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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bioactive Lipid Metabolites in Age-Related Comorbidities: From Mechanisms to Therapeutics
edited by
submission deadline 20 Feb 2026 | Viewed by 182 | Submission Open
Keywords: lipid metabolites; aging; sarcopenia; osteoporosis; osteoarthritis
(This special issue belongs to the Section Biochemistry)
Electrochemistry and Emerging Contaminants: Molecular Insights for Innovative Solutions
edited by
submission deadline 20 Feb 2026 | Viewed by 182 | Submission Open
Keywords: electrochemistry; chemical reactions; removal; environmental pollution
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Transcriptional Regulation and Its Misregulation in Human Diseases: Recent Insights submission deadline 20 Feb 2026 | Viewed by 176 | Submission Open
Keywords: transcription machinery; transcription (co)factors; chromatin regulators; splicing regulators; noncoding RNAs; transcription misregulation; genetic alterations; human diseases; transcriptome profiling; bioinformatics analysis
(This special issue belongs to the Section Molecular Biology)
Recent Research in Nanoelectrochemistry
edited by
submission deadline 20 Feb 2026 | Viewed by 152 | Submission Open
Keywords: nanoelectrochemistry; single-entity electrochemistry; nanoscale imaging; molecular electronics devices; nanostructured electrodes; electrochemical sensors; energy storage; catalysis; biomedical applications
(This special issue belongs to the Section Materials Science)
Advancements in the Electrochemical Detection of Biomolecules: From Sensing to Environmental Applications
edited by
submission deadline 20 Feb 2026 | Viewed by 149 | Submission Open
Keywords: biomolecules; nanomaterials; biorecognition; biomolecular detection; electrochemical
(This special issue belongs to the Section Molecular Biophysics)
Molecular Progress in Male Reproduction
edited by
submission deadline 20 Feb 2026 | Viewed by 146 | Submission Open
Keywords: male infertility; spermatogenesis; epigenetics; sperm function; testicular molecular biology; bioinformatics; reproductive genomics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Advances in Gestational Diabetes Mellitus: 2nd Edition
edited by Natasha Singh
submission deadline 20 Feb 2026 | Viewed by 145 | Submission Open
Keywords: metabolome; placental insulin signaling; DNA methylation; mitochondrial oxidation; MTOR; amino acids lipidomics; proteomics; gluconeogenesis; GDM
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Progress of Cardiovascular and Metabolic Disease
edited by
submission deadline 20 Feb 2026 | Viewed by 119 | Submission Open
Keywords: cardiometabolic continuum; endothelial dysfunction; heart failure; metabolic complications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biophysical Studies of Protein Structure-Function Relationships
edited by , and Velia Minicozzi
submission deadline 20 Feb 2026 | Viewed by 114 | Submission Open
Keywords: protein structure; molecular dynamics; computational modeling; drug discovery
(This special issue belongs to the Section Molecular Biophysics)
Molecular Pathogenesis and Treatment Approaches of Hematological Malignancies
edited by
submission deadline 20 Feb 2026 | Viewed by 107 | Submission Open
Keywords: leukemia; lymphoma; minimal residual disease (MRD); cancer genomic profiling (CGP); molecular targeted therapy
(This special issue belongs to the Section Molecular Oncology)
Decoding Protein Structure and Protein Dynamics in Cancer submission deadline 20 Feb 2026 | Viewed by 106 | Submission Open
Keywords: protein structures; oncogenes; post-translational modifications (PTMs); cancer; proteomics; computational biology; structural biology; molecular modeling; bioinformatics
(This special issue belongs to the Section Molecular Biology)
Advances in Genetic and Epigenetic Research in Skin Diseases
edited by
submission deadline 20 Feb 2026 | Viewed by 89 | Submission Open
Keywords: skin diseases; genodermatoses; psoriasis; atopic dermatitis; hidradenitis; suppurativa; epigenetic regulation; genome-wide association studies (GWAS); next-generation sequencing; translational dermatogenomics; Mendelian randomization; rare disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of the Mitochondria in Human Health and Diseases submission deadline 25 Feb 2026 | 2 articles | Viewed by 14935 | Submission Open
