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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of Biotic and Abiotic Stress Responses in Trees

edited by

Chenghao Li

submission deadline 20 Jun 2026 | Viewed by 155 | Submission Open

Keywords: drought stress; nutrient deficiency; salinity stress; pathogen defense; transcriptional regulation; epigenetic modifications; signal transduction; bioinformatics & multi-omics analysis; breeding for stress resilience

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Mechanobiology of Regeneration

edited by

Christopher Robinson

and Timothy R. Deer

submission deadline 20 Jun 2026 | Viewed by 149 | Submission Open

Keywords: mechanotransduction; regeneration; stem cells; extracellular matrix; tissue repair

(This special issue belongs to the Section Molecular Biophysics)

New Perspectives in Protein Structure

edited by

Csaba Magyar

submission deadline 20 Jun 2026 | Viewed by 142 | Submission Open

Keywords: stability of protein complexes structural; background of protein function; allosteric regulation of proteins; fuzzy complexes; intrinsically disordered proteins; liquid-liquid phase separation; mutual synergistic folding; protein folding; protein structure; protein-protein interactions; transmembrane proteins

(This special issue belongs to the Section Molecular Biophysics)

Recent Advances in Computer-Aided Drug Design

edited by

Cleber Melo-Filho

submission deadline 20 Jun 2026 | Viewed by 127 | Submission Open

Keywords: computer-aided drug design (CADD); quantitative structure-activity/property relationship (QSAR/QSPR); cheminformatics; virtual screening; data curation; in silico; molecular docking; machine learning; deep learning

(This special issue belongs to the Section Molecular Pharmacology)

Gene Regulation in Endocrine Disease, 2nd Edition

edited by

Alberto Falchetti

submission deadline 20 Jun 2026 | Viewed by 125 | Submission Open

Keywords: gene regulation; endocrine disease; endocrinology; diabetes mellitus; thyroid disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Machine Learning Approaches in Drug Molecule Design

edited by

Bing Niu

submission deadline 20 Jun 2026 | Viewed by 123 | Submission Open

Keywords: machine learning; drug design; deep learning; virtual screening; QSAR; molecular property prediction; de novo drug design; pharmacokinetics; computational chemistry; drug discovery

(This special issue belongs to the Section Molecular Informatics)

Wired for Change: Neurotransmitter Plasticity and Circuit Dynamics in Health and Disease

edited by Alessandra Porcu

submission deadline 20 Jun 2026 | Viewed by 113 | Submission Open

Keywords: neurotransmitter; behavioral neuroscience; neuropsychiatric disorders; neurological disorders; neuroplasticity; neuronal circuit

(This special issue belongs to the Section Molecular Neurobiology)

Deciphering the Molecular Mechanisms That Regulate Plant Disease and Immunity

edited by Bourlaye Fofana and

Champa Wijekoon

submission deadline 20 Jun 2026 | Viewed by 75 | Submission Open

Keywords: plants; biotic stressors; molecular mechanisms; omics technologies; plant immunity

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research in Pregnancy-Related Complications

edited by Kallirhoe Kalinderi

submission deadline 25 Jun 2026 | Viewed by 202 | Submission Open

Keywords: preeclampsia; gestetional diabetes mellitus; pregnancy; complications; gene; molecular; pathways; biomarkers; diagnosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Colorectal Cancer: A Molecular Genetics Perspective (2nd Edition)

edited by

Ehsan Gharib

submission deadline 25 Jun 2026 | Viewed by 75 | Submission Open

Keywords: colorectal cancer; chromosomal and microsatellite instability; CpG island methylator phenotype; molecular characteristics; early diagnosis; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functions and Applications of Natural Products: 2nd Edition

edited by

Seung-Hong Lee

submission deadline 25 Jun 2026 | Viewed by 66 | Submission Open

Keywords: natural products; biomedicine/phytomedicine; biologically active extracts and compounds; pharmacological and toxicological mechanisms of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mitochondrial Function in Human Health and Disease: 3rd Edition

edited by

Yumay Chen

submission deadline 25 Jun 2026 | Viewed by 64 | Submission Open

Keywords: mitochondial genesis and disease; mitochondrial function and aging; mitochondrial dysfunction and cancer; mitochondrial function and apoptosis; mitophage; autophage; mitochondrial AKT

(This special issue belongs to the Section Biochemistry)

Molecular Progression of Gut Microbiota—2nd Edition

edited by

Emina Pustijanac

submission deadline 25 Jun 2026 | Viewed by 55 | Submission Open

Keywords: gut microbiota; microbiome; differences in gut microflora; molecular techniques; gut microbiota’ s role and composition; healthy state; dysbiosis

(This special issue belongs to the Section Molecular Microbiology)

