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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Metabolic Syndrome: New Insights in Pathogenesis, Diagnosis, Prevention, and Management submission deadline 20 Sep 2025 | 10 articles | Viewed by 14300 | Submission Open
Keywords: insulin resistance; hypertension; diabetes mellitus; obesity; inflammation; stress; metabolic disorders; reproductive endocrine disorders; polycystic ovarian syndrome; waist circumference; estrogen deficiency; disturbances in adipose tissue; physical inactivity; overnutrition; cardiovascular diseases; abdominal obesity; genetics and epigenetics of metabolic syndrome; computational analysis
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Natural and Synthetic Compounds for Management, Prevention and Treatment of Obesity, 3rd Edition submission deadline 20 Sep 2025 | 4 articles | Viewed by 13405 | Submission Open
Keywords: obesity; adipokines; obesogens; genetic predisposition; natural/synthetic compounds; cardiovascular disorders; type II diabetes; non-alcoholic fatty liver disease; cancer
(This special issue belongs to the Section Molecular Pharmacology)
Advances in the Molecular Diagnosis and Treatment of Pancreatic Cancer
edited by Steven T. Brower and Robert Pergolizzi
submission deadline 20 Sep 2025 | 5 articles | Viewed by 12777 | Submission Open
Keywords: pancreatic cancer; molecular diagnostics; biomarkers; oncogenes; epigenetics; genomic profiling; next-generation sequencing; liquid biopsy; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Molecular Research in Breast Cancer: Pathophysiology and Treatment
edited by Costa Frangou
submission deadline 20 Sep 2025 | 6 articles | Viewed by 12675 | Submission Open
Keywords: breast; biomarker; early detection; immunotherapy; metastasis; microenvironment; outcomes; prognosis; relapse; treatment; tumor
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Editorial Board Members’ Collection Series: Genome Stability submission deadline 20 Sep 2025 | 5 articles | Viewed by 12165 | Submission Open
Keywords: genome stability; DNA damage response; DNA repair; DNA replication; DNA recombination; ATR/ATM pathway; GENOTOXINS
(This special issue belongs to the Section Molecular Genetics and Genomics)
Neurodegenerative Diseases: Molecular Mechanisms and Therapies, 3rd Edition submission deadline 20 Sep 2025 | 4 articles | Viewed by 12097 | Submission Open
Keywords: neurodegeneration; neurodegenerative diseases; protein aggregation; pathogenesis; therapy; mitochondria; neuroinflammation; oxidative stress; cell therapy; clinical trial 
(This special issue belongs to the Section Molecular Neurobiology)
The Emerging Role of Neutrophils in Cancer: Molecular Aspects of Plasticity and Potential Therapeutic Targets
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 11657 | Submission Open
Keywords: neutrophils; cancer; tumor microenvironment; tumor-associated neutrophils; innate immunity
(This special issue belongs to the Section Molecular Oncology)
The Zebrafish Model in Animal and Human Health Research, 2nd Edition submission deadline 20 Sep 2025 | 7 articles | Viewed by 11557 | Submission Open
Keywords: zebrafish; environmental toxicology; predictive toxicology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Bacteria
edited by
submission deadline 20 Sep 2025 | 10 articles | Viewed by 11401 | Submission Open
Keywords: infections; bacteria; molecular biology; antimicrobials; bacterial enzymes; bioremediation
(This special issue belongs to the Section Molecular Microbiology)
Molecular Biology and Hormonal Regulation in Reproductive Processes
edited by and Helena Ban Frangež
submission deadline 20 Sep 2025 | 4 articles | Viewed by 11004 | Submission Open
Keywords: infertility; reproduction; embryos; genetics; epigenetics; signaling pathway; sperm; oocyte
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Tau Pathobiology in Neurodegenerative Diseases: From Molecular Mechanisms to Therapeutic Advances submission deadline 20 Sep 2025 | 3 articles | Viewed by 10494 | Submission Open
Keywords: Alzheimer’ s disease; tauopathies; tau neurotoxicity; cellular and animal models; signaling pathways; tau-targeting therapies  
(This special issue belongs to the Section Molecular Neurobiology)
Molecular and Translational Research on Bone Tumors, 2nd Edition submission deadline 20 Sep 2025 | 2 articles | Viewed by 10451 | Submission Open
Keywords: primary bone tumours; metastatic bone tumour; therapy; biomarkers; epigenetic factors; immune-oncology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
102nd Anniversary of Neurotransmitter Discovery: Cholinergic Pathways in Physiology and Pathophysiology
