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Recent Advances in Regenerative and Anti-Aging Medicine
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Recent Advances in Regenerative and Anti-Aging Medicine

A Special Issue of International Journal of Molecular Sciences (ISSN 1422-0067) belonging to the section "Molecular Biology".

Deadline for manuscript submissions: 31 May 2027 | Viewed by 4234

Editor

Prof. Dr. Takayuki Yoshimoto

E-Mail Website
Guest Editor
Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan
Interests: cytokines; antitumor immunity; vaccine; regenerative medicine; mesenchymal stem cells; autoimmune diseases; allergic diseases; inflammatory dieases; sensitization; hapten
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent advances in regenerative and anti-aging medicine are accelerating through cutting-edge technologies like tissue engineering, stem cell therapy, and gene editing. Stem cells, particularly induced pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs), are being used to regenerate damaged tissues and organs. Gene editing tools such as CRISPR-Cas9 enable precise correction of genetic mutations linked to aging and age-related diseases. Extracellular vesicles and secretomes are emerging as promising cell-free therapies to enhance healing and regeneration. Developments in biomaterials, 3D bioprinting, and organoid technology have improved tissue scaffolding and organ repair. Breakthroughs in senolytics, which target and remove senescent cells, offer new strategies to combat aging and chronic inflammation. Ongoing research and clinical trials are crucial to translating these innovations into mainstream medicine. Collectively, these advances are reshaping regenerative and anti-aging strategies, moving closer to extending healthy lifespan and improving overall quality of life.

Prof. Dr. Takayuki Yoshimoto
Guest Editor

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Keywords

  • induced pluripotent stem cells (iPSCs)
  • mesenchymal stem cells (MSCs)
  • platelet-rich plasma (PRP)
  • placenta
  • organoid
  • secretome
  • exosome
  • senolytics
  • nicotinamide mononucleotide (NMN)
  • nicotinamide adenine dinucleotide+ (NAD+)

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Published Papers (2 papers)

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Research

18 pages, 7522 KB  
Article
Protective Effects of a New Human Placental Extract Against Hair Graying and Chemotherapy-Induced Peripheral Neuropathy
by Eri Horio, Yasuhiro Katahira, Natsuki Yamaguchi, Miki Igarashi, Hideaki Hasegawa, Satomi Miyakawa, Shota Toda, Izuru Mizoguchi, Ning Qu, Hiromitsu Anamizu, Shinichiro Ikeda, Hirohiko Matsumoto and Takayuki Yoshimoto
Int. J. Mol. Sci. 2026, 27(10), 4188; https://doi.org/10.3390/ijms27104188 - 8 May 2026
Viewed by 823
Abstract
As stem cell therapy in regenerative medicine becomes more socially accepted, human perinatal tissue is attracting attention as a source because it can be harvested non-invasively. Human placental extracts (HPEs), which are prepared using acid hydrolysis and autoclaving, have been approved for treating [...] Read more.
As stem cell therapy in regenerative medicine becomes more socially accepted, human perinatal tissue is attracting attention as a source because it can be harvested non-invasively. Human placental extracts (HPEs), which are prepared using acid hydrolysis and autoclaving, have been approved for treating menopausal disorders and liver dysfunction. This study investigated a new HPE formulation prepared under milder conditions by omitting acid hydrolysis and autoclaving to improve its effectiveness. The new HPE contains relatively high-molecular-weight proteins, including high levels of thioredoxin-1, as well as primarily extracellular matrix proteins such as thrombospondin-1. These proteins appear to be intact or partially fragmented, but they can still potentially maintain their domain structure. The HPE showed both antioxidant and neurite outgrowth activities in a neuronal cell line SH-SY5Y. In a mouse model of hair graying caused by X-ray irradiation, multiple administration of the HPE significantly reduced it. Additionally, the HPE, but not heat-inactivated HPE, alleviated the mechanical allodynia in a mouse model with chemotherapy-induced peripheral neuropathy. Due to the fact that HPE can be produced non-invasively in large quantities in a short time without the need for culturing, the new HPE may have the potential to be an effective and feasible therapy via multiple mechanisms. Full article
(This article belongs to the Special Issue Recent Advances in Regenerative and Anti-Aging Medicine)
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15 pages, 2830 KB  
Article
mRNA-Lipid Nanoparticle-Mediated Reprogramming and Standard Sendai Virus Reprogramming: Generation of iPSCs and iPSC-Derived Cardiomyocytes
by Marlon DeBose, Jonathan Choi, Dingqian Ding, Anna G. Griggs, Elisa Marie Gollatz, Evan Scislowicz, Adriana Harbuzariu and Ilanit Itzhaki
Int. J. Mol. Sci. 2026, 27(8), 3588; https://doi.org/10.3390/ijms27083588 - 17 Apr 2026
Viewed by 2433
Abstract
For over a decade, non-integrating Sendai virus vectors have been the gold standard for induced pluripotent stem cell (iPSC) reprogramming. However, as the field shifts toward regenerative and precision medicine and large-scale biorepositories, Sendai virus workflow necessitates dedicated viral-clearance testing, specialized manufacturing controls, [...] Read more.
For over a decade, non-integrating Sendai virus vectors have been the gold standard for induced pluripotent stem cell (iPSC) reprogramming. However, as the field shifts toward regenerative and precision medicine and large-scale biorepositories, Sendai virus workflow necessitates dedicated viral-clearance testing, specialized manufacturing controls, and heightened regulatory oversight, leading to increased cost. While mRNA-based reprogramming offers a non-viral alternative, traditional mRNA delivery methods like electroporation are often physiologically disruptive. This study evaluates an mRNA-reprogramming platform that delivers lipid nanoparticles (mRNA-LNPs) via receptor-mediated endocytosis. By utilizing both Sendai virus and mRNA-LNP approaches to reprogram PBMCs from the same donor, we established a genetically identical starting point. Results demonstrate that mRNA-LNP-reprogrammed iPSCs maintain genomic integrity, retain the donor KCNH2 c.2398+5G>T variant, and exhibit characteristic colony morphology, pluripotency markers, and trilineage differentiation capacity consistent with the Sendai-reprogrammed counterparts. The mRNA-LNP-reprogrammed iPSCs differentiate into iPSC-derived cardiomyocytes presenting sarcomeric structures and electrophysiological activity, recapitulating a disease-specific phenotype. Notably, the mRNA-LNP workflow reached these milestones in significantly fewer passages than the Sendai virus workflow, markedly shortening timelines and reducing costs. These findings highlight mRNA-LNP reprogramming as a potentially attractive and effective, virus-independent platform to support future regenerative and precision medicine initiatives and scalable biobanking. Full article
(This article belongs to the Special Issue Recent Advances in Regenerative and Anti-Aging Medicine)
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