Current Research on Cancer Biology and Therapeutics: Fourth Edition

edited by

Rafael Coveñas Rodríguez

submission deadline 29 Jun 2026 | 3 articles | Viewed by 889 | Submission Open

Keywords: cancer and anticancer peptides; substance P/neurokinin-1 receptor system; neurokinin-1 receptor antagonists

(This special issue belongs to the Section Molecular Oncology)

Pathogenesis and Antiviral Treatment of Emerging and Reemerging Viral Infections

edited by

Luciana Barros de Arruda

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2610 | Submission Open

Keywords: viral replication; antiviral; inflammation; vaccine; arbovirus; respiratory virus; hemorrhagic virus; neurotropic virus

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oxidative Stress Unveiled: Mechanisms and Implications in Cardiac Pathologies

edited by Sukkum Ngullie Chang and Vernat Exil

submission deadline 30 Jun 2026 | Viewed by 418 | Submission Open

Keywords: reactive oxygen species (ROS); electron transport chain (ETC); mitochondrial permeability transition pore (mPTP); endothelial– cardiomyocyte– fibroblast crosstalk; metabolic adaptation; inflammation; cardiovascular disease (CVD)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomaterials and Nanotechnology in Cancer Therapy and Regenerative Medicine

edited by Manoochehr Rasekh

submission deadline 30 Jun 2026 | Viewed by 141 | Submission Open

Keywords: biomaterials; nanoparticle drug delivery; cancer therapy; stimuli-responsive nanocarriers; targeted therapeutics; regenerative medicine; tissue engineering; theranostics

(This special issue belongs to the Section Materials Science)

Unraveling Neurodevelopmental Disorders: A Molecular Perspective

edited by Marija-Magdalena Petrinovic

submission deadline 30 Jun 2026 | Viewed by 80 | Submission Open

Keywords: neurodevelopmental disorders; molecular neuroscience; genetics; epigenetics; functional MRI (fMRI); magnetic resonance spectroscopy (MRS); PET imaging; imaging biomarkers; translational neuroscience; precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Discoveries in Pharmacogenetics: From Bench to Bedside

edited by

Kumaraswamy Naidu Chitrala

submission deadline 30 Jun 2026 | Viewed by 73 | Submission Open

Keywords: pharmacogenetics; clincial practice; artficial intelligence; bioinformatics; personalized medicine; drug response; genetic variations

(This special issue belongs to the Section Molecular Pharmacology)

Latest Research Progress of Biomaterial Modification

edited by

Manuel José Lis

submission deadline 30 Jun 2026 | Viewed by 61 | Submission Open

Keywords: functionalization of carbohydrates; molecular aggregation; simulation of biopolymers; biopolymeric microcapsules; biopolymeric devices

(This special issue belongs to the Section Materials Science)

Thermogenic Adipocytes and Skeletal Muscle: Novel Molecular Targets for the Treatment of Diabetes and Obesity

edited by

Hiroshi Sakaue

submission deadline 30 Jun 2026 | Viewed by 61 | Submission Open

Keywords: metabolic diseases; obesity; type 2 diabetes; molecular signaling pathway

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

From DNA Damage to Cell Death: Emerging Drug Targets and Therapeutic Opportunities

edited by

Mateusz Kciuk

and Beata Marciniak

submission deadline 30 Jun 2026 | Viewed by 41 | Submission Open

Keywords: apoptosis; cancer therapy; cell death pathways; chemoresistance; DNA damage response (DDR); DNA repair inhibitors; drug discovery; ferroptosis; genomic instability; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Anesthetics and Neurovascular Health: Molecular Pathways

edited by Gabriele Melegari

submission deadline 30 Jun 2026 | Viewed by 32 | Submission Open

Keywords: neurovascular paths; blood– brain barrier (BBB) and anesthesia; neurovascular coupling; perioperative neuroprotection; neuroinflammation; endothelial dysfunction; cerebral autoregulation; cerebral blood flow; perioperative brain health

(This special issue belongs to the Section Molecular Neurobiology)

Recent Trends in Metal-Organic and Covalent Organic Frameworks

edited by

Muhammad Asad

submission deadline 30 Jun 2026 | Viewed by 16 | Submission Open

Keywords: metal– organic frameworks; covalent organic frameworks; porous materials; electrocatalysis; sustainable energy systems; adsorption; supercapacitors

(This special issue belongs to the Section Materials Science)

Leukemia in the Omics Era: From Mechanisms to Therapies

edited by Marco Rossi

submission deadline 30 Jun 2026 | Viewed by 12 | Submission Open

Keywords: FLT3 inhibitors; JAK inhibitors; BTK inhibitors; BCL 2 inhibitors; BTK degraders; menin inhibitors; IDH inibitors

