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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Organic/Inorganic Nanocomposites on the Basis of 'Three Pillars' (Organic Compounds, Metal Nanoparticles, and Carbon Nanomaterials)
edited by
submission deadline 20 Jul 2025 | 7 articles | Viewed by 9281 | Submission Open
Keywords: organic/inorganic composites; hybrid materials; composite materials; organic films; polymers; aromatic molecules; metal nanoparticles; carbon nanomaterials; carbon nanotubes; graphene
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Insights into Kidney Injury and Repair
edited by
submission deadline 20 Jul 2025 | 5 articles | Viewed by 8994 | Submission Open
Keywords: kidney injury; renal repair; acute kidney injury (AKI); chronic kidney disease (CKD); sepsis; ischemia-reperfusion (I/R) injury; nephrotoxin exposition; adult renal progenitor cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Metal-Based Drugs and Research on Mechanisms of Action submission deadline 20 Jul 2025 | 3 articles | Viewed by 8957 | Submission Open
Keywords: transition metals; metal complexes; metallodrugs; drug development; synthesis; imaging agents; structure– activity ratio
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanisms of Endothelial Dysfunction: Fourth Edition
edited by
submission deadline 20 Jul 2025 | 5 articles | Viewed by 8890 | Submission Open
Keywords: vascular permeability; atherosclerosis; blood– brain barrier; endothelial adhesion molecules; vasodilation; thrombosis
(This special issue belongs to the Section Molecular Immunology)
Functional Roles of Epithelial and Endothelial Cells submission deadline 20 Jul 2025 | 7 articles | Viewed by 8809 | Submission Open
Keywords: epithelial cells; wound healing; endothelial cells; skin; cornea; functionality; barrier
(This special issue belongs to the Section Biochemistry)
Challenges and Future Perspectives in Treatment for Lung Cancer
edited by Ilaria Marrocco and
submission deadline 20 Jul 2025 | 7 articles | Viewed by 8680 | Submission Open
Keywords: lung cancer; non-small cell lung cancer; small cell lung cancer; chemotherapy; targeted therapy; immunotherapy; drug resistance; drug delivery
(This special issue belongs to the Section Molecular Oncology)
Hepatopancreatic and Intestine Diseases: From Molecular Basis to Therapy
edited by and Emma Folch-Puy
submission deadline 20 Jul 2025 | 4 articles | Viewed by 8459 | Submission Open
Keywords: hepatopancreatic diseases; intestine diseases; molecular basis; therapy; pathogenesis; molecular pathways; pharmacological interventions; surgical techniques; immunotherapies; regenerative medicine approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
A Molecular Perspective on Reproductive Health, 2nd Edition submission deadline 20 Jul 2025 | 4 articles | Viewed by 8384 | Submission Open
Keywords: reproductive function; molecular bases; male; female; reproductive pathology; reproductive physiology
(This special issue belongs to the Section Biochemistry)
Novel Insight into Epigenomic Studies of Human Disease
edited by and Takashi Ito
submission deadline 20 Jul 2025 | 5 articles | Viewed by 8377 | Submission Open
Keywords: epigenetic regulation; DNA methylation; protein methylation; protein acetylation; histone modification; noncoding RNAs (ncRNAs); post-translational modifications (PTMs); chromatin; human disease
(This special issue belongs to the Section Molecular Genetics and Genomics)
Natural Products in Cancer Prevention and Treatment submission deadline 20 Jul 2025 | 7 articles | Viewed by 8316 | Submission Open
Keywords: natural products; cancer; therapeutic strategies; novel molecular pathways
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Versatility of Protein Synthesis in a Test Tube
edited by
submission deadline 20 Jul 2025 | 5 articles | Viewed by 8177 | Submission Open
Keywords: protein synthesis; synthetic biology; cell-free translation; in vitro translation
(This special issue belongs to the Section Molecular Biology)
Glycobiology in Human Health and Disease
edited by Katrin Mani
submission deadline 20 Jul 2025 | 5 articles | Viewed by 8176 | Submission Open
Keywords: glycans and glycoconjugates; glycoproteins; proteoglycans; glycolipids; glycosylation including glycosyltransferases and glycosidases; carbohydrate and glycan metabolism; glycan structure; disease biomarkers; glycan signaling; glycoimmunology; glycomics
(This special issue belongs to the Section Macromolecules)
Recent Advances in Lung Cancer
edited by
submission deadline 20 Jul 2025 | 3 articles | Viewed by 8173 | Submission Open
Keywords: lung cancer; immunotherapy; molecular diagnostic; next-generation sequencing
(This special issue belongs to the Section Molecular Oncology)
Viral Infections and Host Immune Responses
edited by and Maria Teresa Maggiorella
