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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Multiple Sclerosis: The Latest Developments in Immunology and Therapy

edited by

Borros Michael Arneth

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5462 | Submission Open

Keywords: multiple sclerosis; sensory disturbances; movement disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Advances in Plant Abiotic Stress

edited by

Kincső Decsi

submission deadline 30 Nov 2025 | 4 articles | Viewed by 5190 | Submission Open

Keywords: abiotic stress factors; priming effects; defense responses; biochemical pathway analyses; transcriptomics; plant conditioners; next-generation sequencing; genome-wide analyses

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Cardiac Disease

edited by

Daniela Rossin

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4817 | Submission Open

Keywords: innovative cardiac research; multidisciplinary cardiovascular approaches; advances in cardio-vascular diagnosis; novel cardiac therapies; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of NRF2 Pathway in Chronic Diseases

edited by

Ángel Juan García-Yagüe

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3898 | Submission Open

Keywords: chronic diseases; NRF2; oxidative stress; inflammation; neurodegenerative diseases; cardiovascular disease; autoimmune diseases; chronic kidney diseases; liver disease

(This special issue belongs to the Section Biochemistry)

Melatonin: Physiological Effects on Health and Diseases

edited by

Jana Tchekalarova

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3748 | Submission Open

Keywords: hormone melatonin; oxidative stress; sleep; metabolism; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Cardiovascular Diseases: Aging and Other Risk Factors

edited by

Silvia Liskova

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3695 | Submission Open

Keywords: aging; hypertension; endothelium; vascular smooth muscle cells; pulmonary hypertension; atherosclerosis; hyperlipidemia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondrial Biology and Reactive Oxygen Species

edited by

Wieslawa Jarmuszkiewicz

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3632 | Submission Open

Keywords: mitochondrial biology; mitochondrial dysfunction; mitochondrial coenzyme Q; metabolic homeostasis; oxidative stress; reactive oxygen species

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immunophenotyping in Autoimmune Diseases and Cancer, 4th Edition

edited by

Gabor J. Szebeni

and

Attila Balog

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3570 | Submission Open

Keywords: immunophenotyping; immune regulation; multiparameter cytometry; immuno-oncology; anti-tumor immunity; autoimmunity; cancer immunology; protein– protein interactions; structure/function relationships; sulfur amino acids

(This special issue belongs to the Section Molecular Immunology)

Molecular Progression of Genome-Related Diseases: 2nd Edition

edited by

Salvatore Saccone

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3250 | Submission Open

Keywords: next-generation sequencing; genetic diseases; multifactorial diseases; diagnostic tolls; human health

(This special issue belongs to the Section Molecular Genetics and Genomics)

Exploring the Cytoskeleton and Its Regulators: From Structure to Function

edited by

Wan Lee

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3202 | Submission Open

Keywords: cytoskeleton; cytoskeleton-binding protein; cytoskeletal protein; cell signaling; mechanotransduction; cell proliferation; cell migration; cellular motility; cell differentiation; structural biology

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Iron Metabolism, Ferritin and Hepcidin Research: 3rd Edition

edited by

Edina Pandur

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3123 | Submission Open

Keywords: iron; hepcidin; ferroportin; ferritin; regulation; anemia; therapies; cell signaling; inflammation; disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Roles of Phytochemicals and Antioxidants in Colon Cancers

edited by

Nunzio Antonio Cacciola

, Francesca Borrelli and

Paola De Cicco

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2944 | Submission Open

Keywords: colon cancer; colorectal cancer; natural products; drug-resistant; phytochemicals; antioxidants; cellular and molecular mechanisms; anti-cancer activity; prevention; treatments

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Soybean Molecular Breeding

edited by Dong Cao

submission deadline 30 Nov 2025 | 4 articles | Viewed by 2938 | Submission Open

Keywords: soybean; plant architecture; adaptation; yield improvement; molecular breeding; nutritional quality traits; stress tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research in Hematologic Malignancies

edited by

Rachid Lahlil

and

Anne Aries

submission deadline 30 Nov 2025 | 3 articles | Viewed by 2813 | Submission Open

Keywords: therapeutic targets; leukemogenesis; molecular regulation; cancer stem cells; epigenetics; novel biomarkers; non-coding RNA; DNA methylation; chemotherapy and genetic changes; cancer; hematologic malignancies