Keywords: mitochondria; mitochondria contact sites; metabolism; lipids; metabolites
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Multifunctional Nanocomposites for Bioapplications submission deadline 25 Feb 2026 | 6 articles | Viewed by 10013 | Submission Open
Keywords: nanocomposites; biomedical applications; molecular characteristics; metabolic pathways; biomarkers; external stimuli
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Research on Skin Inflammation
edited by
submission deadline 25 Feb 2026 | 6 articles | Viewed by 9802 | Submission Open
Keywords: skin inflammation; molecular diagnosis; dermatitis; molecular pathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Human Retrovirus Infection: 2nd Edition
edited by , and Kotaro Shirakawa
submission deadline 25 Feb 2026 | 4 articles | Viewed by 8656 | Submission Open
Keywords: retrovirus; ATL; HIV-1; AIDS
(This special issue belongs to the Section Molecular Microbiology)
Advancements in Host-Directed Antiviral Therapies submission deadline 25 Feb 2026 | 1 articles | Viewed by 8424 | Submission Open
Keywords: antiviral drugs; drug discovery; host cell targets; HIV; HCV; influenza; SARS-CoV-2
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Cell Proliferation, Senescence and Apoptosis
edited by
submission deadline 25 Feb 2026 | 3 articles | Viewed by 8149 | Submission Open
Keywords: biological molecules; cell proliferation; senescence; apoptosis; human diseases
(This special issue belongs to the Section Molecular Biology)
Understanding Aging in Health and Disease
edited by
submission deadline 25 Feb 2026 | 2 articles | Viewed by 7821 | Submission Open
Keywords: immunosenescence; age-related disease; ageing; oxidative stress; inflammaging
(This special issue belongs to the Section Molecular Biology)
Interactions of Microbiome in Skin, Gastrointestinal, and Mucocutaneous Diseases
edited by Capercomorin S. Pitchumoni and
submission deadline 25 Feb 2026 | 2 articles | Viewed by 7321 | Submission Open
Keywords: human microbiome; immune system; skin disease; gut– skin axis; gut flora; microbe-host interactions; microbial metabolites; dysbiosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Forensic Toxicology: Innovative Approaches in Detection of New Psychoactive Substances
edited by Roberta Tittarelli and Giulio Mannocchi
submission deadline 25 Feb 2026 | 3 articles | Viewed by 7119 | Submission Open
Keywords: addiction; new psychoactive substances; mass spectrometry; biological matrices; diversion; forensic toxicology; drug testing
(This special issue belongs to the Section Molecular Toxicology)
Reproductive Genetics and Epigenetics: Insights into Infertility Failures and Treatment Pathways
edited by
submission deadline 25 Feb 2026 | 3 articles | Viewed by 6608 | Submission Open
Keywords: infertility; epigenetics; polymorphism; gametogenesis; fertilization; embryo development; reproductive organs; congenital malformations
(This special issue belongs to the Section Molecular Genetics and Genomics)
Cellular and Molecular Mechanisms of Cardiovascular Repair
edited by
submission deadline 25 Feb 2026 | 3 articles | Viewed by 6051 | Submission Open
Keywords: fibroblasts; injury repair; cardiac scar; extracellular matrix; fibrosis; angiogenesis; inflammation; cardioprotection
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
From Macrophage Biology to Cell and EV-Based Immunotherapies submission deadline 25 Feb 2026 | 2 articles | Viewed by 5599 | Submission Open
Keywords: macrophage-based; macrophage-targeting; cancer immunotherapies; autoimmunity
(This special issue belongs to the Section Molecular Immunology)
Advancements in Understanding Protein Misfolding Disorders and Cancer
edited by
submission deadline 25 Feb 2026 | 2 articles | Viewed by 5393 | Submission Open
Keywords: protein misfolding; cancer; amyloidosis
(This special issue belongs to the Section Molecular Oncology)
Peptide Self-Assembly
edited by
submission deadline 25 Feb 2026 | 3 articles | Viewed by 5303 | Submission Open
Keywords: peptide assembly; aromatic short peptides; bioinspired supramolecular architectures; functional materials; peptide microfabrication; anticancer therapy; supercapacitor; biosensing
(This special issue belongs to the Section Macromolecules)
Molecular Advances in Electrochemical Materials
edited by
submission deadline 25 Feb 2026 | 2 articles | Viewed by 5124 | Submission Open
