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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Targeting MAPK in Human Diseases

edited by

Elisabetta Rovida

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2330 | Submission Open

Keywords: ERK; DUSP; cancer; inflammation; neurodegenerative diseases; autoimmune diseases; targeted therapy; cell signaling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Organic Compounds in Photodynamic Therapy: Synthesis, Mechanism of Action and Biological Potential

edited by

Maria G. P. M. S. Neves

Nuno M. M. Moura

and

Catarina I. V. Ramos

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2306 | Submission Open

Keywords: organic photosensitizers; photodynamic therapy; synthetic strategies; mechanism of action; cancer cells; microorganisms

(This special issue belongs to the Section Biochemistry)

Mechanism of Cellular Signaling, Dysfunction, and Drug Effects on Alzheimer's Disease

edited by

Eva Kiss

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2288 | Submission Open

Keywords: AD; targeted therapy; Alzheimer's disease; neurodegenerative disease; tau protein

(This special issue belongs to the Section Molecular Neurobiology)

Advancements in Pathogen Detection, Microdevice Technologies and AI-Driven Analysis

edited by

Younseong Song

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2234 | Submission Open

Keywords: pathogen detection; microfluidic; microdevice; AI analysis; virus; bacteria; point-of-care testing; infectious disease; nanotechnology

(This special issue belongs to the Section Molecular Biology)

The Role of Lipids in Human Health

edited by

Angela Maria Rizzo

and Irma Colombo

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2158 | Submission Open

Keywords: lipids; lipidomics; fatty acids; sphingolipids; steroids; metabolism

(This special issue belongs to the Section Biochemistry)

The Role of Macrophages in Tumors

edited by

Julia Kzhyshkowska

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2117 | Submission Open

Keywords: tumor-associated macrophages; transcriptome; metabolome; epigenetics; angiogenesis; metastasis; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Mechanisms and Effects of Endocrine Disruptors and Environmental Contaminants on Human Health

edited by

Margarida Lorigo

submission deadline 20 Mar 2026 | 1 articles | Viewed by 2077 | Submission Open

Keywords: environmental exposure; emerging compounds; human health; risk assessment; adverse outcome pathway; new approach methodologies; one health

(This special issue belongs to the Section Molecular Toxicology)

Mechanistic Insights into Pharmacological and Non-Pharmacological Pain Therapies: From Cellular Responses to Therapy Outcomes

edited by

Sungtae Koo

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1942 | Submission Open

Keywords: neuromodulation; neural plasticity; glial activation; endogenous pain modulation; neuroinflammation; therapeutic mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Bioactive Molecules from Food Waste in Food Packaging Applications

edited by

Jennifer Gubitosa

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1917 | Submission Open

Keywords: wastes upcycling; waste management; circular economy; green chemistry; bioactive molecules; agri-food wastes and by-products; food packaging; active packaging

(This special issue belongs to the Section Materials Science)

Metabolic Regulators of Bone Health

edited by

Akkouch Adil

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1902 | Submission Open

Keywords: bone; osteoporosis; diabetes; obesity; glucose; insulin; lipids; estrogen; microRNA; osteoblasts

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Bioactive Phenolics and Polyphenols 2025

edited by

Davide Barreca

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1890 | Submission Open

Keywords: phenolic metabolism; biological activities; stability to food processing; elicitation; methods of analysis; dietary supplements; nutraceutical ingredients; non-thermal processing; extraction and purification

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advanced Research on Cancer Stem Cells

edited by

Ilze Štrumfa

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1875 | Submission Open

Keywords: cancer stem cells; tumour microenvironment; pancreatic cancer; glioblastoma; gastric cancer; breast cancer; lung cancer; colorectal cancer; renal cancer; liver cancer; melanoma; leukemia; lymphoma

(This special issue belongs to the Section Molecular Oncology)

Bioconjugates and Application

edited by

Gábor Mező

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1871 | Submission Open

Keywords: bioconjugates; targeted therapy; homing moieties; drug delivery; bioconjugates as diagnostic tools; targeted nanoparticles; antibody– drug conjugates; linkage systems

(This special issue belongs to the Section Macromolecules)