(This special issue belongs to the Section Molecular Oncology)

Molecular and Cellular Therapeutics for Respiratory Diseases

edited by

Roberto Plebani

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2769 | Submission Open

Keywords: lung diseases; cystic fibrosis; chronic obstructive pulmonary disease; asthma; drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Cages: Design, Synthesis, and Applications

edited by

Vicente Martí-Centelles

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2542 | Submission Open

Keywords: molecular cages; supramolecular chemistry; synthetic chemistry; self-assembly; molecular design; host– guest chemistry; biological applications

(This special issue belongs to the Section Macromolecules)

Translational Oncology: From Molecular Basis to Therapy

edited by

Mario Cioce

and Gatti Veronica

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2540 | Submission Open

Keywords: cancer; therapy resistance; translational oncology; cancer stem cells; immunotherapy; cancer metabolism; OMICS; patient-derived-organoids; drug repositioning; TKI

(This special issue belongs to the Section Molecular Oncology)

Mast Cells in Human Health and Diseases—3rd Edition

edited by

Giovanna Traina

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2416 | Submission Open

Keywords: mast cells; human diseases; pain; cardiovascular diseases; microbiome; food allergy; stress; cancer

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Therapeutic Targeting of Inflammatory Complications

edited by

Kota V. Ramana

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1973 | Submission Open

Keywords: inflammation; oxidative stress; cytokines; autoimmune diseases; infectious diseases; cancer; targeted therapies; molecular pathways; asthma; sepsis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microglia in Neurological Disorders: Potential Therapeutic Targets and Underlying Mechanisms

edited by

Masashi Tanaka

submission deadline 30 Nov 2025 | 3 articles | Viewed by 1905 | Submission Open

Keywords: cerebral amyloid angiopathy; Alzheimer's disease; amyloid-β fibril formation

(This special issue belongs to the Section Molecular Neurobiology)

Impact of Circulatory and Blood Clotting Dysfunctions in Infectious Diseases

edited by

Hsin-Hou Chang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1878 | Submission Open

Keywords: infectious diseases; circulatory dysfunction; coagulation disorders; endothelial activation; platelet aggregation; anticoagulant therapy; diagnostic biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into the Developmental Origins of Health and Disease, 2nd Edition

edited by

Paramjit S. Tappia

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1632 | Submission Open

Keywords: Developmental Origins of Health and Disease (DOHaD); fetal development; maternal nutrition; molecular programming; epigenetic modifications; environmental exposures; genetic factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Study on Organellar Genomes of Vascular Plants

edited by

Monika Szczecińska

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1532 | Submission Open

Keywords: mitochondrial DNA (mtDNA); chloroplast DNA (cpDNA); plant evolution; plant organellar genome; genomics

(This special issue belongs to the Section Molecular Plant Sciences)

Zebrafish Model for Neurological Research

edited by

Mattia Toni

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1525 | Submission Open

Keywords: zebrafish ; Danio rerio ; brain ; nervous system

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Advances in Biomarkers of Central Nervous System Diseases and Disorders

edited by

David Gurwitz

and

Chiara Villa

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1506 | Submission Open

Keywords: RNA biomarkers; CNS disorders; autism spectrum disorder; precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

Latest Insights into Glycobiology

edited by

Csaba Váradi

and

Cheorl-Ho Kim

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1427 | Submission Open

Keywords: glycosylation; biomarkers; separation techniques; mass spectrometry; multivariate data analysis

(This special issue belongs to the Section Molecular Biology)

Oncogenes and Tumor Suppressors: From Basic Science to Therapeutic Applications

edited by

Ariel Fernando Castro

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1274 | Submission Open

Keywords: oncogenes; tumor suppressors; cancer biology; molecular mechanisms; tumor microenvironment; biomarkers; targeted cancer therapy; cancer initiation and progression

(This special issue belongs to the Section Molecular Oncology)

Cellular and Molecular Mechanisms of Blood–Brain Barrier (BBB) Dysfunction and Dementia

edited by Mark Slevin

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1256 | Submission Open

Keywords: blood– brain barrier; Alzheimer’ s disease; endothelial dysfunction; amyloid beta; tau; neuroinflammation; oxidative stress; aging; gut– brain axis; therapeutic strategies