submission deadline 20 Jul 2025 | 5 articles | Viewed by 8168 | Submission Open
Keywords: virus infections; virus– host interaction; innate immunity; adaptive immunity; host factors; co-infections; acute and chronic infections; restriction factors; therapeutic strategies
(This special issue belongs to the Section Molecular Microbiology)
Prostate Cancer: Novel Research and Innovative Therapeutic Strategies submission deadline 20 Jul 2025 | 4 articles | Viewed by 8113 | Submission Open
Keywords: prostate cancer; therapeutic strategy; castration-resistant PCa
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Biomedical and Tissue Engineering Strategies to Cross the Blood–Brain Barrier for Next-Generation Treatments Against Neurodegenerative Diseases
edited by and Livia La Barbera
submission deadline 20 Jul 2025 | 5 articles | Viewed by 8026 | Submission Open
Keywords: neurodegenerative diseases; Alzheimer’ s disease; CNS; blood– brain barrier; drug delivery systems; nanocarriers; nanomedicine; tissue engineering; theranostics
(This special issue belongs to the Section Molecular Neurobiology)
A Molecular Perspective on the Genetics of Kidney Diseases
edited by Joaquim Calado
submission deadline 20 Jul 2025 | 4 articles | Viewed by 8009 | Submission Open
Keywords: kidney; genetics; solute transport; genomics; inflammation; dysmetabolism
(This special issue belongs to the Section Molecular Genetics and Genomics)
Cutting-Edge Research and Applications of Extracellular Microvesicles in Disease Management
edited by María Isabel Torres
submission deadline 20 Jul 2025 | 5 articles | Viewed by 7973 | Submission Open
Keywords: extraccellular microvesicles; exosome; ectosoma; biomarkers; cargoes of extracellular vesicles; therapeutics; diagnosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Protein–Ligand Interactions
edited by Dong-Jun Yu
submission deadline 20 Jul 2025 | 4 articles | Viewed by 7929 | Submission Open
Keywords: drug design; binding specificity; molecular docking; ligand screening; structural biology; protein– protein interactions; protein– ligand interactions; protein– lipid complexes; protein– nucleic acid interactions
(This special issue belongs to the Section Macromolecules)
Inflammation in Chronic Disease: Molecular Mechanisms and Signaling Pathways
edited by
submission deadline 20 Jul 2025 | 4 articles | Viewed by 7915 | Submission Open
Keywords: inflammation; neuroinflammation; immune response; inflammation-associated disease; inflammation mediators (proteins; enzymes; ecc); cytokines; macrophages; mast cells; monocytes; dendritic cells; oxidative stress; signaling pathways
(This special issue belongs to the Section Molecular Immunology)
Cardiovascular Diseases: Histopathological and Molecular Diagnostics
edited by
submission deadline 20 Jul 2025 | 6 articles | Viewed by 7835 | Submission Open
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Progress of Opioid Research, 2nd Edition submission deadline 20 Jul 2025 | 5 articles | Viewed by 7685 | Submission Open
Keywords: opioids; opioid crisis; pain; analgesic; addiction; dependence; stress; reward; opioid peptides; opioid use disorder
(This special issue belongs to the Section Molecular Pharmacology)
Dopamine, Histamine, Serotonin—Receptors, Ligands and Their Biological Role in Central Nervous System Diseases, 2nd Edition submission deadline 20 Jul 2025 | 4 articles | Viewed by 7633 | Submission Open
Keywords: biogenic amines (histamine; dopamine; serotonin); receptors; ligands; antagonist/inverse agonist; affinity; intrinsic activity; multitarget ligands; molecular modeling; CNS diseases; neurodegeneration; psychiatric disorders; pain; in vitro studies; in silico studies; in vivo studies
(This special issue belongs to the Section Molecular Neurobiology)
New Computational Methodologies for Biomolecule Sequence, Structure and Function Discovery
edited by Fei Guo
submission deadline 20 Jul 2025 | 6 articles | Viewed by 7619 | Submission Open
Keywords: bioinformatics; machine learning; deep learning; biomolecule identification; biological networks; structural proteomics; gene expression analysis; molecular docking; post-translational modifications
(This special issue belongs to the Section Molecular Informatics)
Molecular Metabolisms in Cartilage Health and Diseases: 3rd Edition
edited by
submission deadline 20 Jul 2025 | 5 articles | Viewed by 7200 | Submission Open
Keywords: cartilage; chondrocytes; growth; regeneration; endochondral ossification; arthritis; joint; growth factors; mechanical stress; nutrition
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Hormone Signaling in Human Health and Diseases, 2nd Edition
edited by
submission deadline 20 Jul 2025 | 5 articles | Viewed by 7179 | Submission Open