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 9594 | Submission Open
Keywords: acetylcholine; physiological functions; pathological alterations; cholinergic pathways
(This special issue belongs to the Section Biochemistry)
Advances in Genetics of Human Reproduction submission deadline 20 Sep 2025 | 7 articles | Viewed by 9574 | Submission Open
Keywords: genetic; human reproduction; infertility; medically assisted reproduction; pregnancy complications; recurrent miscarriage
(This special issue belongs to the Section Molecular Genetics and Genomics)
Mitochondrial Dysfunction: A Metabolic, Cardiovascular, Neurodegenerative and Neuromuscular Issue: 2nd Edition
edited by , and Claudia Nesti
submission deadline 20 Sep 2025 | 4 articles | Viewed by 9380 | Submission Open
Keywords: bioenergetics; mitochondrial disorders; biomarkers; OxPhos complexes; mitochondrial DNA; aging; neurodegenerative diseases; cardiovascular diseases; metabolic diseases; therapies to counteract mitochondrial dysfunction TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insight into the Processing and Characterization of Animal Fats and Vegetable Oils
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 8863 | Submission Open
Keywords: lipid molecules; oils; fats; lipase; interesterification; hydrolysis; phospholipids; fatty acids; molecular research; nutrition; cosmetics matrices; medical applications; food; pharmacy; bioengineering; novel applications; biofuels
(This special issue belongs to the Section Molecular Biology)
Current Advances and Perspectives in Microbial Genetics and Genomics
edited by and Lucila Saavedra
submission deadline 20 Sep 2025 | 6 articles | Viewed by 8647 | Submission Open
Keywords: microbial genetics; genomics and metagenomics; gene regulation; microbe– host interactions; adaption and resistance mechanisms; microbial metabolism
(This special issue belongs to the Section Molecular Microbiology)
State-of-the-Art Molecular Oncology in Brazil, 3rd Edition submission deadline 20 Sep 2025 | 4 articles | Viewed by 8567 | Submission Open
Keywords: apoptosis; autophagy; calcium; cancer; cell death; chemotherapy; metabolism; mitochondria; drug resistance; oxidative stress
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of Plant Abiotic Stress Tolerance: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 6 articles | Viewed by 8470 | Submission Open
Keywords: acclimation; drought; salinity; pesticides; high– low temperature; high– low light intensity; nutrient deficiencies; heavy metals; UV radiation; photosynthetic efficiency; ROS; antioxidant mechanisms; redox regulation
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms and Pathophysiology of Sepsis
edited by
submission deadline 20 Sep 2025 | 8 articles | Viewed by 8459 | Submission Open
Keywords: animal models; therapeutic concepts; biomarkers; sepsis; immune suppression; epigenetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Physiological Mechanisms of Exercise
edited by Zoran Nikolovski
submission deadline 20 Sep 2025 | 3 articles | Viewed by 8272 | Submission Open
Keywords: molecular biology; biochemistry and exercise; athletic performance; multi-omic
(This special issue belongs to the Section Molecular Biology)
Arrhythmias: Molecular Mechanisms and Therapeutic Strategies
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 8164 | Submission Open
Keywords: cardiac arrhythmias; atrial fibrillation; ventricular arrhythmia; electrophysiologic alternation; ion channel; connexin; autonomic nerve system dysfunction; sleep-disordered breathing; obstructive sleep apnea
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Editorial Board Members’ Collection Series: Pain submission deadline 20 Sep 2025 | 3 articles | Viewed by 8124 | Submission Open
Keywords: cancer; inflammation; neuropathy; primary sensory neurons; spinal cord; brain
(This special issue belongs to the Section Molecular Pharmacology)
Role of Natural Compounds in Human Health and Disease
edited by Jaewon Shim and
submission deadline 20 Sep 2025 | 6 articles | Viewed by 7906 | Submission Open
Keywords: natural compound; therapeutic applications; action mechanisms of natural compounds; traditional medicine
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research in Spinal Cord Injury
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 7870 | Submission Open
Keywords: spinal cord injury; molecular mechanisms; stem cell therapy; tissue engineering; neuroinflammation; neuroprotection; genetic regulation; epigenetics; therapeutic strategies
(This special issue belongs to the Section Molecular Neurobiology)
