2026 | 1 articles | Viewed by 3493 | Submission Open
Keywords: breast cancer; molecular biology; cell biology; biomarker; novel therapeutics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Respiratory Virus Infection
edited by Nikolaos Siafakas
submission deadline 20 Jan 2026 | 3 articles | Viewed by 3317 | Submission Open
Keywords: respiratory virus; diagnosis; surveillance; epidemiology; therapy; vaccination; influenza virus; coronavirus; respiratory syncytial virus; rhinovirus/enterovirus
(This special issue belongs to the Section Molecular Microbiology)
Molecular Research in Bone and Soft Tissue Tumors
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 3254 | Submission Open
Keywords: sarcoma; therapeutic target; metastasis; anticancer agent; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
The Structures, Syntheses of Natural Products, and Their Biological Effects
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 3100 | Submission Open
Keywords: structures of natural products; syntheses; biological effects; biomedical applications
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Neuroinflammation and Cellular Senescence in Brain Aging and Neurodegeneration: From Molecular Mechanisms to Therapeutic Applications
edited by Jordi Olloquequi and M. Emília Juan
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2878 | Submission Open
Keywords: SASP; glial activation; age-related disorders; neurotherapeutics; molecular signaling
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research in Parkinson's Disease
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2704 | Submission Open
Keywords: Parkinson's disease; molecular regulation; genetic mutations; epigenetics; protein aggregation; mitochondrial dysfunction; neuroinflammation; biomarkers
(This special issue belongs to the Section Molecular Neurobiology)
The Role of Artificial Intelligence in Cancer Treatment: Molecular Perspective
edited by Andra Valentina Krauze
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2678 | Submission Open
Keywords: cancer treatment; artificial intelligence; machine learning; precision medicine; molecular insights
(This special issue belongs to the Section Molecular Informatics)
Hematologic Diseases: Molecular Insights and Novel Methods
edited by and Samantha Bruno
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2613 | Submission Open
Keywords: hematologic malignancies; high-throughput technologies; omics data; biomarkers; drug resistance; minimal residual disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Immunologic Perspectives on Mycobacterium tuberculosis Infection submission deadline 20 Jan 2026 | 1 articles | Viewed by 2557 | Submission Open
Keywords: M. tb infection; molecular immunology; HIV; AIDS; pathogenesis; host immune responses; adjunctive therapy; immune-enhancing agents; antimycobacterial compounds; host-directed therapies; pathogenesis; modulation of host immune responses
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanism and Pathogenesis of Cardiac Disease
edited by Yu-Hsun Kao
submission deadline 20 Jan 2026 | 3 articles | Viewed by 2535 | Submission Open
Keywords: cardiac diseases; cardiac metabolidm; epigenetics; ER stress; mitochondrial dysfunction; molecular mechanisms; therapeutic targets  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Multiple Sclerosis: From Molecular Pathology to Novel Therapeutic Approaches submission deadline 20 Jan 2026 | 3 articles | Viewed by 2504 | Submission Open
Keywords: progression-independent relapses (PIRAs); smouldering-associated worsening (SAW); lack of new relapses and of new magnetic resonance imaging activity (NEIDA); slowly expanding lesions (SEL); no evidence of smouldering disease activity (NESDA); neurofilament (NfL); glial fibrillary acidic protein (GFAP); patient-reported outcome (PRO); paramagnetic rim lesions (PRLs); relapse-associated worsening (RAW)
(This special issue belongs to the Section Molecular Neurobiology)
Fat and Obesity: Molecular Mechanisms and Pathogenesis
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2432 | Submission Open
Keywords: obesity; weight gain; adipogenesis; lipolysis; energy balance; hormones; fat oxidation; nutrition; phytomedicine; drug development; cohort studies; genetics and genomics studies
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Novel Insights into Molecular Mechanisms of Pulmonary Pathology
edited by Qiaozhen Liu
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2424 | Submission Open
