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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Disruption Strategies for Enhancing Tumor Radiosensitization

edited by

Salomé Pires

submission deadline 31 Jul 2026 | Viewed by 155 | Submission Open

Keywords: radiosensitization; radiobiology; tumor microenvironment; DNA damage response; molecular oncology; ionizing radiation; radioresistance; targeted therapy

(This special issue belongs to the Section Molecular Oncology)

Hemodynamic Stress and Endothelial Dysfunction

edited by Guya Diletta Marconi and Pamela Mozetic

submission deadline 31 Jul 2026 | Viewed by 154 | Submission Open

Keywords: hemodynamic stress; microfluidics; organ-on-a-chip; endothelial dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Smart Hydrogels and Tissue Engineering

edited by Mohammad Hossein Asgardoon

submission deadline 31 Jul 2026 | Viewed by 150 | Submission Open

Keywords: hydrogels; tissue engineering; regenerative medicine; vasculogenesis; angiogenesis; adipose tissue engineering; bone regeneration; wound healing; biomaterials

(This special issue belongs to the Section Materials Science)

Current Research on the Structural Biology of Membrane Proteins

edited by

Izuru Kawamura

submission deadline 31 Jul 2026 | Viewed by 149 | Submission Open

Keywords: NMR; X-ray diffraction; cryo-electron microscopy; membrane protein; structure; dynamics; molecular dynamics simulation; vibrational spectroscopy

(This special issue belongs to the Section Molecular Biophysics)

Pharmacological Mechanisms of Natural Products: Biological Targets and Clinical Perspectives

edited by Damião Pergentino De Sousa

submission deadline 31 Jul 2026 | Viewed by 147 | Submission Open

Keywords: central nervous system; inflammation; cancer; infection; metabolism; essential oils; medicinal plants; alkaloids; flavonoids; natural products

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Biophysical Studies on Lipid Membranes

edited by Wallance Moreira Pazin

submission deadline 31 Jul 2026 | Viewed by 147 | Submission Open

Keywords: membrane biophysics; lipid organization; lipid– protein interactions; molecular dynamics simulations; membrane mechanics; nanoscale transport; model membrane systems; biomolecular interactions; membrane structure and dynamics; molecular-level characterization

(This special issue belongs to the Section Molecular Biophysics)

Cellular Stress, Metabolic Disorders and Cardiovascular Diseases: From Molecular Mechanisms to Integrative Pharmacology

edited by Lizhou Fan

submission deadline 31 Jul 2026 | Viewed by 145 | Submission Open

Keywords: cellular stress; metabolic disorders; cardiovascular diseases; integrative pharmacology; ER stress; multi-omics; systems biology; network pharmacology; atherosclerosis; cardioprotection

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Biopolymers: From Natural Origins to Biomedical Hydrogels and Drug Delivery Systems

edited by Abril Fonseca García

submission deadline 31 Jul 2026 | Viewed by 139 | Submission Open

Keywords: polysaccharides; biomaterials; hydrogels; biomedicine; food packaging; water treatment

(This special issue belongs to the Section Macromolecules)

Advances in Photodynamic Therapy and Photodetection: Targeted Approaches and Immunological Perspectives

edited by

Henriëtte S. De Bruijn

submission deadline 31 Jul 2026 | Viewed by 134 | Submission Open

Keywords: photodynamic therapy (PDT); photodetection (PD); photosensitiser; nanoparticles; nanotechnology; targeted therapy; immunotherapy; vaccines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanisms and Therapeutic Strategies for Cognitive Dysfunction

edited by Francesco Amenta and Nalini Chintalapudi

submission deadline 31 Jul 2026 | Viewed by 131 | Submission Open

Keywords: cognitive dysfunction; neurobiological mechanisms; synaptic plasticity; molecular and cellular pathways; neurodegeneration; pharmacological and non-pharmacological interventions; digital health technologies; artificial intelligence in neurology; translational neuroscience; early diagnosis and prevention

(This special issue belongs to the Section Molecular Neurobiology)

Current Trends in Organometallic Chemistry and Its Applications

edited by

Senka Djaković

and Jasmina Lapić

submission deadline 31 Jul 2026 | Viewed by 116 | Submission Open

Keywords: (bio)organometallic chemistry; synthesis; application; structure– property relationships; computational modelling; ligand design; biomedical materials