Keywords: hormone; cell receptor; endocrine signaling; cancer; insulin; oestrogen; testosterone; angiotensin; gonadotropin; thyroid hormone
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Recent Advances in Molecular Mechanisms Underlying Kidney Diseases: Pathophysiology and Therapeutic Targets, 2nd Edition submission deadline 20 Jul 2025 | 4 articles | Viewed by 7105 | Submission Open
Keywords: kidney diseases; pathophysiology; molecular mechanisms; therapeutic targets; acute kidney injury; chronic kidney disease; polycystic kidney disease; end-stage renal disease; IgA nephropathy; diabetic nephropathy; hypertensive nephropathy; renal cancer; kidney infarction; kidney infection; kidney failure; kidney stones; renal tubular acidosis; renal artery stenosis; acute tubular necrosis; glomerulopathy; interstitial nephritis; nephrotic syndrome; simple kidney cyst
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Breakthroughs in Molecular Diagnostic Tools for Human Diseases submission deadline 20 Jul 2025 | 5 articles | Viewed by 6969 | Submission Open
Keywords: molecular pathology; molecular diagnostics; genetics; epigenetics; proteomics; immunohistochemistry; thrombo-embolic disease; sudden cardiac death; molecular pathology of traumatic injuries; hypoxic– ischemic brain damage; experimental models of injury and diseases; targeted therapy of injuries and diseases; drug abuse; histological diagnosis; epigenetics of organs injuries; miRNA and prognosis of diseases; novel approaches and proofs of principle in therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Challenges and Innovation in Neurodegenerative Diseases, 2nd Edition
edited by
submission deadline 20 Jul 2025 | 6 articles | Viewed by 6661 | Submission Open
Keywords: neurodegenerative diseases; pathogenesis; biomarkers; disease model; natural product; new drug discovery; therapy; machine learning; stem cell therapy
(This special issue belongs to the Section Molecular Neurobiology)
Genetic and Epigenetic Influences on Personality Traits and Athletic Performance submission deadline 20 Jul 2025 | 1 articles | Viewed by 6633 | Submission Open
Keywords: genetics; epigenetics; personality traits; athletic performance; polymorphisms; microbiome; neurotransmitters; molecular mechanisms; metabolic health; injury susceptibility
(This special issue belongs to the Section Molecular Genetics and Genomics)
Chimeric Antigen Receptors Against Cancers and Autoimmune Diseases
edited by
submission deadline 20 Jul 2025 | 3 articles | Viewed by 6429 | Submission Open
Keywords: chimeric antigen receptor (CAR); cancer; autoimmune disease; solid tumor; effector cell; CAR format; CAR transfer; tumor microenvironment; targeted antigen
(This special issue belongs to the Section Molecular Immunology)
Microplastics and Nanoplastics Ecotoxicological Effects in Seawater and Freshwater Organisms
edited by
submission deadline 20 Jul 2025 | 3 articles | Viewed by 6376 | Submission Open
Keywords: microplastics; exposure; aquatic organisms; sorption; degradation; bioaccumulation; biomagnification; migration; bioindicators; marine toxins
(This special issue belongs to the Section Molecular Toxicology)
The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation: Third Edition
edited by and
submission deadline 20 Jul 2025 | 5 articles | Viewed by 6338 | Submission Open
Keywords: toll-like receptors (TLR); pathogen associated molecular patterns (PAMPs); sepsis; bacterial infections; viral infections; Myd88; TRIF; NF-kappaB; COVID-19; coagulopathies
(This special issue belongs to the Section Molecular Immunology)
Role of RNA Decay in Bacterial Gene Regulation
edited by Sue Lin-Chao and
submission deadline 20 Jul 2025 | 4 articles | Viewed by 6284 | Submission Open
Keywords: RNA stabilizers; RNA decay; RNA turnover; small regulatory RNAs; post-transcriptional control
(This special issue belongs to the Section Molecular Microbiology)
Role of Proteomics in Human Diseases and Infections
edited by and Kevin Coombs
submission deadline 20 Jul 2025 | 5 articles | Viewed by 6284 | Submission Open
Keywords: proteomics; human diseases; infections; biomarkers; therapeutic targets; disease pathogenesis; host– pathogen interactions; diagnostic tools
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Medical Microbiology
edited by
submission deadline 20 Jul 2025 | 4 articles | Viewed by 6212 | Submission Open
Keywords: clinical microbiology; clinical virology; SARS-CoV-2; HPV; sexually transmitted infections; respiratory viruses; emerging pathogens; opportunistic infections
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms and Signalling Pathways in Cardiovascular Pathophysiology
edited by Ernesto Alejandro Aiello
submission deadline 20 Jul 2025 | 5 articles | Viewed by 6110 | Submission Open
Keywords: heart; vascular; signaling; cardiovascular disease; mechanism
