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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genomic Research in Carcinogenesis, Cancer Progression and Recurrence

edited by

Magdalena Orzechowska

submission deadline 20 Nov 2025 | 1 articles | Viewed by 836 | Submission Open

Keywords: genomic profiling; carcinogenesis; metastasis; recurrence; precision medicine; tumor evolution metrics; sequencing; tumor markers

(This special issue belongs to the Section Molecular Oncology)

Regenerative Medicine: Molecular Mechanisms Driving Tissue Regeneration and Repair

edited by

Christopher Robinson

and Paul Jordan Christo

submission deadline 20 Nov 2025 | 1 articles | Viewed by 803 | Submission Open

Keywords: stem cell; cell signaling; immune modulation; extracellular matrix; remodeling; gene regulation; gene editing; growth factors; extracellular vesicles; small molecules

(This special issue belongs to the Section Molecular Biology)

Precision Medicine in Cancers

edited by

Mehdi Kardoust Parizi

submission deadline 20 Nov 2025 | Viewed by 762 | Submission Open

Keywords: precision medicine; cancer biomarkers; targeted therapy; genomic profiling; personalized treatment; tumor heterogeneity; molecular diagnostics; clinical research

(This special issue belongs to the Section Molecular Oncology)

Chemical and Biotechnological Strategies to Tailor the Properties of Biomaterials

edited by

Eduardo García-Junceda

and

Julia Revuelta

submission deadline 20 Nov 2025 | 1 articles | Viewed by 750 | Submission Open

Keywords: biomaterial functionalization; green chemistry in biomaterials; biotechnological modification; stimuli-responsive materials; translational biomaterials

(This special issue belongs to the Section Materials Science)

Advances in Molecular Research on Plant-Fungi Interactions

edited by Francisca Sempere-Ferre

submission deadline 20 Nov 2025 | 1 articles | Viewed by 743 | Submission Open

Keywords: plant– fungi interactions; mycorrhizal symbiosis; fungal pathogens; effector molecules; plant defense mechanisms; signal transduction; secondary metabolites; microbiome interactions; molecular plant biology; host– pathogen dynamics

(This special issue belongs to the Section Molecular Plant Sciences)

Stem Cell Biology & Regenerative Medicine—2nd Edition

edited by

Rivka Ofir

submission deadline 20 Nov 2025 | 1 articles | Viewed by 739 | Submission Open

Keywords: hiPSC; hES; Crispr; BBB; disease in a dish; neuro-regeneration; pain reliever; scaffold

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Sprouty Proteins in Cancer

edited by Barbara Hausott and

Lars Klimaschewski

submission deadline 20 Nov 2025 | 1 articles | Viewed by 729 | Submission Open

Keywords: sprouty; tumor growth; apoptosis; migration; signaling

(This special issue belongs to the Section Molecular Biology)

Life’s Thermodynamics: Cells and Evolution

edited by

Alberto Schiraldi

submission deadline 20 Nov 2025 | 1 articles | Viewed by 727 | Submission Open

Keywords: cell growth and decay; cell aging; system biology; mathematical modeling; ecological modeling; dissipative adaptation; maximum power principle; evolution of microbial fitness; energy balance in microbial cultures

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Genetics and Breeding Mechanisms in Crops: 3rd Edition

edited by

Shaozhen He

submission deadline 20 Nov 2025 | 1 articles | Viewed by 702 | Submission Open

Keywords: crops; molecular genetics; breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Precision Cancer Medicine: Molecular Insights, Biological Events and Clinical Perspectives

edited by

Dimitrios H. Roukos

submission deadline 20 Nov 2025 | Viewed by 695 | Submission Open

Keywords: multi-omics at bulk level; single-cell multi-omics; precision oncology; precision immune-oncology; tumor molecular profiling

(This special issue belongs to the Section Molecular Oncology)