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Fluorescent Nanoparticles: Composition, Properties, and Biomedical Applications

edited by Bonghwan Chon

submission deadline 1 Aug 2026 | 1 articles | Viewed by 1106 | Submission Open

Keywords: fluorescent nanoparticles; bioimaging; targeted drug delivery; cancer nanotherapy; quantum dots; surface functionalization; biomedical nanotechnology; theragnostic; fluorescence imaging; deep tissue imaging

(This special issue belongs to the Section Molecular Nanoscience)

New Advances in Animal Reproduction

edited by Valdevane Rocha Araújo

submission deadline 10 Aug 2026 | 1 articles | Viewed by 1124 | Submission Open

Keywords: folliculogenesis; oogenesis; oocyte maturation; follicle growth; preantral follicles; antral follicles; spermatogenesis; spermatozoa; bioengineering; scaffolds

(This special issue belongs to the Section Molecular Biology)

Molecular Pathogenesis and Treatments of Pediatric Leukemias

edited by

Joanna Zawitkowska

submission deadline 10 Aug 2026 | Viewed by 256 | Submission Open

Keywords: monoclonal antibodies; tyrosine kinase inhibitors; CAR-T; chemotherapy; drug induced toxicity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathological and Genetic Studies of Alzheimer's Disease and Parkinson's Disease

edited by

Santosh Kumar Prajapati

submission deadline 10 Aug 2026 | Viewed by 162 | Submission Open

Keywords: Alzheimer’ s disease; Parkinson’ s disease; neurodegeneration; genetics; epigenetics; neuroinflammation; biomarkers; multi-omics; gut– brain axis; precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

Thyroid-Related Diseases: Molecular Pathology, Diagnosis and Treatment: 2nd Edition

edited by

Maurizio Martini

and

Vincenzo Fiorentino

submission deadline 20 Aug 2026 | 8 articles | Viewed by 57204 | Submission Open

Keywords: thyroid disease; thyroid nodules; thyroid cancer; thyroid carcinoma; thyroid radiology; thyroid– gut axis; autoimmune thyroid disorders; thyroid hormone; molecular mechanisms; molecular tests

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms Underlying Vulnerability to Stress-Related Disorders

edited by Marta Pardo

submission deadline 20 Aug 2026 | 4 articles | Viewed by 46792 | Submission Open

Keywords: stress-related disorders; post-traumatic stress disorder; molecular mechanisms; pharmacological targets

(This special issue belongs to the Section Molecular Neurobiology)

25th Anniversary of IJMS: Updates and Advances in Molecular Neurobiology

edited by

Kiminobu Sugaya

submission deadline 20 Aug 2026 | 15 articles | Viewed by 34195 | Submission Open

Keywords: molecular neurobiology; neural signaling and gene regulation; synaptic plasticity; neurodevelopment; neurodegeneration; neuroregeneration; neuroinflammation; epigenetics in neuroscience; non-coding RNAs; protein misfolding and aggregation; exosomes and extracellular vesicles; stem cells and neural repair; biomarkers of neurological disease; translational neuroscience; neuropharmacology; brain omics (genomics; proteomics; transcriptomics); neuronal-glial interactions; mitochondrial dysfunction in the nervous system

(This special issue belongs to the Section Molecular Neurobiology)

25th Anniversary of IJMS: Updates and Advances in Molecular Oncology

edited by

Peter J. K. Kuppen

submission deadline 20 Aug 2026 | 20 articles | Viewed by 31211 | Submission Open

Keywords: molecular oncology; cancer epigenetics; tumour heterogeneity; tumour microenvironment; precision oncology; liquid biopsy; cancer immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Bioactive Nutrients Promoting Health Through Gut Microbiota: 3rd Edition

edited by

Baojun Xu

and

Matteo Bordiga

submission deadline 20 Aug 2026 | 4 articles | Viewed by 22129 | Submission Open

Keywords: phytochemicals; complex carbohydrates; gut microbiota; prebiotics; probiotics; inflammation; molecular mechanisms; human health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant Development and Hormonal Signaling

edited by

Naoufal Lakhssassi

submission deadline 20 Aug 2026 | 7 articles | Viewed by 18846 | Submission Open

Keywords: plant growth; reproductive growth; phytohormones; signal transduction; transcription factors; root development; shoot development; floral development; seed development; environmental interactions; regulatory networks; apical dominance

