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Biomaterials and Antibacterial Materials for Medical Applications
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Biomaterials and Antibacterial Materials for Medical Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 20 August 2026 | Viewed by 1595

Special Issue Editor

Dr. Shixiong Yi

E-Mail Website
Guest Editor
College of Textile and Garment, Southwest University, Chongqing 400715, China
Interests: antimicrobial dressings; photoactive materials; biomedical materials

Special Issue Information

Dear Colleagues,

Pathogenic microbial contamination constitutes one of the greatest global challenges that public health is facing today. In recent years, antibiotic-resistant bacteria have become more prevalent because of the misuse of antibiotics. In this regard, the development of effective, low-cost, and environmentally friendly new antibacterial materials for various applications is urgently needed.

This Special Issue aims to provide readers an overview of the state of the art of current research regarding promising biomaterials and antibacterial materials for medical applications. Recent studies on advanced antibacterial materials developed for other applications, including bacterial wastewater treatment and infected wound handling, are also welcome.

Dr. Shixiong Yi
Guest Editor

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Keywords

  • biomaterial science
  • photodynamic antibacterial materials
  • photothermal antibacterial materials
  • advanced antibacterial materials
  • antimicrobial nanostructured materials
  • polymer-based biomaterials
  • infected wound dressings

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Published Papers (2 papers)

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Research

21 pages, 6545 KB  
Article
Combination of Noble Metal and Gold–Silver Nanoclusters as Enhanced Antibacterial Coatings for Ti-Based Medical Implants
by Evgeniia S. Vikulova, Svetlana I. Dorovskikh, David S. Sergeevichev, Tatiana Ya. Guselnikova, Anastasiya D. Fedorenko, Alexander A. Zheravin and Natalya B. Morozova
Int. J. Mol. Sci. 2025, 26(24), 11945; https://doi.org/10.3390/ijms262411945 - 11 Dec 2025
Viewed by 513
Abstract
The surface modification of medical implant materials stands as a favorable strategy to enhance their biological properties including their antibacterial effect and biocompatibility. Recently, both in vitro and in vivo studies have shown that film heterostructures based on a combination of noble metal [...] Read more.
The surface modification of medical implant materials stands as a favorable strategy to enhance their biological properties including their antibacterial effect and biocompatibility. Recently, both in vitro and in vivo studies have shown that film heterostructures based on a combination of noble metal sublayers and an active component, such as silver and gold nanoparticles, offer unique advantages. The present work develops this promising direction and focuses on a series of combinations of noble metal coatings functionalized with bimetallic nanoclusters obtained by vapor-phase deposition methods onto the surfaces of Ti-based implants. This investigation investigates the influence of sequential deposition (AgAu or AuAg) and noble metal component (Ir or Au) on the coating morphology and the active component chemical form and release. Thus, scanning electron microscopy, X-ray photoelectron spectroscopy, and inductively coupled plasma atomic emission spectroscopy have been applied to characterize the samples before and after in vivo biological studies (rat models, 1 and 3 months). Histological and blood analyses confirmed the high biocompatibility of all the heterostructures. The samples also showed a pronounced in vitro biocidal effect against Gram-positive (S. epidermalis) and Gram-negative (P. aeruginosa) bacteria that correlates with a dynamic of silver release. The AuAg/M heterostructures demonstrated superior biological characteristics compared to their AgAu/M counterparts, suggesting enhanced both long-term integration and antibacterial action. Full article
(This article belongs to the Special Issue Biomaterials and Antibacterial Materials for Medical Applications)
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18 pages, 5447 KB  
Article
Development and Application of Visible-Light-Responsive Perylene Diimide Functionalized Silk Fibroin/Polylactic Acid Antibacterial Nanofibrous Membranes
by Sheng Lv, Hongyu Lin, Ying Lin, Qingyan Peng, Yuyang Song, Xiaodong Tan, Xiao Yang and Shixiong Yi
Int. J. Mol. Sci. 2025, 26(23), 11533; https://doi.org/10.3390/ijms262311533 - 28 Nov 2025
Viewed by 660
Abstract
The issue of antibiotic resistance is becoming increasingly severe, urgently requiring the development of new antibacterial strategies. Photodynamic therapy (PDT) has gradually emerged as a promising alternative due to its spatiotemporal controllability, low risk of drug resistance, and broad-spectrum antibacterial properties. However, most [...] Read more.
The issue of antibiotic resistance is becoming increasingly severe, urgently requiring the development of new antibacterial strategies. Photodynamic therapy (PDT) has gradually emerged as a promising alternative due to its spatiotemporal controllability, low risk of drug resistance, and broad-spectrum antibacterial properties. However, most existing photosensitizers (PSs) are hydrophobic, which limits their application efficiency in PDT. To address this problem, we designed and synthesized a water-soluble perylene diimide derivative (PDICN-CBn) as a photosensitizer. By introducing quaternary ammonium salt groups, its water solubility was improved, and antibacterial activity was enhanced. Subsequently, PDICN-CBn was assembled into silk fibroin/polylactic acid (SF/PLA) nanofibrous membranes via electrospinning technology, successfully constructing a visible-light-responsive ternary composite nanofibrous membrane (SF/PLA@PDICN-CBn). Using various characterization methods such as nuclear magnetic resonance (1H-NMR), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM), the microstructure, chemical composition, and structural characteristics of the nanofibrous membranes were systematically analyzed, verifying the successful synthesis of the photosensitizer and its assembly into the nanofibrous membranes. In the reactive oxygen species (ROS) experiment, electron spin resonance (ESR) spectra showed that PDICN-CBn efficiently generated singlet oxygen (1O2), superoxide anion (·O2−), and hydroxyl radical (·OH) under visible light irradiation, confirming its ability to produce different types of ROS through both type I and type II photodynamic reactions. In the antibacterial experiments, Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and methicillin-resistant Staphylococcus aureus (MRSA) were selected for a series of tests, including plate-counting antibacterial assays, bacterial live/dead staining, and SEM observation of morphology. The results showed that 8 μg/mL of PDICN-CBn effectively destroyed the bacterial cell membrane structure and killed bacteria (bactericidal rate > 95%) after 2 h of visible light irradiation. This work successfully developed a novel visible-light-responsive SF/PLA@PDICN-CBn nanofibrous membrane with a dual antibacterial system combining photodynamic and electrostatic adsorption antibacterial properties, providing new ideas and methods for the design and development of photodynamic antibacterial materials. The prepared nanofibrous membrane has potential application values in fields such as wound dressings and medical protective materials and is expected to provide strong support for solving clinical infection problems. Full article
(This article belongs to the Special Issue Biomaterials and Antibacterial Materials for Medical Applications)
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