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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Survival of the Fittest: Physiological Adaptations of Insects in Hostile Environments

edited by

Amit Roy

and

Amrita Chakraborty

submission deadline 20 Nov 2025 | Viewed by 398 | Submission Open

Keywords: insect adaptation; temperature tolerance; insect physiology; detoxification; symbiosis and stress tolerance mechanisms

(This special issue belongs to the Section Molecular Biology)

Life’s Thermodynamics: Cells and Evolution

edited by

Alberto Schiraldi

submission deadline 20 Nov 2025 | 1 articles | Viewed by 398 | Submission Open

Keywords: cell growth and decay; cell aging; system biology; mathematical modeling; ecological modeling; dissipative adaptation; maximum power principle; evolution of microbial fitness; energy balance in microbial cultures

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Genetic Testing and Tailored Treatment for Thyroid Disorders: Molecular Basis and New Trends

edited by

Kyoung Sik Park

submission deadline 20 Nov 2025 | Viewed by 390 | Submission Open

Keywords: thyroid diseases; genetics; personalized medicine; novel therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

ABC Transporters: Where Are We 45 Years On? (2nd Edition)

edited by

Anthony M George

submission deadline 20 Nov 2025 | 1 articles | Viewed by 384 | Submission Open

Keywords: nucleotide-binding cassette; transmembrane binding domain; drug resistance; X-ray and cryo-EM structures; molecular dynamics simulations; ABC transporter

(This special issue belongs to the Section Biochemistry)

Molecular, Translational and Clinical Research of Cancer Structural Biomarkers

edited by

Sabine Mai

submission deadline 20 Nov 2025 | Viewed by 361 | Submission Open

Keywords: structural biomarker; extracellular matrix; nuclear organization; discovery research; translational research; clinical research; cancer staging and prognosis; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Synthesis and Application of Chiral Ligands and Heterocycles in Pharmacological Studies

edited by

István Szatmári

submission deadline 20 Nov 2025 | 1 articles | Viewed by 344 | Submission Open

Keywords: nonracemic amino acids; enantioselective synthesis; chiral catalysis; enantiopure bioconjugates; electron-rich hydroxyquinoline; indole; β -carboline; bioactive compounds

(This special issue belongs to the Section Molecular Pharmacology)

New Advances of Free-Radical Reactions in Organic Chemistry

edited by

José Justicia

submission deadline 20 Nov 2025 | Viewed by 344 | Submission Open

Keywords: free-radical reactions; organic chemistry; organic synthesis; fotoredox reactions; organometallics reactions; computational calculations; free radicals in biology; free radicals in green chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Role of Extracellular Vesicles in Diseases

edited by

Gorjana Rackov

and

Aoife Ward Gahlawat

submission deadline 20 Nov 2025 | Viewed by 339 | Submission Open

Keywords: extracellular vesicles (EVs); biomarkers; disease pathophysiology; miRNAs; intercellular communication; therapeutic targets; mitochondrial transfer; cancer; neurodegenerative disorders; precision medicine

(This special issue belongs to the Section Biochemistry)

Chemical and Biotechnological Strategies to Tailor the Properties of Biomaterials

edited by

Eduardo García-Junceda

and

Julia Revuelta

submission deadline 20 Nov 2025 | Viewed by 324 | Submission Open

Keywords: biomaterial functionalization; green chemistry in biomaterials; biotechnological modification; stimuli-responsive materials; translational biomaterials

(This special issue belongs to the Section Materials Science)

Cancer Models: Development and Applications

edited by

Yong Teng

submission deadline 20 Nov 2025 | Viewed by 317 | Submission Open

Keywords: tumor organoids; animal models of cancer; drug screening models; highly clinically relevant cancer models; technologies related to cancer model development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into the Pathogenesis of Type 1 Diabetes

edited by

Alessandra Fierabracci

submission deadline 20 Nov 2025 | Viewed by 312 | Submission Open

Keywords: type 1 diabetes; insulin-dependent diabetes mellitus; human leukocyte antigen (HLA); pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Structure–Activity Relationships Within Pharmaceutical Interactions and the Discovery of Molecular Targets

edited by

Yoshihiro Uesawa

submission deadline 20 Nov 2025 | Viewed by 306 | Submission Open

Keywords: molecular dynamics; docking simulation; QSAR; moleular initiating event