(This special issue belongs to the Section Molecular Plant Sciences)

IJMS 25th Anniversary: Updates and Progress on Bioactives and Nutraceuticals

edited by

Maurizio Battino

submission deadline 20 Aug 2026 | 9 articles | Viewed by 18210 | Submission Open

Keywords: natural products; bioactive; nutraceutical; nutrient; health; dietary; functional food; vitamins; phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Multiple Sclerosis: From Molecular Pathology to Novel Therapeutic Approaches

edited by

László Vécsei

and

Masaru Tanaka

submission deadline 20 Aug 2026 | 9 articles | Viewed by 16152 | Submission Open

Keywords: progression-independent relapses (PIRAs); smouldering-associated worsening (SAW); lack of new relapses and of new magnetic resonance imaging activity (NEIDA); slowly expanding lesions (SEL); no evidence of smouldering disease activity (NESDA); neurofilament (NfL); glial fibrillary acidic protein (GFAP); patient-reported outcome (PRO); paramagnetic rim lesions (PRLs); relapse-associated worsening (RAW)

(This special issue belongs to the Section Molecular Neurobiology)

New Advances in the Treatment and Diagnosis of Neuromuscular Diseases

edited by Silvia Consalvi

submission deadline 20 Aug 2026 | 2 articles | Viewed by 15817 | Submission Open

Keywords: neuromuscular diseases; gene therapies; stem cell therapy; treatment and diagnosis

(This special issue belongs to the Section Molecular Neurobiology)

Health-Promoting Effects of Medicinal and Edible Plants and Their Molecular Mechanism

edited by

Baojun Xu

and

Matteo Bordiga

submission deadline 20 Aug 2026 | 7 articles | Viewed by 15632 | Submission Open

Keywords: medicinal plants; edible plants; health-promoting effect; molecular mechanism; phytochemicals; diseases; curing targets; signaling pathway

(This special issue belongs to the Section Bioactives and Nutraceuticals)

25th Anniversary of IJMS: Updates and Advances in Macromolecules

edited by

Haiyang Gao

Salah-Eddine Stiriba

and

Zhongzhou Chen

submission deadline 20 Aug 2026 | 5 articles | Viewed by 14327 | Submission Open

Keywords: macromolecules; monomers; lipids; peptides; proteins; carbohydrates; polysaccharides; nucleic acids; modification; functionalization; structure– property relationship

(This special issue belongs to the Section Macromolecules)

Metals and Metal Ions in Human Health, Diseases, and Environment

edited by

Agnieszka Scibior

Juan Llopis

and

Manuel Aureliano

submission deadline 20 Aug 2026 | 7 articles | Viewed by 14035 | Submission Open

Keywords: metal toxicity; metal-based drugs; polyoxometalates; protein metalation; human health problems; diseases; in vitro/in vivo studies; human studies; environmental pollution

(This special issue belongs to the Section Molecular Biology)

Molecular Research in Asthma and Allergy

edited by

Sylwia Smolińska

submission deadline 20 Aug 2026 | 6 articles | Viewed by 13200 | Submission Open

Keywords: asthma; allergy; molecular mechanisms; exposome; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant–Microbe Interactions: 2nd Edition

edited by Jian Jin

submission deadline 20 Aug 2026 | 6 articles | Viewed by 13116 | Submission Open

Keywords: plant; crop; rhizosphere microbiome; microbial colonization; quorum sensing; endophytic microbes

(This special issue belongs to the Section Molecular Plant Sciences)

25th Anniversary of IJMS: Updates and Advances in “Molecular Immunology”

edited by

Julia Kzhyshkowska

submission deadline 20 Aug 2026 | 6 articles | Viewed by 12860 | Submission Open

Keywords: inflammation; innate immunity; adaptive immunity; genetics; epigenetics; immunometabolism; receptors; cytokines; cell therapy; immune checkpoint inhibitors

(This special issue belongs to the Section Molecular Immunology)

Anti-Cancer Drugs: Natural Products, Synthetic Compounds and Potential Pharmacological Effects and Applications

edited by Kaiqun Ren and Hui Zou

submission deadline 20 Aug 2026 | 4 articles | Viewed by 12466 | Submission Open

Keywords: cancer; natural product; synthetic compounds; mechanism; structural modification; pharmacological action