Mycotoxins, Immunity, and Inflammation
edited by
submission deadline 20 Sep 2025 | 5 articles | Viewed by 7841 | Submission Open
Keywords: mycotoxin; immunity; inflammation; immunotoxicity; immunology
(This special issue belongs to the Section Molecular Toxicology)
Zebrafish as a Model in Human Disease: 3rd Edition submission deadline 20 Sep 2025 | 4 articles | Viewed by 7830 | Submission Open
Keywords: zebrafish; CRISPR/Cas9; transgenic lines; biosensors; endothelial cells; extracellular matrix; genetic mutant for human disease modeling; xenografts
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Boosting the Production of Bioactive Compounds: Biotechnology and Metabolic Engineering of Medicinal Plants submission deadline 20 Sep 2025 | 5 articles | Viewed by 7823 | Submission Open
Keywords: bioactive compounds; plant tissue culture; elicitors; metabolic engineering; gene expression; medicinal plants; metabolic pathway; plant biotechnology
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Advances and Insights into Liver Diseases
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 7784 | Submission Open
Keywords: liver; hepatocellular carcinoma; cancer; hepatitis; cirrhosis; encephalopathy; non-alcoholic fatty liver disease; autoimmune diseases; Wilson’ s disease; fatty liver disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research of Metallic Nanoparticles
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 7701 | Submission Open
Keywords: metallic nanoparticles (MNPs); biosensors; synthesis methods; molecular spectroscopy characteristic; molecular medicine; molecular biology
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Research of Epithelial Function and Barrier Dysfunction
edited by Fariba Rezaee
submission deadline 20 Sep 2025 | 4 articles | Viewed by 7516 | Submission Open
Keywords: epithelial cells; actin cytoskeleton; viral infection; apical junctional complex; tight junction; adherens junction; barrier dysfunction; trans-epithelial electrical resistance; permeability; epithelial barrier
(This special issue belongs to the Section Molecular Immunology)
Viral Infections and Immune Responses submission deadline 20 Sep 2025 | 5 articles | Viewed by 7498 | Submission Open
Keywords: virus; infections; immune response; T-cells; B-cells; antibodies; neutralizing activity
(This special issue belongs to the Section Molecular Immunology)
Molecular Biology of Protein Kinases: Regulatory Mechanisms, Therapeutic Targets and Cancer Treatments
edited by Jaw Ji Yang
submission deadline 20 Sep 2025 | 2 articles | Viewed by 7441 | Submission Open
Keywords: protein kinases; signal transduction; cancer therapy; regulatory mechanisms; kinase inhibitors; therapeutic targets; molecular biology; structural biology; translational research; clinical applications
(This special issue belongs to the Section Molecular Biology)
The Role and Mechanism of P2X7 Receptor in Cancer and Inflammatory Diseases
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 7183 | Submission Open
Keywords: P2X7 receptor; inflammation; cancer; purinergic signalling
(This special issue belongs to the Section Molecular Immunology)
The Biochemistry, Molecular and Cell Biology Beyond Flowers
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 6925 | Submission Open
Keywords: flowers; homeotic genes; MADSBox; molecular expression; pollination; stress; transcription factors
(This special issue belongs to the Section Molecular Plant Sciences)
State-of-the-Art Molecular Immunology in Chile, 2nd Edition submission deadline 20 Sep 2025 | 3 articles | Viewed by 6816 | Submission Open
Keywords: innate immunity; adaptive immunity; host– pathogen interactions; immunopathology; osteoimmunology; immunosenescence; immunotherapy; antibody; vaccines; Chile
(This special issue belongs to the Section Molecular Immunology)
Drug Discovery: Design, Synthesis and Activity Evaluation submission deadline 20 Sep 2025 | 4 articles | Viewed by 6764 | Submission Open
Keywords: drug design; organic synthesis; biological activity evaluation; biologically active compounds; diagnostic/therapeutic agents; labeled ligands; structure– activity relationships (SARs); structural biological studies; computational studies; pharmacokinetics/pharmacodynamics; drug delivery
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Melanoma and Skin Cancers: 2nd Edition
edited by , and Maria Grazia Vitale
submission deadline 20 Sep 2025 | 6 articles | Viewed by 6727 | Submission Open
Keywords: melanoma; immunotherapy; biomarkers; translational research; drug repurposing; clinical outcome; prognostic markers; predictive markers; combination immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of Microbe–Skin Interactions