Melanoma: From Molecular Mechanisms to Therapeutics

edited by Dorota Ciołczyk-Wierzbicka

submission deadline 20 Nov 2025 | 1 articles | Viewed by 694 | Submission Open

Keywords: melanoma; molecular mechanism; signaling pathways; genetic mutations; cancer therapy/treatment; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Computational Modelling at the Blood–Brain Barrier

edited by Christian Jorgensen

submission deadline 20 Nov 2025 | Viewed by 689 | Submission Open

Keywords: blood– brain barrier models; molecular dynamics simulations; artificial intelligence; CNS penetration predictive models; asymmetric membranes; efflux pumps

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Pathophysiology and Treatment of Coronary Artery Disease

edited by

Kazufumi Nakamura

submission deadline 20 Nov 2025 | 1 articles | Viewed by 664 | Submission Open

Keywords: coronary artery disease; ischemic cardiomyopathy; immune-related adverse events; CAD associated with autoimmune diseases; coronary artery disease-related cardiomyopathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Endothelial Dysfunction, Inflammation and Cognition

edited by Christelle Basset and Anne S. Prigent-Tessier

submission deadline 20 Nov 2025 | Viewed by 655 | Submission Open

Keywords: inflammation; endothelial dysfunction; cognition; nitric oxide (NO); BDNF; physical exercise

(This special issue belongs to the Section Molecular Biology)

Molecular Research on PRDM Genes

edited by

Erika Zazzo

Ciro Abbondanza

and

Monica Rienzo

submission deadline 20 Nov 2025 | Viewed by 624 | Submission Open

Keywords: PRDM; cancer; gene expression regulation; epigenetic modifications; proliferation; differentiation; gene expression regulation; apoptosis; cancer biomarkers; cancer diagnosis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Conversion and Valorization of Lignocellulosic Biomass

edited by Loredana Marcolongo

submission deadline 20 Nov 2025 | 1 articles | Viewed by 609 | Submission Open

Keywords: lignocellulosic biomass; vegetal and agro processing wast; catalytic and biocatalytic conversion; value added products; lignocellulosic platform; bioprocessing; biorefinery; green chemistry; circular economy; bioeconomy

(This special issue belongs to the Section Biochemistry)

Diabetes: Genetics and Genomics, Hormone Regulation, and Metabolic Control

edited by Maria Stathopoulou

submission deadline 20 Nov 2025 | Viewed by 565 | Submission Open

Keywords: type 1 diabetes; type 2 diabetes; monogenic diabetes; polygenic risk factors; gestational diabetes (GDM); maturity-onset diabetes of the young (MODY); latent autoimmune diabetes in adults (LADAs); genome-wide association studies (GWASs); single nucleotide polymorphisms (SNPs); epigenetic modifications in diabetes; insulin production regulation; hormone action and metabolic control; β -cell dysfunction; gene-environment interactions in diabetes; precision medicine in diabetes treatment; genetics; genomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Survival of the Fittest: Physiological Adaptations of Insects in Hostile Environments

edited by

Amit Roy

and

Amrita Chakraborty

submission deadline 20 Nov 2025 | Viewed by 558 | Submission Open

Keywords: insect adaptation; temperature tolerance; insect physiology; detoxification; symbiosis and stress tolerance mechanisms

(This special issue belongs to the Section Molecular Biology)

Research on Artificial Intelligence in Plant Biology

edited by Haopeng Yu

submission deadline 20 Nov 2025 | Viewed by 544 | Submission Open

Keywords: artificial intelligence; plant biology; RNA regulation; DNA regulatory elements; plant development; plant biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Cancer Models: Development and Applications

edited by

Yong Teng

submission deadline 20 Nov 2025 | Viewed by 491 | Submission Open

Keywords: tumor organoids; animal models of cancer; drug screening models; highly clinically relevant cancer models; technologies related to cancer model development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