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms, Biomarkers, and Therapeutic Targets for Endometriosis

edited by Katharina Proestling and

Iveta Yotova

submission deadline 20 Nov 2025 | Viewed by 304 | Submission Open

Keywords: endometriosis; biomarkers; inflammation; fibrosis; oxidative stress; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biology and Chemistry of Mycotoxins and Phytotoxins, 3rd Edition

edited by

Makoto Kimura

submission deadline 20 Nov 2025 | Viewed by 295 | Submission Open

Keywords: aflatoxins; trichothecenes; fumonisins; ochratoxins; host-specific toxins; Alternaria toxins; emerging mycotoxins; biosynthesis; gene cluster; transcriptional regulation; toxicity; modification; ecological role

(This special issue belongs to the Section Molecular Toxicology)

ROS Signalling and Cell Turnover

edited by

Micol Silic-Benussi

submission deadline 20 Nov 2025 | Viewed by 289 | Submission Open

Keywords: metabolism; lipid droplets; nanoparticles; ROS; cancer therapy; redox homeostasis; mitochondria; cell death

(This special issue belongs to the Section Biochemistry)

New Perspectives on Prostate Cancer Occurrence, Diagnosis, and Treatment

edited by

Michele Marchioni

and

Luigi Schips

submission deadline 20 Nov 2025 | Viewed by 286 | Submission Open

Keywords: prostate cancer; biomarker; diagnosis; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research in Immunotoxicity and Oxidative Stress

edited by

Soo-Jin Choi

submission deadline 20 Nov 2025 | Viewed by 283 | Submission Open

Keywords: toxicity; macrophage activation; pro-inflammation; anti-inflammation; oxidative stress; foods; food additives; nanomaterials; toxicants; natural compounds

(This special issue belongs to the Section Molecular Toxicology)

Molecular Adaptation Mechanisms of Photosynthesis to Environmental Stress

edited by

Michael Moustakas

submission deadline 20 Nov 2025 | Viewed by 281 | Submission Open

Keywords: photosynthesis; molecular mechanisms; environmental adaptation; climate change; stress physiology; biotic stress; abiotic stress; reactive oxygen species

(This special issue belongs to the Section Molecular Plant Sciences)

Peptide Receptor Radionuclide Therapy (PRRT) and Targeted Alpha Therapy (TAT) in Cancer

edited by

Behrooz H. Yousefi

submission deadline 20 Nov 2025 | Viewed by 271 | Submission Open

Keywords: novel radiopharmaceutical synthesis; translational research; theranostic studies; manufacturing of radiopharmaceuticals; therapy efficacy; personalized dosimetry

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Signaling Pathways in Neuroinflammatory Disorders

edited by

Martina Schmidt

and

Karim Rafie

submission deadline 20 Nov 2025 | Viewed by 269 | Submission Open

Keywords: blood– brain barrier; inducible pluripotent stem cells; organoids; scaffolds; neuroinflammation; microglia; mitochondria; endothelial cells; drug screening; virus infections; cryo-EM

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Placental Pathology

edited by

Mary Wallingford

and Ana Correia-Branco

submission deadline 20 Nov 2025 | Viewed by 254 | Submission Open

Keywords: placenta; trophoblast; implantation; obstetrics; pre-eclampsia; placentation; maternal– fetal interface; pregnancy health; placenta diagnostics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Alcohol Metabolism

edited by Takeshi Haseba

submission deadline 20 Nov 2025 | Viewed by 254 | Submission Open

Keywords: alcohol metabolism; ADH1; ADH3; ADH4; MEOS; catalase; ALDH2; pharmacology and toxicology; ROS; alcohol-related disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Mesenteric Adipose Tissue: The New Player in Health and Disease

edited by Eva Pardina and Jose M. Balibrea

submission deadline 20 Nov 2025 | Viewed by 239 | Submission Open

Keywords: mesenteric adipose tissue; obesity; inflammatory bowel diseases; Chron’ s disease; MASLD; metabolic inflammation; metabolic syndrome; mesenteric resections

(This special issue belongs to the Section Molecular Biology)

Deciphering the Multifaceted Mechanisms of Antimicrobial Peptides

edited by

Xiumin Wang

submission deadline 20 Nov 2025 | Viewed by 229 | Submission Open

Keywords: antimicrobial peptides; antimicrobial activity; mechanisms of action; membrane disruption; inhibition of cellular processes; immune modulation

(This special issue belongs to the Section Macromolecules)

Stem Cell Biology & Regenerative Medicine—2nd Edition

edited by

Rivka Ofir

submission deadline 20 Nov 2025 | Viewed by 220 | Submission Open

Keywords: hiPSC; hES; Crispr; BBB; disease in a dish; neuro-regeneration; pain reliever; scaffold

(This special issue belongs to the Section Molecular Biology)

