The Cellular and Molecular Mechanisms of Central Nervous System Injury
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 1
Special Issue Editors
2. Université Paris-Saclay, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LRP/iRCM/IBFJ, F-92265, Fontenay-aux-Roses, France
Interests: glioma stem cells; cell migration; cell invasion; ionizing radiation; DNA repair; telomere; videomicroscopy; neural stem cells
Interests: cancer stem cells; glioma; glioma stem cells; neural stem cells; dental pulp stem cells; cell therapy; niche environment; scaffolds; neurogenesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue of the International Journal of Molecular Sciences highlights recent advances in elucidating the cellular and molecular mechanisms underlying injury to the central nervous system (CNS). CNS damage can result from diverse etiologies, including trauma, ischemia, inflammation, neoplasms, infections, and exposure to external agents such as radiation, chemotherapeutic drugs, or environmental toxins. These insults often lead to persistent neurological dysfunction and limited regenerative capacity, underscoring the urgent need to understand the fundamental biological processes involved for developing effective treatments.
We welcome original research articles, reviews, and perspectives that investigate key mechanisms such as oxidative stress, DNA damage responses, inflammation, apoptosis, neuroregeneration, blood–brain barrier disruption, and altered intercellular communication. Submissions employing in vitro systems, animal models, or patient-derived approaches—including brain organoids, advanced imaging, and high-throughput omics—are particularly encouraged. By integrating multidisciplinary approaches, this Special Issue aims to provide a comprehensive overview of CNS injury and foster the development of innovative diagnostic and therapeutic strategies.
Dr. Laurent Robert Gauthier
Dr. José R. Pineda
Guest Editors
Manuscript Submission Information
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Keywords
- central nervous system damage
- CNS
- oxidative stress
- DNA damage responses
- neuroregeneration
- blood–brain barrier disruption
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