Keywords: fibrosis; infection; COPD; asthma; IPF; pneumonia; lung cancer; molecular mechanism
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pathophysiology and Treatment of Congenital Neuromuscular Disorders
edited by Johan Lindqvist
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2382 | Submission Open
Keywords: nemaline myopathy; hereditary neuromuscular disorder; genetic mutations; pathogenesis; pathophysiology; therapy; myofilament dysfunction; congenital neuromuscular disorders; congenital muscular dystrophy; spinal muscular atrophy; Duchenne muscular dystrophy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Lipid Peroxidation and Protein Carbonylation in Human Diseases
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2368 | Submission Open
Keywords: free radicals; lipid peroxidation; protein carbonylation; apoptosis; autophagy; ferroptosis; antioxidant enzymes
(This special issue belongs to the Section Biochemistry)
Advances in Clostridial and Related Neurotoxins, 3rd Edition
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 2257 | Submission Open
Keywords: botulinum neurotoxin; BoNT; toxicity; molecular mechanisms; recombinant; derivative; clostridium botulinum
(This special issue belongs to the Section Molecular Toxicology)
Research and Innovations in Green Monomers and Macromolecular Materials submission deadline 20 Jan 2026 | 1 articles | Viewed by 2234 | Submission Open
Keywords: green monomers and macromolecular material for a sustainable future; current barriers and future needs of green macromolecular materials; latest breakthroughs and approaches in molecular sciences; bio-based and/or biodegradable polymers based on natural; renewable; and synthetic polymers; synthesis; design; characterization; and development of innovative; technologically advanced; adaptable; and multifunctional green polymers in chemistry; biology; and medicine; relationships between structure; properties; functions; and performance of green polymers; sustainability; recycling; and environmental issues of green macromolecular materials; commercial applications: concepts; methodologies; and tools; 3D printing for personalized consumer products
(This special issue belongs to the Section Materials Science)
Hemophilia: From Pathophysiology to Novel Therapies
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2208 | Submission Open
Keywords: hemophilia; novel therapy in hemophilia; ultra-long half life clotting factor; clotting factor mimics; coagulation rebalancing agent; gene therapy; pathogenesis of hemophilia; molecular biology of hemophilia
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Latest Research on Plant Genomics and Genome Editing, 2nd Edition
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 2190 | Submission Open
Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Advances in Neurologic and Neurodegenerative Disorders submission deadline 20 Jan 2026 | 2 articles | Viewed by 2158 | Submission Open
Keywords: traumatic brain injury; chronic traumatic encephalopathy; Alzheimer’ s disease; motor neuron disease; amyotrophic lateral sclerosis; neurosignalling; neurodegeneration; brain– gut axis impairment; oxidative stress; chronic inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances and Emerging Trends in Marine Natural Products
edited by Rafael Félix and
submission deadline 20 Jan 2026 | 3 articles | Viewed by 2119 | Submission Open
Keywords: marine natural products; bioprospecting; circular bioeconomy; bioactive compounds; antioxidant; antimicrobial; anti-inflammatory; polymers; peptides; genome mining; enzyme inhibitors; plant priming; green extraction methodologies
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Molecular Research of Cartilage: 2nd Edition
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 1989 | Submission Open
Keywords: articular cartilage; cartilage lesions; tissue engineering; cell therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Protein Networks and Their Signaling submission deadline 20 Jan 2026 | 1 articles | Viewed by 1751 | Submission Open
Keywords: protein-protein interaction; chromatin/nucleosome; signaling; protein structure; drug design
(This special issue belongs to the Section Molecular Biology)
Biomarkers in Cardiovascular Diseases: Diagnosis, Pathology and Treatment submission deadline 20 Jan 2026 | 1 articles | Viewed by 1699 | Submission Open
Keywords: heart failure; myocardial remodeling; ischemic heart disease; myocarditis; cardiomyopathies; prevention; diagnosis; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring New Field in Hydrocolloids Research and Applications