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into the Stability and Degradation of Perovskite Solar Cells

edited by

Amal Bouich

submission deadline 30 Jun 2026 | Viewed by 11 | Submission Open

Keywords: perovskite; thin films; solar cells; PCE; stability; molecular structure evolution (perovskite); perovskite precursor molecular design

(This special issue belongs to the Section Materials Science)

Preparation and Applications of Colloidal Emulsions

edited by

Bakht Ramin Shah

submission deadline 30 Jun 2026 | Viewed by 1 | Submission Open

Keywords: emulsions; fabrication and characterization; applications; encapsulation; delivery systems

(This special issue belongs to the Section Molecular Biology)

Gynaecological Diseases: From Emergence to Translational Medicine

edited by

Pawel Kordowitzki

submission deadline 30 Jun 2026 | Submission Open

Keywords: gynaecological diseases; reproductive biology; endometriosis; ovarian dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Molecular Ecology and Genomic Perspectives

edited by

Peng Zhao

submission deadline 1 Jul 2026 | Viewed by 243 | Submission Open

Keywords: genome assembly and annotaion; genomic structure and function of plants; plant molecular ecology; genome prediction and GWAS; gene-editing technologies; transcriptomics and metabolomics; nuclear and organelle genomics

(This special issue belongs to the Section Molecular Plant Sciences)

Breast Cancer: From Molecular Mechanism to Therapeutic Strategy

edited by

Anna Makuch-Kocka

submission deadline 10 Jul 2026 | Viewed by 15 | Submission Open

Keywords: breast cancer; molecular mechanisms; therapeutic strategies; tumor microenvironment; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Molecular Physiopathological Role of Hypoxia

edited by

Michele Aventaggiato

submission deadline 10 Jul 2026 | Viewed by 11 | Submission Open

Keywords: hypoxia; cell metabolism; inflammation; tumor microenvironment; cancer progression; EMT; chronic inflammation; obesity; inflammatory microenvironment; storage disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism of Circadian Rhythm

edited by Rosângela Vieira de Andrade

submission deadline 20 Jul 2026 | 3 articles | Viewed by 25049 | Submission Open

Keywords: circadian cycle; exercise; aging; clock genes; health

(This special issue belongs to the Section Molecular Biology)

Interplay Between the Human Microbiome and Diseases

edited by

Tihamer Molnar

and

Zoltán Péterfi

submission deadline 20 Jul 2026 | 8 articles | Viewed by 13328 | Submission Open

Keywords: microbiome; metagenome; gastrointestinal tract; skin; seminal fluid; lung; saliva; oral mucosa; conjunctiva; dysbiosis; fecal microbiota transplantation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Research for Legume Genomics, Genetics, and Breeding, 2nd Edition

edited by

Naoufal Lakhssassi

submission deadline 20 Jul 2026 | 5 articles | Viewed by 10228 | Submission Open

Keywords: legumes; genomics; plant breeding; seed composition; gene function; biotic and abiotic stress; legume pathogen resistance/mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Bone Metabolism and Bone Diseases

edited by

Giacomina Brunetti

submission deadline 20 Jul 2026 | 3 articles | Viewed by 4135 | Submission Open

Keywords: bone metabolism; bone diseases; osteoclast; osteoblasts and osteocytes; bone remodelling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Addiction

edited by

Aleksandra Suchanecka

and

Jolanta Chmielowiec

submission deadline 20 Jul 2026 | 2 articles | Viewed by 2532 | Submission Open

Keywords: addiction; dependence; neurobiology; reward; neuroplasticity; biostatistics

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Molecular Biology on Mycobacteria: 2nd Edition

edited by

Rita Macedo

submission deadline 20 Jul 2026 | 2 articles | Viewed by 2301 | Submission Open

Keywords: genus Mycobacterium; non-tuberculous mycobacteria; Mycobacterium tuberculosis; Mycobacterium leprae; molecular diagnosis; molecular surveillance methodologies; molecular resistance prediction

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Sjögren's Syndrome, 4th Edition

edited by

Biji Theyilamannil Kurien

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1701 | Submission Open

Keywords: autoimmunity; sjö gren’ s syndrome; autoantibodies; salivary gland; lacrimal gland; dry eyes/mouth

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Nanotechnology in Drug Delivery

edited by

Omar Mertins

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1084 | Submission Open

Keywords: smart nanoparticles; hybrid nanomaterial; functionalization; drug targeting; liposome; cubosome; polypeptide; polymers; biomolecules; cancer; vaccine; antimicrobial; antiparasite; antioxidant; immunomodulatory; genetic therapy; nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Nanoparticle-Based Biosensors and Their Applications

edited by

Edyta Proniewicz

submission deadline 20 Jul 2026 | 1 articles | Viewed by 959 | Submission Open

Keywords: biosensors; metal nanoparticles (MNPs); synthesis methods; molecular spectroscopy characteristics; molecular medicine; molecular biology

