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Molecular Genetics and Genomics of Aquatic Crustaceans

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 633

Special Issue Editors


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Guest Editor
State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China
Interests: aquaculture; breeding; molecular
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Key Laboratory of South China Sea Fishery Resources Exploitation and Utilization, Ministry of Agriculture, South China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou 510300, China
Interests: germplasm resource evaluation; breeding; genetic improvement

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Guest Editor
Key Laboratory of East China Sea Fishery Resources Exploitation, Ministry of Agriculture and Rural Affairs, East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China
Interests: aquaculture; genetics; breeding

Special Issue Information

Dear Colleagues,

Genomics and molecular genetics have revolutionized our understanding of biological systems, providing insights into genome structure, function, and evolution and their applications in breeding and biotechnology. In recent years, advances in sequencing technologies and bioinformatics tools have greatly enhanced genomic research, enabling comprehensive studies on genotype–phenotype relationships across diverse species. While significant progress has been made in plant and terrestrial animal genomics, aquatic crustaceans—a highly diverse and ecologically significant group—remain relatively understudied at the genomic level.

This Special Issue, “Molecular Genetics and Genomics of Aquatic Crustaceans”, will highlight recent advancements in genomic research on crustaceans, including crabs, lobsters, shrimp, and other aquatic arthropods. We welcome contributions covering a wide range of topics, such as genome sequencing and assembly, comparative genomics, genome evolution, gene editing (e.g., CRISPR), transcriptomics (RNA-seq), expression profiling, functional genomics, epigenetics, SNP discovery, genome-wide association studies (GWASs), and genomic selection. By showcasing cutting-edge research articles in this field, we hope to foster a deeper understanding of crustacean biology and support applications in aquaculture, conservation, and evolutionary studies.

Prof. Dr. Xianhong Meng
Prof. Dr. Falin Zhou
Prof. Dr. Lingbo Ma
Guest Editors

Manuscript Submission Information

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Keywords

  • genome sequencing
  • epigenomics
  • CRISPR/Cas9 gene editing
  • transcriptomics
  • gene expression profiling
  • genome-wide association studies (GWASs)
  • quantitative trait loci (QTL) mapping
  • genomic selection
  • marker-assisted selection (MAS)
  • molecular markers

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Published Papers (1 paper)

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Research

21 pages, 4068 KB  
Article
Integrin β Regulates the Hepatopancreas Antiviral Innate Immune System by Affecting the Expression of Antimicrobial Peptides in Penaeus vannamei
by Bingbing Yang, Li Zhang, Kun Luo, Sheng Luan, Jie Kong, Qiang Fu, Jiawang Cao, Baolong Chen, Ping Dai, Xupeng Li and Xianhong Meng
Int. J. Mol. Sci. 2025, 26(17), 8478; https://doi.org/10.3390/ijms26178478 - 31 Aug 2025
Viewed by 533
Abstract
Penaeus vannamei aquaculture production accounts for the majority of total shrimp aquaculture output, but it has suffered a severe decline in production and economic losses due to WSSV disease. Therefore, elucidating the relationship between the host immune system and pathogens is crucial for [...] Read more.
Penaeus vannamei aquaculture production accounts for the majority of total shrimp aquaculture output, but it has suffered a severe decline in production and economic losses due to WSSV disease. Therefore, elucidating the relationship between the host immune system and pathogens is crucial for shrimp disease prevention and control. Integrins, as receptor-related molecules, have been shown to participate in various physiological functions, including cell migration, organismal development, and the pathogenesis of multiple diseases. However, the regulatory mechanisms of integrin genes in the shrimp immune system remain unclear. This study reports that integrins may regulate the Toll, IMD, and STAT signaling pathways in P. vannamei by influencing Spätzle, TLR, and Domeless, thereby affecting the shrimp’s innate immune system against diseases. Additionally, integrins can inhibit viral entry and replication. Through RNA interference (RNAi) experiments, it was found that knocking down Pv-Integrin β increases the viral load of white spot syndrome virus (WSSV), making shrimp more susceptible to WSSV and giving rise to increasing mortality. Further research indicates that Pv-Integrin β acts as an upstream recognition receptor in the disease resistance immune pathway, influencing other signaling pathway receptors to regulate the innate immune system. Importantly, knocking down Pv-Integrin β upregulates the expression of antimicrobial peptides such as ALF1 and ALF2, but reduces the expression of Crustin1, Crustin2 and prophenoloxidase. In conclusion, this study reveals that Pv-Integrin β regulates the disease resistance immune signaling pathways by affecting the related receptors. Full article
(This article belongs to the Special Issue Molecular Genetics and Genomics of Aquatic Crustaceans)
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