ROS Signalling and Cell Turnover

edited by

Micol Silic-Benussi

submission deadline 20 Nov 2025 | Viewed by 466 | Submission Open

Keywords: metabolism; lipid droplets; nanoparticles; ROS; cancer therapy; redox homeostasis; mitochondria; cell death

(This special issue belongs to the Section Biochemistry)

Genetic Testing and Tailored Treatment for Thyroid Disorders: Molecular Basis and New Trends

edited by

Kyoung Sik Park

submission deadline 20 Nov 2025 | Viewed by 456 | Submission Open

Keywords: thyroid diseases; genetics; personalized medicine; novel therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Insights into the Pathogenesis of Type 1 Diabetes

edited by

Alessandra Fierabracci

submission deadline 20 Nov 2025 | Viewed by 455 | Submission Open

Keywords: type 1 diabetes; insulin-dependent diabetes mellitus; human leukocyte antigen (HLA); pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular, Translational and Clinical Research of Cancer Structural Biomarkers

edited by

Sabine Mai

submission deadline 20 Nov 2025 | Viewed by 450 | Submission Open

Keywords: structural biomarker; extracellular matrix; nuclear organization; discovery research; translational research; clinical research; cancer staging and prognosis; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Application of Nanomaterials and Molecular Detection in Human Diseases

edited by

Liangcan He

submission deadline 20 Nov 2025 | Viewed by 433 | Submission Open

Keywords: cancer; infectious diseases; neurological diseases; hematological disorders; cardiovascular diseases; nanoparticles; nanodrug delivery; nanoimaging

(This special issue belongs to the Section Materials Science)

Molecular Adaptation Mechanisms of Plants to Environmental Stress

edited by

Michael Moustakas

submission deadline 20 Nov 2025 | Viewed by 432 | Submission Open

Keywords: signal perception; signal transduction; post-translational modifications; stress response genes; reactive oxygen species; osmoprotectant; antioxidants; plant hormones; stress-related proteins; climate change; biotic stress; abiotic stress

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Biology and Chemistry of Mycotoxins and Phytotoxins, 3rd Edition

edited by

Makoto Kimura

submission deadline 20 Nov 2025 | Viewed by 393 | Submission Open

Keywords: aflatoxins; trichothecenes; fumonisins; ochratoxins; host-specific toxins; Alternaria toxins; emerging mycotoxins; biosynthesis; gene cluster; transcriptional regulation; toxicity; modification; ecological role

(This special issue belongs to the Section Molecular Toxicology)

Peptide Receptor Radionuclide Therapy (PRRT) and Targeted Alpha Therapy (TAT) in Cancer

edited by

Behrooz H. Yousefi

submission deadline 20 Nov 2025 | Viewed by 392 | Submission Open

Keywords: novel radiopharmaceutical synthesis; translational research; theranostic studies; manufacturing of radiopharmaceuticals; therapy efficacy; personalized dosimetry

(This special issue belongs to the Section Molecular Oncology)

Structure–Activity Relationships Within Pharmaceutical Interactions and the Discovery of Molecular Targets

edited by

Yoshihiro Uesawa

submission deadline 20 Nov 2025 | Viewed by 375 | Submission Open

Keywords: molecular dynamics; docking simulation; QSAR; moleular initiating event

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms and Performances of Photocatalysis

edited by

Shaojun Yuan

submission deadline 20 Nov 2025 | Viewed by 366 | Submission Open

Keywords: photocatalytic materials; photocatalysis; energy conversion; environmental remediation; carbon dioxide reduction; organic synthesis

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Advances in Alcohol Metabolism

edited by Takeshi Haseba

submission deadline 20 Nov 2025 | Viewed by 363 | Submission Open

Keywords: alcohol metabolism; ADH1; ADH3; ADH4; MEOS; catalase; ALDH2; pharmacology and toxicology; ROS; alcohol-related disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Role of Protein Post-Translational Modifications in Cancer: Mechanisms and Therapeutic Opportunities

edited by

Mauro Salvi

Wei-Chien Huang

and

Josefa León

submission deadline 20 Nov 2025 | Viewed by 358 | Submission Open

Keywords: phosphorylation; acetylation; methylation; sumoylation; ubiquitination; glycosylation; acylation; signal transduction; inhibitors