New Insights into Epilepsy: From Molecular Physiology to Pathology

edited by Paolo Mainardi

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1849 | Submission Open

Keywords: epilepsy; molecular pathology; disease; therapeutic strategies; celluar advance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Nanoparticle Composites: Functionalization and Application

edited by

Jovan M. Nedeljković

and

Vesna Lazić

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1841 | Submission Open

Keywords: nanoparticles; nanocomposites; synthesis; functionalization; interface; photocatalysis; antimicrobial nanoparticles; nanomedicine; theoretical modelling; computer simulations

(This special issue belongs to the Section Molecular Nanoscience)

Recent Advances in Nanomedicines Against Bacterial Infections

edited by

Stephanie Andrade

, Nuno Guimarães,

Maria João Ramalho

and

Joana A. Loureiro

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1827 | Submission Open

Keywords: nanotechnology; nanoparticle; nanocarriers; nanoantibiotic; drug delivery system; targeted delivery; theranostic; infectious diseases; antibacterial agent; antimicrobial resistance; biomedical application

(This special issue belongs to the Section Molecular Nanoscience)

Vitamin D Signaling in Human Health and Diseases

edited by

Daniela Rovito

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1820 | Submission Open

Keywords: vitamin D receptor; vitamin D; prevention; therapeutic potential; mineral homeostasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Research of Kidney Diseases

edited by Andrea Angioi

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1769 | Submission Open

Keywords: molecular genetics; kidney disease; biomarkers; cellular signaling; target therapeutics; innovative treatments

(This special issue belongs to the Section Molecular Biology)

Molecular Diagnosis and Targeted Therapies in Ischemic Stroke

edited by Alicia Aliena-Valero and María Castelló-Ruiz

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1759 | Submission Open

Keywords: ischemic stroke; cerebral protection; repair treatments; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bee Products and Their Flavonoids: Recent Advances in Molecular Mechanisms, Therapeutic Applications, and Innovative Delivery Systems

edited by

Nada Orsolic

and

Maja Jazvinšćak Jembrek

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1732 | Submission Open

Keywords: honeybee products; flavonoids; bioactive compounds; biological activity; pharmacological activity; health benefits; side effects; disease prevention; antioxidant activity; apitherapy; nutritional properties; innovative technical approaches

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Transplantation and Machine Perfusion

edited by

Joan Roselló-Catafau

and

Arnau Panisello-Roselló

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1726 | Submission Open

Keywords: transplantation (liver; kidney; and other organs); primary failure; ischemia-reperfusion injury; static graft preservation; HOPE; NMP; cell signaling; glycocalyx; metabolomics; mitochondria; sterile inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Statistical Methods in Gene Expression Analysis, Functional Genomics, Genetics, and Biochemistry

edited by Łukasz Huminiecki

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1700 | Submission Open

Keywords: multi-omics; statistics; gene expression analysis

(This special issue belongs to the Section Molecular Informatics)

Gene Function, Molecular Mechanisms, and Crop Breeding

edited by Hongwei Lu

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1697 | Submission Open

Keywords: molecular biology; gene function; molecular mechanism; crop breeding; molecular biology; agronomic traits; gene discovery; genomics; bioinfomatics; gene regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Cotton Molecular Genomics and Genetics (Third Edition)

edited by

Jie Sun

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1662 | Submission Open

Keywords: cotton; biotic or abiotic stress; disease resistance; fiber yield and quality; gene editing; gene identification and function validation; genome-wide association study; QTL identification

(This special issue belongs to the Section Molecular Plant Sciences)

Green Chemical Pesticide Design, Synthesis and Evaluation

edited by Ranfeng Sun

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1649 | Submission Open

Keywords: green pesticides; natural products; action mechanism of pesticides; synthesis

(This special issue belongs to the Section Biochemistry)

Solanaceae Biology: From Genetics to Metabolism

edited by

Pengxiang Fan

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1583 | Submission Open

Keywords: Solanaceae; nightshade family; tomato; potato; tobacco; eggplant; genetics; metabolism; crop improvement; specialized metabolite

(This special issue belongs to the Section Molecular Plant Sciences)