Keywords: electrochemical materials; molecular design; energy storage; electrocatalysis; sensing applications; nanomaterials; sustainable materials; hybrid systems; interface engineering; green chemistry
(This special issue belongs to the Section Materials Science)
Chemistry Triggered by Low-Energy Particles
edited by Hassan Abdoul-Carime
submission deadline 25 Feb 2026 | 3 articles | Viewed by 4927 | Submission Open
Keywords: low energy (< 50 eV); photons; electrons; ions; gas phase; single molecules; clusters; condensed phase liquids and films; experimental techniques; density functional theory; IA-based prediction models
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Heart Failure Risk Factors and Therapies on a Molecular Basis
edited by
submission deadline 25 Feb 2026 | 2 articles | Viewed by 4094 | Submission Open
Keywords: heart failure; risk factors; inflammatory; neutrophils; cytokines; pharmacological; therapies; molecular-based processes
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Heavy Metal Exposure on Health
edited by
submission deadline 25 Feb 2026 | 3 articles | Viewed by 3468 | Submission Open
Keywords: heavy metals; toxic metal exposure; oxidative stress; mitochondrial dysfunction; epigenetic alterations; physiological and molecular pathways of cellular toxicology; biomarkers of toxicity; chelating agents; antioxidants; therapies or treatments
(This special issue belongs to the Section Molecular Toxicology)
Phytochemical Dynamics: Plant Metabolite Responses to Environmental Factors
edited by
submission deadline 25 Feb 2026 | 2 articles | Viewed by 3298 | Submission Open
Keywords: plant metabolites; phytochemicals; biotic and abiotic factors; environmental influences; biochemical pathways; interactions
(This special issue belongs to the Section Molecular Plant Sciences)
Advances and Current Challenges in Plasma Medicine submission deadline 25 Feb 2026 | 2 articles | Viewed by 3202 | Submission Open
Keywords: plasma medicine; plasma pharmacology; plasma oncology; plasma bioengineering; plasma agronomy; plasma and food; plasma and automotive; plasma and aerospace; plasma diagnostics; plasma material processing; plasma polymerization and coating; simulation of plasma phenomena during interaction with matter
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cell Fate Decisions: Autophagy, Apoptosis, Pyroptosis, Necroptosis, Ferroptosis and PANoptosis in Health and Disease
edited by
submission deadline 25 Feb 2026 | 1 articles | Viewed by 2385 | Submission Open
Keywords: inflammation; autophagy; apoptosis; pyroptosis; necroptosis; PANoptosis; ferroptosis; cell death; cell survival
(This special issue belongs to the Section Molecular Biology)
Immune Regulation in Lung Diseases submission deadline 25 Feb 2026 | 3 articles | Viewed by 2382 | Submission Open
Keywords: lung disease; immune system; lung immune cells; lung epithelial cells; therapy
(This special issue belongs to the Section Molecular Immunology)
Obesity: From Cellular Mechanism to Potential Molecular Therapies
edited by
submission deadline 25 Feb 2026 | 1 articles | Viewed by 1850 | Submission Open
Keywords: metabolic pathways; gene expression; epigenetics; obesity-related comorbidities; molecular biomarkers; adipogenesis; therapeutic interventions; small molecules; gene therapy/gene editing; obesity and cancer
(This special issue belongs to the Section Molecular Biology)
The Regulation of Microorganisms on Human Endocrine and Metabolic Systems
edited by Thi Phuong Nam Bui and Valentina Tremaroli
submission deadline 25 Feb 2026 | 1 articles | Viewed by 1418 | Submission Open
Keywords: human gut microbiome; endocrine signaling; metabolism; obesity; type 2 diabetes; cardiometabolic diseases
(This special issue belongs to the Section Molecular Microbiology)
Extracellular Vesicles: Functions and Therapeutic Applications
edited by Deepshikha Tewari
submission deadline 25 Feb 2026 | Viewed by 949 | Submission Open
Keywords: extracellular vesicles; exosome; cell-to-cell communication; diagnosis; treatment; molecular markers; diseases
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanism and Pathogenesis of Neuroinflammation in Neurological Disorders
edited by
submission deadline 25 Feb 2026 | Viewed by 545 | Submission Open
Keywords: age-related disorders; Alzheimer’ s disease; amyloid-β ; bioactive molecules; cognitive impairment; dementia; glial activation; microglia; neuroinflammation; neurological disorders; neurotherapeutics; tau hyperphosphorylation