(This special issue belongs to the Section Molecular Neurobiology)

Pancreatic Disease: From Molecular Basis to Novel Therapies—2nd Edition

edited by

Agnieszka B. Bialkowska

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1238 | Submission Open

Keywords: pancreatitis; acinar-to-ductal neoplasia; early pancreatic neoplasia; fibroinflammatory disease; pancreatic cancer; diabetes Mellitus

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Plant Biology and Biotechnology: Focus on Genomics, Bioinformatics and AI

edited by

Yuriy L. Orlov

and

Ming Chen

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1183 | Submission Open

Keywords: gene expression regulation in plants; ncRNA and gene editing in plants; AI applications in plant bioinformatics; molecular mechanisms of stress resistance in plants; ncRNA and gene editing in plants; plant– pathogen interactions; systems biology and ecological networks for agrobiology; next-generation sequencing in plants; modeling of plant cell growth; gene networks and pathway modeling in plants; computer phenotyping of plants

(This special issue belongs to the Section Molecular Informatics)

Dermatology: Advances in Pathophysiology and Therapies (3rd Edition)

edited by

Montserrat Fernández-Guarino

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1177 | Submission Open

Keywords: immunodermatology; cutaneous lymphoma; cutaneous drug reaction; erythroderma; psoriasis; atopic dermatitis; eczematous reactions; cutaneous manifestation of systemic diseases; cutaneous vasculitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Innate Immune System in Renal Diseases

edited by

Takashi Oda

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1155 | Submission Open

Keywords: innate immune system; acquired immunity; complement system; dendritic cells; monocyte/macrophages (Mϕ); polymorphonuclear leukocytes; NK/NKT cells; innate lymphoid cells (ILCs); AKI; CKD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Multifunctional Magnetic Nanoparticles: Synthesis, Properties, and Biomedical Applications

edited by

Krishtappa Manjunatha

submission deadline 30 Nov 2025 | Viewed by 1147 | Submission Open

Keywords: magnetic nanoparticles; molecular functionalization; magnetocaloric materials; drug delivery systems; molecular imaging; magnetic memory; nanocomposites; nanophosphors; environmental remediation; energy storage materials; magnetic biosensing; biofunctional interfaces

(This special issue belongs to the Section Molecular Nanoscience)

Steroids in Human Disease and Health

edited by

Martin Hill

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1127 | Submission Open

Keywords: steroid metabolism; steroids and endocrinopathies; steroids and inflammation; corticosteroids; mineralocorticoids; neuroactive steroids; steroids and neuropsychiatric diseases; steroids and reproduction; steroidomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms of Neurological and Psychiatric Disease, 2nd Edition

edited by

Giuseppina Martella

and Maria Meringolo

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1105 | Submission Open

Keywords: Alzheimer's and Parkinson's diseases; epilepsy; migraine; essential tremors; stroke; depression; anxiety disorders; cognitive impairment

(This special issue belongs to the Section Molecular Neurobiology)

Advancing Molecular Science Through Reproducible qPCR: MIQE Guidelines and Beyond

edited by

Stephen Bustin

submission deadline 30 Nov 2025 | 1 articles | Viewed by 962 | Submission Open

Keywords: MIQE; qPCR; reverse transcription

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Enhancing Stem Cell Grafting in Tissue Regeneration and Repair

edited by

Yuanyuan Zhang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 888 | Submission Open

Keywords: stem cell therapy; tissue regeneration; graft enhancement; molecular mechanisms; engraftment; biomaterials; immunomodulation

(This special issue belongs to the Section Molecular Biology)

The Role of Micro-RNA in Gastrointestinal Cancers—from Molecules to Novel Therapies

edited by

Jacek Baj

submission deadline 30 Nov 2025 | 1 articles | Viewed by 887 | Submission Open

Keywords: micro-RNA; gastrointestinal cancer; gastric cancer; hepatocellular carcinoma; pancreatic cancer; colorectal cancer; neuroendocrine tumor; esophageal cancer; gallbladder cancer; rectal cancer

(This special issue belongs to the Section Molecular Oncology)