(This special issue belongs to the Section Molecular Nanoscience)

Insights into the Pathogenesis, Molecular Landscape and Therapeutics of Triple-Negative Breast Cancer

edited by Rebecca Chin

submission deadline 20 Jul 2026 | 1 articles | Viewed by 622 | Submission Open

Keywords: breast cancer; cancer stemness; therapeutic resistance; brain metastasis; epigenetic mechanisms; chromatin remodeling; multi-omics approaches; high-throughput screening; patient-derived organoids

(This special issue belongs to the Section Molecular Oncology)

Neuronal Differentiation: From Pathology to Therapeutic Strategies

edited by

Marzia Lecchi

submission deadline 20 Jul 2026 | Viewed by 342 | Submission Open

Keywords: neuronal differentiation; molecular mechanisms of neurodifferentiation; neurodegenerative diseases; ischemic stroke; spinal cord and brain injury; neural tissue recovery; regeneration therapy; stem cells

(This special issue belongs to the Section Molecular Neurobiology)

G Protein-Coupled Receptors: Signaling, Regulation and Therapeutic Opportunities, 2nd Edition

edited by

Joanna Filipowska

submission deadline 20 Jul 2026 | Viewed by 177 | Submission Open

Keywords: GPCR; cell signaling; small-molecule drugs; biased signaling; endosomal signaling; post-translational modification; GPCR internalization; phosphorylation barcode

(This special issue belongs to the Section Molecular Pharmacology)

Recent Molecular Research on Photocatalytic Applications

edited by Hassan Ait Ahsaine

submission deadline 20 Jul 2026 | Viewed by 128 | Submission Open

Keywords: photocatalysis; photocatalytic degradation; molecular catalysts; photocatalysts; functional materials

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Natural Product-Inspired Anticancer Drug Development

edited by

Erzsébet Mernyák

submission deadline 20 Jul 2026 | Viewed by 126 | Submission Open

Keywords: anticancer; antiproliferative; cytotoxic; natural product; drug development; semi-synthesis; total synthesis; structure– activity relationship; computational simulation; enzyme inhibition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Chronic Airway Diseases: Molecular Basis and Advanced Therapeutics

edited by

S. Lorraine Martin

submission deadline 20 Jul 2026 | Viewed by 79 | Submission Open

Keywords: chronic airway diseases; asthma; chronic obstructive pulmonary disease (COPD); cystic fibrosis; bronchiectasis; pulmonary fibrosis; airway remodeling; cytokines; inflammation; immune dysregulation; mucociliary clearance; microbiome; epithelial– mesenchymal transition (EMT); molecular mechanisms; biomarkers; proteases; protease inhibitors; precision medicine; targeted therapeutics; RNA-based and gene therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Natural Compounds in the Prevention and Treatment of Human and Veterinary Diseases

edited by

Fabiana Superti

and

Anna Scotto D'Abusco

submission deadline 20 Jul 2026 | Viewed by 38 | Submission Open

Keywords: bioactive natural substances; nutraceuticals; drug discovery; drug resistance; inflammation; antioxidant; health promotion; prevention; treatment; synergistic effect; molecular mechanism; computational analysis; repurposed molecules

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Evolving Landscape of Cardiovascular Pathophysiology

edited by

Pooja Shivshankar

submission deadline 25 Jul 2026 | Viewed by 42 | Submission Open

Keywords: biomarker discovery in cardiovascular pathophysiology; precision diagnostics-novel contrast agents combined with PET/CT; MRI; machine learning/AI and clinical implementations in cardiology; cardio-metabolic disease; inflammation and immunity in cardiovascular diseases; mechanisms of non-coding RNAs and microRNAs in cardiac diseases; translational research in large animals bridging the rodent re-search with human pathophysiology; targeted therapies- genetic therapies/gene editing approach (CRISPR); stem cell therapies; and therapeutic mRNA and siRNA-based approaches

(This special issue belongs to the Section Biochemistry)

Neurobiology Linking Alcohol Addiction to Psychiatry Symptoms

edited by

Jorge Manzanares

and

Francisco Navarrete

submission deadline 30 Jul 2026 | Viewed by 89 | Submission Open

Keywords: alcohol use disorder (AUD); psychiatry; neurobiology; biomarkers; translational

(This special issue belongs to the Section Molecular Neurobiology)

Cancer Drug Resistance and Therapeutic Targets

edited by

Sanjay K. Srivastava

submission deadline 30 Jul 2026 | Viewed by 89 | Submission Open

Keywords: drug resistance; therapeutic targets; efflux transporters’ oncogenic signaling pathways; tumor microenvironment; dna damage/repair; personalized therapies

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 3201-3250 on page 65 of 66.

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