Nucleic Acid Aptamers in Molecular Medicine

edited by

Silvia Catuogno

submission deadline 20 Nov 2025 | Viewed by 219 | Submission Open

Keywords: aptamers; SELEX; targeted therapy; drug delivery; diagnosis; biomarker discovery

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Performances of Photocatalysis

edited by

Shaojun Yuan

submission deadline 20 Nov 2025 | Viewed by 219 | Submission Open

Keywords: photocatalytic materials; photocatalysis; energy conversion; environmental remediation; carbon dioxide reduction; organic synthesis

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advances in Yeast Engineering and Stress Responses

edited by

Joaquin Ariño

and

Pau Ferrer

submission deadline 20 Nov 2025 | Viewed by 218 | Submission Open

Keywords: stress tolerance; cellular adaptation; nutrient limitation; gene expression; metabolic engineering; synthetic biology; strain robustness; fermentation efficiency; bioprocess optimization

(This special issue belongs to the Section Molecular Microbiology)

Applications of Phytochemicals in Drug Synthesis

edited by

Gregorio Peron

submission deadline 20 Nov 2025 | Viewed by 211 | Submission Open

Keywords: natural products; phytochemistry; chemical synthesis; drugs; medicinal plants; natural sources; byproducts

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Urothelial Cancer: From Translational Medicine to Recent Innovations in Therapeutic Management

edited by Alessio Bruni

submission deadline 20 Nov 2025 | Viewed by 207 | Submission Open

Keywords: urothelial cancer; bladder cancer; radiation therapy; trimodality approach; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Advanced Research in Nanophotonics and Biophotonics

edited by

Prabhakar Pradhan

submission deadline 20 Nov 2025 | Viewed by 204 | Submission Open

Keywords: biophotonics; spectroscopy; light scattering; Raman/FTIR; cancer; Alzheimer's and Parkinson’ s diseases; nanophotonics; plasmonics; nano-biophotonics

(This special issue belongs to the Section Molecular Nanoscience)

Computational Approaches for Protein Design

edited by Livija Jakaite and

Mahesh Narayan

submission deadline 20 Nov 2025 | Viewed by 202 | Submission Open

Keywords: computational protein design; molecular structure prediction; deep learning; protein structure and function prediction

(This special issue belongs to the Section Molecular Biophysics)

Neuroinflammation: From Molecular Mechanisms to Therapy

edited by

Silvia Alboni

and Miriam Ciani

submission deadline 20 Nov 2025 | Viewed by 199 | Submission Open

Keywords: neuroinflammation; neurodegenerative diseases; psychiatric disorders; molecular and cellular targets

(This special issue belongs to the Section Molecular Neurobiology)

Preparations and Applications of Aerogels and/or Cryogels: From a Molecular Perspective

edited by

Angelika Kmita

and

Dorota Lachowicz

submission deadline 20 Nov 2025 | Viewed by 197 | Submission Open

Keywords: inorganic and/or organic aerogels; hybrid materials; eco-friendly materials; diagnosis

(This special issue belongs to the Section Materials Science)

Advanced Research on Cholangiocarcinoma: From Bench to Bedside

edited by

Masaru Katoh

, Simona Tavolari and

Giovanni Brandi

submission deadline 20 Nov 2025 | Viewed by 195 | Submission Open

Keywords: risk factors; next-generation sequencing; actionable targets; FGFR2; BAP1; IDH1; tissular/circulating biomarkers; cancer resistance; immune microenvironment; in vitro and in vivo models; clinical trials

(This special issue belongs to the Section Molecular Oncology)

Molecular Studies on the Impact of Microbiome on Anticancer Drug Resistance

edited by

Francesca Benedetti

and

Davide Zella

submission deadline 20 Nov 2025 | Viewed by 191 | Submission Open

Keywords: microbiome; cancer; anticancer drugs; chemoresistance; immune modulation

(This special issue belongs to the Section Molecular Microbiology)

The Importance of Inflammation as a Link Between Adipokines and Myokines in Obesity

edited by

Maria Greabu

submission deadline 20 Nov 2025 | Viewed by 191 | Submission Open

Keywords: inflammation; adipokines; myokines; obesity; adipose tissue; muscle

(This special issue belongs to the Section Molecular Immunology)