Focus on the Tryptophan Pathway

edited by

Burkhard Poeggeler

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1564 | Submission Open

Keywords: aging; indole-3-propionic acid; kynurenic acid; melatonin; serotonin; tryptophan

(This special issue belongs to the Section Molecular Biology)

Nanostructures: From Synthesis, Modification to Biomedical Applications

edited by Kleoniki Giannousi and

Catherine Dendrinou-Samara

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1528 | Submission Open

Keywords: nanostructures; post-synthetic methods; multi-drug resistant bacteria; amyloidopathies; neurodegeneration; photocatalysis; biosensors

(This special issue belongs to the Section Molecular Nanoscience)

Gene Mutations in Cancer

edited by

Lucie Benešová

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1512 | Submission Open

Keywords: oncogenetics; somatic mutations; intratumor mutational heterogeneity; tumor mutational burden; circulating tumor DNA; liquid biopsy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Inflammatory Bowel Disease: Molecular Insights—2nd Edition

edited by

Belal Chami

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1475 | Submission Open

Keywords: genomic sequencing; microbiome; dysbiosis; commensal flora; omics; immunobiology; colitis; Crohn’ s disease; ulcerative colitis; multiomics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetics and Omics in Autoimmune Diseases

edited by

Julian Ramírez-Bello

submission deadline 20 Mar 2026 | 3 articles | Viewed by 1455 | Submission Open

Keywords: autoimmune diseases; genetics; genomics; omics; single-nucleotide variants; copy number variants; variation; susceptibility; mRNAs; microRNAs; long non-coding RNAs; masive sequencing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research on Microbial Natural Products

edited by Wenli Li

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1395 | Submission Open

Keywords: microbial natural products; biosynthetic gene clusters; structural elucidation; metabolic engineering; synthetic biology; bioactivity profiling; sustainable biomanufacturing

(This special issue belongs to the Section Molecular Microbiology)

Biological Barriers: Consciousness and Mental Illness

edited by

Adonis Sfera

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1343 | Submission Open

Keywords: cell membranes; transport protein regulation; blood– brain barrier; epithelial barriers; gut barrier; respiratory barriers; blood– saliva barrier; biological barriers and pathological changes; protection of biological barriers in diseases

(This special issue belongs to the Section Molecular Biology)

Molecular Studies of Hematologic Malignancies

edited by

Myunggon Ko

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1275 | Submission Open

Keywords: hematologic malignancies; molecular mechanisms; genetic and epigenetic aberrations; molecular diagnosis; targeted therapy and biomarkers

(This special issue belongs to the Section Molecular Oncology)

Cutting Edge Advances in Antitumor Properties of Natural Products

edited by

Francesca Giordano

and

Maria Luisa Panno

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1261 | Submission Open

Keywords: natural product; cancer; cell signaling; cell death and differentiation; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Various Diseases and Drugs Involved in Vascular Tone Regulation in Cardiovascular Disease

edited by

Ju-Tae Sohn

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1255 | Submission Open

Keywords: vasoconstriction; vasodilation; calcium; protein kinase C; Rho-kinase; hypertension; nitric oxide

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Plant Breeding

edited by

Hélia Cardoso

, Sandra Correia and

Isaura Castro

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1192 | Submission Open

Keywords: plant breeding; proteomics; metabolomics; epigenomics; gene editing

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Drug Treatment in Alzheimer’s Disease

edited by

Roberto Dominici

and Diego Dolcetta

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1131 | Submission Open

Keywords: Alzheimer’ s disease (AD); glia; immune system; neurotoxicity; inflammation; beta-Amyloid (bA); neurofibrillary tangles (NFTs)

(This special issue belongs to the Section Molecular Neurobiology)

Peptide and Protein Metalation

edited by

Antonello Merlino

Irene Russo Krauss

and

Giarita Ferraro

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1044 | Submission Open

Keywords: metallodrugs; metal ions; metal complexes; metal– protein interaction; metal– peptide interaction

(This special issue belongs to the Section Biochemistry)