(This special issue belongs to the Section Molecular Pharmacology)

Studies on Lactic Acid Bacteria and Their Products in Health and Diseases: 3rd Edition

edited by

Ilavenil Soundharrajan

submission deadline 20 Aug 2026 | 7 articles | Viewed by 12096 | Submission Open

Keywords: lactic acid bacteria; probiotics health benefits; gut microbiota modulation; functional foods with biological applications; immunomodulatory mechanisms; antimicrobial peptide production and its mechanisms; host-microbe interactions; functional dairy and meat products; inflammatory bowel diseases; metabolic health improvement; bioactive microbial metabolites; food safety and management; metabolic diseases and disorders; antibiotic-associated complications

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Cytokines and Autoantibodies Against Cytokines in Health and Disease

edited by

Juan Bautista De Sanctis

submission deadline 20 Aug 2026 | 1 articles | Viewed by 11790 | Submission Open

Keywords: cytokine; autoantibodies; cytokine therapy; cytokine inhibition

(This special issue belongs to the Section Molecular Immunology)

Molecular and Cellular Mechanisms of Skin Diseases (Second Edition)

edited by

Elisabetta Palazzo

submission deadline 20 Aug 2026 | 5 articles | Viewed by 11009 | Submission Open

Keywords: hyperproliferative skin diseases; psoriasis; keratinocyte carcinoma; actinic keratosis; atopic dermatitis; skin inflammation; inflammation-associated skin diseases; epidermal differentiation; epidermal cell metabolism; 3D models; in vivo models

(This special issue belongs to the Section Molecular Biology)

New Advances in Cancer Genomics

edited by

Yoshihito Kano

submission deadline 20 Aug 2026 | 7 articles | Viewed by 10915 | Submission Open

Keywords: cancer genomics; biomarker discovery; precision oncology; KRAS and undruggable targets; artificial intelligence in oncology; multi-omics data integration; drug discovery

(This special issue belongs to the Section Molecular Biology)

New Insights into Plant Stress

edited by

Pandiyan Muthuramalingam

Subramani Pandian

and

Hyunsuk Shin

submission deadline 20 Aug 2026 | 4 articles | Viewed by 10678 | Submission Open

Keywords: abiotic stress; biotic stress; bioinformatics; artificial intelligence; biotechnology; breeding; crop plants; horticultural plants; GWAS; CRISPR-Cas; multi-omics; genomics; epigenomics; transcriptomics; proteomics; genetic diversity; gene expression

(This special issue belongs to the Section Molecular Plant Sciences)

Circulating Non-Coding RNAs as Diagnostic and Prognostic Markers of Human Diseases: 3rd Edition

edited by

Kyriacos N. Felekkis

and

Christos Papaneophytou

submission deadline 20 Aug 2026 | 7 articles | Viewed by 10603 | Submission Open

Keywords: miRNA; gene expression regulation; diagnosis; prognosis; therapy; biomarkers

(This special issue belongs to the Section Biochemistry)

Plant Molecular Regulatory Networks and Stress Responses

edited by

Xiujun Zhang

submission deadline 20 Aug 2026 | 5 articles | Viewed by 10504 | Submission Open

Keywords: plant stress response; stress response gene; regulatory mechanism; gene regulatory network; transcriptional regulation; post-transcriptional regulation; multi-omics integration; single-cell RNA-seq; spatial genomics; bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

Chronic Kidney Disease: From Molecular Mechanisms to Therapeutic Approaches

edited by

Ligia Petrica

submission deadline 20 Aug 2026 | 6 articles | Viewed by 10502 | Submission Open

Keywords: genetics; epigenetics; inflammation; metabolomics; oxiative stress

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Depression—2nd Edition

edited by

Magdalena Sowa-Kućma

submission deadline 20 Aug 2026 | 2 articles | Viewed by 9851 | Submission Open

Keywords: depression; epigenetics; animal models of depression; serotonin; glutamate; dopamine; neurotrophic factors

(This special issue belongs to the Section Molecular Neurobiology)

