Hematopoietic Stem Cells: Molecular Insights into Homeostasis, Disease, and Aging
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 29 January 2026 | Viewed by 119
Special Issue Editor
Special Issue Information
Dear Colleagues,
Hematopoietic stem cells (HSCs) sustain lifelong blood cell production through their capacity for self‑renewal and multilineage differentiation. Dysregulation of the molecular mechanisms that maintain HSC homeostasis can lead to hematological disorders such as bone marrow failure, clonal hematopoiesis, and leukemia. Moreover, aging-associated alterations in HSCs have been linked to impaired immune function and increased disease susceptibility in the elderly.
This Special Issue will focus specifically on the molecular mechanisms of HSC senescence and its contribution to the pathogenesis of age-related disorders. We invite cutting-edge research and reviews exploring the cellular and molecular drivers of HSC functional decline, such as DNA damage responses, epigenetic drift, and metabolic reprogramming. We particularly welcome studies on the interplay between clonal hematopoiesis, inflammation, and age-related diseases, and those employing single-cell or spatial transcriptomics to dissect HSC heterogeneity. From a translational perspective, this issue will also highlight the implications of HSC senescence in bone marrow failure and leukemia predisposition, aiming to foster new therapeutic strategies against age-related pathologies.
Dr. Yoshikazu Matsuoka
Guest Editor
Manuscript Submission Information
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Keywords
- hematopoietic stem cells (HSCs)
- senescence
- hematopoietic homeostasis
- epigenetic drift
- DNA damage responses
- metabolic reprogramming
- hematological disorders
- inflammation
- environmental stress
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