Molecular Insights into the Obstetrics and Gynecology

edited by

Gaspare Cucinella

submission deadline 20 Mar 2026 | Viewed by 993 | Submission Open

Keywords: ginecology; pelvic disorders; endometrial; cervical and ovarian cancers; covid and pregnancy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oxygen Variations, 3rd Edition

edited by

Gerardo Bosco

Costantino Balestra

and

Simona Mrakic-Sposta

submission deadline 20 Mar 2026 | Viewed by 989 | Submission Open

Keywords: hypoxia; hyperoxia; normoxia; biochemichal response; integrative approach; normo-hypo-hyperbaric; molecular research; gene expression; adaptive reactions; extreme environments

(This special issue belongs to the Section Molecular Biology)

Genetic and Epigenetic Insights into Extracellular Vesicles

edited by

Dimitrios Vlachakis

and

George P. Chrousos

submission deadline 20 Mar 2026 | Viewed by 980 | Submission Open

Keywords: exosomes; extracellular vesicles; cell– cell communication; endocrinology

(This special issue belongs to the Section Biochemistry)

Advancements in Novel Drug Delivery Systems for Gene and Drug Delivery

edited by

Rosamaria Pennisi

submission deadline 20 Mar 2026 | 1 articles | Viewed by 968 | Submission Open

Keywords: drug and gene delivery; novel drug delivery systems; nanoparticle-based delivery systems

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Brain Plasticity

edited by

Beatrice Uguagliati

submission deadline 20 Mar 2026 | 2 articles | Viewed by 937 | Submission Open

Keywords: neurophysiology; neurobiology; synapses; synaptic plasticity; microglia; astrocytes; dendritic spines; neurodevelopment; neurodevelopmental disease; learning and memory; neuropharmacology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Tolerance Mechanisms in Plants Under Stress

edited by

Lujun Yu

submission deadline 20 Mar 2026 | 1 articles | Viewed by 888 | Submission Open

Keywords: stress; tolerance; gene family; phytohormones; mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Functional Studies and Deep Phenotyping in Monogenic Forms of Diabetes, Severe Insulin Resistance and Hypoglycemia

edited by Fabrizio Barbetti

submission deadline 20 Mar 2026 | 2 articles | Viewed by 864 | Submission Open

Keywords: monogenic diabetes; neonatal diabetes mellitus; MODY; severe insulin resistance; insulin receptor; lipodystrophy; hyperinsulinemic hypoglycemia; ABCC8/KCNJ11 dominant forms of HH

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Microgravity, Cell Shape and Gene Expression: State of the Art, Challenges and Prospects

edited by Masahiro Terada

submission deadline 20 Mar 2026 | 1 articles | Viewed by 826 | Submission Open

Keywords: microgravity; space radiation; closed environment; space flight; parabolic flight; clinostat; human; rodent; microorganism; countermeasure; artificial gravity

(This special issue belongs to the Section Molecular Biology)

Advances in Plant Biotechnology: From Pathogen Diagnostics to Disease Management

edited by

Abdul Kader Jailani Amirudeen

submission deadline 20 Mar 2026 | 1 articles | Viewed by 779 | Submission Open

Keywords: plant pathogens; diagnostic; isothermal; biosensor; RNAi; CRISPRi; QTL mapping; GWAS; MAS or MABC

(This special issue belongs to the Section Molecular Plant Sciences)

Current Research on Colloidal Emulsions: Preparation and Applications

edited by Alexander Djerdjev

submission deadline 20 Mar 2026 | 1 articles | Viewed by 761 | Submission Open

Keywords: emulsion formulation and stability; nano-; micro-; and high-internal-phase emulsions; drug delivery; aerogels; pickering emulsions; food emulsions; oil– water interface; surfactants; zeta potential at hydrophobic interfaces; advances in emulsion technology

(This special issue belongs to the Section Materials Science)

Genetic Mechanisms of Neurological Disorders

edited by

Patrícia Maciel

and Sara Duarte-Silva

submission deadline 20 Mar 2026 | 1 articles | Viewed by 753 | Submission Open

Keywords: neurodevelopmental disorders; neurodegenerative disorders; neuropsychiatric disorders; genetics; molecular biology; cellular models; animal models; pathogenesis; biomarkers; therapeutic targets; drug discovery; therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Displaying special issue 1201-1250 on page 25 of 64.

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