(This special issue belongs to the Section Molecular Neurobiology)
New Insights into Molecular Mechanisms of Chronic Kidney Disease submission deadline 25 Feb 2026 | Viewed by 531 | Submission Open
Keywords: chronic kidney disease; molecular mechanism; signaling pathways; endothelial dysfunction; inflammation; genetic variants; epigenetics; oxidative stress
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Thyroid Cancer: From Pathophysiology to Novel Therapies
edited by Miklós Bodor
submission deadline 25 Feb 2026 | Viewed by 501 | Submission Open
Keywords: thyroid cancer; therapies; cell signaling; biomarker; kinase inhibitors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Shaping Macrophages Polarization as an Emerging Therapeutic Approach submission deadline 25 Feb 2026 | Viewed by 424 | Submission Open
Keywords: macrophage polarization; M1 macrophages; M2 macrophages; immune modulation; small molecules; therapeutic strategies; inflammation; cancer immunotherapy; drug resistance
(This special issue belongs to the Section Molecular Immunology)
Advanced Molecular Research in Thromboinflammation
edited by Emanuele Valeriani
submission deadline 25 Feb 2026 | Viewed by 383 | Submission Open
Keywords: blood coagulation factors; blood platelets; endothelium; inflammation; thromboinflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research on Signal Transduction Mechanisms of Cancer Cells
edited by
submission deadline 25 Feb 2026 | Viewed by 375 | Submission Open
Keywords: signal transduction mechanisms; cancer cell invasion; cancer cell metastasis; tumorigenesis; cell proliferation
(This special issue belongs to the Section Molecular Oncology)
Brain Cancers: Molecular Diagnostic and Therapeutic Approaches submission deadline 25 Feb 2026 | Viewed by 372 | Submission Open
Keywords: brain tumors; gliomas; meningiomas; pituitary tumors; molecular diagnosis; liquid biopsy; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Perspectives in Nanoadsorption
edited by Carmen María Del Hoyo Martinez
submission deadline 25 Feb 2026 | Viewed by 341 | Submission Open
Keywords: nanoadsorption; nanomaterials; molecular mechanism; emerging contaminants removal in pharmaceutical and food industries; X-ray diffraction (XRD); thermal analysis techniques (DSC); Fourier-transform infrared spectroscopy (FTIR); Raman spectroscopy; molecular functionalization in nanoadsorption
(This special issue belongs to the Section Materials Science)
New Advances in Type 2 Diabetes and Its Complications: 2nd Edition
edited by
submission deadline 25 Feb 2026 | Viewed by 297 | Submission Open
Keywords: diabetes type 2; diabetes complications; pathophysiology of type 2 diabetes; new diabetes treatment; cardiovascular disease; stroke; peripheral artery disease; chronic kidney disease; retinopathy; neuropathy; non-alcoholic fatty liver disease in diabetes
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Advancements in Functional Materials
edited by
submission deadline 25 Feb 2026 | Viewed by 251 | Submission Open
Keywords: synthesis of specialty compounds; specialty compounds in functional materials; special applications: self-cleaning; anti-icing; self-healing; biocidal; etc.; properties; special-purpose functional materials
(This special issue belongs to the Section Materials Science)
Advances in the Design, Synthesis, and Characterization of Metal Complexes with Multifaceted Biological Activities
edited by
submission deadline 25 Feb 2026 | Viewed by 192 | Submission Open
Keywords: metal complexes; molecular design; biological activity; structure– activity relationships; therapeutic applications
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Endothelial Cells in Vascular Health and Immunity
edited by and Xianming Zhang
submission deadline 25 Feb 2026 | Viewed by 172 | Submission Open
Keywords: endothelial cells; vascular health; cardiovascular disease; kidney disease; lung injury; inflammation; regenerative medicine; molecular therapy
(This special issue belongs to the Section Biochemistry)
Nanocompounds for Drug Delivery submission deadline 25 Feb 2026 | Viewed by 103 | Submission Open
Keywords: nanocompounds; drug delivery systems; targeted delivery; stimuli-responsive nanocarriers; hybrid nanostructures; controlled release; biocompatibility; photodynamic therapy (PDT); photothermal therapy (PTT)
(This special issue belongs to the Section Molecular Nanoscience)
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