Nutrition, Inflammation, and Chronic Kidney Disease

edited by

Denise Mafra

submission deadline 30 Nov 2025 | 1 articles | Viewed by 886 | Submission Open

Keywords: chronic kidney disease; inflammation; nutrients; bioactive compounds

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Modeling: Latest Advances and Applications, 2nd Edition

edited by

Maria Alexandra Mernea

and

Dan Florin Mihǎilescu

submission deadline 30 Nov 2025 | 1 articles | Viewed by 871 | Submission Open

Keywords: molecular modeling; computational chemistry; drug design; material science; biomolecular interactions; algorithmic advances; theoretical chemistry; simulation techniques; predictive modeling; interdisciplinary applications

(This special issue belongs to the Section Molecular Biophysics)

Liver Diseases: From Pathophysiology to Novel Therapeutic Approaches

edited by Clare Selden

submission deadline 30 Nov 2025 | 1 articles | Viewed by 859 | Submission Open

Keywords: liver disease molecular mechanisms treatments for liver disease somatic cell therapy; ATMP medical device molecular approaches; molecular signatures; RNA therapies; “ omics” for liver disease pathobiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Structural Codes of Sphingolipids and Their Involvement in Diseases

edited by

Sandro Sonnino

and

Elena Chiricozzi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 856 | Submission Open

Keywords: sphingolipids; sphingolipid hydrophilic head; sphingolipid hydrophobic tail; sphingolipid signalling; sphingolipid diseases

(This special issue belongs to the Section Biochemistry)

Climate Change Mitigation Strategies in Grapevine Molecular, Biochemical, and Physiological Performance

edited by

Sandra Pereira

submission deadline 30 Nov 2025 | 1 articles | Viewed by 851 | Submission Open

Keywords: grapevine growth; climate change; abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Highlights in Pathophysiology of the Musculoskeletal System, 3rd Edition

edited by

Marta Anna Szychlinska

Rosario Barone

and

Giovanna Calabrese

submission deadline 30 Nov 2025 | 1 articles | Viewed by 850 | Submission Open

Keywords: musculoskeletal; skeletal; tendon; ligament; intervertebral; articular cartilage; osteoarthritis; rheumatoid arthritis; sarcopenia; muscle wasting; osteoporosis; bone necrosis; synovium; pain; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanisms of Resistance to Melanoma Immunotherapy

edited by Marko B. Lens

submission deadline 30 Nov 2025 | 1 articles | Viewed by 839 | Submission Open

Keywords: melanoma; immune checkpoint inhibitors; PD-1

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms Governing Lipid Metabolism in Health and Disease

edited by

Christina E. Kostara

submission deadline 30 Nov 2025 | 1 articles | Viewed by 828 | Submission Open

Keywords: lipidomics; lipid biomarkers; lipid metabolism; cardiovascular disease; cardiometabolic diseases; non-alcoholic fatty liver disease; diabetes; lipoproteins; NMR spectroscopy; mass spectrometry

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hormonal Regulatory Networks in Aging, Cancers, Alzheimer’s Disease, and Therapeutics

edited by

Pulak R. Manna

submission deadline 30 Nov 2025 | 1 articles | Viewed by 805 | Submission Open

Keywords: hormonal imbalance and aging; endocrinology; physiology and pathophysiology; steroidogenesis; sex hormones and neurosteroids; age-related complications and diseases; tumorigenesis; hormone-dependent cancers; neurodegenrative diseases; Alzheimer’ s disease; therapeutics; healthy aging

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Cyclic Nucleotide-Signaling in Cells and Tissues: Molecular, Functional, and Pharmacological Aspects

edited by

Jens Schlossmann

submission deadline 30 Nov 2025 | 1 articles | Viewed by 774 | Submission Open

Keywords: cyclic nucleotide; cNMP; cAMP; cGMP; cCMP; cUMP; cGAMP; signaling proteins; signal transduction pathways; scaffolds; nitric oxide; natriuretic peptides; adenylyl cyclases; guanylyl cyclases; kinases; phosphodiesterases; channels; (patho)physiology; pharmacology

(This special issue belongs to the Section Biochemistry)

Advances in Traits in Animals and Aquatic Species, and Their Improvement Technologies

edited by

Lishi Yang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 774 | Submission Open

Keywords: biotechnology; genetic breeding; stress responses; epigenetics; non-coding RNAs; gene regulation; molecular ecology; animals; aquaculture; development

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms in Mitochondria-Targeted Drug Delivery System

edited by

Maria Manuel Oliveira

and