Challenges and Future Perspectives in Treatment for Lung Cancer: 2nd Edition

edited by Ilaria Marrocco and

Donatella Romaniello

submission deadline 20 Aug 2026 | 2 articles | Viewed by 9841 | Submission Open

Keywords: lung cancer; non-small cell lung cancer; small cell lung cancer; chemotherapy; targeted therapy; immunotherapy; drug resistance; drug delivery

(This special issue belongs to the Section Molecular Oncology)

Advances in Antimicrobial Nanomaterials 2.0

edited by

Irena Maliszewska

submission deadline 20 Aug 2026 | 4 articles | Viewed by 9552 | Submission Open

Keywords: metallic nanoparticles; bimetallic nanoparticles; antimicrobial activity; polymeric nanomaterials; nanoplatforms; nanoparticle functionalization; delivery of antimicrobial agents

(This special issue belongs to the Section Molecular Nanoscience)

Biochemistry and Molecular Biology of Coronaviruses

edited by

Shu-Qun Liu

submission deadline 20 Aug 2026 | 6 articles | Viewed by 9346 | Submission Open

Keywords: SARS-CoV; MERS-CoV; COVID-19; RNA viruses; infection; antivirals; vaccines; therapeutics; host-virus interactions

(This special issue belongs to the Section Molecular Microbiology)

Advances in Amyloid Aggregation and Its Inhibition: Implementing Insights from Physiological Conditions

edited by

Andrius Sakalauskas

submission deadline 20 Aug 2026 | 4 articles | Viewed by 9273 | Submission Open

Keywords: protein aggregation; amyloid; physiological conditions; aggregation inhibition; neurodegenerative diseases; amyloidosis

(This special issue belongs to the Section Molecular Neurobiology)

MicroRNAs and mRNA in Human Health and Disease

edited by

Paulina Gil-Kulik

submission deadline 20 Aug 2026 | 7 articles | Viewed by 9257 | Submission Open

Keywords: stem cells; mesenchymal stem cells; gene expression; microRNA; mRNA

(This special issue belongs to the Section Molecular Biology)

25th Anniversary of IJMS: Updates and Advances in Molecular Informatics

edited by

M. Natália D.S. Cordeiro

and

Giulio Vistoli

submission deadline 20 Aug 2026 | 10 articles | Viewed by 9113 | Submission Open

Keywords: AI-guided drug repurposing; virtual screening in personalized medicine; machine learning for toxicity prediction; network-based biomarkers in complex diseases; in silico pharmacokinetics and ADMET profiling; data-driven materials design; deep learning for molecular property prediction; AI-assisted nanomaterial synthesis; systems biology models for metabolic engineering

(This special issue belongs to the Section Molecular Informatics)

Toxicity Mechanism of Emerging Pollutants: 2nd Edition

edited by

Monika Naumowicz

and

Joanna Kotyńska

submission deadline 20 Aug 2026 | 6 articles | Viewed by 8849 | Submission Open

Keywords: emerging pollutant; toxicology; cancer; EDC; pesticides; microplastic; human cell lines; environment; molecular mechanisms

(This special issue belongs to the Section Molecular Toxicology)

Molecular Insights into Antimicrobial Activity

edited by

Liliana Mititelu Tartau

submission deadline 20 Aug 2026 | 2 articles | Viewed by 8508 | Submission Open

Keywords: antimicrobial activity; antimicrobial agents; antimicrobial peptides; phytochemicals with antimicrobial properties; antimicrobial synergy; pathogen-specific targeting; antimicrobial resistance; biomedical science; nanotechnology in antimicrobials; genomic

(This special issue belongs to the Section Molecular Microbiology)

Rapeseed: Genetic Breeding, Key Trait Mining and Genome

edited by Hongbo Chao

submission deadline 20 Aug 2026 | 4 articles | Viewed by 8029 | Submission Open

Keywords: rapeseed (Brassica napus L.); genetic breeding; genomic improvement; molecular markers; genome-wide association studies (GWAS); multi-omics integration; CRISPR gene editing; marker-assisted selection (MAS); stress resistance traits; yield and oil content improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Biomarkers in Precision Medicine

edited by

Zhidong Zhou

submission deadline 20 Aug 2026 | 1 articles | Viewed by 7674 | Submission Open

Keywords: biomarkers; precision medicine; novel techniques; artificial intelligence

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 1001-1050 on page 21 of 65.

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