(This special issue belongs to the Section Biochemistry)

Molecular Research on Potential New Antidepressant Drugs

edited by

Marta Jóźwiak-Bębenista

and

Anna Stasiak

submission deadline 20 Nov 2025 | Viewed by 342 | Submission Open

Keywords: antidepressant drug discovery; treatment-resistant depression; neuroinflammation; neuroplasticity; hallucinogens and psychedelics; CNS drug development; molecular targets for depression; neurotransmitter systems (serotonin; norepinephrine; dopamine); preclinical research (in vitro; in vivo; in silico); psychiatric disorders

(This special issue belongs to the Section Molecular Pharmacology)

New Advances in Genetic and Molecular Mechanisms Underlying Agronomic Traits in Crops

edited by Hongbin Zhang

submission deadline 20 Nov 2025 | Viewed by 328 | Submission Open

Keywords: agronomic traits; crops; vegetable crops; fruit trees; genetic; molecular; high-throughput sequencing; agronomic genes

(This special issue belongs to the Section Molecular Plant Sciences)

Cardiomyopathy: From Molecular Pathology to Treatment

edited by

Andrea Sonaglioni

and

Gian Luigi Nicolosi

submission deadline 20 Nov 2025 | Viewed by 327 | Submission Open

Keywords: obesity; myocardial fibrosis; subclinical myocardial dysfunction; fibrotic remodeling; microRNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Preparations and Applications of Aerogels and/or Cryogels: From a Molecular Perspective

edited by

Angelika Kmita

and

Dorota Lachowicz

submission deadline 20 Nov 2025 | Viewed by 325 | Submission Open

Keywords: inorganic and/or organic aerogels; hybrid materials; eco-friendly materials; diagnosis

(This special issue belongs to the Section Materials Science)

Molecular Mechanism of Hypertension-Induced Renal Injury

edited by

Ningjun Li

and Guangbi Li

submission deadline 20 Nov 2025 | Viewed by 325 | Submission Open

Keywords: hypertension; renal injury; molecular mechanisms; chronic kidney disease; pharmacological interventions; vascular biology; renoprotection; blood pressure regulation; toxicology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Deciphering the Multifaceted Mechanisms of Antimicrobial Peptides

edited by

Xiumin Wang

submission deadline 20 Nov 2025 | Viewed by 323 | Submission Open

Keywords: antimicrobial peptides; antimicrobial activity; mechanisms of action; membrane disruption; inhibition of cellular processes; immune modulation

(This special issue belongs to the Section Macromolecules)

Mesenteric Adipose Tissue: The New Player in Health and Disease

edited by Eva Pardina and Jose M. Balibrea

submission deadline 20 Nov 2025 | Viewed by 316 | Submission Open

Keywords: mesenteric adipose tissue; obesity; inflammatory bowel diseases; Chron’ s disease; MASLD; metabolic inflammation; metabolic syndrome; mesenteric resections

(This special issue belongs to the Section Molecular Biology)

Molecular Pharmacological Advances in Gastrointestinal Health

edited by

Mirjana Stupnisek

submission deadline 20 Nov 2025 | Viewed by 309 | Submission Open

Keywords: gastrointestinal disorders; gastrointestinal healing; gut microbiota; inflammatory bowel disease; irritable bowel syndrome; gastrointestinal cancer; Crohn’ s disease; metabolic syndrome; cytoprotective agents; nonsteroidal anti-inflammatory drugs’ toxicity

(This special issue belongs to the Section Molecular Pharmacology)