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 6703 | Submission Open
Keywords: colonization; cosmetics; diseases (e.g.; acne; diabetic foot syndrome (DFS); psoriasis; etc.); health; immunity; lipidomics; metabolomics; metagenomics; neurotransmitter; physiology; skin habitat; skin microbiota; prebiotics; probiotics; wound healing
(This special issue belongs to the Section Molecular Microbiology)
New Insights into Anti-cancer Drug Discovery and Development
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 6695 | Submission Open
Keywords: anti-cancer drug resistant; cancer recurrence; cancer metastasis; cancer stem cells; target validation; target identification; metabolic reprogramming of cancer stem cells; unmet medical needs
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Basis of Pancreatic Secretion and Metabolism
edited by
submission deadline 20 Sep 2025 | 5 articles | Viewed by 6680 | Submission Open
Keywords: exocrine of the pancreas; endocrine of the pancreas; acute pancreatitis; chronic pancreatitis; cystic fibrosis; pancreatic metabolic hormones; pancreatic metabolic disease; mechanism of pancreatic bicarbonate secretion; the sodium bicarbonate cotransporter (NBC); cystic fibrosis transmembrane conductance regulator (CFTR); regulators of the ion channels and ion transporters involved in secretion
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
CNS Injuries: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 6492 | Submission Open
Keywords: stroke; TBI; brain edema; SCI; spinal cord edema; neuroinflammation; neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
Application of Natural Products in Biomedicine and Pharmacotherapy: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 6 articles | Viewed by 6483 | Submission Open
Keywords: natural products; biomedicine; genotoxicity; epigenetics; aging
(This special issue belongs to the Section Molecular Pharmacology)
Oxidative Stress and Cell Damage
edited by Haruhiko Inufusa, Koji Abe and Shigeru Hirano
submission deadline 20 Sep 2025 | 2 articles | Viewed by 6412 | Submission Open
Keywords: oxidative stress; damages on cells; organs; body; prevention damages; parameter of oxidative stress; antioxidants
(This special issue belongs to the Section Molecular Biology)
Flow Cytometry: Applications and Challenges
edited by
submission deadline 20 Sep 2025 | 5 articles | Viewed by 6358 | Submission Open
Keywords: flow cytometry; non-conventional flow cytometry; hematology; morphology; molecular tests; cell biology; immunology; target therapy; microbiology; antigens; functional mechanisms; new technologies
(This special issue belongs to the Section Molecular Biology)
Redox Homeostasis and Oxidative Stress in Human Metabolism and Disease:2nd Edition submission deadline 20 Sep 2025 | 6 articles | Viewed by 6283 | Submission Open
Keywords: antioxidants; biomarkers; cellular functions; disease etiology; disease progression; metabolic disorders; metabolic signaling; oxidative stress; pathophysiological states; reactive oxygen species; redox homeostasis; redox signaling
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in Research for Legume Genomics, Genetics, and Breeding, 2nd Edition
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 6195 | Submission Open
Keywords: legumes; genomics; plant breeding; seed composition; gene function; biotic and abiotic stress; legume pathogen resistance/mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Apoptosis and Autophagy as Strategies in Cancer Treatment
edited by Dorota Ciołczyk-Wierzbicka
submission deadline 20 Sep 2025 | 3 articles | Viewed by 6100 | Submission Open
Keywords: apoptosis; autophagy; cancer therapy/treatment; drug resistance; signaling pathways
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactive Compounds and Their Anticancer Effects
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 6087 | Submission Open
Keywords: ferroptosis; natural compounds; bioactive compounds; p53; anti-cancer drugs
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms and Therapies for Metabolic-Associated Fatty Liver Diseases
edited by Yi-Ming Arthur Chen
submission deadline 20 Sep 2025 | 2 articles | Viewed by 5986 | Submission Open
Keywords: metabolic-associated fatty liver disease; MAFLD; metabolic dysfunction-associated steatohepatitis; MASH; molecular mechanism; genetic polymorphism; individualized medicine; prevention; new drug development; health supplements; diagnosis; epidemiology; lifestyle
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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