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Genitourinary Cancers
edited by and
submission deadline 20 Jul 2025 | 2 articles | Viewed by 6089 | Submission Open
Keywords: genitourinary cancer; molecular markers; oxi-inflammation; tumor microenvironmental; natural products
(This special issue belongs to the Section Molecular Oncology)
Molecular Diagnostics and Therapeutics of Epileptic Neurodevelopment
edited by Christalena Sofocleous
submission deadline 20 Jul 2025 | 2 articles | Viewed by 6082 | Submission Open
Keywords: epileptic neurodevelopment; molecular diagnostics; next-generation sequencing; genetics; epigenetics; pathogenic/likely pathogenic variants; therapeutics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research on Nucleic Acids: Therapeutic Potential and Applications, 2nd Edition submission deadline 20 Jul 2025 | 4 articles | Viewed by 5997 | Submission Open
Keywords: aptamer; decoy; DNAzyme; ribozyme; siRNA; miRNA; antisense oligonucleotide; antigene strategy; G-quadruplex; triplex
(This special issue belongs to the Section Biochemistry)
Host-Pathogen Interaction, 6th Edition
edited by
submission deadline 20 Jul 2025 | 3 articles | Viewed by 5971 | Submission Open
Keywords: microorganisms; pathogen; bacteria; yeasts; protozoa; host organisms
(This special issue belongs to the Section Molecular Microbiology)
Genetic and Epigenetic Regulation of Reproduction submission deadline 20 Jul 2025 | 4 articles | Viewed by 5955 | Submission Open
Keywords: gene expression; gene mapping; germ cells; epigenetic factors; DNA methylation; histone modification; fertility; molecular diagnostics; next generation sequencing; prenatal diagnosis
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Mechanisms and Therapy of Cardiomyopathy submission deadline 20 Jul 2025 | 3 articles | Viewed by 5920 | Submission Open
Keywords: cardiomyopathy; nutrition; exercise; pharmacology; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Targeted Treatments in Cancer: 2nd Edition submission deadline 20 Jul 2025 | 3 articles | Viewed by 5716 | Submission Open
Keywords: TAT (targeting alpha therapy); nuclear medicine; cancer treatment; imaging; radioisotope (RI); surface marker; TRT (targeted radioisotope therapy)
(This special issue belongs to the Section Molecular Oncology)
New Insights into Aquaporins: 2nd Edition submission deadline 20 Jul 2025 | 4 articles | Viewed by 5509 | Submission Open
Keywords: aquaporin; membrane channel; regulation; pathophysiology; drug target
(This special issue belongs to the Section Molecular Biology)
New Insights into Gene Expression Regulation in the Next-Generation Sequencing (NGS) Era
edited by
submission deadline 20 Jul 2025 | 5 articles | Viewed by 5479 | Submission Open
Keywords: alternative splicing; DNA methylation; histone modification; RNA sequencing; epigenome; metagenomics; single-cell sequencing; spatial sequencing; microenvironment; microbiome profile
(This special issue belongs to the Section Molecular Genetics and Genomics)
Mitochondrial Function in Human Health and Disease: 2nd Edition
edited by
submission deadline 20 Jul 2025 | 4 articles | Viewed by 5427 | Submission Open
Keywords: mitochondial genesis and disease; mitochondrial function and aging; mitochondrial dysfunction and cancer; mitochondrial function and apoptosis; mitophage; autophage; mitochondrial AKT TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Biochemistry)
Molecular Insights into Macromolecules Structure, Function, and Regulation: 2nd Edition
edited by
submission deadline 20 Jul 2025 | 3 articles | Viewed by 5416 | Submission Open
Keywords: conformational dynamics; structural modeling; docking; molecular recognition; regulation mechanism; rational design; molecular dynamic simulation
(This special issue belongs to the Section Molecular Biophysics)
Advances and Perspectives in Limbal Epithelial Stem Cells and Their Niche
edited by and Ursula Schlötzer-Schrehardt
submission deadline 20 Jul 2025 | 3 articles | Viewed by 5407 | Submission Open
Keywords: limbal epithelial stem cells; ocular surface; limbal stem cell niche; homeostasis; limbal mesenchymal stromal cells; regeneration; limbal melanocytes; extracellular matrix components
(This special issue belongs to the Section Biochemistry)
Molecular Research and Cellular Biology of Breast Cancer submission deadline 20 Jul 2025 | 6 articles | Viewed by 5383 | Submission Open
Keywords: molecular mechanisms of tumor growth and diffusion; cancer cell biology; biology of tumor micro-environmental cells; MDR; hormone dependency; HER2 positive breast cancer; TNBC; genetic and epigenetic alterations; pro-tumor and anti-tumor immune responses; conventional and biological therapies; blood and tissue biomarkers
(This special issue belongs to the Section Molecular Oncology)
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