Macrophage Metabolic Reprogramming in Inflammation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 20 August 2026 | Viewed by 1170
Special Issue Editors
Interests: Immune response; immunometabolism; macrophages; mitochondria dynamics
Interests: Immune response; immunometabolism; macrophages; mitochondria dynamics
Special Issue Information
Dear Colleagues,
Macrophages stand at the frontline of tissue defense and repair, orchestrating immune responses while preserving homeostasis. As tissue-resident immune cells or recruited cells, they eliminate pathogens, apoptotic cells, and debris, while also supporting tissue regeneration after injury. Their hallmark plasticity enables them to swiftly adapt to diverse microenvironmental cues through polarization, acquiring specialized functional phenotypes. Metabolic reprogramming is a crucial driver of this plasticity, allowing macrophages to flip between oxidative phosphorylation and glycolysis based on the stimulus type. Such metabolic alterations not only determine macrophage activation states but also their potential to influence inflammation, tissue remodeling, and disease development. With growing evidence linking macrophage metabolism to conditions ranging from infection and cancer to obesity, diabetes, and cardiovascular disease, understanding these mechanisms has become a priority for both basic and translational research. This Special Issue brings together cutting-edge insights into macrophage metabolic reprogramming across diverse inflammatory contexts to advance novel therapeutic strategies that harness or modulate macrophage metabolism for improved clinical outcomes.
Dr. Ricardo Sánchez-Rodríguez
Dr. Roberta Angioni
Guest Editors
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Keywords
- inflammation
- immunometabolism
- metabolic rewiring
- glycolysis
- krebs cycle
- glutaminolysis
- innate immune response
- macrophages
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