Advances in Inflammasomes
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 430
Special Issue Editor
Interests: inflammation; inflammasome; NLRP3; gasdermin; gastrointestinal cancers; viral vectors; signaling pathways; genome editing; light and electron microscopy; protein and nucleic acids quantification and analysis; flow-cytometer and cell sorting; cell death assay; immune cell isolation from tissue/biopsy; TRIM-away system; RNAi; cloning; gene overexpression; ELISA; cell biology; intracellular ion fluxes
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Special Issue Information
Dear Colleagues,
This Special Issue is supervised by Dr. Roberto Negro and assisted by Dr. Valentina Arrè (National Institute of Gastroenterology “S. de Bellis”, IRCCS Research Hospital).
Inflammasomes are supramolecular cytosolic structures found in all innate immune cells, and they auto-assemble into micrometer-size complexes upon endogenous or exogenous insults, ultimately triggering the inflammatory response. By promoting the release of bioactive interleukin-1β and interleukin-18 into the bloodstream, inflammasomes detect and respond to a wide range of cellular stresses. Concomitantly, inflammasome activation culminates in a highly inflammatory form of programmed cell death, termed pyroptosis, which is mediated by a ring-shaped structure of Gasdermin proteins capable of permeabilizing the plasma membrane. However, the detailed molecular mechanisms underlying this process remain under intense investigation. Recent research has revealed the broader implications of inflammasome activity in human health and disease. Although an essential defense against infection, abnormal inflammasome activation is increasingly recognized as a contributor to complex diseases, including cancer, neurodegenerative diseases, metabolic syndromes, and autoimmune disorders. The integration of advanced omics technologies is revolutionizing our understanding of inflammasome biology, thus facilitating the discovery of novel small-molecule inhibitors and predictive biomarkers as well as paving the way for the development of tailored treatments based on patient’s inflammasome-related molecular profiles.
This Special Issue aims to provide a comprehensive overview of recent advances in inflammasome biology. We welcome original research articles, reviews, and short communications that explore the molecular mechanisms of inflammasome activation, its regulation, interaction with the microbiota, and its dual roles in health and disease. Particular interest will be given to translational and therapeutic perspectives, including novel inhibitors, biomarkers, and clinical implications.
By bringing together cutting-edge research in this field, we hope this Special Issue will offer new insights into inflammasome-mediated pathways and promote the development of innovative strategies to modulate inflammasome activity for therapeutic benefit.
We look forward to your contributions to this exciting and rapidly evolving area of immunology.
Dr. Roberto Negro
Guest Editor
Manuscript Submission Information
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Keywords
- inflammasome
- pyroptosis
- innate immunity
- cancer
- neurodegenerative diseases
- microbiota
- gasdermin
- ninjurin
- drug screening
- personalized treatments
- multi-omics analysis
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