Nucleic Acid Aptamers in Molecular Medicine

edited by

Silvia Catuogno

submission deadline 20 Nov 2025 | Viewed by 307 | Submission Open

Keywords: aptamers; SELEX; targeted therapy; drug delivery; diagnosis; biomarker discovery

(This special issue belongs to the Section Molecular Biology)

Allosteric Modulation of Kinases in Cancer Therapeutic Strategies and Challenges

edited by

Nidhi Joshi

submission deadline 20 Nov 2025 | Viewed by 302 | Submission Open

Keywords: kinase signaling; allosteric modulators; cancer therapy; drug resistance; molecular mechanisms; protein– protein interactions; targeted therapy; conformational changes; ATP-competitive inhibitors; drug design

(This special issue belongs to the Section Molecular Biology)

Nanoformulations for the Treatment of Human Diseases

edited by Sergio Acin Martinez

submission deadline 20 Nov 2025 | Viewed by 300 | Submission Open

Keywords: nanomedicine; nanomaterials nanomedicine; liposomes; nanocrystal; polymeric nanoparticles

(This special issue belongs to the Section Molecular Nanoscience)

Neuroinflammation: From Molecular Mechanisms to Therapy

edited by

Silvia Alboni

and Miriam Ciani

submission deadline 20 Nov 2025 | Viewed by 299 | Submission Open

Keywords: neuroinflammation; neurodegenerative diseases; psychiatric disorders; molecular and cellular targets

(This special issue belongs to the Section Molecular Neurobiology)

Platelets at the Intersection of Atherosclerosis Processes

edited by

Maria Greabu

submission deadline 20 Nov 2025 | Viewed by 298 | Submission Open

Keywords: platelets; inflammation; atherosclerosis; endothelial cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in the Biological Function of Tyrosinase

edited by

Kazumasa Wakamatsu

submission deadline 20 Nov 2025 | Viewed by 295 | Submission Open

Keywords: tyrosinase-related proteins; tyrosinase; melanogenesis; copper; zinc; metal enzymes; tyrosinase inhibitor; pigmentation disorders

(This special issue belongs to the Section Molecular Biology)

The Importance of Inflammation as a Link Between Adipokines and Myokines in Obesity

edited by

Maria Greabu

submission deadline 20 Nov 2025 | Viewed by 295 | Submission Open

Keywords: inflammation; adipokines; myokines; obesity; adipose tissue; muscle

(This special issue belongs to the Section Molecular Immunology)

Cutting-Edge Advances in New Anticancer Agents: Design, Synthesis and Application

edited by Mahendiran Dharmasivam

submission deadline 20 Nov 2025 | Viewed by 290 | Submission Open

Keywords: combination therapies in oncology; small-molecule inhibitors in cancer treatment; natural-product-based cancer therapeutics; immunotherapy advancements in oncology; targeting metastatic dormancy in cancer; modulating the tumour microenvironment for therapeutic benefit; three-dimensional cancer models in drug discovery; predictive biomarkers for chemoresistance; medicinal chemistry approaches in anticancer agent design; drug development strategies for resistant cancers

(This special issue belongs to the Section Molecular Oncology)

Advanced Research in Nanophotonics and Biophotonics

edited by

Prabhakar Pradhan

submission deadline 20 Nov 2025 | Viewed by 275 | Submission Open

Keywords: biophotonics; spectroscopy; light scattering; Raman/FTIR; cancer; Alzheimer's and Parkinson’ s diseases; nanophotonics; plasmonics; nano-biophotonics

(This special issue belongs to the Section Molecular Nanoscience)

Bitter Taste Receptors in Health and Disease: From Molecular Mechanisms to Translational Applications

edited by

Luigia Grazia Fresu

and

Maria Talmon

submission deadline 20 Nov 2025 | Viewed by 274 | Submission Open

Keywords: bitter taste receptors; TAS2Rs; immune disease; immunity response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

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