edited by , Cristina Elena Dinu-Pirvu and
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1682 | Submission Open
Keywords: drug delivery systems; controlled-release; targeted delivery; wound healing; tissue engineering; bioadhesive agents; transdermal patches; mucoadhesive hydrogels; ophthalmic preparations; oral disintegrating films; gastroretentive systems; rheology modifiers; textural characteristics; stabilizing agents; encapsulation for protection and stability (drugs; probiotics and bioactive compounds); 3D bioprinting; nutraceutical delivery
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Virus Infection and Infectious Diseases: Unraveling Mechanisms, Innovations and Therapeutic Strategies—Second Edition
edited by Jung-Hyun Lee
submission deadline 20 Jan 2026 | 2 articles | Viewed by 1600 | Submission Open
Keywords: mechanism of virus infection; host immune responses; innovations in diagnostics and surveillance; therapeutic strategies; epidemiology and global health; data science for infectious disease; zoonotic transmission; virus evolution
(This special issue belongs to the Section Molecular Immunology)
The Pathogenesis of Alcohol-Associated Hepatitis and Its Therapies
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1573 | Submission Open
Keywords: alcohol-associted hepatitis; acute kidney injury; hepatic encephalopathy; adaptive immune response; innate immune response; neutrophilia
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Autophagy and Kidney Diseases
edited by Francesco Reggiani
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1563 | Submission Open
Keywords: autophagy; kidney diseases; cellular homeostasis; molecular signaling; autophagy biomarkers; renal homeostasis; autophagy modulators
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Dysregulation of Bone Health–a Matter of Several Culprits
edited by Ana Gomes
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1554 | Submission Open
Keywords: bone metabolism; osteoporosis; osteopenia; low-impact fractures; osteoimmunology; leptin; lung disorders; cancer; renal disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Protein Signal Transduction in the Nucleus
edited by Jaekyung Shim
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1551 | Submission Open
Keywords: inner nuclear membrane protein; protein network; LEM-domain proteins; nuclear lamina; signal transcription; transcriptional regulation
(This special issue belongs to the Section Molecular Biology)
Molecular and Cellular Mechanisms of Skin Diseases (Second Edition)
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 1449 | Submission Open
Keywords: hyperproliferative skin diseases; psoriasis; keratinocyte carcinoma; actinic keratosis; atopic dermatitis; skin inflammation; inflammation-associated skin diseases; epidermal differentiation; epidermal cell metabolism; 3D models; in vivo models
(This special issue belongs to the Section Molecular Biology)
Genomics of Human Disease
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1398 | Submission Open
Keywords: genome-wide association study (GWAS); next-generation sequencing (NGS); multi-omics analysis; epidemiology data analysis; precision medicine approaches; disease prediction analysis
(This special issue belongs to the Section Molecular Genetics and Genomics)
Role of HLA (Human Leucocyte Antigen) in Human Diseases submission deadline 20 Jan 2026 | 1 articles | Viewed by 1389 | Submission Open
Keywords: HLA (human leukocyte antigen); molecular immunology; autoimmune diseases; HLA genetics; antigen presentation; HLA and cancer; immunotherapy and HLA; immune responses; immunity and HLA; infectious diseases and HLA; innate and adaptive immunity; organ transplantation and HLA; HLA and immune responses; HLA genotypes and susceptibility; autoimmunity and HLA; HLA and infectious diseases; HLA and personalized therapies; molecular mechanisms of HLA; HLA mutations; experimental models of HLA; HLA and inflammation; HLA biomarkers; HLA and immunosuppression; immune tolerance and HLA; immune evasion by HLA
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring the Complex Interplay Between Metabolic Diseases, MASLD, and Liver Cancer submission deadline 20 Jan 2026 | 2 articles | Viewed by 1364 | Submission Open
Keywords: hepatocellular carcinoma; MASLD; MASH; obesity; insulin resistance; dyslipidemia; liver cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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