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Environmental Pollutants Exposure and Toxicity

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 559

Special Issue Editor


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Guest Editor
Department of Applied Genomics and GMO, National Centre of Public Health and Analyses, 15, Ivan Geshov, Blvd, 1431 Sofia, Bulgaria
Interests: toxicology; biochemistry; molecular biology; in vitro methods; health risk assessment

Special Issue Information

Dear Colleagues,

The challenges of modern times are particularly pronounced in our living, urban and working environment. We are exposed to a variety of chemical substances both as a result of human activity and natural sources.

Despite advances regarding the determination of the toxicological characteristics of chemical substances, we are now faced with problems caused by the simultaneous explosion of various pollutants from the environment, even in values at the regulatory limit values. For example, new categories of pollutants, including endocrine disruptors, persistent organic pollutants, microplastics, fine and ultrafine dust particles, etc., have been discovered. In addition, a novel approach employed in toxicological research is the application of alternative in vitro and in silico methods.

We welcome researchers in the field of toxicology and human and environmental safety to submit reviews or original scientific articles to this Special Issue. The scope of this Special Issue includes recent advances in the study of molecular mechanisms with toxic effects, as well as the application of molecular methods for the assessment of safety and the development of new informative biomarkers. We also welcome research in the field of modelling and computational toxicology.

Prof. Dr. Tzveta Georgieva
Guest Editor

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Keywords

  • environmental pollutants exposure assessment
  • molecular methods
  • biomarkers
  • human safety
  • environmental safety

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Published Papers (1 paper)

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Research

16 pages, 2062 KB  
Article
Discovery of Blood-Based Proteins That Mark Benzo[a]pyrene Modulation of Autoimmunity
by Kameron Kennicott, Yilin Nie and Yun Liang
Int. J. Mol. Sci. 2025, 26(20), 10242; https://doi.org/10.3390/ijms262010242 - 21 Oct 2025
Viewed by 91
Abstract
Environmental pollutants are thought to shape our immune landscape and drive the rise in autoimmune disease incidence worldwide. However, the molecular underpinnings of environmental impact on autoimmunity remain elusive and a quantitative measurement for immune dysfunction as a result of environmental exposure is [...] Read more.
Environmental pollutants are thought to shape our immune landscape and drive the rise in autoimmune disease incidence worldwide. However, the molecular underpinnings of environmental impact on autoimmunity remain elusive and a quantitative measurement for immune dysfunction as a result of environmental exposure is yet to be developed. To this end, we have performed a discovery study to identify blood-based, immune-associated proteins regulated by benzo[a]pyrene (BaP) using the autoimmune-prone murine model MRL. We report the upregulation of autoimmune-associated cytokines including IL1a and IFNg by BaP, months before the manifestation of autoimmune phenotypes. Additionally, the increased levels of proteins such as IL16, IL22 and SNCA in male MRL mice upon BaP exposure may be a molecular link to the increased risk in end organ damage in subsets of autoimmune disease patients. Further comparison with the transcriptomic analysis of BaP-stimulated skin and lungs suggests distinct patterns of immune regulation in peripheral organs versus blood. Altogether, our study supports the need for the early detection of BaP-induced immune changes for the prevention and management of autoimmune diseases and provides leads for the future development of these blood-based biomarkers. Full article
(This article belongs to the Special Issue Environmental Pollutants Exposure and Toxicity)
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