Platelets at the Intersection of Atherosclerosis Processes

edited by

Maria Greabu

submission deadline 20 Nov 2025 | Viewed by 191 | Submission Open

Keywords: platelets; inflammation; atherosclerosis; endothelial cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Protein Post-Translational Modifications in Cancer: Mechanisms and Therapeutic Opportunities

edited by

Mauro Salvi

Wei-Chien Huang

and

Josefa León

submission deadline 20 Nov 2025 | Viewed by 188 | Submission Open

Keywords: phosphorylation; acetylation; methylation; sumoylation; ubiquitination; glycosylation; acylation; signal transduction; inhibitors

(This special issue belongs to the Section Biochemistry)

Natural Product and Enzyme Inhibition for Disease Management

edited by

Viet Phong Nguyen

and

Le Ba Vinh

submission deadline 20 Nov 2025 | Viewed by 186 | Submission Open

Keywords: bioactive compounds; natural sources; enzyme inhibition; drug discovery; cancer; cardiovascular diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanism of Hypertension-Induced Renal Injury

edited by

Ningjun Li

and Guangbi Li

submission deadline 20 Nov 2025 | Viewed by 186 | Submission Open

Keywords: hypertension; renal injury; molecular mechanisms; chronic kidney disease; pharmacological interventions; vascular biology; renoprotection; blood pressure regulation; toxicology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Potential New Antidepressant Drugs

edited by

Marta Jóźwiak-Bębenista

and

Anna Stasiak

submission deadline 20 Nov 2025 | Viewed by 185 | Submission Open

Keywords: antidepressant drug discovery; treatment-resistant depression; neuroinflammation; neuroplasticity; hallucinogens and psychedelics; CNS drug development; molecular targets for depression; neurotransmitter systems (serotonin; norepinephrine; dopamine); preclinical research (in vitro; in vivo; in silico); psychiatric disorders

(This special issue belongs to the Section Molecular Pharmacology)

Mechanism(s) of HFpEF and HFrEF

edited by

Suresh C. Tyagi

submission deadline 20 Nov 2025 | Viewed by 184 | Submission Open

Keywords: HFpEF; HFrEF; diabetes; hypertension; obesity; microbiota; epigenetics; probiotics; postbiotics

(This special issue belongs to the Section Molecular Biology)

Molecular Pathology and Treatment of Heart Failure

edited by

Giuseppe Armentaro

submission deadline 20 Nov 2025 | Viewed by 177 | Submission Open

Keywords: heart failure; oxidative stress; platelet activation; inflammation; biomarkers; pathophysiology; comorbidities

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genomic Research in Carcinogenesis, Cancer Progression and Recurrence

edited by

Magdalena Orzechowska

submission deadline 20 Nov 2025 | Viewed by 176 | Submission Open

Keywords: genomic profiling; carcinogenesis; metastasis; recurrence; precision medicine; tumor evolution metrics; sequencing; tumor markers

(This special issue belongs to the Section Molecular Oncology)

Molecular Science of Anesthesia

edited by Jose Luis Guerrero Orriach and Maria Dolores Carmona-Luque

submission deadline 20 Nov 2025 | Viewed by 171 | Submission Open

Keywords: anesthesia; nervous system; signal; receptor

(This special issue belongs to the Section Molecular Biology)

Glial Cells in Neurodegenerative Disorders

edited by Daniel Souza Monteiro de Araujo

submission deadline 20 Nov 2025 | Viewed by 168 | Submission Open

Keywords: glial cells; microglia; astrocytes; oligodendrocytes; neurodegenerative disorders

(This special issue belongs to the Section Molecular Neurobiology)

Innovations in Photodynamic Therapy: New Horizons in Breast Cancer Care

edited by Sandeep Surendra Panikar

submission deadline 20 Nov 2025 | Viewed by 168 | Submission Open

Keywords: noninvasive therapy; tumor targeting; breast cancer therapy; oncology; photosensitizers; theranostics; precision medicine

(This special issue belongs to the Section Molecular Oncology)

The Role of Amyloid in Neurological Diseases

edited by Silvia Purro

submission deadline 20 Nov 2025 | Viewed by 164 | Submission Open

Keywords: amyloid-beta (Aβ ); tau protein; TDP43; synuclein; huntingtin; prion-like mechanisms; amyloid structures; genetic factors; cell-to-cell transmission; pathogenesis mechanisms; protein aggregation; Biomarkers; CNS amyloid clearance and degradation

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Pathophysiology and Treatment of Coronary Artery Disease

edited by

Kazufumi Nakamura

submission deadline 20 Nov 2025 | Viewed by 159 | Submission Open

Keywords: coronary artery disease; ischemic cardiomyopathy; immune-related adverse events; CAD associated with autoimmune diseases; coronary artery disease-related cardiomyopathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 3201-3250 on page 65 of 70.

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